Screening models diuretics and analgesics

The document summarizes various in vivo and in vitro screening models used to test analgesics and diuretics. It describes several common in vivo models that use thermal, electrical or chemical stimuli to induce pain in mice or rats, such as the tail flick test, hot plate test, and formalin test. It provides details on procedures, evaluation methods, and principles of selected models, including the tail immersion test, grid shock test, and monkey shock titration test. The document also briefly mentions some in vitro models like receptor binding assays.