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Diondra Eka Rizkiawan
Malinda Evelyn
Kevin Christian Tjandra
Utilization of
Modified Induced
Pluripotent Stem
Cells As The Latest
Advanced Therapy
of Glaucoma
Introduction
Glaucoma
> 76 million sufferers
2nd leading cause of blindness
Optic disc cupping Visual field decreased High intraocular pressure (IOP)
No cure yet
(Available treatment slows the progression of retinal ganglion cell damage)
Stem cell technological therapy
Repair glaucomatous retinal ganglion cell damage
Methods
01 02 03 04
Identifying research question
i. Does induced pluripotent stem
cell therapy have the potential to
treat intraocular glaucomatous
damage?
ii. What modifications are needed
in stem cell therapy for
intraocular glaucomatous
damage?
Identifying relevant studies
Literature search : Jan – Feb 2021
Seven online database (Pubmed,
ScienceDirect®, Proquest,
EBSCOhost®, SAGE®, Clinicalkey®,
and Scopus)
Study selection
• Title and abstract screening
• Full article screening
Inclusion criteria: Journals published in
English in the last 10 years
Exclusion criteria: journals were not fully
accessible
Charging the data
The information displayed:
Author, year of publication, study
objectives, location, and design,
inclusion and exclusion criteria,
results
Summarising
and reporting
the result
Results
Skreening
Synthesized
articles
Articles
that
meet
inclusion
criteria
Identification
Articles identified via
additioanl searches
(n =331)
Articles screening
(title and abstract)
(n = 53)
Excluded
articles
(n = 1879)
Full articles were
asessed
(n = 35)
Full articles
excluded
(n = 26)
Synthesized articles
(n = 9)
Articles identified via
database search
(n = 1931)
Duplicate articles were excluded from
the selection (n = 1900)
Results summary of the characteristics of the selected studies
Discussion
Adult fibroblast cell
iPS
Oct 3/4 Sox2
Klf4
c-Myc
Cultered in extracellular matrix
Neurotrophic pathways
Trabecular
meshwork cell
Retinal
ganglion cell
Modified iPS
Transplantation
Open-angle glaucoma Closed-angle glaucoma
Increased trabecular meshwork resistance Obstruction to trabecular meshwork
Stem cell therapy
(induced pluripotent stem cells (iPS))
Optic nerve degeneration
Modified iPS
- Ephrin
- Proteoglican
- Cell-adhesion
molecule
- Semaphorin
- Cadherin
- BDNF
- GDNF
- CNTF
Modified IPS
Conclusion
• iPS can differentiate to replace damaged trabecular meshwork
cells and retinal ganglion cells in glaucoma.
• Addition of ephrin molecules, proteoglycans, cell-adhesion
molecules, semaphorin, cadherin, and combination of stem
cells with neuroprotective factors such as BDNF, GDNF, CNTF
are required so that stem cells that have differentiated into
trabecular meshwork cells and retinal ganglion cells can reach
the central nervous system.
1. Makhani K, Ali SM, Siddiqui S. Therapeutic potential of
totipotent, pluripotent and multipotent stem cells.
2015;2(5):136-141.
2. Abu-Hassan DW, Li X, Ryan EI, Acott TS, Kelley MJ.
Induced pluripotent stem cells restore function in a human
cell loss model of open-angle glaucoma. Stem Cells.
2015;33(3):751-761.
3. Ji S-L, Tang S-B. Differentiation of retinal ganglion cells from
induced pluripotent stem cells: a review. Int J Ophthalmol.
2019;12(1):152-160.
4. Deng F, Chen M, Liu Y, et al. Stage-specific differentiation of
iPSCs toward retinal ganglion cell lineage. Mol Vis.
2016;22:536-547.
5. Osterhout JA, Josten N, Yamada J, et al. Cadherin-6
mediates axon-target matching in a non-image-forming visual
circuit. Neuron. 2011;71(4):632-639..
6. He C-W, Liao C-P, Pan C-L. Wnt signalling in the
development of axon, dendrites and synapses. Open Biol.
2018;8(10):180116.
Recommendation
Further research on the
effectiveness of using
modified stem cells as a
therapy for glaucoma and
in vivo research can be
carried out.
References
THANK YOU

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Presentation_bagus tentang glaucoma gitu.pptx

