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Scop database

The SCOP database classifies protein structures hierarchically and describes evolutionary relationships between proteins. It was created in 1994 at the Centre for Protein Engineering and is maintained manually. SCOP links to the Protein Data Bank to obtain structural classifications for each protein structure directly and can also be searched to find a protein's structural class, fold, and domain information.

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SCOP Database Sayantani Roy MTCT 2nd Year Jadavpur University
Structural Classification of Proteins (SCOP) • SCOP database describes structural and evolutionary relationship between proteins of known structures. • SCOP was created in 1994 in the Centre for Protein Engineering and the Laboratory of Molecular Biology. It was maintained by Alexey G. Murzin and his colleagues in the centre for protein engineering. • SCOP database is a largely manual classification of protein structures and amino acid sequences. • The SCOP database is freely accessible on the internet.
Structural Classification of Proteins (SCOP) • The source of protein structures is the Protein Data Bank(PDB). SCOP database has been linked from the PDB to obtain the structural class information of each protein directly. • On the other hand, one can search the SCOP database for obtaining the structural class, fold, and domain information
Structural Classification of Proteins (SCOP) SCOP describes protein structures using a hierarchical classification scheme: • Class: Classes based mainly secondary structure contain and organization; e.g., beta sheets. • Fold: Each class contains a number of distinct folds. Folds grouping structurally similar superfamilies; For example, the "All-α proteins" class contains >280 distinct folds • Superfamily: The domains in a fold are grouped into superfamilies, which have at least a distant common ancestor.
Structural Classification of Proteins (SCOP) •SCOP describes protein structures using a hierarchical classification scheme: • Family: The domains in a superfamily are grouped into families, which containing proteins with similar sequences but typically distinct functions. • Protein domain: The domains in families are grouped into protein domains, which is either originated from different biological species or represent different isoforms within the same species. • Species: Species representing a distinct protein sequence and its naturally occurring or artificially created variants. • Domain: part of a protein. For simple proteins, it can be the entire protein.
REFERENCES • https://en.wikipedia.org/wiki/Structural_Classification_of_Proteins_d atabase • https://web.stanford.edu/class/cs273/refs/SCOP_original.pdf • https://www.powershow.com/view/11cef4- NzcwN/SCOP_DATABASE_powerpoint_ppt_presentation
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