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Drugs used in congestive Heart failure
→ When a heart fails to pump blood in a quantity sufficient to fulfill the body requirements a
condition of Congestive Heart Failures.
→ Also Known as heart failure.
CHF due to
Narrowing of arteries
Congenital Heart defects Infection or defect in heart valve
➤Myocarditis (Infection of heart muscles)
➤ Cardiomyopathy (disease of heart muscles)
Symptoms
● Fatique
● Swelling or odema
● Shortness of breath
● Increased Urination.
Classification
1) Drugs with Positive Inotropic Effects:
● Cardiac glycosides: Digoxin, Digitoxin, Oubain.
● Bipyridines Or Phosphodiestrase Inhibitors: Amrinone, Milrinone.
● B adrenergic agonist: Dobutamine, Dopamine.
2) Drugs without Positive Inotropic Effects:
● Diuretics: Chlorothiazides, Furosemide, spironollectone.
● ACEI: Captopril, ramipril.
● B Blockers: Atenolol, propranolol.
● Vasodilators: Nitrates, Hydralazine.
Pharmacological Action:
● Heart: They Provide strength the heart muscles and increase the contraction force of
heart.
● Kidney: They Increase the blood flow to the kidney this increase urination and relifes
odema patient with cardiac odema
● Effect on CNS: Digitalis may produced symptoms of visual disturbances such as
blurring of vision etc.
● They cause Vasodilation.
Indications
● They are used to treat Congestive heart failure.
● Circulatory Shock
● Cardiac Arrhythmia etc.
Contraindications
● Hypersensitivity
● Hypokalamia
● Pulmonic Valve disease
● Aortic Diseases
Doses
● Milrinone: (0.375mcg/kg/min) maximum 1.13 mg kg/d.
● Amrinone (5-15mcg/kg/min) maximum 10mg/d.
● Dobutamine (2.5-10mcg/kg/min) maximum 40 mcg/kg In divided dose Dopamine
(0.2-1mg/kg/min) maxm. 300-1200 mg in divided dose.
Drug Therapy For Shock
→ Shock is a condition in which our body cells does not get proper amount of oxygen (Hypoxia)
→ Which result in decreasement in tissue perfusion
Oxygen (02)-Tissue Perfusion-Cell Death-Organ Damage-Like Heart etc.....
Classification
1) Sympathomimetics Amines: Dobutamines, Adrenaline
2) a-adrenorecptor blocking agent: Pentolamine, Phenoxybenzamine.
3) Dextrox: Vasodilators, Diuretics.
Pharmacological Action
● Increase in Heart Rate
● Increase in Cardiac output
● Increase in Positive Inotropic effect
Indication
● It is used to treat shock.
● It is used to treat septic shocks (due to infection)
● It is used to treat CHF
Contraindication
● Severe Hypertension.
● Hypokalamia
● Myocarditis
● Arrhythmias.
Doses
● Dopamine 0.2-1 mg/kg/min
● Dobutamine 2.5-10 mg/kg/min

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Unit 5th topic Drugs used in congestive Heart failure and shock.pdf

  • 1. Drugs used in congestive Heart failure → When a heart fails to pump blood in a quantity sufficient to fulfill the body requirements a condition of Congestive Heart Failures. → Also Known as heart failure. CHF due to Narrowing of arteries Congenital Heart defects Infection or defect in heart valve ➤Myocarditis (Infection of heart muscles) ➤ Cardiomyopathy (disease of heart muscles) Symptoms ● Fatique ● Swelling or odema ● Shortness of breath ● Increased Urination. Classification 1) Drugs with Positive Inotropic Effects: ● Cardiac glycosides: Digoxin, Digitoxin, Oubain. ● Bipyridines Or Phosphodiestrase Inhibitors: Amrinone, Milrinone. ● B adrenergic agonist: Dobutamine, Dopamine. 2) Drugs without Positive Inotropic Effects: ● Diuretics: Chlorothiazides, Furosemide, spironollectone. ● ACEI: Captopril, ramipril. ● B Blockers: Atenolol, propranolol. ● Vasodilators: Nitrates, Hydralazine.
  • 2. Pharmacological Action: ● Heart: They Provide strength the heart muscles and increase the contraction force of heart. ● Kidney: They Increase the blood flow to the kidney this increase urination and relifes odema patient with cardiac odema ● Effect on CNS: Digitalis may produced symptoms of visual disturbances such as blurring of vision etc. ● They cause Vasodilation. Indications ● They are used to treat Congestive heart failure. ● Circulatory Shock ● Cardiac Arrhythmia etc. Contraindications ● Hypersensitivity ● Hypokalamia ● Pulmonic Valve disease ● Aortic Diseases Doses ● Milrinone: (0.375mcg/kg/min) maximum 1.13 mg kg/d. ● Amrinone (5-15mcg/kg/min) maximum 10mg/d. ● Dobutamine (2.5-10mcg/kg/min) maximum 40 mcg/kg In divided dose Dopamine (0.2-1mg/kg/min) maxm. 300-1200 mg in divided dose.
  • 3. Drug Therapy For Shock → Shock is a condition in which our body cells does not get proper amount of oxygen (Hypoxia) → Which result in decreasement in tissue perfusion Oxygen (02)-Tissue Perfusion-Cell Death-Organ Damage-Like Heart etc..... Classification 1) Sympathomimetics Amines: Dobutamines, Adrenaline 2) a-adrenorecptor blocking agent: Pentolamine, Phenoxybenzamine. 3) Dextrox: Vasodilators, Diuretics. Pharmacological Action ● Increase in Heart Rate ● Increase in Cardiac output ● Increase in Positive Inotropic effect Indication ● It is used to treat shock. ● It is used to treat septic shocks (due to infection) ● It is used to treat CHF Contraindication ● Severe Hypertension. ● Hypokalamia ● Myocarditis ● Arrhythmias. Doses ● Dopamine 0.2-1 mg/kg/min ● Dobutamine 2.5-10 mg/kg/min