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Debo vacunar a mi hijo?
Enfermedad Papiloma virus Humano.
Información: diversas fuentes. Técnica, Científica, Industrial.
Técnica:
Afirmativa:
Contexto España. (mejor sanidad pública a nivel mundial).
Vademecum.es
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Antiinfecciosos para uso sistémico > Vacunas > Vacunas antivirales > Vacuna
contra papilomavirus
Mecanismo de acción
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Vacuna nonavalente recombinante adyuvada no infecciosa, inmuniza frente al virus del
papiloma humano.
Indicaciones terapéuticas
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Inmunización activa de individuos ≥ 9 años frente a las siguientes enfermedades por
VPH: lesiones precancerosas y canceres que afectan al cuello de útero, vulva, vagina y
ano causados por los tipos del VPH de la vacuna; verrugas genitales (Condiloma
acuminata) causados por tipos específicos del VPH.
Posología
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Modo de administración
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Se debe administrar mediante iny. IM en la región deltoidea de la parte superior del
brazo o en la zona anterolateral superior del muslo. No debe ser inyectada por vía
intravascular, SC o intradérmica. No se debe mezclar en la misma jeringa con ninguna
otra vacuna o solución
Contraindicaciones
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Hipersensibilidad.
Advertencias y precauciones
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Valorar riesgo/beneficio; sin datos en < 9 años ni en ≥ 27 años; prever síncope o
respuesta vasovagal a la iny. (especialmente en adolescentes) y posible reacción
anafiláctica; en enf. febril aguda grave, posponer la vacunación; en pacientes con
trombocitopenia o trastornos de coagulación, riesgo de hemorragia por su
administración IM; individuos con la respuesta inmune alterada (debido al uso de una
terapia inmunosupresora potente, defecto genético, infección por VIH u otras causas),
podrían no responder a la vacuna; no sustituye al cribado rutinario del cáncer de cuello
de útero (seguir recomendaciones locales) ni a la toma de precauciones frente a ETS;
sólo para uso profiláctico; duración de protección no establecida.
Interacciones
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
No se ha estudiado en los ensayos clínicos la seguridad e inmunogenicidad en
individuos que habían recibido inmunoglobulina o productos derivados de sangre
durante los 3 meses previos a la 1ª dosis de la vacuna.
Embarazo
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Contraindicado. La vacunación se debe posponer hasta el término del embarazo.
Lactancia
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
La vacuna puede ser utilizada durante el período de lactancia. En los ensayos clínicos de
la vacuna, un total de 92 mujeres estuvieron en periodo de lactancia durante el periodo
de vacunación. En los estudios la inmunogenicidad de la vacuna fue comparable entre
las mujeres en periodo de lactancia y en las que no estaban en periodo de lactancia
durante la administración de la vacuna. Además el perfil de acontecimientos adversos
en las mujeres en periodo de lactancia fue comparable al perfil global de seguridad de la
población. No hubo acontecimientos adversos graves relacionados con la vacuna
notificados en recién nacidos con lactancia materna durante el periodo de vacunación.
Efectos sobre la capacidad de conducir
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Tiene un efecto nulo o insignificante sobre la capacidad para conducir o utilizar
máquinas. Sin embargo, algunos de los efectos mencionados en la sección "Reacciones
adversas", pueden afectar temporalmente la capacidad de conducir o utilizar máquinas.
Reacciones adversas
Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58)
Cefalea, mareo; náuseas; pirexia, fatiga, trastornos en el lugar de iny.: eritema, dolor,
hinchazón, hematomas, prurito.
Fuente: Monografía propiedad editorial de Vidal Vademecum
INFORMACION
CIENTÍFICA mejor revista científica del mundo new england Journal of medicine
New england latest post.
http://www.nejm.org/medical-research/viral-infections#qs=%3Fsubtopic%3Dviral-
infections%26category%3Dresearch
http://www.nejm.org/doi/full/10.1056/NEJMoa1612296
SOURCE INFORMATION
From the Department of Epidemiology Research, Statens Serum Institut, Copenhagen (N.M.S., B.P., D.M.-N., H.S., A.H.); and the Clinical Epidemiology Unit, Department of Medicine, Solna,
Karolinska Institutet, Stockholm (B.P.).
Address reprint requests to Dr. Scheller at the Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark, or a
nims@ssi.dk.
Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes
Nikolai M. Scheller, M.D., Björn Pasternak, M.D., Ph.D., Ditte Mølgaard-Nielsen, M.Sc., Henrik Svanström, Ph.D., and Anders Hviid, Dr.Med.Sci.
N Engl J Med 2017; 376:1223-1233March 30, 2017DOI: 10.1056/NEJMoa1612296
Share:
BACKGROUND
The quadrivalent human papillomavirus (HPV) vaccine is recommended for all girls and women 9 to 26 years of age. Some women will have inadvertent
exposure to vaccination during early pregnancy, but few data exist regarding the safety of the quadrivalent HPV vaccine in this context.
METHODS
We assessed a cohort that included all the women in Denmark who had a pregnancy ending between October 1, 2006, and November 30, 2013. Using
nationwide registers, we linked information on vaccination, adverse pregnancy outcomes, and potential confounders among women in the cohort. Women who
had vaccine exposure during the prespecified time windows were matched for propensity score in a 1:4 ratio with women who did not have vaccine exposure
during the same time windows. Outcomes included spontaneous abortion, stillbirth, major birth defect, small size for gestational age, low birth weight, and
preterm birth.
RESULTS
In matched analyses, exposure to the quadrivalent HPV vaccine was not associated with significantly higher risks than no exposure for major birth defect (65
cases among 1665 exposed pregnancies and 220 cases among 6660 unexposed pregnancies; prevalence odds ratio, 1.19; 95% confidence interval [CI], 0.90
to 1.58), spontaneous abortion (20 cases among 463 exposed pregnancies and 131 cases among 1852 unexposed pregnancies; hazard ratio, 0.71; 95% CI,
0.45 to 1.14), preterm birth (116 cases among 1774 exposed pregnancies and 407 cases among 7096 unexposed pregnancies; prevalence odds ratio, 1.15;
95% CI, 0.93 to 1.42), low birth weight (76 cases among 1768 exposed pregnancies and 277 cases among 7072 unexposed pregnancies; prevalence odds
ratio, 1.10; 95% CI, 0.85 to 1.43), small size for gestational age (171 cases among 1768 exposed pregnancies and 783 cases among 7072 unexposed
pregnancies; prevalence odds ratio, 0.86; 95% CI, 0.72 to 1.02), or stillbirth (2 cases among 501 exposed pregnancies and 4 cases among 2004 unexposed
pregnancies; hazard ratio, 2.43; 95% CI, 0.45 to 13.21).
CONCLUSIONS
Quadrivalent HPV vaccination during pregnancy was not associated with a significantly higher risk of adverse pregnancy outcomes than no such exposure.
(Funded by the Novo Nordisk Foundation and the Danish Medical Research Council.)
Informacion Industrial (novo nordisc)
Format: Abstract
Send to
Nat Genet. 2015 Feb;47(2):158-63. doi: 10.1038/ng.3178. Epub 2015 Jan 12.
Genome-wide profiling of HPV integration in cervical cancer identifies clustered
genomic hot spots and a potential microhomology-mediated integration mechanism.
Hu Z1, Zhu D1, Wang W2, Li W3, Jia W4, Zeng X5, Ding W1, Yu L1, Wang
X1, Wang L1, Shen H1, Zhang C1, Liu H5, Liu X5, Zhao Y5,Fang X5, Li S6, Chen
W5, Tang T7, Fu A8, Wang Z8, Chen G1, Gao Q1, Li S1, Xi L1, Wang C1, Liao
S1, Ma X1, Wu P1, Li K1, Wang S1,Zhou J9, Wang J10, Xu X5, Wang H1, Ma D1.
Author information
1
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, Hubei, China.
2
Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical
University, Guangzhou, China.
3
1] Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. [2] School of
Bioscience and Bioengineering, South China University of Technology, Guangzhou,
China.
4
1] Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. [2] Department of
Computer Science, City University of Hong Kong, Hong Kong, China.
5
Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China.
6
Department of Computer Science, City University of Hong Kong, Hong Kong, China.
7
WuHan Frasergen Bioinformatics Co., Ltd , Wuhan, China.
8
Wuhan Institute of Biotechnology, Wuhan, China.
9
Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong
University of Science and Technology, Wuhan, Hubei, China.
10
1] Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. [2] School of
Bioscience and Bioengineering, South China University of Technology, Guangzhou,
China. [3] Princess Al Jawhara Center of Excellence in the Research of Hereditary
Disorders, King Abdulaziz University, Jeddah, Saudi Arabia. [4] The Novo Nordisk
Foundation Center for Basic Metabolic Research, University of Copenhagen,
Copenhagen, Denmark. [5] Centre for iSequencing, Aarhus University, Aarhus,
Denmark.
Abstract
Human papillomavirus (HPV) integration is a key genetic event in cervical
carcinogenesis. By conducting whole-genome sequencing and high-throughput viral
integration detection, we identified 3,667 HPV integration breakpoints in 26 cervical
intraepithelial neoplasias, 104 cervical carcinomas and five cell lines. Beyond
recalculating frequencies for the previously reported frequent integration sites
POU5F1B (9.7%), FHIT (8.7%), KLF12 (7.8%), KLF5 (6.8%), LRP1B (5.8%) and
LEPREL1 (4.9%), we discovered new hot spots HMGA2 (7.8%), DLG2 (4.9%) and
SEMA3D (4.9%). Protein expression from FHIT and LRP1B was downregulated when
HPV integrated in their introns. Protein expression from MYC and HMGA2 was
elevated when HPV integrated into flanking regions. Moreover, microhomologous
sequence between the human and HPV genomes was significantly enriched near
integration breakpoints, indicating that fusion between viral and human DNA may have
occurred by microhomology-mediated DNA repair pathways. Our data provide insights
into HPV integration-driven cervical carcinogenesis.
Comment in
Artifacts in the data of Hu et al. [Nat Genet. 2016]
Reply to Artifacts in the data of Hu et al. [Nat Genet. 2016]
PMID:
25581428
DOI:
10.1038/ng.3178
[Indexed for MEDLINE]
Informacion Negativa
Científica e industrial
PubMed Commons
0 comments
Informacion negativa técnica.
http://www.nhs.uk/Conditions/vaccinations/Pages/hpv-vaccine-cervarix-gardasil-side-
effects.aspx
HPV vaccine side
effects
The most common side effects of the HPV vaccine include swelling, redness and pain at the site of the injection, and headaches
- although these are generally tolerable and short lived.
Very common side effects of the HPV vaccine
More than one in 10 girls who have the Gardasil HPV vaccine experience:
• injection site problems such as redness, bruising, itching, swelling, pain or cellulitis
• headaches
Common side effects
More than one in 100 girls who have the Gardasil HPV vaccine experience:
• fever
• nausea (feeling sick)
• painful arms, hands, legs or feet
Rare side effects
Around one in 10,000 girls who have the Gardasil HPV vaccine experience
• an itchy red rash (urticaria, or 'hives')
Very rare side effects
Fewer than one in 10,000 girls who have the Gardasil HPV vaccine experience:
• restriction of the airways and difficult breathing (bronchospasm)
Side effects of unknown frequency
It is not possible to reliably estimate how frequently other side effects occur. This is because information is received from people
reporting side effects themselves, rather than controlled, clinical tests.
The frequency of these side-effects is unknown:
• blood problems, leading to unexplained bruising or bleeding
• chills
• fainting or brief loss of consciousness
• feeling dizzy
• general feeling of being unwell
• Guillain Barré syndrome
• joint pain
• lymphadenopathy
• muscle pain or tenderness
• seizures (fits)
• tiredness
• vomiting
• weakness
If you feel unwell or have concerns about a side effect after having the HPV vaccine, seek medical advice. If you feel very ill, get
medical help straight away. Contact your prescriber, pharmacist or nurse.
Allergic reactions
In rare cases, it is possible for someone who has had the HPV vaccine to experience a more severe allergic reaction, known as
an anaphylactic reaction. Signs of an anaphylactic reaction include:
• breathing difficulties and wheezing
• swollen eyes, lips, genitals, hands, feet and other areas (this is calledangioedema)
• itching
• a strange metallic taste in the mouth
• sore, red, itchy eyes
• changes in heart rate
• loss of consciousness
Be reassured that severe reactions like this are extremely rare, in the order of around one in a million.
If your daughter has a severe allergic reaction, the healthcare professional giving the vaccine will be fully trained in how to deal
with it. Individuals recover completely with treatment,
usually within a few hours.
If you are with someone and they start to experience the symptoms of anaphylaxis, dial 999 immediately to request an
ambulance.
See the treatment of anaphylaxis for more information.
Chronic fatigue and the HPV vaccine
There have been reports in the press alleging that girls have developed chronic fatigue syndrome after HPV vaccination.
The cause of CFS (otherwise known as ME, or myalgic encephalomyelitis) is not known, but it does occur naturally in
teenagers, and is more common in girls than boys.
There are no more cases of CFS than would be expected in teenage girls and there is no evidence to link CFS to the HPV
vaccine.
The WHO Global Advisory Committee on Vaccine Safety (GACVS) regularly review the emerging international evidence on the
safety of HPV vaccination and issued a statement in March 2014 concluding there is no proven link between the HPV
vaccination and autoimmune disease, of which many think CFS/ME is an example.
How to spot and report side effects
The Yellow Card Scheme allows you to report suspected side effects from any medicine you are taking including vaccines. It is
run by the Medicines and Healthcare Products Regulatory Agency.
Find out how to report a vaccine side effect.
http://www.nhs.uk/Conditions/vaccinations/Pages/reporting-side-effects.aspx
how to report side effects
Vaccine side effects
It's natural to be concerned that you or your child will have a side effect after having a vaccination.
While all vaccines have the potential to cause side effects in some people, the reality is that most tend to be mild and don't last
longer than a few days. Some people don't get any side effects at all.
Common vaccine side effects
Common side effects of any vaccine can include:
• injection site reactions (pain, swelling and redness)
• mild fever
• shivering
• fatigue
• headache
• muscle and joint pain
Rare vaccine side effects
A far less common, but serious, vaccine side effect is an immediate allergic reaction, also known as an anaphylactic reaction.
