ANTIEPILEPTIC DRUH
•Phenytoin (Na channel
blocker)
PHOSPHENYTOIN-PRODRUG
•Water soluble prodrug
•Administration-IV/IM
•Use-Status epilepticus
AT TOXIC DOSES(ACUTE HIGH DOSE)
Cerebellar symptoms
*Ataxia
*Vertigo
*Nystagmus
*Diplopia
USES
*Generalised tonic-clonic seizure
*partial seizure
*Antiarrythmic drug
*Enhance wound healing
*Trigeminal neuralgia
ADVERSE EFFECTS •Gum hypertrophy
•Hirsutism
•Lymphadenopathy
•Teratogenic syndrome
•Megaloblastic anemia
•Hyperglycemia
•Osteomalecia/Rickets
Thank you

Phenytoin