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Geetha Manjunath, PhD
Founder and CEO
NIRAMAI Health Analytix
Taking an idea to a Product in Health
diagnostics
2
Breast Cancer - Leading Cause of Cancer Deaths in Women
Women develop a breast abnormality
in their lifetime
684,000
Deaths in 2020
1 in 12
Early Detection is key to survival!
2.2 Million new cases
Asia
346,009 cases
50.5%
Breast Ultrasound
• Correlation modality
• Subjective, highly trained
professionals required to
perform and interpret
• PCPNDT act limits
portability and use for
community screening
Mammography
• High cost of equipment and
infrastructure
• High-skilled, human resource
intensive
• Uncomfortable experience
• Reduced sensitivity in dense
breasts - 62% to 68%
Clinical Breast Examination
• Low sensitivity of
28% to 54%
• Detects only palpable
lumps > 2 cm
• Subjective – dependent on
the skill of the personnel
Gaps in Current modalities
Radiation-free Infrared Imaging
4
Abnormal Tissue Thermal Image
Several advantages, but
 Difficult to interpret
 Subjective Opinion
 Error Prone
 Not a standard modality
Thermal Sensor
Thermal
Sensor
NIRAMAI
Thermalytix
Software
✔ Automated
✔ Real time
✔ Affordable
✔ Accurate
✔ Highly Sensitive
✔ Early Detection
✔ Portable
✔ Safe
✔ Non-invasive
Thermalytix – A New Approach
Instead of looking for lumps, we look for abnormal activity.
Thermal
Sensor
NIRAMAI
Thermalytix
Software
✔ Automated
✔ Real time
✔ Affordable
✔ Accurate
✔ Highly Sensitive
✔ Early Detection
✔ Portable
✔ Safe
✔ Non-invasive
31 International patents
(11 US granted patents)
Thermalytix – A New Approach
Our Innovation
A Novel Cancer Screening Test
that is Affordable, Accessible, Safe and
Works for women of all age groups and
breast densities.
+ No see. No touch.
NIRAMAI Thermalytix™
Privacy-Aware, Early-Stage Breast Cancer Detection
8
Powered by Artificial Intelligence
 Can detect cancer much before a lump is felt
 Works for women of all ages, and men too!
 No Radiation
 Affordable
 Portable, light, small screening device
 Non-contact, Non-invasive, Privacy Aware
No Touch
No See
No Pain
No Radiation
Watch this demo video here
6
Thermalytix : Computer Aided Analysis using AI/ML
11
Thermalytix
Automatic Generation of Thermal Analysis Report
Reviewed by Trained Radiologist
12 Thermalytix 360
Regulatory Approvals Quality certifications
March 27, 2022
13
India All Countries in Europe
Many in Asian & African
International Quality
Standard
QMS for Canada,
US, Japan,
Australia, Brazil
EU Cybersecurity
Compliance
Compliant with
EU GDPR
510(k) clearance for
SMILE-100
Philippines
Kenya
UAE
Thermalytix™ - Clinically Validated
Latest list of publications available at
http://niramai.com/publications
42 International Peer Reviewed Publications
Screening Sensitivity : 100 %
False Positive Rate : 7.6 %
0
10
20
30
40
50
60
70
80
90
100
Sensitivity Specificity
NIRAMAI Thermalytix
Overall Asymptomatic Symptomatic
Ref: Observational Study to Evaluate the Clinical Efficacy of Thermalytix for
Detecting Breast Cancer in Symptomatic and Asymptomatic Women, ASCO
JCO, Oct 2020
Higher sensitivity than Mammography
Comparison
with
Mammography
Higher sensitivity than 2D Mammography
15
Reference: [9]
Thermalytix™
generated
Patient Report
Five thermal
image views
The Product : A Cloud Service / SaaS
Cloud Hosted
GDPR Compliant
16
Deployed in 200+ Hospitals in India 10000+ Outreach camps
Private Screening @ Home
170,000+ women screened
Commercial in India, Kenya,
UAE, Philippines, Turkey,
Sweden, Bulgaria, USA
Customers and Partners (India)
Hospitals
Outreach Partners
Corporate Customers
Testimonials from corporates
and end users
“A very good initiative for
creating awareness and early
detection of disease. The
experience is very
overwhelming and
satisfactory.” – Prerna
“Keep up the good work and
help women lead a cancer
free life :) “ – Deepti Saini
“It is an amazing experience from
the last test I did and works on body
heat. While the last one was a
painful experience. It should be
encouraged in every place for all
women to take care of their health”
– Ingrid
“It was very convenient and
comfortable. Very good experience.”
