Gel electrophoresis is a method used to separate biomolecules like DNA and proteins based on size and charge. It works by applying an electric current to move the charged molecules through a gel matrix. There are two main types of gels used: agarose gels separate larger DNA fragments, while polyacrylamide gels are better for separating smaller DNA and protein molecules. The gel allows visualization of the separated biomolecules which can then be analyzed.
This document summarizes a presentation on discovering inhibitors for the histone-lysine N-methyltransferase SETD2 using an in silico approach. It discusses methyltransferases and histone methyltransferases as a potential target. The hypothesis is that selective, high-affinity SETD2 inhibitors can be identified by targeting its SAM binding site. The methodology involves generating pharmacophore models using software and screening databases of compounds. Results show two pharmacophore models and top-hit compounds identified. The conclusions are that the SETD2 binding site is a potential drug target and compounds with high predicted binding energies were identified. Future work involves refining models and testing top compounds in assays.
The document introduces Aixam's new Coupé model, which will be unveiled for the first time at the 2012 Paris Motor Show. The Coupé is a stylish two-seater addition to Aixam's lineup of no-license vehicles. It has a distinctive coupé-inspired body shape with a sloped roofline and rear spoiler. The Coupé is available in three trim levels and can be personalized with various color and design options. It is constructed with high quality materials and focuses on safety, reliability, and environmental friendliness as with other Aixam models. An electric version of the Coupé will also be shown.
Liberalism & its Effect on Society an Introduction by Hamza Andreas TzortzisAbdullah Bin Ahmad
1. Liberalism emerged in response to specific historical circumstances in Europe, namely religious conflicts between Catholicism and Protestantism. The theorists who developed Liberalism's core values of individualism and rights did so as a temporary solution rather than through rigorous philosophical inquiry.
2. Liberalism's foundation of individualism has been criticized as philosophically flawed because it views humans as isolated from their social contexts and obligations, which does not align with reality.
3. Modern Western societies that embrace Liberal values are exhibiting increasing social problems, indicating Liberalism's values may be contributing to social breakdown rather than cohesion. Research shows the values a society propagates can influence its members' behaviors.
Gel electrophoresis is a method used to separate biomolecules like DNA and proteins based on size and charge. It works by applying an electric current to move the charged molecules through a gel matrix. There are two main types of gels used: agarose gels separate larger DNA fragments, while polyacrylamide gels are better for separating smaller DNA and protein molecules. The gel allows visualization of the separated biomolecules which can then be analyzed.
This document summarizes a presentation on discovering inhibitors for the histone-lysine N-methyltransferase SETD2 using an in silico approach. It discusses methyltransferases and histone methyltransferases as a potential target. The hypothesis is that selective, high-affinity SETD2 inhibitors can be identified by targeting its SAM binding site. The methodology involves generating pharmacophore models using software and screening databases of compounds. Results show two pharmacophore models and top-hit compounds identified. The conclusions are that the SETD2 binding site is a potential drug target and compounds with high predicted binding energies were identified. Future work involves refining models and testing top compounds in assays.
The document introduces Aixam's new Coupé model, which will be unveiled for the first time at the 2012 Paris Motor Show. The Coupé is a stylish two-seater addition to Aixam's lineup of no-license vehicles. It has a distinctive coupé-inspired body shape with a sloped roofline and rear spoiler. The Coupé is available in three trim levels and can be personalized with various color and design options. It is constructed with high quality materials and focuses on safety, reliability, and environmental friendliness as with other Aixam models. An electric version of the Coupé will also be shown.
Liberalism & its Effect on Society an Introduction by Hamza Andreas TzortzisAbdullah Bin Ahmad
1. Liberalism emerged in response to specific historical circumstances in Europe, namely religious conflicts between Catholicism and Protestantism. The theorists who developed Liberalism's core values of individualism and rights did so as a temporary solution rather than through rigorous philosophical inquiry.
2. Liberalism's foundation of individualism has been criticized as philosophically flawed because it views humans as isolated from their social contexts and obligations, which does not align with reality.
3. Modern Western societies that embrace Liberal values are exhibiting increasing social problems, indicating Liberalism's values may be contributing to social breakdown rather than cohesion. Research shows the values a society propagates can influence its members' behaviors.
This document provides quotes from classical Islamic scholars highlighting the importance and obligation of the Khilafah. The scholars state that the Khilafah is necessary to implement Islam, maintain security, administer justice, and defend the Muslim lands and people. They argue that there must be a single leader to fulfill these vital responsibilities, and that appointing a Khaleefah is an obligation upon Muslims according to the Quran and Sunnah. The document aims to remind Muslims of the critical role of the Khilafah system as understood by early Islamic scholars.