These are dramatic and potentially life-threatening. However, they are very rare – occurring in less than one in a million cases
– and are completely reversible if treated promptly by healthcare staff.
To have a balanced view, potential side effects have to be weighed against the expected benefits of vaccination in preventing
the serious complications of disease.
Read more about the benefits and risks of vaccination.
Not all illnesses that occur after vaccination will be a side effect. Because millions of people every year are vaccinated, it's
inevitable that some will go on to develop a coincidental infection or illness shortly afterwards.
What to do if your child is unwell after having a vaccination
Most common side effects in babies and young children are at the site of the injection, and include:
• swelling
• redness
• a small hard lump
These symptoms usually pass within a couple of days and you don't need to do anything about them.
Children may sometimes develop a high temperature (fever). If this happens, keep your child cool.
Make sure they don't wear too many layers of clothes or blankets and give them plenty of cool drinks. You can also give them a
dose of infant paracetamol or ibuprofen liquid according to the instructions on the bottle.
Read an NHS leaflet about the common side effects of vaccinations that may occur in babies and children under the age of five
(PDF, 118kb), and how to treat them.
Find out about a vaccine's side effects
A patient information leaflet (PIL) is included in the pack of each dose of vaccine, and lists its potential side effects.
You can also read vaccine PILs online on the electronic Medicines Compendium (eMC) website.
Reporting a vaccine side effect
If you, a doctor, nurse or pharmacist suspects that you or your child has had a possible side effect to a vaccine, it can
be reported through theYellow Card Scheme.
The Yellow Card Scheme is run by the Medicines and Healthcare products Regulatory Agency (MHRA) and is designed to pick
up unexpected problems or new side effects.
If a serious new side effect is identified, the MHRA will follow up the report. It may change the way a vaccine is used, or it may
even be taken off the market.
How to use the Yellow Card Scheme
Tell your doctor, nurse or pharmacist about the suspected side effect, and they'll report it for you. Alternatively, you can report it
yourself by:
• using the Yellow Card Scheme online reporting system
• picking up a Yellow Card form at your GP surgery or local pharmacy – complete the form and send it to the address
provided
• calling the Yellow Card freephone hotline on 0808 100 3352, Monday to Friday, 10am to 2pm
Now, read more about the safety of vaccinations, or about the side effects of each vaccine:
• side effects of the 5-in-1 infant vaccine
• side effects of the 4-in-1 pre-school booster
• side effects of the 3-in-1 teenage booster
• side effects of the MMR vaccine
• side effects of the chickenpox vaccine
• side effects of the Men C vaccine
• side effects of the Men B vaccine
• side effects of the Men ACWY vaccine
• side effects of the Hib/Men C booster
• side effects of the pneumococcal vaccine
• side effects of the HPV (cervical cancer) vaccine
• side effects of the BCG vaccine
• side effects of the flu vaccine
• side effects of the children's flu vaccine
• side effects of the rotavirus vaccine
• side effects of the shingles vaccine
CDC opinion on vaccine safety
https://www.cdc.gov/vaccinesafety/research/publications/index.html
Frequently Asked Questions about HPV Vaccine Safety
Recommend on FacebookTweet
Featured Resource: HPV Vaccine (Gardasil) is Safe
HPV Vaccine (Gardasil) is Safe[PDF - 241 KB]
• What human papillomavirus (HPV) vaccines are available in the United States?
• Are HPV vaccines safe?
• How does CDC make sure HPV vaccines are safe?
• How do the benefits of HPV vaccines compare to the risks?
• Have serious problems been reported after people receive HPV vaccines?
• Can HPV vaccine damage women’s ovaries?
• Has HPV vaccine ever been linked to Guillain-Barré syndrome?
• Can HPV vaccines cause Postural Orthostatic Tachycardia Syndrome (POTS)?
• Has anyone died after receiving HPV vaccines?
• Have FDA and CDC changed any recommendations for the use of HPV vaccines based on vaccine safety monitoring?
• Do HPV vaccines hurt?
• Are HPV vaccines safe for pregnant women?
• Is there anyone who should not get the HPV vaccine?
• What if I have, or my child has, a problem after getting the HPV vaccine?
• Where can I find more information about HPV vaccines?
What HPV vaccines are available in the United States?
There are three HPV vaccines that are licensed for use in the United States by the FDA and recommended by CDC. These vaccines are Gardasil 9,
Gardasil, and Cervarix.
Gardasil 9 Gardasil Cervarix
Who makes
it?
Merck & Co.,
Inc.
Merck & Co.,
Inc.
GlaxoSmithKline plc
What kinds
of HPV
does it
protect
against?
HPV types 16,
18, 6, 11, 31, 33,
45, 52, and 58
which cause
several types of
cancer and
genital warts
HPV types 16,
18, 6, and 11,
which cause
several types of
cancer and
genital warts
HPV types 16, 18,
which cause several
types of cancer
Who should
get the
vaccine?*
• Routine vaccination for
girls and boys aged 11 or
12 years
• Catch-up vaccination
for teen girls and young
women through age 26
• Catch-up vaccination
for teen boys and young
men through age 21
• Routine
vaccination for girls
aged 11 or 12
years
• Catch-up
vaccination for
teen girls and
young women
through age 26
• Gay, bisexual, and
other men who have sex
with men through age 26
• People with
compromised immune
systems (including people
living with HIV/AIDS)
through age 26
When
should the
vaccine be
given?
• CDC recommends that 11- to 12-year-olds
receive two doses of HPV vaccine at least six
months apart The first dose is routinely
recommended at 11-12 years old
• The second dose of the vaccine should be
administered 6 to 12 months after the first dose
• Vaccination with the two-dose series can be
started at age 9 and through age 14
• Two doses of HPV vaccine given at least six
months apart at ages 11 and 12 years will provide
Gardasil 9 Gardasil Cervarix
safe, effective, and long-lasting protection against
HPV cancers
• Teens and young adults who start the series
later, at ages 15 through 26 years, will need three
doses of HPV vaccine to protect against cancer-
causing HPV infection
• Adolescents aged 9 through 14 years who
have already received two doses of HPV vaccine
less than 5 months apart, will require a third dose
• Three doses are recommended for people
with weakened immune systems aged 9-26 years
*Recommendations from CDC and the Advisory Committee on Immunization Practices
To find out more about HPV vaccination, please visit www.cdc.gov/HPV.
Top of Page
Are HPV vaccines safe?
Yes. All three HPV vaccines – Gardasil 9, Gardasil, and Cervarix – are safe, effective, and recommended by CDC. Many studies have looked at the
safety of HPV vaccines in the United States. An overview of these studies can be found on thevaccine safety publications page.
Vaccines, like any medicine, can have side effects. Some people who get an HPV vaccine have no side effects at all. Some people report having
mild side effects, like a sore arm from the shot for a day or two. The most common side effects are usually mild and go away on their own.
Common Side Effects of HPV Vaccine:
• Pain, redness, or swelling in the arm where the shot was given
• Fever
• Headache or feeling tired
• Nausea
• Muscle or joint pain
Fainting (also known as syncope) and related symptoms (such as jerking movements) can happen after any medical procedure. Some people,
especially teens, faint after getting vaccinated. To prevent fainting and related injuries, people receiving HPV vaccines should sit or lie down during
vaccination, then remain seated for 15 minutes after the shot.
Top of Page
How does CDC make sure HPV vaccines are safe?
All vaccines used in the United States are required to go through years of extensive safety testing before they are licensed by the U.S. Food and
Drug Administration (FDA). After vaccines are licensed, CDC and FDA continue to monitor each vaccine to make sure it is safe and effective.
CDC’s The Journey of Your Child's Vaccine explains how all vaccines are developed, tested, and continually monitored.
Each HPV vaccine was closely studied in clinical trials to make sure it was safe:
• Gardasil 9 was studied in more than 15,000 females and males.
• Gardasil was studied in 29,000 females and males.
• Cervarix was studied in more than 30,000 females.
These clinical trials showed HPV vaccines to be safe and effective. Each vaccine continues to be monitored for any safety problems. This
monitoring is especially looking for any rare or new problems that may happen after vaccination.
CDC uses three systems to monitor the safety of vaccines after they are licensed:
• The Vaccine Adverse Event Reporting System (VAERS)
• The Vaccine Safety Datalink (VSD)
• The Clinical Immunization Safety Assessment (CISA) Network.
Read more about these systems on the Vaccine Safety Monitoring at CDC web page.
Top of Page
How do the benefits of HPV vaccines compare to the risks?
CDC has carefully studied the risks and benefits of HPV vaccination. HPV vaccination is recommended because the benefits, such as prevention of
cancer, far outweigh the risks of possible side effects.
Health decisions are personal, and each person should make choices that are right for themselves and their families. It is important to remember
that choosing not to vaccinate is not a risk-free choice—HPV vaccines prevent serious cancers and other diseases in both males and females.
Top of Page
Have serious problems been reported after people receive HPV vaccines?
Nearly 90 million doses of HPV vaccines were distributed in the United States from June 2006 through March 2016. Most of CDC’s HPV vaccine
safety monitoring and research has focused on Gardasil because this vaccine has accounted for 87% of HPV vaccine doses distributed in the
United States. From June 2006 through March 2016, about 79 million doses of Gardasil were distributed in the United States. During the same
period, VAERS received 33,945 US reports of adverse events following Gardasil vaccination. There have been 232 US VAERS reports of adverse
events following Cervarix (with 720,000 doses distributed) since licensure through March 31, 2016. VAERS has received 1,447 reports of adverse
events following Gardasil 9 since licensure through March 31, 2016. About 10 million doses of Gardasil 9 have been distributed in the United States.
Any medicine or vaccine can cause adverse events, and (as with any vaccine or medicine) it is difficult to determine whether or not the HPV vaccine
caused a particular adverse event.
Which adverse events are considered “serious”?
An adverse event is defined by law as serious if it is life threatening or results in death, a persistent or significant disability or incapacity, congenital
anomaly or birth defect, hospitalization, or prolongation of existing hospitalization.
In the VAERS reports, the most frequently reported symptoms overall were: fainting; dizziness; headache; nausea; fever; and pain, redness, and
swelling in the arm where the shot was given. Of the reports to VAERS, 7% were classified as “serious.” About 14% of the VAERS reports were not
related to health problems, but were reported for reasons such as improper vaccine storage or the vaccine being given to someone for whom it was
not recommended.
Top of Page
Can HPV vaccines damage women’s ovaries?
CDC is aware of public concern about the safety of human papillomavirus (HPV) vaccine. Since 2006, HPV vaccine safety monitoring and studies
conducted by CDC, FDA and other organizations have confirmed that this vaccine has an excellent safety record without evidence that it causes
reproductive problems in women.
What is premature ovarian failure?
Also known as “primary ovarian insufficiency” or “premature menopause,” this is a condition in which a woman’s ovaries stop functioning before age
40. Causes of premature ovarian failure include:
• Genetics
• Chemicals in the environment
• Cancer treatments
• Cigarettes
• Autoimmune disorders
• Some viral infections
However, in many cases it’s impossible to determine the cause. CDC and FDA have not found any proof that Gardasil causes premature ovarian
failure.
To read more about HPV and vaccine safety, go to HPV Vaccine Safety.
How has FDA and CDC looked for problems?
Before Gardasil was licensed, its safety was extensively studied in clinical trials. These studies found no difference in amenorrhea (when a woman
of reproductive age doesn’t have a period) between women who got Gardasil compared to women who received a placebo (a shot with no medicine
in it). Premature ovarian failure (POF) was not found to happen among women in the Gardasil clinical trials.
Between June 2006 and September 2015, more than 80 million doses of Gardasil were distributed for use in the United States. The Vaccine
Adverse Event Reporting System (VAERS) received 16 reports of premature ovarian failure and 10 reports of related conditions (ovarian disorder or
ovarian failure) being diagnosed at some time after the women received Gardasil vaccination. When adverse events are reported, it does not
necessarily mean they are caused by a vaccination. To understand this better, FDA and CDC looked into the reports to see if there was a pattern
that might show if the vaccine was causing the problem. There were no patterns among these VAERS reports, so it seems unlikely that the
vaccine is causing the problem.
CDC continues to monitor and evaluate the safety of HPV vaccine. Even though VAERS did not see a pattern among reports for POF, the VSD is
conducting a study to examine this issue further.
Does HPV vaccine prevent any conditions that lead to loss of a woman’s fertility?
HPV vaccination prevents infection with the HPV types that most commonly cause cervical cancer. In some cases, women develop cervical cancer
before starting or finish having children. Treatment for cervical cancer (removal of the cervix and uterus, chemotherapy, and/or radiation) can keep a
woman from being able to be pregnant. Preventing cervical cancer through HPV vaccination reduces this risk.
CDC works closely with the American Academy of Pediatrics (AAP) and the American Academy of Family Physicians (AAFP) on HPV vaccination,
both of which have information available on their websites:
HPV Vaccine Recommendations [PDF - 660 KB]
AAFP Human Papillomavirus Vaccine
American College of Obstetrics and Gynecologists posts guidelines and recommendations
Top of Page
Has HPV vaccine ever been linked to Guillain-Barré syndrome?
Guillain-Barré syndrome (GBS) is a rare disorder where a person’s own immune system damages nerve cells, causing muscle weakness and
sometimes paralysis. Most people recover fully from GBS, but some experience long-term nerve damage.
CDC’s Vaccine Safety Datalink conducted monitoring for GBS following Gardasil vaccination from August 2006 to February 2012. During this period
just over 1.4 million doses of Gardasil were administered in the Vaccine Safety Datalink population. CDC did not identify any cases of GBS among
females aged 9-26 years old following Gardasil vaccination.
Top of Page
Can HPV vaccines cause Postural Orthostatic Tachycardia Syndrome (POTS)?
POTS is a condition that causes lightheadedness or fainting and a rapid increase in heartbeat upon standing. The cause is unknown, but doctors
think POTS may be associated with a number of risk factors and syndromes, including: a recent viral illness, physical deconditioning, chronic fatigue
syndrome and nervous system problems. In November 2015, the European Medicine’s Agency completed a detailed review of available POTS
data[PDF - 72 KB] from young women who received HPV vaccines. The review found that the evidence does not support a causal link between HPV
vaccines and POTS.
