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Probiotics

The document discusses probiotics, defined as live microorganisms that confer health benefits when administered adequately. It covers their history, importance in human health, various strains, mechanisms of action, advantages, classification, and commercial examples, emphasizing their role in gut health and cancer prevention. Additionally, it highlights the distinction between probiotics and antibiotics, detailing the potential downsides and the status of probiotics in India.

Healthcare◦
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Probiotics :The friendly microbial consortia Anirban Chakrabarty 3rd yr; Microbiology(Hons) Email: anirbanchakrabarty1996@gmail.com
Presentation layout  Introduction.  History of probiotics.  General characteristics of probiotics.  Why are probiotics important to human health?  Some probiotics strains.  Mechanism of action  Advantages of host and type of advantages.  Classification of probiotics and examples.  Probiotics but not antibiotics, explanation with AAD.  Some probiotic food.  Probiotics and cancer.  Disadvantages of probiotics  Status of probiotics in india  India and global probiotics manufactures.
What are Probiotics? “Live microorganisms which when administered in adequate amounts confer a health benefit on the host "as defined by WHO. •WHY PROBIOTICS? Antibiotic therapy kills both pathogenic and beneficial bacteria, thus affecting digestion and growth.  For non antibiotic disease prevention microbiologist turned to PROBIOTICS so called because they complete and throw out rather than kill bad bacteria as antibiotic would do.
• In 1907 Metchnikoff proposed that the acid producing bacteria in fermented milk products could prevent “fouling” in the large intestine and if consumed regularly, lead to a longer, healthier life.
Characteristics of Effective Probiotics • Able to survive the passage through the digestive system. • Able to attach to the intestinal epithelia of the host . • Colonization at the GI tract and shows antimicrobial property. • Be easily cultured. • Able to maintain good viability. • Able to utilize the nutrients and substrates in a normal diet. • non pathogenic and non toxic. • Capable of exerting a beneficial effect on the host. • Stability of desired characteristics during processing, storage and transportation. • Withstand with HCl in the stomach and bile salt in the intestine. • Anti-inflammatory, antimutagenic, immunostimulatory, anticarcinogenic activity(reduction of carcinogens) in clinical trails.
Probiotic strains Lactobacillus species- • L. acidophilus • L. plantarum • L. casei subspecies rhamnosus • L. brevis • L. delbreuckii subspecies bulgaricus Bifidobacterium species- • B. adolescentis • B. bifidum • B. longum • B. infantis • B. breve Others –  Streptococcus salivarius ssp. thermophilus Lactococcus lactis ssp. lactis Lactococcus lactis s ssp. cremoris Enterococcus faecium Leuconostoc mesenteroides ssp. dextranicum Propionibacterium freudenreichii Pediococcus acidilactici Saccharomyces boulardii
Mechanism of action
Advantages and benefits of host
Type of advantages
Classification of probiotics (wrt to their commercial application) Feed probiotics Water probiotics Soil probiotics Gut probiotics
Examples of the commercial feed probiotics
Some examples of commercial water probiotics
Examples of some SBOs strains
Some commercial gut probiotics Name of the company or industry Commercial name of the probiotics Composition of the probiotics Benefits from the probiotics 1. GROWEL FORMULATIONS PVT. LTD. Hyderabad-50039 BIOLACT BIOLACT contains starch, protein, fat digestive enzymes a mixture of various probiotics -> Lactobacillus sp., Saccharomyces, Streptococcus lactis and various vitamins Contains high amount of vit –c which acts as antioxidant, improves immunity . 2.SYNGERY BIOTECHNOLOGIES Hyderabad-500076 LACTOPLUS Lactic acid bacillus,.It is a source of mineral, amino acids and vitamin like thiamine ,riboflavin, vit-A,B-12, vit-E. These bacteria displace pathogens by competitive process which is better than antibiotics and these produce bacteriocins.
Probiotics but not antibiotics
Antibiotic Associated Diarrhea Disease Antibiotic treatment Disturbance of gut microbiota Clostridium overgrowth produces toxins Probiotics Diarrhea Balance Microbiota
Examples of Probiotic foods
Probiotics and Cancer Probiotics 20  Oligofructose plus two probiotic strains (L. acidophilus and L. casei) supplementation in humans helped to decrease levels of these gut flora enzymes.  Probiotics reduce absorption of harmful mutagens that may contribute to colon carcinogenesis. 20 Enzymes of Gut Flora Glycosidase β- glucuronidase Azoreductase Nitroreductase
Disadvantages
Thank you for your attention.