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Biochempeg https://www.biochempeg.com
Polyethylene Glycol (PEG) Hydrogel Based 3D
Bioprinting
In the past few decades, the fields of tissue engineering and regenerative medicine
dedicated to creating functional tissue constructs mimicking native tissues to repair and/or
replace damaged tissues or entire organs have developed rapidly. Three-dimensional (3D)
bioprinting is one of the most advanced technologies in this field. 3D bioprinting involves
building tissues or organs layer by layer using a bottom-up approach. The purpose of 3D
bioprinting is to imitate the natural cellular architecture in a certain way by depositing
materials and cells in a specific way that can restore the normal structure and functionality
of complex tissues. In 3D bioprinting, cells or biomolecules are directly printed on a
substrate in a specific pattern so that the cells can be fixed together to form the desired 3D
construct.
3D Bioprinting of tissue and organs.
The most commonly used polymers in 3D printing technology are as follows:
poly(ε-caprolactone) (PCL), poly(lactic acid) (PLA), poly(lactic-glycolic acid) (PLGA),
Biochempeg https://www.biochempeg.com
hydrogel-based polymers as Alginate, gelatin and polyethylene glycol (PEG)-based
materials. Here, we will discuss the details of PEG hydrogel-based 3D bioprinting.
Hydrogels, a 3D network of molecules composed of hydrophilic polymer chains, play a
vital role in cell-filled 3D bioprinting, and those hydrogels mimic the physical and
biochemical characteristics of natural extracellular matrix (ECM). It can be designed in
any shape, size or form, and can absorb a thousand times its dry weight in a water-rich
environment. Hydrogels that exhibit orthogonal control of multiple properties in cellular
microenvironment should meet some of the physical and biological requirements to apply
in 3D bioprinting. The main requirement is the biocompatibility of the material. Similarly,
the hydrogel should have immunocompatibility and will not facilitate obvious inflammation
at in vivo microenvironment. Most naturally-derived polymers (including alginate, chitosan,
gelatin, hyaluronic acid and cellulose) always show good biocompatibility, and few
synthetic polymers (such as PEG and its derivatives) show good biocompatibility under
both in vitro and in vivo conditions. In addition to biocompatibility, several other factors
must be considered, including mass transfer, biodegradability, target microenvironment,
mechanical properties, and the impact of cross-linking reactions on cell viability.
PEG is one of the most widely studied hydrogels for cell research and drug delivery in
tissue engineering scaffolds. PEG is a synthetic material formed by polymerization of
ethylene oxide, highly valuable for its hydrophilicity that facilitates exchange of cell's
nutrients and waste due to its inherent molecular structure. There are two hydroxyl end
groups around the PEG diol, which can be converted into other functional groups, such as
carboxyl, methoxy , thiol, amines, vinyl sulfanes, azides, acetylenes and acrylates.
Photopolymerization is the most common strategy for preparing PEG hydrogels, which
can provide more spatial and temporal control for in-situ manufacturing of scaffolds. PEG
diacrylate (PEGDMA), PEG dimethacrylate (PEGDMA) and and multi-arm PEG acrylate
(n-PEG-Acr) are the main types of PEG macromers used in photopolymerization to PEG
hydrogels, which are not naturally biodegradable. It is important to note that PEG-derived
materials allow hydrogel to be photo-crosslinked, which provides better mechanical
stability after bioprinting.
Biochempeg https://www.biochempeg.com
Hydrogel
type
Advantages Disadvantages Applications
PEG-based
derivatives
· Properties of the PEG-based
derivatives can be easily manipulated
using chemical modification
techniques
· Good mechanical stability can be
achieved
· Shows relatively good mechanical
stability
· ​ Mostly light polymerizable material
within a short time
· Synthetic material
· Does not provide biological cues for
cell proliferation
· Cell viability depends on the
photocrosslinking time, the intensity
of the light, and photoinitiator
Vascular
tissue
Bone tissue
Cartilage
tissue
The advantages and disadvantages of PEG-based hydrogel with its respective application
in the biomedical field.