From June 2006 through September 2015, when about 80 million doses of Gardasil doses have been given out in the United States, VAERS have
received 13 reports of POTS following 4vHPV. There are no unusual or unexpected patterns detected among these cases of POTS following
Gardasil vaccination. CDC monitoring through VAERS has not detected any safety concern of POTS following HPV vaccination.
Top of Page
Has anyone died after receiving an HPV vaccine?
Some deaths among people who received an HPV vaccine have been reported to VAERS. This does not mean that the vaccine caused the
death, only that the death occurred after the person got the vaccine. CDC and FDA review all available information on reports of death following all
vaccines, including HPV vaccines.
From June 2006 through September 2015, when about 80 million doses of HPV vaccine had been given out in the United States, VAERS received
117 reports of death after people received the Gardasil vaccine. Among the 117 reports of death, many could not be further studied because there
was not enough information included in the report to verify that a person had died. In 51 of the reports, CDC reviewed medical records, autopsy
reports, or death certificates and verified that the person had died. After careful review of every reported case of death that has happened after
Gardasil vaccination, CDC concluded:
• There is no diagnosis that would suggest Gardasil caused the death
o There is no pattern of death occurring with respect to time after vaccination
o There is no consistent vaccine dose number or combination of vaccines given among the reports
Top of Page
Have FDA and CDC changed any HPV vaccine recommendations based on vaccine safety
monitoring?
Yes. When fainting (or syncope) was found to happen after vaccination, FDA changed Gardasil’s guidance for doctors to include information about
preventing falls and injuries from fainting after HPV vaccination. CDC and the Advisory Committee on Immunization Practices included this guidance
in the recommendations for HPV vaccination. CDC continues to remind doctors and nurses to observe this guidance and to share this information
with all their patients.
Top of Page
Do HPV vaccines hurt?
Some people who get the HPV vaccine may have some pain in the arm where the shot was given. Usually this pain is mild and goes away within a
few days. Swelling and redness also sometimes occur after HPV vaccination.
CDC is aware of reports (in Japan and elsewhere) of chronic pain following HPV vaccines. Some of these reports might be potential cases of
Complex Regional Pain Syndrome (CRPS), a rare condition of persistent pain that usually affects arms, legs, hands or feet after an injury or trauma
to that limb. In November 2015, the European Medicine’s Agency completed a detailed review of available data on CRPS[PDF - 72 KB] in young
women who received HPV vaccines. The review found that the evidence does not support a causal link between HPV vaccines and CRPS.
A published article found 21 reports of CRPS to VAERS following to Gardasil between June 2006 and July 2015 concluding that CRPS following
Gardasil is rare. CDC monitoring through VAERS has not detected any safety concern for CRPS following HPV vaccination.
Top of Page
Are HPV vaccines safe for pregnant women?
Because the vaccines weren’t tested in pregnant women during clinical trials, HPV vaccines are not currently recommended for pregnant women.
However, some pregnant women receive HPV vaccines because they don’t know that they are pregnant at the time of vaccination.
CDC and vaccine manufacturers have monitored and studied HPV vaccine safety in women who received the vaccine when they were pregnant.
Close monitoring has not found any health concerns. If a woman receives HPV vaccine and later learns that she is pregnant, there is no reason to
be alarmed.
Any woman who learns she was pregnant at the time she received an HPV vaccine is encouraged to contact the vaccine manufacturer. This will
help us learn how pregnant women respond to the vaccine.
• Pregnant women who received Gardasil 9 or Gardasil can contact Merck at 1-877-888-4231 if they have questions related to getting
the vaccine while pregnant.
o Doctors should report Gardasil 9 vaccination during pregnancy as early in the pregnancy as possible usingMerck
Pregnancy Registries.
• Pregnant women who received Cervarix can contact GlaxoSmithKline at 1-888-452-9622
Top of Page
Is there anyone who should not get an HPV vaccine?
Some people should not get the HPV vaccine or should wait.
• Anyone who has ever had a life-threatening allergic reaction to any component of HPV vaccine, or to a previous dose of HPV vaccine,
should not get the vaccine.
o If you or your child is considering receiving Gardasil 9 or Gardasil, tell your doctor about any severe allergies, including
an allergy to yeast.
o If you or your child is considering receiving Cervarix, tell your doctor about any severe allergies, including an allergy to
latex.
• HPV vaccine is not recommended for pregnant women. However, receiving HPV vaccine when pregnant is not cause for alarm.
Women who are breastfeeding may get the vaccine.
• People who are mildly ill (low-grade fever of less than 101 degrees, a cold, runny nose, or cough) when a dose of HPV vaccine is
planned can still be vaccinated. People with a moderate or severe illness should wait until they are better.
Top of Page
What if I have, or my child has, a problem after getting an HPV vaccine?
If you or your child is having a severe allergic reaction or other health emergency, call 9-1-1 or go to the nearest hospital.
Look for any signs or symptoms that concern you, such as signs of a severe allergic reaction, very high fever, or behavior changes. Signs of a
severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. These
would start a few minutes to a few hours after the shot is given.
After seeing a doctor, the reaction should be reported to the Vaccine Adverse Event Reporting System (VAERS). This system is used to report any
side effect or adverse event following vaccination. Your doctor can file this report, or you can do it yourself through the VAERS website or by calling
1-800-822-7967.
Top of Page
Where can I find more information about HPV vaccines?
For additional information on HPV vaccines and CDC’s recommendations, please visit CDC's Human Papillomavirus (HPV) website.
Top of Page
Related Links
• Diseases and the Vaccines that Prevent Them: HPV – English[PDF - 5.4 MB]
• Diseases and the Vaccines that Prevent Them: HPV – Spanish[PDF - 531 KB]
• Who Should Not Get Vaccinated
• Fainting After Vaccination
• Frequently Asked Questions About Vaccine Safety
IN SPANISH
https://www.cdc.gov/vaccines/vpd-vac/hpv/downloads/dis-HPV-color-office-sp.pdf
https://www.cdc.gov/vaccines/parents/diseases/teen/hpv-indepth-color-sp.pdf
las ENFERMEDADES y las VACUNAS PARA PREVENIRLAS Actualizado el
03/3/2016 VPH us del papiloma humano también conocido como vir Como padres,
usted hace todo lo que puede para proteger la salud de sus hijos ahora y en el futuro. En
la actualidad, tenemos un arma muy poderosa para prevenir varios tipos de cáncer en
nuestros niños: la vacuna contra el VPH. El VPH y el cáncer VPH es la abreviatura de
virus del papiloma humano, un tipo de virus muy común. Cada año, en los Estados
Unidos, aproximadamente 17 500 mujeres y 9 300 hombres son afectados por cánceres
asociados al VPH. Muchos de estos cánceres podrían prevenirse con vacunas. Tanto en
los hombres como en las mujeres, el VPH puede causar cáncer de ano y cáncer de boca
o de garganta (cáncer orofaríngeo). Además puede causar cánceres de cuello uterino, de
vulva y de vagina en las mujeres, y cáncer de pene en los hombres. Para las mujeres,
hay pruebas para detectar la mayoría de los casos de cáncer de cuello uterino con una
prueba de Papanicoláu. Desafortunadamente, no hay pruebas de detección de rutina para
otros cánceres relacionados con el VPH para las mujeres ni para los hombres, y estos
cánceres pueden causar dolor, sufrimiento y hasta la muerte. Por esta razón es tan
importante la vacuna que previene la mayoría de estos tipos de cáncer. Más información
sobre la vacuna contra el VPH El VPH se transmite de una persona a otra durante el
contacto sexual de piel a piel, incluidas las relaciones sexuales vaginales, orales y
anales. El VPH es más común en las personas al final de la adolescencia y a comienzos
de la década de los veinte años. Casi todas las personas sexualmente activas contraerán
este virus en algún momento de su vida, aunque la mayoría de ellas ni siquiera lo sabrá.
La mayoría de las veces, el cuerpo se defiende en forma natural del VPH, antes de que
cause problemas de salud. Pero en algunos casos, el cuerpo no lo combate y el VPH
puede causar problemas como el cáncer y las verrugas genitales. Las verrugas genitales
no son una enfermedad mortal, pero pueden causar estrés emocional y su tratamiento
puede ser muy molesto. En los Estados Unidos, cerca del 1 de cada 100 adultos
sexualmente activos tiene verrugas genitales en algún momento. La vacuna contra el
VPH se recomienda para los niños y niñas preadolescentes de 11 o 12 años. Todos los
preadolescentes necesitan vacunarse contra el VPH para que puedan estar protegidos
contra las infecciones por este virus que pueden causar cáncer. Los adolescentes y los
adultos jóvenes que no comenzaron o terminaron las series de vacunas contra el VPH
también necesitan vacunarse. Las mujeres jóvenes pueden recibir esta vacuna hasta los
27 años y los hombres jóvenes hasta los 22. Los hombres jóvenes que tengan relaciones
sexuales con otros hombres o que tengan sistemas inmunitarios debilitados también
pueden recibir la vacuna contra el VPH hasta los 27 años. Las vacunas contra el VPH se
administran en una serie de inyecciones que se aplican durante varios meses. La mejor
manera de acordarse de que le pongan a su hijo todas las inyecciones que necesita, es
hacer citas para las que falten antes de irse del consultorio del médico o del centro
médico. ¿Es segura la vacuna contra el VPH? Sí. Las vacunas contra el VPH se han
estudiado muy cuidadosamente, y los CDC y la Administración de Alimentos y
Medicamentos (FDA) las siguen vigilando. No se han asociado problemas de seguridad
graves a estas vacunas. Los estudios siguen mostrando que las vacunas contra el VPH
son seguras. Los efectos secundarios reportados con más frecuencia después de la
vacunación contra el VPH son leves e incluyen dolor y enrojecimiento en el área del
brazo donde se aplicó la inyección, fiebre, mareos y náuseas. Algunos preadolescentes y
adolescentes pueden desmayarse después de recibir una inyección o hacerse cualquier
otro procedimiento médico. Sentarse o recostarse por unos 15 minutos después de
recibir inyecciones puede ayudar a prevenir lesiones que pueden ocurrir si su hijo se cae
al desmayarse. Los efectos secundarios graves de las vacunas contra el VPH son muy
poco frecuentes. Los niños con alergias graves a la levadura o al látex no deben recibir
ciertas vacunas contra el VPH.Asegúrese de decirle al médico o enfermero si su hijo
tiene alergias graves. ¿Por qué mi hijo necesita esa vacuna ahora? Las vacunas contra el
VPH brindan la mejor protección a los niños y niñas que reciben las tres dosis y que
tienen tiempo para desarrollar una respuesta inmunitaria antes de que comiencen a tener
actividad sexual con otra persona. Esto no significa que su hijo o hija preadolescente
esté listo para tener relaciones sexuales. De hecho, se trata precisamente de lo contrario.
Es importante que su hijo o hija esté protegido antes de que usted o ellos piensen en este
tema. La respuesta inmunitaria a esta vacuna es mejor en los preadolescentes y esto
podría significar una mejor protección para su hijo o hija. CS HCVG15-PTT-104
DISTRIBUIDO POR: Ayuda para pagar por las vacunas del programa VFC en
http://www.cdc.gov/spanish/especialesCDC/ ProgramaVacunas/ El programa de
Vacunas para Niños (VFC, por sus siglas en inglés) proporciona vacunas para niños de
hasta 18 años que no tengan seguro médico, que cumplan con los requisitos para recibir
Medicaid, o que sean indoamericanos o nativos de Alaska. Infórmese más acerca Ya sea
que tenga seguro o que su hijo cumpla los requisitos del programa VFC, algunos
consultorios médicos también pueden cobrar una tarifa por la aplicación de las vacunas.
La historia de Jacquelyn “Yo estaba sana y tuve cáncer de cuello de útero”. Al final de
mis 20 años y principios de mis 30, antes de que naciera mi hija, tuve algunos exámenes
de Papanicolaou anormales y me hicieron pruebas adicionales. Me dijeron que tenía el
tipo de VPH que puede causar cáncer y displasia leve. Durante tres años más, mis
pruebas fueron normales. Pero cuando me realizaron el primer examen de Papanicolaou
después de que naciera mi hijo, me dijeron que necesitaban realizar una biopsia. Los
resultados dieron que era cáncer y mi médico me envió a un oncólogo.
Afortunadamente, el cáncer estaba en un estadio temprano. Los ganglios linfáticos
estaban limpios y no necesitaba radiación. Pero debían realizarme una histerectomía
total. Mi marido y yo hemos estado juntos por 15 años y planeábamos tener más hijos.
Estamos tan agradecidos por nuestros dos hermosos hijos, pero esperábamos tener más,
lo que no sucederá ahora. Lo bueno fue que detectaron el cáncer a tiempo, pero las
complicaciones siguen teniendo un impacto en mi vida y en mi familia. En los próximos
años me tengo que realizar exámenes pélvicos y de Papanicolaou cada algunos meses,
los médicos miden los marcadores de tumores y me deben realizar radiografías y
ecografías con regularidad, por si acaso. Tengo tantas citas médicas que me alejan de mi
familia, mis amigos y mi trabajo. Lo peor es que cada vez que el teléfono suena y sé que
es mi oncólogo, contengo la respiración hasta que me da los resultados. Tengo
esperanzas de poder llevar una vida completa y sana, pero siempre pienso en el cáncer.
En tan poco tiempo, pasé de tener una vida sana y planificar más hijos a tener una
histerectomía total e intentar asegurarme de no tener cáncer de nuevo. Es abrumador. Y
soy una de las personas con suerte. En última instancia, debo asegurarme de estar sana y
estar presente para mis hijos. Quiero ver a mis nietos crecer. Haré todo lo posible para
que mi hijo y mi hija no deban pasar por esto. Cuando cumplan los 11 años, los
vacunaré contra el VPH. Le digo a todo el mundo, a mis amigos y familiares, que sus
hijos necesitan la serie de vacunas contra el VPH para protegerlos de este tipo de
cáncer. ¿Y esto es para los niños varones también? ¡La vacuna contra el VPH también
es para los niños varones! Esta vacuna puede ayudar a prevenir que los niños varones
contraigan la infección por los tipos del VPH que pueden causar cánceres de boca,
garganta, pene y ano. Esta vacuna también puede ayudar a prevenir las verrugas
genitales. Es probable que vacunar a los niños varones también beneficie a las mujeres
al reducir la transmisión de los virus del VPH. Infórmese más acerca del VPH y de la
vacuna contra el VPH en www.cdc.gov/hpv/ Obtenga más información sobre las
vacunas recomendadas para los preadolescentes y adolescentes 800-CDC-INFO (800-
232-4636) www.cdc.gov/vaccines/teens
INFORMACION NEGATIVA NO CIENTIFICA
http://www.telegraph.co.uk/news/2016/05/10/teenage-girl-dies-five-days-after-
receiving-hpv-vaccine-jab/
"More than three million girls have been vaccinated so far in the UK with HPV
vaccine, and tens of millions more have been vaccinated globally. As with all
vaccines, safety remains under continual review, and HPV vaccine has a very
good safety record," a spokesman for the Medicines and Healthcare Regulatory
Agency told the Manchester Evening News.