This document discusses the nature and principles of Islam as a way of life. It explains that early Islamic scholars viewed the Quran and teachings of Prophet Muhammad as providing guidance for all aspects of life, including political and economic matters. It argues that Islam establishes a holistic system that addresses both individual and societal issues, and which was perfectly suited for its time. The document emphasizes that Muhammad should be seen as the sole authority and example for Muslims, as he embodied compassion and wisdom that can guide people of all eras.
The essential elements of the islamic disposition nafsiyyahAbdullah Bin Ahmad
The document discusses the importance of having an Islamic personality composed of both an Islamic mentality and Islamic behavioral disposition. It emphasizes that one must adhere to the rules of the Shariah in both thought and action to truly have an Islamic personality. The document is intended to remind Da'wah carriers of essential Islamic elements as they work to establish the Khilafah, including hastening to adhere to the Shariah in all matters.
Introducing the literary and linguistic excellence of the qur’anAbdullah Bin Ahmad
This document discusses the immense impact of the Quran on global politics and billions of individuals throughout history. It argues that the Quran presents a unique paradigm of social and political thought that was previously unknown. The document also highlights the Quran's literary excellence, describing it as a new genre of speech that was able to transform disparate Arab tribes into a unified civilization. It provides perspectives from various scholars on the Quran's sublime rhetoric, richly varied rhythms, and ability to convey concepts in a profound and inimitable way.
1) Many arguments against the existence of a creator such as scientific, moral and logical arguments are flawed because they assume science can study everything and apply human attributes to God.
2) Things in the universe cannot change form or function without external factors imposing rules, showing things are controlled by a creator rather than merely being matter.
3) Problems in the world are man-made, not the fault of God, and cult-like theories with no evidence should not be accepted as truth.
4) Rational thinking using our senses and minds leads to the inevitable conclusion that all things rely on external factors and laws, indicating they were created by something outside of themselves.
This document provides an introduction to Islamic jurisprudence (fiqh) and its methodology (usul al-fiqh). It defines key terms like fiqh, shariah, hukm sharii, and the sources of Islamic law. It encourages Muslims to work together to establish an Islamic state (al-Khilafah) that implements shariah fully and benefits all people. It aims to develop a cohesive understanding of usul al-fiqh among Muslims.
This document provides quotes from classical Islamic scholars highlighting the importance and obligation of the Khilafah. The scholars state that the Khilafah is necessary to implement Islam, maintain security, administer justice, and defend the Muslim lands and people. They argue that there must be a single leader to fulfill these vital responsibilities, and that appointing a Khaleefah is an obligation upon Muslims according to the Quran and Sunnah. The document aims to remind Muslims of the critical role of the Khilafah system as understood by early Islamic scholars.
This document discusses the nature and principles of Islam as a way of life. It explains that early Islamic scholars viewed the Quran and teachings of Prophet Muhammad as providing guidance for all aspects of life, including political and economic matters. It argues that Islam establishes a holistic system that addresses both individual and societal issues, and which was perfectly suited for its time. The document emphasizes that Muhammad should be seen as the sole authority and example for Muslims, as he embodied compassion and wisdom that can guide people of all eras.
The essential elements of the islamic disposition nafsiyyahAbdullah Bin Ahmad
The document discusses the importance of having an Islamic personality composed of both an Islamic mentality and Islamic behavioral disposition. It emphasizes that one must adhere to the rules of the Shariah in both thought and action to truly have an Islamic personality. The document is intended to remind Da'wah carriers of essential Islamic elements as they work to establish the Khilafah, including hastening to adhere to the Shariah in all matters.
Introducing the literary and linguistic excellence of the qur’anAbdullah Bin Ahmad
This document discusses the immense impact of the Quran on global politics and billions of individuals throughout history. It argues that the Quran presents a unique paradigm of social and political thought that was previously unknown. The document also highlights the Quran's literary excellence, describing it as a new genre of speech that was able to transform disparate Arab tribes into a unified civilization. It provides perspectives from various scholars on the Quran's sublime rhetoric, richly varied rhythms, and ability to convey concepts in a profound and inimitable way.
1) Many arguments against the existence of a creator such as scientific, moral and logical arguments are flawed because they assume science can study everything and apply human attributes to God.
2) Things in the universe cannot change form or function without external factors imposing rules, showing things are controlled by a creator rather than merely being matter.
3) Problems in the world are man-made, not the fault of God, and cult-like theories with no evidence should not be accepted as truth.
4) Rational thinking using our senses and minds leads to the inevitable conclusion that all things rely on external factors and laws, indicating they were created by something outside of themselves.
This document provides an introduction to Islamic jurisprudence (fiqh) and its methodology (usul al-fiqh). It defines key terms like fiqh, shariah, hukm sharii, and the sources of Islamic law. It encourages Muslims to work together to establish an Islamic state (al-Khilafah) that implements shariah fully and benefits all people. It aims to develop a cohesive understanding of usul al-fiqh among Muslims.