Biochempeg specializes exclusively in the development and manufacturing of high-quality
polyethylene glycol (PEG) products and derivatives, and related custom synthesis and
PEGylation services. Biochempeg caters to the PEGylation needs of the pharmaceutical,
biotechnology, medical device and diagnostics, and emerging chemical specialty markets,
from laboratory scale through large commercial scale. And we can provide PEG
derivatives for 3D bioprinting. Suggested Biochempeg PEG derivative for 3D bioprinting:
Catalog No. Name
HO009009 AC-PEG-AC
HE009074 AC-PEG-RGD
References:
Hydrogel-based 3D bioprinting: A comprehensive review on cell-laden hydrogels, bioink
formulations, and future perspectives, doi: 10.1016/j.apmt.2019.100479
Current Developments in 3D Bioprinting for Tissue and Organ Regeneration–A
Review, doi: 10.3389/fmech.2020.589171

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Polyethylene glycol (peg) hydrogel based 3 d bioprinting biochempeg

  • 1. Biochempeg https://www.biochempeg.com Polyethylene Glycol (PEG) Hydrogel Based 3D Bioprinting In the past few decades, the fields of tissue engineering and regenerative medicine dedicated to creating functional tissue constructs mimicking native tissues to repair and/or replace damaged tissues or entire organs have developed rapidly. Three-dimensional (3D) bioprinting is one of the most advanced technologies in this field. 3D bioprinting involves building tissues or organs layer by layer using a bottom-up approach. The purpose of 3D bioprinting is to imitate the natural cellular architecture in a certain way by depositing materials and cells in a specific way that can restore the normal structure and functionality of complex tissues. In 3D bioprinting, cells or biomolecules are directly printed on a substrate in a specific pattern so that the cells can be fixed together to form the desired 3D construct. 3D Bioprinting of tissue and organs. The most commonly used polymers in 3D printing technology are as follows: poly(ε-caprolactone) (PCL), poly(lactic acid) (PLA), poly(lactic-glycolic acid) (PLGA),
  • 2. Biochempeg https://www.biochempeg.com hydrogel-based polymers as Alginate, gelatin and polyethylene glycol (PEG)-based materials. Here, we will discuss the details of PEG hydrogel-based 3D bioprinting. Hydrogels, a 3D network of molecules composed of hydrophilic polymer chains, play a vital role in cell-filled 3D bioprinting, and those hydrogels mimic the physical and biochemical characteristics of natural extracellular matrix (ECM). It can be designed in any shape, size or form, and can absorb a thousand times its dry weight in a water-rich environment. Hydrogels that exhibit orthogonal control of multiple properties in cellular microenvironment should meet some of the physical and biological requirements to apply in 3D bioprinting. The main requirement is the biocompatibility of the material. Similarly, the hydrogel should have immunocompatibility and will not facilitate obvious inflammation at in vivo microenvironment. Most naturally-derived polymers (including alginate, chitosan, gelatin, hyaluronic acid and cellulose) always show good biocompatibility, and few synthetic polymers (such as PEG and its derivatives) show good biocompatibility under both in vitro and in vivo conditions. In addition to biocompatibility, several other factors must be considered, including mass transfer, biodegradability, target microenvironment, mechanical properties, and the impact of cross-linking reactions on cell viability. PEG is one of the most widely studied hydrogels for cell research and drug delivery in tissue engineering scaffolds. PEG is a synthetic material formed by polymerization of ethylene oxide, highly valuable for its hydrophilicity that facilitates exchange of cell's nutrients and waste due to its inherent molecular structure. There are two hydroxyl end groups around the PEG diol, which can be converted into other functional groups, such as carboxyl, methoxy , thiol, amines, vinyl sulfanes, azides, acetylenes and acrylates. Photopolymerization is the most common strategy for preparing PEG hydrogels, which can provide more spatial and temporal control for in-situ manufacturing of scaffolds. PEG diacrylate (PEGDMA), PEG dimethacrylate (PEGDMA) and and multi-arm PEG acrylate (n-PEG-Acr) are the main types of PEG macromers used in photopolymerization to PEG hydrogels, which are not naturally biodegradable. It is important to note that PEG-derived materials allow hydrogel to be photo-crosslinked, which provides better mechanical stability after bioprinting.
  • 3. Biochempeg https://www.biochempeg.com Hydrogel type Advantages Disadvantages Applications PEG-based derivatives · Properties of the PEG-based derivatives can be easily manipulated using chemical modification techniques · Good mechanical stability can be achieved · Shows relatively good mechanical stability · ​ Mostly light polymerizable material within a short time · Synthetic material · Does not provide biological cues for cell proliferation · Cell viability depends on the photocrosslinking time, the intensity of the light, and photoinitiator Vascular tissue Bone tissue Cartilage tissue The advantages and disadvantages of PEG-based hydrogel with its respective application in the biomedical field. Biochempeg specializes exclusively in the development and manufacturing of high-quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. Biochempeg caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale. And we can provide PEG derivatives for 3D bioprinting. Suggested Biochempeg PEG derivative for 3D bioprinting: Catalog No. Name HO009009 AC-PEG-AC HE009074 AC-PEG-RGD References: Hydrogel-based 3D bioprinting: A comprehensive review on cell-laden hydrogels, bioink formulations, and future perspectives, doi: 10.1016/j.apmt.2019.100479 Current Developments in 3D Bioprinting for Tissue and Organ Regeneration–A Review, doi: 10.3389/fmech.2020.589171