Teenage girl dies five days after
receiving HPV vaccine jab
•
•
•
Shazel Zaman CREDIT: MEN
• Telegraph Reporters
10 MAY 2016 • 2:32AM
Ateenage girl died hours after being sent home from hospital diagnosed with a
stomach bug.
Shazel Zaman, 13, received a cervical cancer jab five days earlier after which
she started vomiting and suffering from dizziness and a severe headache. As her
symptoms got worse she was taken to Bury's Fairfield Hospital.
Doctors told the teenager's family that they believed she might have a stomach
bug and told them to bring her back to hospital if her condition worsened, the
Manchester Evening News reported. An hour later she was found unconscious
with no pulse at her home in Bury. She was declared dead in hospital
around four hours later.
Shazel's family claims that a doctor dismissed that her condition was linked to
the HPV vaccine jab and said she "came across as a lazy child" before sending
her home. Pennine Acute NHS Trust, which runs the hospital, has now launched
an investigation into the standard of care Shazel received at the hospital.
Shazel’s family believe her death is linked directly to her having the vaccine.
Her sister, Maham Hussain, 19, told the Manchester Evening News: “She had
the injection on the Wednesday. On Friday she was complaining of a sore arm -
no swelling just redness.
“On the Saturday she complained of a severe headache, and by the evening she
was throwing up. Come Sunday she was very pale, and my aunt took her to
Fairfield.
Maham Hussain, Shazel's sister CREDIT: MEN
“Whilst she was there she was in and out of consciousness. My aunt had to get a
wheelchair for her.
“She had a blood test, and her heart rate checked, and everything was said to be
normal.
“She was asked to provide a urine test and when my aunt took her to the toilet
she fell to the floor, she was so drowsy.
"My aunt took her back to the doctor and that’s when the doctor made the
comment that Shazel ‘came across as a lazy child’."
Shazel’s aunt, Saimah Naseem, who took her to Fairfield, said: “I was shocked.
That was a horrible thing to say. One of the nurses also made the comment
‘she’s fine’.”
The teenager was given her second course of the HPV vaccine at Derby High
School in Bury on April 13. She died on April 17.
Shahad's sister added: “I was at home when Shazel returned. She was in a really
bad state. As soon as she came home my aunt put her to bed.
“My aunt gave her water so she wouldn’t dehydrate. My aunt and grandmother
kept checking on her.
“An hour later she went blue. She had no pulse. The paramedics were here in
seven minutes but she was not responding.
“At hospital it was just the machines that were keeping her alive.”
The family said that following her death she underwent a CT scan and then paid
£670 for an MRI scan at Oldham Royal Hospital.
Both tests were inconclusive and an autopsy has now been carried out. Results
will not be available for several months.
“The family strongly believe that there is a link between her death and the
vaccination," Ms Hussain told the Manchester newspaper:
“Before that she was perfectly normal, and active. Our own GP was really
shocked that she had passed away. The reason we are speaking out is to raise
awareness of what might happen.
“I don’t think the hospital took her seriously. If they had done more tests they
could have picked something up.”
In a letter to the child’s mother, Rob Barrow, Assistant Directorate Manager at
Pennine Acute NHS Trust said: “In line with national and Trust policy, we will
be undertaking an investigation looking at the care and treatment of your
daughter whilst under the care of the Trust.”
He added: “I know there are questions you may wish to raise to be considered as
part of the investigation.”
In a statement Gill Harris, Chief Nurse at The Pennine Acute Hospitals NHS
Trust, said: “Our thoughts are with the family and we offer them our sincere
condolences for their tragic loss. We have started a full clinical review to
examine the circumstances surrounding Shazel Zaman’s death to understand
what happened following her attendance at our A&E department in April. We
intend to share the findings from our review with the family, with the Coroner’s
office, as well as with our own staff.”
Deputy Bury Coroner, Lisa Hashmi has also commenced an investigation but
will assess evidence before deciding whether to have a full inquest if she deems
Shazel’s death "unnatural".
"More than three million girls have been vaccinated so far in the UK with HPV
vaccine, and tens of millions more have been vaccinated globally. As with all
vaccines, safety remains under continual review, and HPV vaccine has a very
good safety record," a spokesman for the Medicines and Healthcare Regulatory
Agency told the Manchester Evening News.
“We are aware of the tragic death of a young girl, and our thoughts are with her
family. As with any serious adverse events, we will establish the facts, but there
has been no suggestion from safety monitoring so far that the vaccine has been
responsible for any deaths.”
Since 2008, girls aged 12 and 13 in the UK have been routinely given a
vaccination for the human papilloma virus (HPV) as part of the NHS childhood
vaccination programme. The vaccine protects from cervical and throat cancers
as well as genital warts.
According to Cancer Research UK, cervical cancer is the second most common
cancer in women under the age of 35. In the UK, 2,900 women a year are
diagnosed with cervical cancer, that's around eight women every day.
"Brian Shilhavy"
Dr. Andrew Moulden
https://www.amazon.com/Medical-Doctors-Opposed-Forced-Vaccinations-
ebook/dp/B00YVU2K0I/ref=pd_sim_351_1
http://healthimpactnews.com/2014/gardasil-vaccine-one-more-girl-dead/
Gardasil Vaccine: One More Girl Dead
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Meredith Prohaska was 12 years old. Photo courtesy of WISN.
Health Impact News Editor Comments
The sudden death of a 12-year-old girl in Waukesha, Wisconsin, just hours after receiving the HPV Gardasil vaccine has shocked the girl’s family, and sent local
media out asking questions as to how this could happen. Here is a report from WISN 12 News.
Dr. Geoffrey Swain of the local health department was interviewed to give the standard CDC reply, which is similar to almost every other vaccine, stating that
severe reactions like this resulting in death are “very rare,” and about “1 out of a million”.
Assuming that there is some data to back up the claim of only “1 out of a million,” how many doses of the HPV vaccine are administered every year? According
to the latest statistics (July 2014) published by the U.S. Department of Health and Human Services here (page 7), over 9 million per year. So the government
admits that at least 9 girls per year are killed by the HPV vaccine. How many parents know this prior to taking a doctor’s advice to administer this vaccine that is
supposedly a protection against cervical cancer caused by the human papillomavirus, a sexually transmitted disease?
Apparently, when the news broke that 12-year-old Meredith Prohaska died after receiving the HPV vaccine, at least one other parent contacted a local news
station in the area to report she also had a serious adverse reaction to the HPV vaccine with her 17-year-old daughter, who needed urgent care at a local
hospital. The local news affiliate asked the question: “So what are the odds another local girl had a similar reaction after getting the shot?”
Here is the report:
These local news media, possibly covering the HPV vaccine for the first time, were all quick to interview and provide links to the official CDC view of the vaccine.
But here are some other facts regarding the vaccine that they failed to disclose, probably because they did not take the time to look outside of the standard
government response to events like this, or their station managers did not allow them to give any other news outside of what the CDC claims.
1. There are many more reported side effects than just death from the HPV vaccine.
They include:
Premature menopause or infertility
See:
• Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune/inflammatory syndrome induced by adjuvants. July
2013, American Journal of Reproductive Immunology
• Dr. Deirdre Little, a pediatrician in Australia, was the first one to sound the alarm over the HPV vaccine causing premature menopause when she
observed it in one of her 16 year old patients in 2012.
• Two sisters from Wisconsin say a cervical cancer vaccine shut down their ovaries and almost certainly left them unable to get pregnant
Narcolepsy and Autoimmune Disorders
See: Narcolepsy and Cataplexy after Gardasil?
Guillain–Barré syndrome (GBS), stroke, venous thromboembolism (VTE), appendicitis, seizures, syncope (fainting), and allergic reactions.
See: CDC HPV Vaccine Facts
2. Countries Outside the U.S. Are Halting HPV Vaccines: Lawsuits due to Damages are Mounting
See:
• Gardasil Vaccine: Spain Joins Growing List of Countries to File Criminal Complaints
• Supreme Court in India to Rule on Merck Fraud Regarding HPV Vaccine Deaths
• French Medical Professionals ask: Are HPV vaccines necessary?
• Merck’s Former Doctor Predicts that Gardasil will Become the Greatest Medical Scandal of All Time
• Japan Halts HPV Vaccine and Begins Full-Scale Probe over Safety Issues
• 10 More Young Women File Criminal Complaints due to Injuries from Gardasil Vaccine in France
• HPV Vaccine: Israel Health Ministry Considers Canceling Vaccination Due to Side Effects
3. You Cannot Sue the Manufacturer of Vaccines in the U.S. – They have total legal immunity
Most of the U.S. public is unaware that a U.S. citizen, by law, cannot sue a pharmaceutical company for damages resulting from vaccines. Congress gave them
total legal immunity in 1986, and that law was upheld by the U.S. Supreme Court in 2011. There is a special “vaccine court” called the National Vaccine Injury
Compensation Program that is funded through a tax on vaccines. If you are injured or killed by a vaccine, you must hire an attorney and fight tax-funded
government attorneys to seek damages, as you cannot sue the drug manufacturers. It can take 10 years or longer to win your case and be compensated. The
U.S. Department of Health and Human Services usually publishes a report every couple months on settlements on their website. Here is the latest one.
4. The U.S. Government Earns Royalties from the sale of the Gardasil HPV Vaccine.
Dr. Eric Suba tried to use the Freedom of Information Act to find out how much money the National Institute of Health (NIH) earned from the sale of Gardasil, but
they refused to report the amount of revenue the government earns from this vaccine (although not denying they do earn royalties). Did you know that the
government earns royalties from the sale of the Gardasil vaccine? Does your doctor promoting the HPV vaccine know this?
5. Julie Gerberding was in charge of the CDC the years the FDA approved Gardasil as a
vaccine and is now the president of Merck’s Vaccine division, a $5 billion dollar a year
operation
Julie Gerberding was in charge of the CDC from 2002 to 2009, which includes the years the FDA approved Gardasil as a vaccine. Soon after she took over the
CDC, she reportedly completely overhauled the agency’s organizational structure, and many of the CDC’s senior scientists and leaders either left or announced
plans to leave. Some have claimed that almost all of the replacements Julie Gerberding appointed had ties to the vaccine industry.
Gerberding resigned from the CDC on January 20, 2009, and is now the president of Merck’s Vaccine division, a 5 billion dollar a year operation, and the
supplier of the largest number of vaccines the CDC recommends (article here).
6. Black Women who are Vaccinated with Gardasil are Vaccinated Against the Wrong Strains
Scientists at the Duke University School of Medicine discovered that African American women carry HPV strains not found in the Gardasil vaccine. Study
here. Moshella Roberts, a 20-year-old African American woman died needlessly from the HPV vaccine.
Do your own research!
While it is encouraging to see local news affiliates report deaths and injuries due to the Gardasil vaccine, they need to do more research to present all of the
facts, rather than just parroting what the CDC says. Of course to raise the issue of the “Gardasil controversy” could jeopardize your journalistic career, and force
you into apologizing for suggesting the vaccine is anything but totally safe. Just askKatie Couric.
In the meantime, do your own research before making any decisions on the Gardasil vaccine!
Comment on this story at VaccineImpact.com
See Also:
Parents of HPV Vaccine Victims Protest in the Streets of Colombia
More info on the Gardasil HPV Vaccine.
Say NO to Mandatory Vaccines T-Shirt
100% Pre-shrunk Cotton
Order here!
Make a Statement for Health Freedom!
Big Pharma and government health authorities are trying to pass laws mandating vaccines for all children, and even adults.
Show your opposition to forced vaccinations and support the cause of Vaccine Impact, part of theHealth Impact News network.
Order here!
Dr. Andrew Moulden: Every Vaccine Produces Harm
eBook – Available for immediate download.
Canadian physician Dr. Andrew Moulden provided clear scientific evidence to prove that every dose of vaccine given to a child or an adult produces harm. The
truth that he uncovered was rejected by the conventional medical system and the pharmaceutical industry. Nevertheless, his warning and his message to
America remains as a solid legacy of the man who stood up against big pharma and their program to vaccinate every person on the Earth.
Dr. Moulden died unexpectedly in November of 2013 at age 49.
Because of the strong opposition from big pharma concerning Dr. Moulden’s research, we became concerned that the name of this brilliant researcher and his
life’s work had nearly been deleted from the internet. His reputation was being disparaged, and his message of warning and hope was being distorted and
buried without a tombstone. This book summarizes his teaching and is a must-read for everyone who wants to learn the “other-side” of the vaccine debate that
the mainstream media routinely censors.
Read:
Read Dr. Andrew Moulden: Every Vaccine Produces Harm on your mobile device!
on your mobile device!
$3.99
Medical Doctors Opposed to Forced Vaccinations – Should Their Views be Silenced?
eBook – Available for immediate download.
One of the biggest myths being propagated in the compliant mainstream media today is that doctors are either pro-vaccine or anti-vaccine, and that the anti-
vaccine doctors are all “quacks.”
However, nothing could be further from the truth in the vaccine debate. Doctors are not unified at all on their positions regarding “the science” of vaccines, nor
are they unified in the position of removing informed consent to a medical procedure like vaccines.
The two most extreme positions are those doctors who are 100% against vaccines and do not administer them at all, and those doctors that believe that ALL
vaccines are safe and effective for ALL people, ALL the time, by force if necessary.
