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HLB SCALE

The document provides information about short term training conducted at Oniosome Healthcare Pvt. Ltd., including topics covered such as calibration of glassware, determination of melting point and solubility of drugs, determination of hydrophilic-lipophilic balance (HLB) value, thin layer chromatography, high performance liquid chromatography, friability, dissolution, disintegration, and UV spectroscopy. It then discusses the definition of HLB value, how it indicates the polarity of surfactant molecules on a scale of 1-40, and how lipophilic and hydrophilic portions of surfactant molecules affect oil and water solubility. Finally, it outlines methods for determining HLB values and requirements, and applications of surfactants based

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BRIEF PRESENTATION of SHORT TERMTRAINING at ONIOSOME HEALTHCARE PVT.LTD. MOHALI PRESENTED BY : DHRITIMAN BHARGAB B.PHARMA MUR1600162 ROLL NO. 160100960013
TRAINING PERIOD : 03rd June to 03rd July 2019 WHATI DIDIN MY TRAININGPERIOD: TOPICS : Calibration of glasswares, Determined the melting point and solubility of given drugs, Determination of HLB value, TLC, HPLC, Friability, Dissolution, Disintegration, UV spectroscopy, Prepared acid buffer solution and sodium alginate beeds…………………
DETERMINATION OF HYDROPHILIC –LIPHOPHILIC BALANCE VALUE
INTRODUCTION In past fifty years, there has been a tremendous growth in the field of surfactants. The term surfactants include emulsifiers, wetting agents, suspending agents, detergents, anti-foam compounds and many others.  Therefore, there classification is very important to choose suitable surfactant to give maximum effect. William Griffin, in the late 1940s, introduced the Hydrophilic-Lipophilic Balance system (HLB) as a way of figuring out which emulsifier would work best with the oil phase of an emulsified product
DEFINITION: It is the relative efficiency of the hydrophilic portion of the surfactant molecule to its lipophilic portion of the same molecule . Emulsifiers / Surfactants are characterized according to the "balance" between the hydrophilic ("water-loving") and lipophilic ("oil-loving") portions of their molecules. An emulsifier that is lipophilic in character is assigned a low HLB number and an emulsifier that is hydrophilic in character is assigned a high number.
The midpoint is approximately ten and the assigned values have ranged from one to forty. The hydrophilic-lipophilic balance (HLB) number indicates the polarity of the molecules in a range of 1-40, with the most commonly used emulsifiers having a value between 1 and 20. The HLB number increases with increasing hydrophilicity. Lipophilic tails align with oil Hydrophilic heads align with water
Lipophilic Tail & Hydrophilic Head  The theory behind HLB is that emulsifier having low HLB value tend to be oil soluble and materials having high values tend to be water soluble.  However, this doesn’t always be right, e.g., two emulsifiers may have the same HLB and exhibit different solubility characteristics.  Further, one should take a point into consideration that chemical type alone doesn’t establish hydrophilic-lipophilic balance.  Thus, soaps may range from strongly hydrophilic for sodium laurate to strongly lipophilic for aluminium oleate; esters, ether-esters, and ethers may range from low to high HLB’s, sulphates and sulfonates may range from medium to high.
Determination of HLB For most polyhydric alcohol fatty acid esters approximate values may be calculated with the formula: Where, • S= saponification number of the ester • A= acid number of the acid
Determination of HLB “Requirement” The desired HLB numbers can also be achieved by mixing lipophilic and hydrophilic surfactants.  William Griffin devised HLB System to calculated amount of emulsifier to get the desired HLB.
hlb scale :
Applications of Surfactants depending on HLB The HLB system is very useful to distinguish the surfactants according to their applications. Generally, the applications for nonionic surfactants within the following HLB ranges are as follows:HLB range Application 4-6 w/o emulsifiers 7-9 wetting agents 8-18 o/w emulsifiers 13-15 Detergents 10-18 Solubilizers
Advantages : Gives stable emulsion. Works best with nonionic surfactants. Disadvantages : HLB is only a good approximation.  Doesn’t always work.
HLB VALUE OF SOME SURFACTANTS :
Let’s conclude by : The HLB system, though it does not indicate the overall efficiency of the surfactant, it does tell “what it will do” i.e. what kind of an emulsion or product to expect. By so doing, it enables us to compare various chemical types of surfactants at their optimum balance. The HLB system appears to be suitable for all types of problems employing surface active agents.
HLB SCALE