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Packaging machine
1
Guided by:
Dr. Lalit Kumar
Department of Pharmaceutics
MCOPS
Manipal Academy of Higher Education
Presented by:
PARAG RAJ BEHURA
Reg. No :190617006
M.Pharm (Industrial Pharmacy)
Department of Pharmaceutics
MCOPS
Manipal Academy of Higher Education
Blister packaging machine
Under blister packaging machine they are classified -:
(i) Thermoforming blistering machine
(ii) Cold form blistering machine
(iii) Thermo-cold complex blistering machine
The essential parts and functions of an intermittently operating packaging machine
include the following;
• The unwinding station: The unwinding station supplies the forming films and
the lidding material at a rate corresponding to the speed of the packaging machine.
2
• The heating station: The heating station raises the temperature of the plastic
forming films to a level suitable for deep drawing. Forming films containing the
polyvinyl chloride (PVC) support material are heated to 120–140 ˚C.
Polypropylene (PP) forming films are heated to140-150 ˚C). Heating station is
present only in thermoform & thermo-cold form blistering machines.
• The forming station: The forming station forms the plastic blister cavities via
compressed air or die plates & in case of cold forming machine via punching
pins.
Punch pins material: TEFLON
• The cooling station: The cooling station cools PP films after the forming
process. Laminates containing PVC or aluminium do not need to be cooled.
3
• The feeding machine: The loading area fills the blister cavities with product.
The feeding machine can be linked, or the product to be packaged can simply be
swept into the blisters.
• The Sealing station: The sealing station heat seals the lidding material to the
forming film that contains the product.
• The printing station: Print or engrave the batch number & expiry date over the
blister.
• Trimming Station: Cuts the blisters into individual unit
4
Thermoforming blistering machine
• In the case of thermoforming, a plastic film or sheet is unwound from the
reel and guided though a pre-heating station on the blister line.
• The temperature of preheating cause the plastic to soften and become
pliable.
• The warm plastic arrive at forming station where pressure of 4 to 8 bar will
form blister cavity into a negative mold .
• The mold is cooled such that the plastic becomes rigid again and maintains
its shape when removed from the mold .
E.g.- ALU-PVC machine
5
Machine operation
Heating the plastic
Thermoforming it into blister cavities
Loading the blister with the product
Placing lidding material over the blister
Heat-sealing the package
6
7
ADVANTAGE
• The basic material used is PVC and polyvinyl chloride, for ease of
thermoforming and low cost .
• The faulty blister card can be rejected via the inspecting camera or naked eyes.
• The feeder used is of low cost and easily operated .
DISADVANTAGE
• The protective properties are not strong because of PVCs poor barrier Against
moisture and oxygen ingress .
• Not suitable for light sensitive drugs because of the transparency of PVC .