Very few doctors fall into either of these two extremist positions, and yet it is the extreme pro-vaccine position that is presented by the U.S. Government and
mainstream media as being the dominant position of the medical field.
In between these two extreme views, however, is where the vast majority of doctors practicing today would probably categorize their position. Many doctors who
consider themselves “pro-vaccine,” for example, do not believe that every single vaccine is appropriate for every single individual.
Many doctors recommend a “delayed” vaccine schedule for some patients, and not always the recommended one-size-fits-all CDC childhood schedule. Other
doctors choose to recommend vaccines based on the actual science and merit of each vaccine, recommending some, while determining that others are not
worth the risk for children, such as the suspect seasonal flu shot.
These doctors who do not hold extreme positions would be opposed to government-mandated vaccinations and the removal of all parental exemptions.
In this eBook, I am going to summarize the many doctors today who do not take the most extremist pro-vaccine position, which is probably not held by very
many doctors at all, in spite of what the pharmaceutical industry, the federal government, and the mainstream media would like the public to believe.
Read:
Medical Doctors Opposed to Forced Vaccinations – Should Their Views be Silenced?
on your mobile device!
$0.99
Published on August 11, 2014
Tags: gardasil, HPV vaccine
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Pequeño análisis sobre la necesidad de Vacunar y su impacto en la sociedad en medios comunes y científicos #papillomavirus @jiwitmanuel @xemide

  • 1. Debo vacunar a mi hijo? Enfermedad Papiloma virus Humano. Información: diversas fuentes. Técnica, Científica, Industrial. Técnica: Afirmativa: Contexto España. (mejor sanidad pública a nivel mundial). Vademecum.es Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Antiinfecciosos para uso sistémico > Vacunas > Vacunas antivirales > Vacuna contra papilomavirus Mecanismo de acción Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Vacuna nonavalente recombinante adyuvada no infecciosa, inmuniza frente al virus del papiloma humano. Indicaciones terapéuticas Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Inmunización activa de individuos ≥ 9 años frente a las siguientes enfermedades por VPH: lesiones precancerosas y canceres que afectan al cuello de útero, vulva, vagina y ano causados por los tipos del VPH de la vacuna; verrugas genitales (Condiloma acuminata) causados por tipos específicos del VPH. Posología Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Modo de administración Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Se debe administrar mediante iny. IM en la región deltoidea de la parte superior del brazo o en la zona anterolateral superior del muslo. No debe ser inyectada por vía intravascular, SC o intradérmica. No se debe mezclar en la misma jeringa con ninguna otra vacuna o solución Contraindicaciones Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Hipersensibilidad. Advertencias y precauciones Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Valorar riesgo/beneficio; sin datos en < 9 años ni en ≥ 27 años; prever síncope o respuesta vasovagal a la iny. (especialmente en adolescentes) y posible reacción anafiláctica; en enf. febril aguda grave, posponer la vacunación; en pacientes con trombocitopenia o trastornos de coagulación, riesgo de hemorragia por su administración IM; individuos con la respuesta inmune alterada (debido al uso de una
  • 2. terapia inmunosupresora potente, defecto genético, infección por VIH u otras causas), podrían no responder a la vacuna; no sustituye al cribado rutinario del cáncer de cuello de útero (seguir recomendaciones locales) ni a la toma de precauciones frente a ETS; sólo para uso profiláctico; duración de protección no establecida. Interacciones Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) No se ha estudiado en los ensayos clínicos la seguridad e inmunogenicidad en individuos que habían recibido inmunoglobulina o productos derivados de sangre durante los 3 meses previos a la 1ª dosis de la vacuna. Embarazo Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Contraindicado. La vacunación se debe posponer hasta el término del embarazo. Lactancia Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) La vacuna puede ser utilizada durante el período de lactancia. En los ensayos clínicos de la vacuna, un total de 92 mujeres estuvieron en periodo de lactancia durante el periodo de vacunación. En los estudios la inmunogenicidad de la vacuna fue comparable entre las mujeres en periodo de lactancia y en las que no estaban en periodo de lactancia durante la administración de la vacuna. Además el perfil de acontecimientos adversos en las mujeres en periodo de lactancia fue comparable al perfil global de seguridad de la población. No hubo acontecimientos adversos graves relacionados con la vacuna notificados en recién nacidos con lactancia materna durante el periodo de vacunación. Efectos sobre la capacidad de conducir Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Tiene un efecto nulo o insignificante sobre la capacidad para conducir o utilizar máquinas. Sin embargo, algunos de los efectos mencionados en la sección "Reacciones adversas", pueden afectar temporalmente la capacidad de conducir o utilizar máquinas. Reacciones adversas Papilomavirus (tipos humanos 6, 11, 16, 18, 31, 33, 45, 52, 58) Cefalea, mareo; náuseas; pirexia, fatiga, trastornos en el lugar de iny.: eritema, dolor, hinchazón, hematomas, prurito. Fuente: Monografía propiedad editorial de Vidal Vademecum INFORMACION CIENTÍFICA mejor revista científica del mundo new england Journal of medicine New england latest post. http://www.nejm.org/medical-research/viral-infections#qs=%3Fsubtopic%3Dviral- infections%26category%3Dresearch http://www.nejm.org/doi/full/10.1056/NEJMoa1612296 SOURCE INFORMATION From the Department of Epidemiology Research, Statens Serum Institut, Copenhagen (N.M.S., B.P., D.M.-N., H.S., A.H.); and the Clinical Epidemiology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm (B.P.). Address reprint requests to Dr. Scheller at the Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark, or a nims@ssi.dk.
  • 3. Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes Nikolai M. Scheller, M.D., Björn Pasternak, M.D., Ph.D., Ditte Mølgaard-Nielsen, M.Sc., Henrik Svanström, Ph.D., and Anders Hviid, Dr.Med.Sci. N Engl J Med 2017; 376:1223-1233March 30, 2017DOI: 10.1056/NEJMoa1612296 Share: BACKGROUND The quadrivalent human papillomavirus (HPV) vaccine is recommended for all girls and women 9 to 26 years of age. Some women will have inadvertent exposure to vaccination during early pregnancy, but few data exist regarding the safety of the quadrivalent HPV vaccine in this context. METHODS We assessed a cohort that included all the women in Denmark who had a pregnancy ending between October 1, 2006, and November 30, 2013. Using nationwide registers, we linked information on vaccination, adverse pregnancy outcomes, and potential confounders among women in the cohort. Women who had vaccine exposure during the prespecified time windows were matched for propensity score in a 1:4 ratio with women who did not have vaccine exposure during the same time windows. Outcomes included spontaneous abortion, stillbirth, major birth defect, small size for gestational age, low birth weight, and preterm birth. RESULTS In matched analyses, exposure to the quadrivalent HPV vaccine was not associated with significantly higher risks than no exposure for major birth defect (65 cases among 1665 exposed pregnancies and 220 cases among 6660 unexposed pregnancies; prevalence odds ratio, 1.19; 95% confidence interval [CI], 0.90 to 1.58), spontaneous abortion (20 cases among 463 exposed pregnancies and 131 cases among 1852 unexposed pregnancies; hazard ratio, 0.71; 95% CI, 0.45 to 1.14), preterm birth (116 cases among 1774 exposed pregnancies and 407 cases among 7096 unexposed pregnancies; prevalence odds ratio, 1.15; 95% CI, 0.93 to 1.42), low birth weight (76 cases among 1768 exposed pregnancies and 277 cases among 7072 unexposed pregnancies; prevalence odds ratio, 1.10; 95% CI, 0.85 to 1.43), small size for gestational age (171 cases among 1768 exposed pregnancies and 783 cases among 7072 unexposed pregnancies; prevalence odds ratio, 0.86; 95% CI, 0.72 to 1.02), or stillbirth (2 cases among 501 exposed pregnancies and 4 cases among 2004 unexposed pregnancies; hazard ratio, 2.43; 95% CI, 0.45 to 13.21). CONCLUSIONS Quadrivalent HPV vaccination during pregnancy was not associated with a significantly higher risk of adverse pregnancy outcomes than no such exposure. (Funded by the Novo Nordisk Foundation and the Danish Medical Research Council.) Informacion Industrial (novo nordisc) Format: Abstract Send to Nat Genet. 2015 Feb;47(2):158-63. doi: 10.1038/ng.3178. Epub 2015 Jan 12. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Hu Z1, Zhu D1, Wang W2, Li W3, Jia W4, Zeng X5, Ding W1, Yu L1, Wang X1, Wang L1, Shen H1, Zhang C1, Liu H5, Liu X5, Zhao Y5,Fang X5, Li S6, Chen W5, Tang T7, Fu A8, Wang Z8, Chen G1, Gao Q1, Li S1, Xi L1, Wang C1, Liao S1, Ma X1, Wu P1, Li K1, Wang S1,Zhou J9, Wang J10, Xu X5, Wang H1, Ma D1. Author information 1 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 2 Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • 4. 3 1] Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. [2] School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China. 4 1] Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. [2] Department of Computer Science, City University of Hong Kong, Hong Kong, China. 5 Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. 6 Department of Computer Science, City University of Hong Kong, Hong Kong, China. 7 WuHan Frasergen Bioinformatics Co., Ltd , Wuhan, China. 8 Wuhan Institute of Biotechnology, Wuhan, China. 9 Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 10 1] Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. [2] School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China. [3] Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia. [4] The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. [5] Centre for iSequencing, Aarhus University, Aarhus, Denmark. Abstract Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis. By conducting whole-genome sequencing and high-throughput viral integration detection, we identified 3,667 HPV integration breakpoints in 26 cervical intraepithelial neoplasias, 104 cervical carcinomas and five cell lines. Beyond recalculating frequencies for the previously reported frequent integration sites POU5F1B (9.7%), FHIT (8.7%), KLF12 (7.8%), KLF5 (6.8%), LRP1B (5.8%) and LEPREL1 (4.9%), we discovered new hot spots HMGA2 (7.8%), DLG2 (4.9%) and SEMA3D (4.9%). Protein expression from FHIT and LRP1B was downregulated when HPV integrated in their introns. Protein expression from MYC and HMGA2 was elevated when HPV integrated into flanking regions. Moreover, microhomologous sequence between the human and HPV genomes was significantly enriched near integration breakpoints, indicating that fusion between viral and human DNA may have occurred by microhomology-mediated DNA repair pathways. Our data provide insights into HPV integration-driven cervical carcinogenesis. Comment in Artifacts in the data of Hu et al. [Nat Genet. 2016] Reply to Artifacts in the data of Hu et al. [Nat Genet. 2016] PMID: 25581428 DOI:
  • 5. 10.1038/ng.3178 [Indexed for MEDLINE] Informacion Negativa Científica e industrial PubMed Commons 0 comments Informacion negativa técnica. http://www.nhs.uk/Conditions/vaccinations/Pages/hpv-vaccine-cervarix-gardasil-side- effects.aspx HPV vaccine side effects The most common side effects of the HPV vaccine include swelling, redness and pain at the site of the injection, and headaches - although these are generally tolerable and short lived. Very common side effects of the HPV vaccine More than one in 10 girls who have the Gardasil HPV vaccine experience: • injection site problems such as redness, bruising, itching, swelling, pain or cellulitis • headaches Common side effects More than one in 100 girls who have the Gardasil HPV vaccine experience: • fever • nausea (feeling sick) • painful arms, hands, legs or feet Rare side effects Around one in 10,000 girls who have the Gardasil HPV vaccine experience • an itchy red rash (urticaria, or 'hives') Very rare side effects Fewer than one in 10,000 girls who have the Gardasil HPV vaccine experience: • restriction of the airways and difficult breathing (bronchospasm) Side effects of unknown frequency
  • 6. It is not possible to reliably estimate how frequently other side effects occur. This is because information is received from people reporting side effects themselves, rather than controlled, clinical tests. The frequency of these side-effects is unknown: • blood problems, leading to unexplained bruising or bleeding • chills • fainting or brief loss of consciousness • feeling dizzy • general feeling of being unwell • Guillain Barré syndrome • joint pain • lymphadenopathy • muscle pain or tenderness • seizures (fits) • tiredness • vomiting • weakness If you feel unwell or have concerns about a side effect after having the HPV vaccine, seek medical advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist or nurse. Allergic reactions In rare cases, it is possible for someone who has had the HPV vaccine to experience a more severe allergic reaction, known as an anaphylactic reaction. Signs of an anaphylactic reaction include: • breathing difficulties and wheezing • swollen eyes, lips, genitals, hands, feet and other areas (this is calledangioedema) • itching • a strange metallic taste in the mouth • sore, red, itchy eyes • changes in heart rate • loss of consciousness Be reassured that severe reactions like this are extremely rare, in the order of around one in a million. If your daughter has a severe allergic reaction, the healthcare professional giving the vaccine will be fully trained in how to deal with it. Individuals recover completely with treatment, usually within a few hours. If you are with someone and they start to experience the symptoms of anaphylaxis, dial 999 immediately to request an ambulance. See the treatment of anaphylaxis for more information. Chronic fatigue and the HPV vaccine There have been reports in the press alleging that girls have developed chronic fatigue syndrome after HPV vaccination.
  • 7. The cause of CFS (otherwise known as ME, or myalgic encephalomyelitis) is not known, but it does occur naturally in teenagers, and is more common in girls than boys. There are no more cases of CFS than would be expected in teenage girls and there is no evidence to link CFS to the HPV vaccine. The WHO Global Advisory Committee on Vaccine Safety (GACVS) regularly review the emerging international evidence on the safety of HPV vaccination and issued a statement in March 2014 concluding there is no proven link between the HPV vaccination and autoimmune disease, of which many think CFS/ME is an example. How to spot and report side effects The Yellow Card Scheme allows you to report suspected side effects from any medicine you are taking including vaccines. It is run by the Medicines and Healthcare Products Regulatory Agency. Find out how to report a vaccine side effect. http://www.nhs.uk/Conditions/vaccinations/Pages/reporting-side-effects.aspx how to report side effects Vaccine side effects It's natural to be concerned that you or your child will have a side effect after having a vaccination. While all vaccines have the potential to cause side effects in some people, the reality is that most tend to be mild and don't last longer than a few days. Some people don't get any side effects at all. Common vaccine side effects Common side effects of any vaccine can include: • injection site reactions (pain, swelling and redness) • mild fever • shivering • fatigue • headache • muscle and joint pain Rare vaccine side effects A far less common, but serious, vaccine side effect is an immediate allergic reaction, also known as an anaphylactic reaction. These are dramatic and potentially life-threatening. However, they are very rare – occurring in less than one in a million cases – and are completely reversible if treated promptly by healthcare staff. To have a balanced view, potential side effects have to be weighed against the expected benefits of vaccination in preventing the serious complications of disease. Read more about the benefits and risks of vaccination. Not all illnesses that occur after vaccination will be a side effect. Because millions of people every year are vaccinated, it's inevitable that some will go on to develop a coincidental infection or illness shortly afterwards.