– Bhavya
“Thank you so much for
conducting this camp in our
offices. I heard great feedback
from most of the employees.
Everybody was very appreciative
of the team and the technology
used by Niramai. Great Going!” –
Corporate 1
“Great technology – completely
non invasive and very
comfortable”
“Very nicely organised and fast
process”
“Thank you for providing this
service in our office facility &the
staff was helpful and instructions
very clear.” – Corporate 2
Adopted as State level screening by Punjab for all Districts
Rural camps
Flexible Deployment Options
District Hospital
HUB
SPOKE
PHC
SPOKE
PHC
SPOKE
PHC
Sub-
centre
SPOKE
PHC
Sub-
centre
Sub-
centre
One Thermalytix
device can service
multiple PHCs + DH
as it is portable
Can also be deployed
inside a mobile
medical unit
Africa
23
Philippines
Making Breast Screening Accessible
Mythri
• Low-cost Mobile based Breast Cancer Screening
• Affordable solution for rural camps, PHCs
• For Private Clinics, Gyneacologists
• Future use – Selfie At Home Device
Niramai Pod
• Instant Reporting
• For non-clinical venues
Niramai Confidential 25
Mythri Device
Mobile Medical Unit – Privacy Aware Instant Reporting
26
Go to Market Channels
27
Clinical / B2B2C
 Hospitals
 Primary Care
 Wellness Clinics
 OBG Gynecologists
Outreach / B2B2C
 Government
 Employee Wellness
 Pharma Companies
 Insurance
B2C
 Direct-to-Home
 Mobile Selfie (WIP)
A Universal Cancer Screening Test
Addressing the accuracy gap in dense breasts
Better Patient Experience
Improving Affordability
and Accessibility
Creating a breakthrough in breast cancer screening
My Key Learnings
2018
2017 2019 2020 2022
2021
Monolithic
Architecture
(1) Improve ML
classification
(2) Migration to Python
(3) DL for segmentation
(4) Quality Checks
Algo 1 Algo 2 Algo 4 + B-Score
(1) Improve ML
classification
(2) Migration to Python
(3) DL for Tagging
(4) Health Risk
Assessment
(1) Improve ML
classification
(2) Migration to Python
(3) SMILE-100
(4) Explore
Containerization
Scalability
(1) Improve ML
classification
(2) Containerize ML
Services
(3) SMILE-100
(4) Containerization
(5) MaThAI
(1) Improve ML
classification
(2) Containerize ML
Services
(3) MaThAI
(4) Cost Optimization
50% Cost Reduction
Sens + Spec: 1.58 Sens + Spec: 1.65
Algo 3
Sens + Spec: 1.72
Algo 4
Sens + Spec: 1.72
Sens + Spec: 1.72 Sens > 95%
Algo 4 + B-Score Algo 4 + B-Score
Sens > 95%,
Personalized Risk
2 Granted Patents 6 Granted Patents 10 Granted Patents 15 Granted Patents 24 Granted Patents 30 Granted Patents
Product Improvements over time
Hard Lessons Learnt
Adequate Performance Testing
Appropriate Reference as comparator
Prospective, Blinded Studies by
independent parties
Real World Field Study
Pilot Studies on intended population
Regulatory Clearances
Intended Use and Claims
Explainability for Upstream Workflow
Health Economics
Improving Access = Affordability +
Acceptability + Availability
Soft Lessons Learnt
 Passion
 Don’t be afraid
 Dream Big. Everything is Possible
 Hard work and Perseverance
 Fail early
 Teamwork & Collaboration
 Learn one new thing everyday…..
