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Crossing the Valley of Death: The Translational Funding and Management Gap Moderator:   Sharon Begley, Science Editor,  Newsweek Panelists: Robi Blumenstein, President, CHDI Management/CHDI Foundation Randall Carpenter, Co-Founder, President and Chief Executive Officer, Seaside Therapeutics Dennis Purcell, Managing Partner, Aisling Capital Amy Comstock Rick, Chief Executive Officer, Parkinson's Action Network Christian Loucq, PATH Malaria Vaccine Initiative
Brain  Developmental Disorders
 
Translating the mGluR Theory into  Novel Therapeutics Scientific Discovery Druggable Targets Efficacy in Model System Candidate Drug IND-enabling Research Human Trials
Seaside Therapeutics Model Venture Philanthropy Seed Funding Core Competency in Translational Medicine Collaborative Business Model Foundations –  FRAXA, Autism Speaks, NFXF Merck & Co, Inc.   –  R&D Collaboration NIH UO1 Translational Research Cooperative Agreement NIMH, NICHD, BPCA, NINDS, FRAXA & Autism Speaks Baylor Medical Center   –  Behavioral Research Vanderbilt University –  Drug Discovery Correlagen Diagnostics –  Companion Diagnostic
Basic  Research  Prototype Design or Discovery Preclinical  Development Clinical Development FDA Filing/ Approval & Launch  Preparation The Development Pipeline and Valley of Death
Basic  Research [Mostly NIH Funded] Prototype Design or Discovery Preclinical  Development Clinical Development [Mostly Large Pharma] FDA Filing/ Approval & Launch  Preparation The Development Pipeline and Valley of Death [Inconsistent  Funding] [Inconsistent  Funding]
The Development Pipeline and Valley of Death Various Solutions Prototype Design or Discovery Preclinical  Development Clinical Development [Mostly Large Pharma] FDA Filing/ Approval & Launch  Preparation Private Foundation Research NIH - SBIR Venture Philanthropy [Inconsistent  Funding] [Inconsistent  Funding] NIH – CTSA’s TATRC Basic  Research [Mostly NIH Funded] TRND

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Valley of Death Panel Slides at the Partnering for Cures Conference, December 2, 2009

  • 1. Crossing the Valley of Death: The Translational Funding and Management Gap Moderator: Sharon Begley, Science Editor, Newsweek Panelists: Robi Blumenstein, President, CHDI Management/CHDI Foundation Randall Carpenter, Co-Founder, President and Chief Executive Officer, Seaside Therapeutics Dennis Purcell, Managing Partner, Aisling Capital Amy Comstock Rick, Chief Executive Officer, Parkinson's Action Network Christian Loucq, PATH Malaria Vaccine Initiative
  • 3.  
  • 4. Translating the mGluR Theory into Novel Therapeutics Scientific Discovery Druggable Targets Efficacy in Model System Candidate Drug IND-enabling Research Human Trials
  • 5. Seaside Therapeutics Model Venture Philanthropy Seed Funding Core Competency in Translational Medicine Collaborative Business Model Foundations – FRAXA, Autism Speaks, NFXF Merck & Co, Inc. – R&D Collaboration NIH UO1 Translational Research Cooperative Agreement NIMH, NICHD, BPCA, NINDS, FRAXA & Autism Speaks Baylor Medical Center – Behavioral Research Vanderbilt University – Drug Discovery Correlagen Diagnostics – Companion Diagnostic
  • 6. Basic Research Prototype Design or Discovery Preclinical Development Clinical Development FDA Filing/ Approval & Launch Preparation The Development Pipeline and Valley of Death
  • 7. Basic Research [Mostly NIH Funded] Prototype Design or Discovery Preclinical Development Clinical Development [Mostly Large Pharma] FDA Filing/ Approval & Launch Preparation The Development Pipeline and Valley of Death [Inconsistent Funding] [Inconsistent Funding]
  • 8. The Development Pipeline and Valley of Death Various Solutions Prototype Design or Discovery Preclinical Development Clinical Development [Mostly Large Pharma] FDA Filing/ Approval & Launch Preparation Private Foundation Research NIH - SBIR Venture Philanthropy [Inconsistent Funding] [Inconsistent Funding] NIH – CTSA’s TATRC Basic Research [Mostly NIH Funded] TRND