  • 8. What to do if your child is unwell after having a vaccination Most common side effects in babies and young children are at the site of the injection, and include: • swelling • redness • a small hard lump These symptoms usually pass within a couple of days and you don't need to do anything about them. Children may sometimes develop a high temperature (fever). If this happens, keep your child cool. Make sure they don't wear too many layers of clothes or blankets and give them plenty of cool drinks. You can also give them a dose of infant paracetamol or ibuprofen liquid according to the instructions on the bottle. Read an NHS leaflet about the common side effects of vaccinations that may occur in babies and children under the age of five (PDF, 118kb), and how to treat them. Find out about a vaccine's side effects A patient information leaflet (PIL) is included in the pack of each dose of vaccine, and lists its potential side effects. You can also read vaccine PILs online on the electronic Medicines Compendium (eMC) website. Reporting a vaccine side effect If you, a doctor, nurse or pharmacist suspects that you or your child has had a possible side effect to a vaccine, it can be reported through theYellow Card Scheme. The Yellow Card Scheme is run by the Medicines and Healthcare products Regulatory Agency (MHRA) and is designed to pick up unexpected problems or new side effects. If a serious new side effect is identified, the MHRA will follow up the report. It may change the way a vaccine is used, or it may even be taken off the market. How to use the Yellow Card Scheme Tell your doctor, nurse or pharmacist about the suspected side effect, and they'll report it for you. Alternatively, you can report it yourself by: • using the Yellow Card Scheme online reporting system • picking up a Yellow Card form at your GP surgery or local pharmacy – complete the form and send it to the address provided • calling the Yellow Card freephone hotline on 0808 100 3352, Monday to Friday, 10am to 2pm Now, read more about the safety of vaccinations, or about the side effects of each vaccine: • side effects of the 5-in-1 infant vaccine • side effects of the 4-in-1 pre-school booster • side effects of the 3-in-1 teenage booster • side effects of the MMR vaccine • side effects of the chickenpox vaccine • side effects of the Men C vaccine • side effects of the Men B vaccine • side effects of the Men ACWY vaccine • side effects of the Hib/Men C booster • side effects of the pneumococcal vaccine
  • 9. • side effects of the HPV (cervical cancer) vaccine • side effects of the BCG vaccine • side effects of the flu vaccine • side effects of the children's flu vaccine • side effects of the rotavirus vaccine • side effects of the shingles vaccine CDC opinion on vaccine safety https://www.cdc.gov/vaccinesafety/research/publications/index.html Frequently Asked Questions about HPV Vaccine Safety Recommend on FacebookTweet Featured Resource: HPV Vaccine (Gardasil) is Safe HPV Vaccine (Gardasil) is Safe[PDF - 241 KB] • What human papillomavirus (HPV) vaccines are available in the United States? • Are HPV vaccines safe? • How does CDC make sure HPV vaccines are safe? • How do the benefits of HPV vaccines compare to the risks? • Have serious problems been reported after people receive HPV vaccines? • Can HPV vaccine damage women’s ovaries? • Has HPV vaccine ever been linked to Guillain-Barré syndrome? • Can HPV vaccines cause Postural Orthostatic Tachycardia Syndrome (POTS)? • Has anyone died after receiving HPV vaccines? • Have FDA and CDC changed any recommendations for the use of HPV vaccines based on vaccine safety monitoring? • Do HPV vaccines hurt? • Are HPV vaccines safe for pregnant women? • Is there anyone who should not get the HPV vaccine?
  • 10. • What if I have, or my child has, a problem after getting the HPV vaccine? • Where can I find more information about HPV vaccines? What HPV vaccines are available in the United States? There are three HPV vaccines that are licensed for use in the United States by the FDA and recommended by CDC. These vaccines are Gardasil 9, Gardasil, and Cervarix. Gardasil 9 Gardasil Cervarix Who makes it? Merck & Co., Inc. Merck & Co., Inc. GlaxoSmithKline plc What kinds of HPV does it protect against? HPV types 16, 18, 6, 11, 31, 33, 45, 52, and 58 which cause several types of cancer and genital warts HPV types 16, 18, 6, and 11, which cause several types of cancer and genital warts HPV types 16, 18, which cause several types of cancer Who should get the vaccine?* • Routine vaccination for girls and boys aged 11 or 12 years • Catch-up vaccination for teen girls and young women through age 26 • Catch-up vaccination for teen boys and young men through age 21 • Routine vaccination for girls aged 11 or 12 years • Catch-up vaccination for teen girls and young women through age 26 • Gay, bisexual, and other men who have sex with men through age 26 • People with compromised immune systems (including people living with HIV/AIDS) through age 26 When should the vaccine be given? • CDC recommends that 11- to 12-year-olds receive two doses of HPV vaccine at least six months apart The first dose is routinely recommended at 11-12 years old • The second dose of the vaccine should be administered 6 to 12 months after the first dose • Vaccination with the two-dose series can be started at age 9 and through age 14 • Two doses of HPV vaccine given at least six months apart at ages 11 and 12 years will provide
  • 11. Gardasil 9 Gardasil Cervarix safe, effective, and long-lasting protection against HPV cancers • Teens and young adults who start the series later, at ages 15 through 26 years, will need three doses of HPV vaccine to protect against cancer- causing HPV infection • Adolescents aged 9 through 14 years who have already received two doses of HPV vaccine less than 5 months apart, will require a third dose • Three doses are recommended for people with weakened immune systems aged 9-26 years *Recommendations from CDC and the Advisory Committee on Immunization Practices To find out more about HPV vaccination, please visit www.cdc.gov/HPV. Top of Page Are HPV vaccines safe? Yes. All three HPV vaccines – Gardasil 9, Gardasil, and Cervarix – are safe, effective, and recommended by CDC. Many studies have looked at the safety of HPV vaccines in the United States. An overview of these studies can be found on thevaccine safety publications page. Vaccines, like any medicine, can have side effects. Some people who get an HPV vaccine have no side effects at all. Some people report having mild side effects, like a sore arm from the shot for a day or two. The most common side effects are usually mild and go away on their own. Common Side Effects of HPV Vaccine: • Pain, redness, or swelling in the arm where the shot was given • Fever • Headache or feeling tired • Nausea • Muscle or joint pain Fainting (also known as syncope) and related symptoms (such as jerking movements) can happen after any medical procedure. Some people, especially teens, faint after getting vaccinated. To prevent fainting and related injuries, people receiving HPV vaccines should sit or lie down during vaccination, then remain seated for 15 minutes after the shot. Top of Page How does CDC make sure HPV vaccines are safe? All vaccines used in the United States are required to go through years of extensive safety testing before they are licensed by the U.S. Food and Drug Administration (FDA). After vaccines are licensed, CDC and FDA continue to monitor each vaccine to make sure it is safe and effective.
  • 12. CDC’s The Journey of Your Child's Vaccine explains how all vaccines are developed, tested, and continually monitored. Each HPV vaccine was closely studied in clinical trials to make sure it was safe: • Gardasil 9 was studied in more than 15,000 females and males. • Gardasil was studied in 29,000 females and males. • Cervarix was studied in more than 30,000 females. These clinical trials showed HPV vaccines to be safe and effective. Each vaccine continues to be monitored for any safety problems. This monitoring is especially looking for any rare or new problems that may happen after vaccination. CDC uses three systems to monitor the safety of vaccines after they are licensed: • The Vaccine Adverse Event Reporting System (VAERS) • The Vaccine Safety Datalink (VSD) • The Clinical Immunization Safety Assessment (CISA) Network. Read more about these systems on the Vaccine Safety Monitoring at CDC web page. Top of Page How do the benefits of HPV vaccines compare to the risks? CDC has carefully studied the risks and benefits of HPV vaccination. HPV vaccination is recommended because the benefits, such as prevention of cancer, far outweigh the risks of possible side effects. Health decisions are personal, and each person should make choices that are right for themselves and their families. It is important to remember that choosing not to vaccinate is not a risk-free choice—HPV vaccines prevent serious cancers and other diseases in both males and females. Top of Page Have serious problems been reported after people receive HPV vaccines? Nearly 90 million doses of HPV vaccines were distributed in the United States from June 2006 through March 2016. Most of CDC’s HPV vaccine safety monitoring and research has focused on Gardasil because this vaccine has accounted for 87% of HPV vaccine doses distributed in the United States. From June 2006 through March 2016, about 79 million doses of Gardasil were distributed in the United States. During the same period, VAERS received 33,945 US reports of adverse events following Gardasil vaccination. There have been 232 US VAERS reports of adverse events following Cervarix (with 720,000 doses distributed) since licensure through March 31, 2016. VAERS has received 1,447 reports of adverse events following Gardasil 9 since licensure through March 31, 2016. About 10 million doses of Gardasil 9 have been distributed in the United States. Any medicine or vaccine can cause adverse events, and (as with any vaccine or medicine) it is difficult to determine whether or not the HPV vaccine caused a particular adverse event. Which adverse events are considered “serious”? An adverse event is defined by law as serious if it is life threatening or results in death, a persistent or significant disability or incapacity, congenital anomaly or birth defect, hospitalization, or prolongation of existing hospitalization.
  • 13. In the VAERS reports, the most frequently reported symptoms overall were: fainting; dizziness; headache; nausea; fever; and pain, redness, and swelling in the arm where the shot was given. Of the reports to VAERS, 7% were classified as “serious.” About 14% of the VAERS reports were not related to health problems, but were reported for reasons such as improper vaccine storage or the vaccine being given to someone for whom it was not recommended. Top of Page Can HPV vaccines damage women’s ovaries? CDC is aware of public concern about the safety of human papillomavirus (HPV) vaccine. Since 2006, HPV vaccine safety monitoring and studies conducted by CDC, FDA and other organizations have confirmed that this vaccine has an excellent safety record without evidence that it causes reproductive problems in women. What is premature ovarian failure? Also known as “primary ovarian insufficiency” or “premature menopause,” this is a condition in which a woman’s ovaries stop functioning before age 40. Causes of premature ovarian failure include: • Genetics • Chemicals in the environment • Cancer treatments • Cigarettes • Autoimmune disorders • Some viral infections However, in many cases it’s impossible to determine the cause. CDC and FDA have not found any proof that Gardasil causes premature ovarian failure. To read more about HPV and vaccine safety, go to HPV Vaccine Safety. How has FDA and CDC looked for problems? Before Gardasil was licensed, its safety was extensively studied in clinical trials. These studies found no difference in amenorrhea (when a woman of reproductive age doesn’t have a period) between women who got Gardasil compared to women who received a placebo (a shot with no medicine in it). Premature ovarian failure (POF) was not found to happen among women in the Gardasil clinical trials. Between June 2006 and September 2015, more than 80 million doses of Gardasil were distributed for use in the United States. The Vaccine Adverse Event Reporting System (VAERS) received 16 reports of premature ovarian failure and 10 reports of related conditions (ovarian disorder or ovarian failure) being diagnosed at some time after the women received Gardasil vaccination. When adverse events are reported, it does not necessarily mean they are caused by a vaccination. To understand this better, FDA and CDC looked into the reports to see if there was a pattern that might show if the vaccine was causing the problem. There were no patterns among these VAERS reports, so it seems unlikely that the vaccine is causing the problem. CDC continues to monitor and evaluate the safety of HPV vaccine. Even though VAERS did not see a pattern among reports for POF, the VSD is conducting a study to examine this issue further. Does HPV vaccine prevent any conditions that lead to loss of a woman’s fertility? HPV vaccination prevents infection with the HPV types that most commonly cause cervical cancer. In some cases, women develop cervical cancer before starting or finish having children. Treatment for cervical cancer (removal of the cervix and uterus, chemotherapy, and/or radiation) can keep a woman from being able to be pregnant. Preventing cervical cancer through HPV vaccination reduces this risk. CDC works closely with the American Academy of Pediatrics (AAP) and the American Academy of Family Physicians (AAFP) on HPV vaccination, both of which have information available on their websites: HPV Vaccine Recommendations [PDF - 660 KB] AAFP Human Papillomavirus Vaccine American College of Obstetrics and Gynecologists posts guidelines and recommendations Top of Page Has HPV vaccine ever been linked to Guillain-Barré syndrome? Guillain-Barré syndrome (GBS) is a rare disorder where a person’s own immune system damages nerve cells, causing muscle weakness and sometimes paralysis. Most people recover fully from GBS, but some experience long-term nerve damage. CDC’s Vaccine Safety Datalink conducted monitoring for GBS following Gardasil vaccination from August 2006 to February 2012. During this period just over 1.4 million doses of Gardasil were administered in the Vaccine Safety Datalink population. CDC did not identify any cases of GBS among females aged 9-26 years old following Gardasil vaccination.