Saving Many Lives … with AI
geetha@niramai.com

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"Taking an idea to a Product in Health diagnostics" by Dr. Geetha Manjunath, Niramai Health Analytix

  • 1. Geetha Manjunath, PhD Founder and CEO NIRAMAI Health Analytix Taking an idea to a Product in Health diagnostics
  • 2. 2 Breast Cancer - Leading Cause of Cancer Deaths in Women Women develop a breast abnormality in their lifetime 684,000 Deaths in 2020 1 in 12 Early Detection is key to survival! 2.2 Million new cases Asia 346,009 cases 50.5%
  • 3. Breast Ultrasound • Correlation modality • Subjective, highly trained professionals required to perform and interpret • PCPNDT act limits portability and use for community screening Mammography • High cost of equipment and infrastructure • High-skilled, human resource intensive • Uncomfortable experience • Reduced sensitivity in dense breasts - 62% to 68% Clinical Breast Examination • Low sensitivity of 28% to 54% • Detects only palpable lumps > 2 cm • Subjective – dependent on the skill of the personnel Gaps in Current modalities
  • 4. Radiation-free Infrared Imaging 4 Abnormal Tissue Thermal Image Several advantages, but  Difficult to interpret  Subjective Opinion  Error Prone  Not a standard modality Thermal Sensor
  • 5. Thermal Sensor NIRAMAI Thermalytix Software ✔ Automated ✔ Real time ✔ Affordable ✔ Accurate ✔ Highly Sensitive ✔ Early Detection ✔ Portable ✔ Safe ✔ Non-invasive Thermalytix – A New Approach
  • 6. Instead of looking for lumps, we look for abnormal activity. Thermal Sensor NIRAMAI Thermalytix Software ✔ Automated ✔ Real time ✔ Affordable ✔ Accurate ✔ Highly Sensitive ✔ Early Detection ✔ Portable ✔ Safe ✔ Non-invasive 31 International patents (11 US granted patents) Thermalytix – A New Approach
  • 7. Our Innovation A Novel Cancer Screening Test that is Affordable, Accessible, Safe and Works for women of all age groups and breast densities. + No see. No touch.
  • 8. NIRAMAI Thermalytix™ Privacy-Aware, Early-Stage Breast Cancer Detection 8 Powered by Artificial Intelligence  Can detect cancer much before a lump is felt  Works for women of all ages, and men too!  No Radiation  Affordable  Portable, light, small screening device  Non-contact, Non-invasive, Privacy Aware
  • 9. No Touch No See No Pain No Radiation
  • 10. Watch this demo video here 6
  • 11. Thermalytix : Computer Aided Analysis using AI/ML 11 Thermalytix
  • 12. Automatic Generation of Thermal Analysis Report Reviewed by Trained Radiologist 12 Thermalytix 360
  • 13. Regulatory Approvals Quality certifications March 27, 2022 13 India All Countries in Europe Many in Asian & African International Quality Standard QMS for Canada, US, Japan, Australia, Brazil EU Cybersecurity Compliance Compliant with EU GDPR 510(k) clearance for SMILE-100 Philippines Kenya UAE
  • 14. Thermalytix™ - Clinically Validated Latest list of publications available at http://niramai.com/publications 42 International Peer Reviewed Publications Screening Sensitivity : 100 % False Positive Rate : 7.6 % 0 10 20 30 40 50 60 70 80 90 100 Sensitivity Specificity NIRAMAI Thermalytix Overall Asymptomatic Symptomatic Ref: Observational Study to Evaluate the Clinical Efficacy of Thermalytix for Detecting Breast Cancer in Symptomatic and Asymptomatic Women, ASCO JCO, Oct 2020
  • 15. Higher sensitivity than Mammography Comparison with Mammography Higher sensitivity than 2D Mammography 15 Reference: [9]
  • 16. Thermalytix™ generated Patient Report Five thermal image views The Product : A Cloud Service / SaaS Cloud Hosted GDPR Compliant 16
  • 17. Deployed in 200+ Hospitals in India 10000+ Outreach camps Private Screening @ Home 170,000+ women screened Commercial in India, Kenya, UAE, Philippines, Turkey, Sweden, Bulgaria, USA