8
Cold form blistering machine
• In case of cold forming, an aluminium based laminate film is simply
pressed into a mold by means of a stamp
• The aluminium will be elongated and maintained the formed shape. In
industry these blisters are called cold form foil( CFF) blisters
• Example: ALU-ALU Machine Operation
9
Machine operation
Installing the Aluminium Foil
Cold forming it into blister cavities via punch pins
Loading the blister with the product
Placing lidding material over the blister
heat-sealing the package
Cutting into individual blisters
10
11
ADVANTAGE
• Aluminium offers a near complete barrier for water and oxygen,
allowing an extended product expiry date
DISADVANTAGE
• Slower speed of production
• Package is opaque, making the inspecting system complicated and
costly
• Cost of cold forming aluminum film is higher than PVC
• The larger size of blister card increases the material cost
12
Thermo-cold complex blistering machine
Example: ALU-Tropical Machine Operation
Heating the plastic
Thermoforming it into blister cavities
Loading the blister with the product
Placing lidding material over the blister
Heat-sealing the package
Installing the aluminium foil
Cold forming it into blister Pouch & seal it on thermoformed blister to give extra
protection
Cutting into individual blisters
13
14

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Raj packaging machine

  • 1. Packaging machine 1 Guided by: Dr. Lalit Kumar Department of Pharmaceutics MCOPS Manipal Academy of Higher Education Presented by: PARAG RAJ BEHURA Reg. No :190617006 M.Pharm (Industrial Pharmacy) Department of Pharmaceutics MCOPS Manipal Academy of Higher Education
  • 2. Blister packaging machine Under blister packaging machine they are classified -: (i) Thermoforming blistering machine (ii) Cold form blistering machine (iii) Thermo-cold complex blistering machine The essential parts and functions of an intermittently operating packaging machine include the following; • The unwinding station: The unwinding station supplies the forming films and the lidding material at a rate corresponding to the speed of the packaging machine. 2
  • 3. • The heating station: The heating station raises the temperature of the plastic forming films to a level suitable for deep drawing. Forming films containing the polyvinyl chloride (PVC) support material are heated to 120–140 ˚C. Polypropylene (PP) forming films are heated to140-150 ˚C). Heating station is present only in thermoform & thermo-cold form blistering machines. • The forming station: The forming station forms the plastic blister cavities via compressed air or die plates & in case of cold forming machine via punching pins. Punch pins material: TEFLON • The cooling station: The cooling station cools PP films after the forming process. Laminates containing PVC or aluminium do not need to be cooled. 3
  • 4. • The feeding machine: The loading area fills the blister cavities with product. The feeding machine can be linked, or the product to be packaged can simply be swept into the blisters. • The Sealing station: The sealing station heat seals the lidding material to the forming film that contains the product. • The printing station: Print or engrave the batch number & expiry date over the blister. • Trimming Station: Cuts the blisters into individual unit 4
  • 5. Thermoforming blistering machine • In the case of thermoforming, a plastic film or sheet is unwound from the reel and guided though a pre-heating station on the blister line. • The temperature of preheating cause the plastic to soften and become pliable. • The warm plastic arrive at forming station where pressure of 4 to 8 bar will form blister cavity into a negative mold . • The mold is cooled such that the plastic becomes rigid again and maintains its shape when removed from the mold . E.g.- ALU-PVC machine 5
  • 6. Machine operation Heating the plastic Thermoforming it into blister cavities Loading the blister with the product Placing lidding material over the blister Heat-sealing the package 6
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  • 8. ADVANTAGE • The basic material used is PVC and polyvinyl chloride, for ease of thermoforming and low cost . • The faulty blister card can be rejected via the inspecting camera or naked eyes. • The feeder used is of low cost and easily operated . DISADVANTAGE • The protective properties are not strong because of PVCs poor barrier Against moisture and oxygen ingress . • Not suitable for light sensitive drugs because of the transparency of PVC . 8
  • 9. Cold form blistering machine • In case of cold forming, an aluminium based laminate film is simply pressed into a mold by means of a stamp • The aluminium will be elongated and maintained the formed shape. In industry these blisters are called cold form foil( CFF) blisters • Example: ALU-ALU Machine Operation 9
  • 10. Machine operation Installing the Aluminium Foil Cold forming it into blister cavities via punch pins Loading the blister with the product Placing lidding material over the blister heat-sealing the package Cutting into individual blisters 10
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  • 12. ADVANTAGE • Aluminium offers a near complete barrier for water and oxygen, allowing an extended product expiry date DISADVANTAGE • Slower speed of production • Package is opaque, making the inspecting system complicated and costly • Cost of cold forming aluminum film is higher than PVC • The larger size of blister card increases the material cost 12
  • 13. Thermo-cold complex blistering machine Example: ALU-Tropical Machine Operation Heating the plastic Thermoforming it into blister cavities Loading the blister with the product Placing lidding material over the blister Heat-sealing the package Installing the aluminium foil Cold forming it into blister Pouch & seal it on thermoformed blister to give extra protection Cutting into individual blisters 13
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