  • 14. Top of Page Can HPV vaccines cause Postural Orthostatic Tachycardia Syndrome (POTS)? POTS is a condition that causes lightheadedness or fainting and a rapid increase in heartbeat upon standing. The cause is unknown, but doctors think POTS may be associated with a number of risk factors and syndromes, including: a recent viral illness, physical deconditioning, chronic fatigue syndrome and nervous system problems. In November 2015, the European Medicine’s Agency completed a detailed review of available POTS data[PDF - 72 KB] from young women who received HPV vaccines. The review found that the evidence does not support a causal link between HPV vaccines and POTS. From June 2006 through September 2015, when about 80 million doses of Gardasil doses have been given out in the United States, VAERS have received 13 reports of POTS following 4vHPV. There are no unusual or unexpected patterns detected among these cases of POTS following Gardasil vaccination. CDC monitoring through VAERS has not detected any safety concern of POTS following HPV vaccination. Top of Page Has anyone died after receiving an HPV vaccine? Some deaths among people who received an HPV vaccine have been reported to VAERS. This does not mean that the vaccine caused the death, only that the death occurred after the person got the vaccine. CDC and FDA review all available information on reports of death following all vaccines, including HPV vaccines. From June 2006 through September 2015, when about 80 million doses of HPV vaccine had been given out in the United States, VAERS received 117 reports of death after people received the Gardasil vaccine. Among the 117 reports of death, many could not be further studied because there was not enough information included in the report to verify that a person had died. In 51 of the reports, CDC reviewed medical records, autopsy reports, or death certificates and verified that the person had died. After careful review of every reported case of death that has happened after Gardasil vaccination, CDC concluded: • There is no diagnosis that would suggest Gardasil caused the death o There is no pattern of death occurring with respect to time after vaccination o There is no consistent vaccine dose number or combination of vaccines given among the reports Top of Page Have FDA and CDC changed any HPV vaccine recommendations based on vaccine safety monitoring? Yes. When fainting (or syncope) was found to happen after vaccination, FDA changed Gardasil’s guidance for doctors to include information about preventing falls and injuries from fainting after HPV vaccination. CDC and the Advisory Committee on Immunization Practices included this guidance in the recommendations for HPV vaccination. CDC continues to remind doctors and nurses to observe this guidance and to share this information with all their patients. Top of Page Do HPV vaccines hurt? Some people who get the HPV vaccine may have some pain in the arm where the shot was given. Usually this pain is mild and goes away within a few days. Swelling and redness also sometimes occur after HPV vaccination. CDC is aware of reports (in Japan and elsewhere) of chronic pain following HPV vaccines. Some of these reports might be potential cases of Complex Regional Pain Syndrome (CRPS), a rare condition of persistent pain that usually affects arms, legs, hands or feet after an injury or trauma to that limb. In November 2015, the European Medicine’s Agency completed a detailed review of available data on CRPS[PDF - 72 KB] in young women who received HPV vaccines. The review found that the evidence does not support a causal link between HPV vaccines and CRPS. A published article found 21 reports of CRPS to VAERS following to Gardasil between June 2006 and July 2015 concluding that CRPS following Gardasil is rare. CDC monitoring through VAERS has not detected any safety concern for CRPS following HPV vaccination. Top of Page Are HPV vaccines safe for pregnant women? Because the vaccines weren’t tested in pregnant women during clinical trials, HPV vaccines are not currently recommended for pregnant women. However, some pregnant women receive HPV vaccines because they don’t know that they are pregnant at the time of vaccination. CDC and vaccine manufacturers have monitored and studied HPV vaccine safety in women who received the vaccine when they were pregnant. Close monitoring has not found any health concerns. If a woman receives HPV vaccine and later learns that she is pregnant, there is no reason to be alarmed. Any woman who learns she was pregnant at the time she received an HPV vaccine is encouraged to contact the vaccine manufacturer. This will help us learn how pregnant women respond to the vaccine.
  • 15. • Pregnant women who received Gardasil 9 or Gardasil can contact Merck at 1-877-888-4231 if they have questions related to getting the vaccine while pregnant. o Doctors should report Gardasil 9 vaccination during pregnancy as early in the pregnancy as possible usingMerck Pregnancy Registries. • Pregnant women who received Cervarix can contact GlaxoSmithKline at 1-888-452-9622 Top of Page Is there anyone who should not get an HPV vaccine? Some people should not get the HPV vaccine or should wait. • Anyone who has ever had a life-threatening allergic reaction to any component of HPV vaccine, or to a previous dose of HPV vaccine, should not get the vaccine. o If you or your child is considering receiving Gardasil 9 or Gardasil, tell your doctor about any severe allergies, including an allergy to yeast. o If you or your child is considering receiving Cervarix, tell your doctor about any severe allergies, including an allergy to latex. • HPV vaccine is not recommended for pregnant women. However, receiving HPV vaccine when pregnant is not cause for alarm. Women who are breastfeeding may get the vaccine. • People who are mildly ill (low-grade fever of less than 101 degrees, a cold, runny nose, or cough) when a dose of HPV vaccine is planned can still be vaccinated. People with a moderate or severe illness should wait until they are better. Top of Page What if I have, or my child has, a problem after getting an HPV vaccine? If you or your child is having a severe allergic reaction or other health emergency, call 9-1-1 or go to the nearest hospital. Look for any signs or symptoms that concern you, such as signs of a severe allergic reaction, very high fever, or behavior changes. Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. These would start a few minutes to a few hours after the shot is given. After seeing a doctor, the reaction should be reported to the Vaccine Adverse Event Reporting System (VAERS). This system is used to report any side effect or adverse event following vaccination. Your doctor can file this report, or you can do it yourself through the VAERS website or by calling 1-800-822-7967. Top of Page Where can I find more information about HPV vaccines? For additional information on HPV vaccines and CDC’s recommendations, please visit CDC's Human Papillomavirus (HPV) website. Top of Page Related Links • Diseases and the Vaccines that Prevent Them: HPV – English[PDF - 5.4 MB] • Diseases and the Vaccines that Prevent Them: HPV – Spanish[PDF - 531 KB] • Who Should Not Get Vaccinated • Fainting After Vaccination • Frequently Asked Questions About Vaccine Safety IN SPANISH https://www.cdc.gov/vaccines/vpd-vac/hpv/downloads/dis-HPV-color-office-sp.pdf https://www.cdc.gov/vaccines/parents/diseases/teen/hpv-indepth-color-sp.pdf las ENFERMEDADES y las VACUNAS PARA PREVENIRLAS Actualizado el 03/3/2016 VPH us del papiloma humano también conocido como vir Como padres, usted hace todo lo que puede para proteger la salud de sus hijos ahora y en el futuro. En
  • 16. la actualidad, tenemos un arma muy poderosa para prevenir varios tipos de cáncer en nuestros niños: la vacuna contra el VPH. El VPH y el cáncer VPH es la abreviatura de virus del papiloma humano, un tipo de virus muy común. Cada año, en los Estados Unidos, aproximadamente 17 500 mujeres y 9 300 hombres son afectados por cánceres asociados al VPH. Muchos de estos cánceres podrían prevenirse con vacunas. Tanto en los hombres como en las mujeres, el VPH puede causar cáncer de ano y cáncer de boca o de garganta (cáncer orofaríngeo). Además puede causar cánceres de cuello uterino, de vulva y de vagina en las mujeres, y cáncer de pene en los hombres. Para las mujeres, hay pruebas para detectar la mayoría de los casos de cáncer de cuello uterino con una prueba de Papanicoláu. Desafortunadamente, no hay pruebas de detección de rutina para otros cánceres relacionados con el VPH para las mujeres ni para los hombres, y estos cánceres pueden causar dolor, sufrimiento y hasta la muerte. Por esta razón es tan importante la vacuna que previene la mayoría de estos tipos de cáncer. Más información sobre la vacuna contra el VPH El VPH se transmite de una persona a otra durante el contacto sexual de piel a piel, incluidas las relaciones sexuales vaginales, orales y anales. El VPH es más común en las personas al final de la adolescencia y a comienzos de la década de los veinte años. Casi todas las personas sexualmente activas contraerán este virus en algún momento de su vida, aunque la mayoría de ellas ni siquiera lo sabrá. La mayoría de las veces, el cuerpo se defiende en forma natural del VPH, antes de que cause problemas de salud. Pero en algunos casos, el cuerpo no lo combate y el VPH puede causar problemas como el cáncer y las verrugas genitales. Las verrugas genitales no son una enfermedad mortal, pero pueden causar estrés emocional y su tratamiento puede ser muy molesto. En los Estados Unidos, cerca del 1 de cada 100 adultos sexualmente activos tiene verrugas genitales en algún momento. La vacuna contra el VPH se recomienda para los niños y niñas preadolescentes de 11 o 12 años. Todos los preadolescentes necesitan vacunarse contra el VPH para que puedan estar protegidos contra las infecciones por este virus que pueden causar cáncer. Los adolescentes y los adultos jóvenes que no comenzaron o terminaron las series de vacunas contra el VPH también necesitan vacunarse. Las mujeres jóvenes pueden recibir esta vacuna hasta los 27 años y los hombres jóvenes hasta los 22. Los hombres jóvenes que tengan relaciones sexuales con otros hombres o que tengan sistemas inmunitarios debilitados también pueden recibir la vacuna contra el VPH hasta los 27 años. Las vacunas contra el VPH se administran en una serie de inyecciones que se aplican durante varios meses. La mejor manera de acordarse de que le pongan a su hijo todas las inyecciones que necesita, es hacer citas para las que falten antes de irse del consultorio del médico o del centro médico. ¿Es segura la vacuna contra el VPH? Sí. Las vacunas contra el VPH se han estudiado muy cuidadosamente, y los CDC y la Administración de Alimentos y Medicamentos (FDA) las siguen vigilando. No se han asociado problemas de seguridad graves a estas vacunas. Los estudios siguen mostrando que las vacunas contra el VPH son seguras. Los efectos secundarios reportados con más frecuencia después de la vacunación contra el VPH son leves e incluyen dolor y enrojecimiento en el área del brazo donde se aplicó la inyección, fiebre, mareos y náuseas. Algunos preadolescentes y adolescentes pueden desmayarse después de recibir una inyección o hacerse cualquier otro procedimiento médico. Sentarse o recostarse por unos 15 minutos después de recibir inyecciones puede ayudar a prevenir lesiones que pueden ocurrir si su hijo se cae al desmayarse. Los efectos secundarios graves de las vacunas contra el VPH son muy poco frecuentes. Los niños con alergias graves a la levadura o al látex no deben recibir ciertas vacunas contra el VPH.Asegúrese de decirle al médico o enfermero si su hijo tiene alergias graves. ¿Por qué mi hijo necesita esa vacuna ahora? Las vacunas contra el VPH brindan la mejor protección a los niños y niñas que reciben las tres dosis y que
  • 17. tienen tiempo para desarrollar una respuesta inmunitaria antes de que comiencen a tener actividad sexual con otra persona. Esto no significa que su hijo o hija preadolescente esté listo para tener relaciones sexuales. De hecho, se trata precisamente de lo contrario. Es importante que su hijo o hija esté protegido antes de que usted o ellos piensen en este tema. La respuesta inmunitaria a esta vacuna es mejor en los preadolescentes y esto podría significar una mejor protección para su hijo o hija. CS HCVG15-PTT-104 DISTRIBUIDO POR: Ayuda para pagar por las vacunas del programa VFC en http://www.cdc.gov/spanish/especialesCDC/ ProgramaVacunas/ El programa de Vacunas para Niños (VFC, por sus siglas en inglés) proporciona vacunas para niños de hasta 18 años que no tengan seguro médico, que cumplan con los requisitos para recibir Medicaid, o que sean indoamericanos o nativos de Alaska. Infórmese más acerca Ya sea que tenga seguro o que su hijo cumpla los requisitos del programa VFC, algunos consultorios médicos también pueden cobrar una tarifa por la aplicación de las vacunas. La historia de Jacquelyn “Yo estaba sana y tuve cáncer de cuello de útero”. Al final de mis 20 años y principios de mis 30, antes de que naciera mi hija, tuve algunos exámenes de Papanicolaou anormales y me hicieron pruebas adicionales. Me dijeron que tenía el tipo de VPH que puede causar cáncer y displasia leve. Durante tres años más, mis pruebas fueron normales. Pero cuando me realizaron el primer examen de Papanicolaou después de que naciera mi hijo, me dijeron que necesitaban realizar una biopsia. Los resultados dieron que era cáncer y mi médico me envió a un oncólogo. Afortunadamente, el cáncer estaba en un estadio temprano. Los ganglios linfáticos estaban limpios y no necesitaba radiación. Pero debían realizarme una histerectomía total. Mi marido y yo hemos estado juntos por 15 años y planeábamos tener más hijos. Estamos tan agradecidos por nuestros dos hermosos hijos, pero esperábamos tener más, lo que no sucederá ahora. Lo bueno fue que detectaron el cáncer a tiempo, pero las complicaciones siguen teniendo un impacto en mi vida y en mi familia. En los próximos años me tengo que realizar exámenes pélvicos y de Papanicolaou cada algunos meses, los médicos miden los marcadores de tumores y me deben realizar radiografías y ecografías con regularidad, por si acaso. Tengo tantas citas médicas que me alejan de mi familia, mis amigos y mi trabajo. Lo peor es que cada vez que el teléfono suena y sé que es mi oncólogo, contengo la respiración hasta que me da los resultados. Tengo esperanzas de poder llevar una vida completa y sana, pero siempre pienso en el cáncer. En tan poco tiempo, pasé de tener una vida sana y planificar más hijos a tener una histerectomía total e intentar asegurarme de no tener cáncer de nuevo. Es abrumador. Y soy una de las personas con suerte. En última instancia, debo asegurarme de estar sana y estar presente para mis hijos. Quiero ver a mis nietos crecer. Haré todo lo posible para que mi hijo y mi hija no deban pasar por esto. Cuando cumplan los 11 años, los vacunaré contra el VPH. Le digo a todo el mundo, a mis amigos y familiares, que sus hijos necesitan la serie de vacunas contra el VPH para protegerlos de este tipo de cáncer. ¿Y esto es para los niños varones también? ¡La vacuna contra el VPH también es para los niños varones! Esta vacuna puede ayudar a prevenir que los niños varones contraigan la infección por los tipos del VPH que pueden causar cánceres de boca, garganta, pene y ano. Esta vacuna también puede ayudar a prevenir las verrugas genitales. Es probable que vacunar a los niños varones también beneficie a las mujeres al reducir la transmisión de los virus del VPH. Infórmese más acerca del VPH y de la vacuna contra el VPH en www.cdc.gov/hpv/ Obtenga más información sobre las vacunas recomendadas para los preadolescentes y adolescentes 800-CDC-INFO (800- 232-4636) www.cdc.gov/vaccines/teens
  • 18. INFORMACION NEGATIVA NO CIENTIFICA http://www.telegraph.co.uk/news/2016/05/10/teenage-girl-dies-five-days-after- receiving-hpv-vaccine-jab/ "More than three million girls have been vaccinated so far in the UK with HPV vaccine, and tens of millions more have been vaccinated globally. As with all vaccines, safety remains under continual review, and HPV vaccine has a very good safety record," a spokesman for the Medicines and Healthcare Regulatory Agency told the Manchester Evening News. Teenage girl dies five days after receiving HPV vaccine jab • • • Shazel Zaman CREDIT: MEN • Telegraph Reporters 10 MAY 2016 • 2:32AM Ateenage girl died hours after being sent home from hospital diagnosed with a stomach bug. Shazel Zaman, 13, received a cervical cancer jab five days earlier after which she started vomiting and suffering from dizziness and a severe headache. As her symptoms got worse she was taken to Bury's Fairfield Hospital. Doctors told the teenager's family that they believed she might have a stomach bug and told them to bring her back to hospital if her condition worsened, the Manchester Evening News reported. An hour later she was found unconscious with no pulse at her home in Bury. She was declared dead in hospital around four hours later. Shazel's family claims that a doctor dismissed that her condition was linked to the HPV vaccine jab and said she "came across as a lazy child" before sending her home. Pennine Acute NHS Trust, which runs the hospital, has now launched an investigation into the standard of care Shazel received at the hospital.