  • 18. Customers and Partners (India) Hospitals Outreach Partners Corporate Customers
  • 19. Testimonials from corporates and end users “A very good initiative for creating awareness and early detection of disease. The experience is very overwhelming and satisfactory.” – Prerna “Keep up the good work and help women lead a cancer free life :) “ – Deepti Saini “It is an amazing experience from the last test I did and works on body heat. While the last one was a painful experience. It should be encouraged in every place for all women to take care of their health” – Ingrid “It was very convenient and comfortable. Very good experience.” – Bhavya “Thank you so much for conducting this camp in our offices. I heard great feedback from most of the employees. Everybody was very appreciative of the team and the technology used by Niramai. Great Going!” – Corporate 1 “Great technology – completely non invasive and very comfortable” “Very nicely organised and fast process” “Thank you for providing this service in our office facility &the staff was helpful and instructions very clear.” – Corporate 2
  • 20. Adopted as State level screening by Punjab for all Districts
  • 22. Flexible Deployment Options District Hospital HUB SPOKE PHC SPOKE PHC SPOKE PHC Sub- centre SPOKE PHC Sub- centre Sub- centre One Thermalytix device can service multiple PHCs + DH as it is portable Can also be deployed inside a mobile medical unit
  • 24. Making Breast Screening Accessible Mythri • Low-cost Mobile based Breast Cancer Screening • Affordable solution for rural camps, PHCs • For Private Clinics, Gyneacologists • Future use – Selfie At Home Device Niramai Pod • Instant Reporting • For non-clinical venues
  • 26. Mobile Medical Unit – Privacy Aware Instant Reporting 26
  • 27. Go to Market Channels 27 Clinical / B2B2C  Hospitals  Primary Care  Wellness Clinics  OBG Gynecologists Outreach / B2B2C  Government  Employee Wellness  Pharma Companies  Insurance B2C  Direct-to-Home  Mobile Selfie (WIP) A Universal Cancer Screening Test
  • 28. Addressing the accuracy gap in dense breasts Better Patient Experience Improving Affordability and Accessibility Creating a breakthrough in breast cancer screening
  • 30. 2018 2017 2019 2020 2022 2021 Monolithic Architecture (1) Improve ML classification (2) Migration to Python (3) DL for segmentation (4) Quality Checks Algo 1 Algo 2 Algo 4 + B-Score (1) Improve ML classification (2) Migration to Python (3) DL for Tagging (4) Health Risk Assessment (1) Improve ML classification (2) Migration to Python (3) SMILE-100 (4) Explore Containerization Scalability (1) Improve ML classification (2) Containerize ML Services (3) SMILE-100 (4) Containerization (5) MaThAI (1) Improve ML classification (2) Containerize ML Services (3) MaThAI (4) Cost Optimization 50% Cost Reduction Sens + Spec: 1.58 Sens + Spec: 1.65 Algo 3 Sens + Spec: 1.72 Algo 4 Sens + Spec: 1.72 Sens + Spec: 1.72 Sens > 95% Algo 4 + B-Score Algo 4 + B-Score Sens > 95%, Personalized Risk 2 Granted Patents 6 Granted Patents 10 Granted Patents 15 Granted Patents 24 Granted Patents 30 Granted Patents Product Improvements over time
  • 31. Hard Lessons Learnt Adequate Performance Testing Appropriate Reference as comparator Prospective, Blinded Studies by independent parties Real World Field Study Pilot Studies on intended population Regulatory Clearances Intended Use and Claims Explainability for Upstream Workflow Health Economics Improving Access = Affordability + Acceptability + Availability
  • 32. Soft Lessons Learnt  Passion  Don’t be afraid  Dream Big. Everything is Possible  Hard work and Perseverance  Fail early  Teamwork & Collaboration  Learn one new thing everyday…..
  • 33. Saving Many Lives … with AI geetha@niramai.com