  • 1. Diondra Eka Rizkiawan Malinda Evelyn Kevin Christian Tjandra Utilization of Modified Induced Pluripotent Stem Cells As The Latest Advanced Therapy of Glaucoma
  • 2. Introduction Glaucoma > 76 million sufferers 2nd leading cause of blindness Optic disc cupping Visual field decreased High intraocular pressure (IOP) No cure yet (Available treatment slows the progression of retinal ganglion cell damage) Stem cell technological therapy Repair glaucomatous retinal ganglion cell damage
  • 3. Methods 01 02 03 04 Identifying research question i. Does induced pluripotent stem cell therapy have the potential to treat intraocular glaucomatous damage? ii. What modifications are needed in stem cell therapy for intraocular glaucomatous damage? Identifying relevant studies Literature search : Jan – Feb 2021 Seven online database (Pubmed, ScienceDirect®, Proquest, EBSCOhost®, SAGE®, Clinicalkey®, and Scopus) Study selection • Title and abstract screening • Full article screening Inclusion criteria: Journals published in English in the last 10 years Exclusion criteria: journals were not fully accessible Charging the data The information displayed: Author, year of publication, study objectives, location, and design, inclusion and exclusion criteria, results Summarising and reporting the result
  • 4. Results Skreening Synthesized articles Articles that meet inclusion criteria Identification Articles identified via additioanl searches (n =331) Articles screening (title and abstract) (n = 53) Excluded articles (n = 1879) Full articles were asessed (n = 35) Full articles excluded (n = 26) Synthesized articles (n = 9) Articles identified via database search (n = 1931) Duplicate articles were excluded from the selection (n = 1900)
  • 5. Results summary of the characteristics of the selected studies
  • 6.
  • 7.
  • 8. Discussion Adult fibroblast cell iPS Oct 3/4 Sox2 Klf4 c-Myc Cultered in extracellular matrix Neurotrophic pathways Trabecular meshwork cell Retinal ganglion cell Modified iPS Transplantation Open-angle glaucoma Closed-angle glaucoma Increased trabecular meshwork resistance Obstruction to trabecular meshwork Stem cell therapy (induced pluripotent stem cells (iPS)) Optic nerve degeneration Modified iPS - Ephrin - Proteoglican - Cell-adhesion molecule - Semaphorin - Cadherin - BDNF - GDNF - CNTF Modified IPS
  • 9. Conclusion • iPS can differentiate to replace damaged trabecular meshwork cells and retinal ganglion cells in glaucoma. • Addition of ephrin molecules, proteoglycans, cell-adhesion molecules, semaphorin, cadherin, and combination of stem cells with neuroprotective factors such as BDNF, GDNF, CNTF are required so that stem cells that have differentiated into trabecular meshwork cells and retinal ganglion cells can reach the central nervous system.
  • 10. 1. Makhani K, Ali SM, Siddiqui S. Therapeutic potential of totipotent, pluripotent and multipotent stem cells. 2015;2(5):136-141. 2. Abu-Hassan DW, Li X, Ryan EI, Acott TS, Kelley MJ. Induced pluripotent stem cells restore function in a human cell loss model of open-angle glaucoma. Stem Cells. 2015;33(3):751-761. 3. Ji S-L, Tang S-B. Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review. Int J Ophthalmol. 2019;12(1):152-160. 4. Deng F, Chen M, Liu Y, et al. Stage-specific differentiation of iPSCs toward retinal ganglion cell lineage. Mol Vis. 2016;22:536-547. 5. Osterhout JA, Josten N, Yamada J, et al. Cadherin-6 mediates axon-target matching in a non-image-forming visual circuit. Neuron. 2011;71(4):632-639.. 6. He C-W, Liao C-P, Pan C-L. Wnt signalling in the development of axon, dendrites and synapses. Open Biol. 2018;8(10):180116. Recommendation Further research on the effectiveness of using modified stem cells as a therapy for glaucoma and in vivo research can be carried out. References

Editor's Notes

  1. Glaucoma is one of the optic neuropathy disorders characterized by the progressive degeneration of retinal ganglion cells, which eventually lead to cupping of the optic disc and decreased visual field [1]. Glaucoma is also closely related to an increase in intraocular pressure, which results in optic nerve damage, characterized by the loss of retinal ganglion cells. Globally, in 2020 more than 76 million people are suffering from glaucoma, and it is expected to increase up to 111.8 million people by 2040 [2] [3]. Glaucoma is also a severe and complex medical problem because it often causes blindness. Handling and treating glaucoma cases are not easy, especially because no therapy can cure glaucoma. Current treatment, both medical and surgical, is focused solely on lowering intraocular pressure Therefore, researchers have been looking into the potential use of modified stem cell therapy to treat intraocular damage in glaucoma cases