  • 19. Shazel’s family believe her death is linked directly to her having the vaccine. Her sister, Maham Hussain, 19, told the Manchester Evening News: “She had the injection on the Wednesday. On Friday she was complaining of a sore arm - no swelling just redness. “On the Saturday she complained of a severe headache, and by the evening she was throwing up. Come Sunday she was very pale, and my aunt took her to Fairfield. Maham Hussain, Shazel's sister CREDIT: MEN “Whilst she was there she was in and out of consciousness. My aunt had to get a wheelchair for her. “She had a blood test, and her heart rate checked, and everything was said to be normal. “She was asked to provide a urine test and when my aunt took her to the toilet she fell to the floor, she was so drowsy. "My aunt took her back to the doctor and that’s when the doctor made the comment that Shazel ‘came across as a lazy child’." Shazel’s aunt, Saimah Naseem, who took her to Fairfield, said: “I was shocked. That was a horrible thing to say. One of the nurses also made the comment ‘she’s fine’.” The teenager was given her second course of the HPV vaccine at Derby High School in Bury on April 13. She died on April 17.
  • 20. Shahad's sister added: “I was at home when Shazel returned. She was in a really bad state. As soon as she came home my aunt put her to bed. “My aunt gave her water so she wouldn’t dehydrate. My aunt and grandmother kept checking on her. “An hour later she went blue. She had no pulse. The paramedics were here in seven minutes but she was not responding. “At hospital it was just the machines that were keeping her alive.” The family said that following her death she underwent a CT scan and then paid £670 for an MRI scan at Oldham Royal Hospital. Both tests were inconclusive and an autopsy has now been carried out. Results will not be available for several months. “The family strongly believe that there is a link between her death and the vaccination," Ms Hussain told the Manchester newspaper: “Before that she was perfectly normal, and active. Our own GP was really shocked that she had passed away. The reason we are speaking out is to raise awareness of what might happen. “I don’t think the hospital took her seriously. If they had done more tests they could have picked something up.” In a letter to the child’s mother, Rob Barrow, Assistant Directorate Manager at Pennine Acute NHS Trust said: “In line with national and Trust policy, we will be undertaking an investigation looking at the care and treatment of your daughter whilst under the care of the Trust.” He added: “I know there are questions you may wish to raise to be considered as part of the investigation.” In a statement Gill Harris, Chief Nurse at The Pennine Acute Hospitals NHS Trust, said: “Our thoughts are with the family and we offer them our sincere condolences for their tragic loss. We have started a full clinical review to examine the circumstances surrounding Shazel Zaman’s death to understand what happened following her attendance at our A&E department in April. We intend to share the findings from our review with the family, with the Coroner’s office, as well as with our own staff.” Deputy Bury Coroner, Lisa Hashmi has also commenced an investigation but will assess evidence before deciding whether to have a full inquest if she deems Shazel’s death "unnatural". "More than three million girls have been vaccinated so far in the UK with HPV vaccine, and tens of millions more have been vaccinated globally. As with all vaccines, safety remains under continual review, and HPV vaccine has a very good safety record," a spokesman for the Medicines and Healthcare Regulatory Agency told the Manchester Evening News. “We are aware of the tragic death of a young girl, and our thoughts are with her family. As with any serious adverse events, we will establish the facts, but there has been no suggestion from safety monitoring so far that the vaccine has been responsible for any deaths.”
  • 21. Since 2008, girls aged 12 and 13 in the UK have been routinely given a vaccination for the human papilloma virus (HPV) as part of the NHS childhood vaccination programme. The vaccine protects from cervical and throat cancers as well as genital warts. According to Cancer Research UK, cervical cancer is the second most common cancer in women under the age of 35. In the UK, 2,900 women a year are diagnosed with cervical cancer, that's around eight women every day. "Brian Shilhavy" Dr. Andrew Moulden https://www.amazon.com/Medical-Doctors-Opposed-Forced-Vaccinations- ebook/dp/B00YVU2K0I/ref=pd_sim_351_1 http://healthimpactnews.com/2014/gardasil-vaccine-one-more-girl-dead/ Gardasil Vaccine: One More Girl Dead 872K 990 16 Share 7 Share 101 843
  • 22. Meredith Prohaska was 12 years old. Photo courtesy of WISN. Health Impact News Editor Comments The sudden death of a 12-year-old girl in Waukesha, Wisconsin, just hours after receiving the HPV Gardasil vaccine has shocked the girl’s family, and sent local media out asking questions as to how this could happen. Here is a report from WISN 12 News. Dr. Geoffrey Swain of the local health department was interviewed to give the standard CDC reply, which is similar to almost every other vaccine, stating that severe reactions like this resulting in death are “very rare,” and about “1 out of a million”. Assuming that there is some data to back up the claim of only “1 out of a million,” how many doses of the HPV vaccine are administered every year? According to the latest statistics (July 2014) published by the U.S. Department of Health and Human Services here (page 7), over 9 million per year. So the government admits that at least 9 girls per year are killed by the HPV vaccine. How many parents know this prior to taking a doctor’s advice to administer this vaccine that is supposedly a protection against cervical cancer caused by the human papillomavirus, a sexually transmitted disease? Apparently, when the news broke that 12-year-old Meredith Prohaska died after receiving the HPV vaccine, at least one other parent contacted a local news station in the area to report she also had a serious adverse reaction to the HPV vaccine with her 17-year-old daughter, who needed urgent care at a local hospital. The local news affiliate asked the question: “So what are the odds another local girl had a similar reaction after getting the shot?” Here is the report: These local news media, possibly covering the HPV vaccine for the first time, were all quick to interview and provide links to the official CDC view of the vaccine. But here are some other facts regarding the vaccine that they failed to disclose, probably because they did not take the time to look outside of the standard government response to events like this, or their station managers did not allow them to give any other news outside of what the CDC claims. 1. There are many more reported side effects than just death from the HPV vaccine. They include: Premature menopause or infertility See: • Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune/inflammatory syndrome induced by adjuvants. July 2013, American Journal of Reproductive Immunology • Dr. Deirdre Little, a pediatrician in Australia, was the first one to sound the alarm over the HPV vaccine causing premature menopause when she observed it in one of her 16 year old patients in 2012. • Two sisters from Wisconsin say a cervical cancer vaccine shut down their ovaries and almost certainly left them unable to get pregnant
  • 23. Narcolepsy and Autoimmune Disorders See: Narcolepsy and Cataplexy after Gardasil? Guillain–Barré syndrome (GBS), stroke, venous thromboembolism (VTE), appendicitis, seizures, syncope (fainting), and allergic reactions. See: CDC HPV Vaccine Facts 2. Countries Outside the U.S. Are Halting HPV Vaccines: Lawsuits due to Damages are Mounting See: • Gardasil Vaccine: Spain Joins Growing List of Countries to File Criminal Complaints • Supreme Court in India to Rule on Merck Fraud Regarding HPV Vaccine Deaths • French Medical Professionals ask: Are HPV vaccines necessary? • Merck’s Former Doctor Predicts that Gardasil will Become the Greatest Medical Scandal of All Time • Japan Halts HPV Vaccine and Begins Full-Scale Probe over Safety Issues • 10 More Young Women File Criminal Complaints due to Injuries from Gardasil Vaccine in France • HPV Vaccine: Israel Health Ministry Considers Canceling Vaccination Due to Side Effects 3. You Cannot Sue the Manufacturer of Vaccines in the U.S. – They have total legal immunity Most of the U.S. public is unaware that a U.S. citizen, by law, cannot sue a pharmaceutical company for damages resulting from vaccines. Congress gave them total legal immunity in 1986, and that law was upheld by the U.S. Supreme Court in 2011. There is a special “vaccine court” called the National Vaccine Injury Compensation Program that is funded through a tax on vaccines. If you are injured or killed by a vaccine, you must hire an attorney and fight tax-funded government attorneys to seek damages, as you cannot sue the drug manufacturers. It can take 10 years or longer to win your case and be compensated. The U.S. Department of Health and Human Services usually publishes a report every couple months on settlements on their website. Here is the latest one. 4. The U.S. Government Earns Royalties from the sale of the Gardasil HPV Vaccine. Dr. Eric Suba tried to use the Freedom of Information Act to find out how much money the National Institute of Health (NIH) earned from the sale of Gardasil, but they refused to report the amount of revenue the government earns from this vaccine (although not denying they do earn royalties). Did you know that the government earns royalties from the sale of the Gardasil vaccine? Does your doctor promoting the HPV vaccine know this? 5. Julie Gerberding was in charge of the CDC the years the FDA approved Gardasil as a vaccine and is now the president of Merck’s Vaccine division, a $5 billion dollar a year operation Julie Gerberding was in charge of the CDC from 2002 to 2009, which includes the years the FDA approved Gardasil as a vaccine. Soon after she took over the CDC, she reportedly completely overhauled the agency’s organizational structure, and many of the CDC’s senior scientists and leaders either left or announced plans to leave. Some have claimed that almost all of the replacements Julie Gerberding appointed had ties to the vaccine industry. Gerberding resigned from the CDC on January 20, 2009, and is now the president of Merck’s Vaccine division, a 5 billion dollar a year operation, and the supplier of the largest number of vaccines the CDC recommends (article here). 6. Black Women who are Vaccinated with Gardasil are Vaccinated Against the Wrong Strains Scientists at the Duke University School of Medicine discovered that African American women carry HPV strains not found in the Gardasil vaccine. Study here. Moshella Roberts, a 20-year-old African American woman died needlessly from the HPV vaccine. Do your own research! While it is encouraging to see local news affiliates report deaths and injuries due to the Gardasil vaccine, they need to do more research to present all of the facts, rather than just parroting what the CDC says. Of course to raise the issue of the “Gardasil controversy” could jeopardize your journalistic career, and force you into apologizing for suggesting the vaccine is anything but totally safe. Just askKatie Couric. In the meantime, do your own research before making any decisions on the Gardasil vaccine! Comment on this story at VaccineImpact.com See Also: Parents of HPV Vaccine Victims Protest in the Streets of Colombia More info on the Gardasil HPV Vaccine. Say NO to Mandatory Vaccines T-Shirt
  • 24. 100% Pre-shrunk Cotton Order here! Make a Statement for Health Freedom! Big Pharma and government health authorities are trying to pass laws mandating vaccines for all children, and even adults. Show your opposition to forced vaccinations and support the cause of Vaccine Impact, part of theHealth Impact News network. Order here! Dr. Andrew Moulden: Every Vaccine Produces Harm
  • 25. eBook – Available for immediate download. Canadian physician Dr. Andrew Moulden provided clear scientific evidence to prove that every dose of vaccine given to a child or an adult produces harm. The truth that he uncovered was rejected by the conventional medical system and the pharmaceutical industry. Nevertheless, his warning and his message to America remains as a solid legacy of the man who stood up against big pharma and their program to vaccinate every person on the Earth. Dr. Moulden died unexpectedly in November of 2013 at age 49. Because of the strong opposition from big pharma concerning Dr. Moulden’s research, we became concerned that the name of this brilliant researcher and his life’s work had nearly been deleted from the internet. His reputation was being disparaged, and his message of warning and hope was being distorted and buried without a tombstone. This book summarizes his teaching and is a must-read for everyone who wants to learn the “other-side” of the vaccine debate that the mainstream media routinely censors. Read: Read Dr. Andrew Moulden: Every Vaccine Produces Harm on your mobile device! on your mobile device! $3.99
  • 26. Medical Doctors Opposed to Forced Vaccinations – Should Their Views be Silenced? eBook – Available for immediate download. One of the biggest myths being propagated in the compliant mainstream media today is that doctors are either pro-vaccine or anti-vaccine, and that the anti- vaccine doctors are all “quacks.” However, nothing could be further from the truth in the vaccine debate. Doctors are not unified at all on their positions regarding “the science” of vaccines, nor are they unified in the position of removing informed consent to a medical procedure like vaccines. The two most extreme positions are those doctors who are 100% against vaccines and do not administer them at all, and those doctors that believe that ALL vaccines are safe and effective for ALL people, ALL the time, by force if necessary. Very few doctors fall into either of these two extremist positions, and yet it is the extreme pro-vaccine position that is presented by the U.S. Government and mainstream media as being the dominant position of the medical field. In between these two extreme views, however, is where the vast majority of doctors practicing today would probably categorize their position. Many doctors who consider themselves “pro-vaccine,” for example, do not believe that every single vaccine is appropriate for every single individual. Many doctors recommend a “delayed” vaccine schedule for some patients, and not always the recommended one-size-fits-all CDC childhood schedule. Other doctors choose to recommend vaccines based on the actual science and merit of each vaccine, recommending some, while determining that others are not worth the risk for children, such as the suspect seasonal flu shot. These doctors who do not hold extreme positions would be opposed to government-mandated vaccinations and the removal of all parental exemptions. In this eBook, I am going to summarize the many doctors today who do not take the most extremist pro-vaccine position, which is probably not held by very many doctors at all, in spite of what the pharmaceutical industry, the federal government, and the mainstream media would like the public to believe. Read: Medical Doctors Opposed to Forced Vaccinations – Should Their Views be Silenced? on your mobile device! $0.99
  • 27. Published on August 11, 2014 Tags: gardasil, HPV vaccine Share This Story, Choose Your Platform!
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