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Nutrition
&
OCD
Manuela Zapata
What is OCD
TABLE OF CONTENTS
Traditional
Treatments
Nutritional
Treatments
01
02
03
A behavioral and mental disorder which is
characterized by obsessive thoughts and
compulsions that impact daily living
What is OCD?
1
Symptoms
Obsessions
● Specific fears
○ Dirt/germs
○ Making a
mistake
○ Causing harm
● Need for order or
symmetry
● Excessive concern
with morality
Compulsions
● Washing
● Number rituals
● Arranging things
in specific ways
● Repeatedly
checking things
● Constantly
seeking
reassurance.
Causes
Biology Genetics
Environment
- Communication problems
between the brain's deeper
structures and the front part of
the brain
- Low serotonin levels, impact
severity of symptoms
- Mendelian-dominant model
- No specific genes
- Traumas
- Home environment
- Need for a sense of control
Diagnostic and Statistical Manual of
Mental Disorders (DSM-5)
Yale-Brown Obsessive-Compulsive Scale
(Y-BOCS)
Diagnosis
Y-BOCS
Traditional
Treatments 2
Cognitive Behavioral
Therapy (CBT)
● Exposure and response
prevention (ERP)
Main Treatments
Selective Serotonin
Reuptake Inhibitors (SSRIs)
● Blocks the reabsorption of
serotonin so it stays in the
synapse longer
● Zoloft, Prozac, Paxil
Deep Brain Stimulation
(DMS)
● Specifically targets deep
brain areas like basal
ganglia and caudate
nucleus
● 60% effective
Cognitive Behavioral
Therapy (CBT)
● Expensive
● Only magages symptoms
Drawbacks of Main Treatments
Selective Serotonin
Reuptake Inhibitors (SSRIs)
● Nausea, nervousness,
insomnia, and diarrhea,
headaches and issues
concerning libido
● Not easily available for
everyone
Deep Brain Stimulation
(DMS)
● Extremely invasive
● Stroke, seizures, infection,
and trouble concentrating
after the procedure
Nutritional
Treatments
3
➢ Involved in the metabolism
of homocysteine
○ If raised can increase
risk of developing
OCD
Nutritional Treatments
Tryptophan
➢ Important for synthesis of
tryptophan hydroxylase
➢ Needed to make serotonin
Vitamin B12
➢ Precursor to serotonin
Vitamin D
➢ Binds to glutamate, which is
usually elevated in OCD
patients
➢ Manages symptom severity
N-Acetyl Cysteine
(NAC)
Studies
● Esnafoğlu & Yaman. 2017
○ Negative correlation
between B12 levels and Y-
BOCS scores (p:0.018)
● Türksoy et al. 2014
○ Found B12 levels
significantly lower in OCD
patients (p: 0.038)
● Soyak & Karakükc. 2022
○ OCD group had lower
vitamin D levels
(p<0.001)
○ Vitamin D was negatively
correlated to Y-BOCS
scores (P< 0.001)
Vitamin D
Vitamin B12
Studies
● Hood et al. 2017
○ Depletion had a negative
correlation with Y-BOCS
feeling of control and
intrusive thoughts
(p:0.05)
● Lafleur et al. 2006
○ Supplementation of NAC
(600 mg/daily) showed
significant decrease in
Y-BOCS (p< 0.05)
NAC
Tryptophan
Where to find
What about
specific diets?
★ No specific diets have been
identified for treating OCD
★ Mediterranean diet seems to contain
most food that carry the important
nutrients for OCD
Questions?
Sources
1. NIH. (2022, September). Obsessive-Compulsive Disorder. National Institute of Mental Health (NIMH). https://www.nimh.nih.gov/health/topics/obsessive-compulsive-
disorder-ocd
2. Kellner, M. (2010). Drug treatment of obsessive-compulsive disorder. Dialogues in Clinical Neuroscience, 12(2), 187–197.
3. Bandelow, B., Zohar, J., Hollander, E., Kasper, S., Möller, H.-J., WFSBP Task Force on Treatment Guidelines for Anxiety, Obsessive-Compulsive and Post-Traumatic
Stress Disoders, Zohar, J., Hollander, E., Kasper, S., Möller, H.-J., Bandelow, B., Allgulander, C., Ayuso-Gutierrez, J., Baldwin, D. S., Buenvicius, R., Cassano, G., Fineberg,
N., Gabriels, L., Hindmarch, I., … Vega, J. (2008). World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of
anxiety, obsessive-compulsive and post-traumatic stress disorders—First revision. The World Journal of Biological Psychiatry: The Official Journal of the World
Federation of Societies of Biological Psychiatry, 9(4), 248–312. https://doi.org/10.1080/15622970802465807
4. Medications for OCD » Department of Psychiatry » College of Medicine » University of Florida. (n.d.). RetrievedMarch 2, 2023, from
https://psychiatry.ufl.edu/patient-care-services/ocd-program/medications-for-ocd/
5. International OCD Foundation | Exposure and Response Prevention (ERP). (n.d.). International OCD Foundation. Retrieved March 30, 2023, from
https://iocdf.org/about-ocd/ocd-treatment/erp/
6. Foa, E. B. (2010). Cognitive behavioral therapy of obsessive-compulsive disorder. Dialogues in Clinical Neuroscience, 12(2), 199–207.
7. Mar-Barrutia, L., Real, E., Segalás, C., Bertolín, S., Menchón, J. M., & Alonso, P. (2021). Deep brain stimulation for obsessive-compulsive disorder:A systematic review
of worldwide experience after 20 years. World Journal of Psychiatry, 11(9), 659–680. https://doi.org/10.5498/wjp.v11.i9.659
8. Deep Brain Stimulation for OCD | Mount Sinai—New York. (n.d.). Mount Sinai Health System. Retrieved March 3, 2023, from
https://www.mountsinai.org/care/psychiatry/services/ocd-tics/dbs
9. Deep brain stimulation—Mayo Clinic. (n.d.). Retrieved March 3, 2023, from https://www.mayoclinic.org/tests-procedures/deep-brain-stimulation/about/pac-
20384562
10. Eslamzadeh, M., Kamrani, M., Googheri, Z., Ziaee, M., & Anahitaarabi. (2020). Comparison of Vitamin B12 and Folic Acid Serum Levels in patients with obsessive-
compulsive disorder versus healthy group. Pakistan Journal of Medical and Health Sciences, 14.
11. Soyak, H. M., & Karakükcü, Ç. (2022). Investıgation of vitamin D levels in obsessive-compulsive disorder. Indian Journal of Psychiatry, 64(4), 349–353.
https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_26_22
12. Hood, S. D., Broyd, A., Robinson, H., Lee, J., Hudaib, A.-R., & Hince, D. A. (2017). Effects of tryptophan depletion on selective serotonin reuptake inhibitor-remitted
patients with obsessive compulsive disorder. Journal of Psychopharmacology, 31(12), 1615–1623. https://doi.org/10.1177/0269881117736916
13. Lafleur, D. L., Pittenger, C., Kelmendi, B., Gardner, T., Wasylink, S., Malison, R. T., Sanacora, G., Krystal, J. H., & Coric, V. (2006). N-acetylcysteine augmentation in
serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology, 184(2), 254–256. https://doi.org/10.1007/s00213-005-0246-6

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Nutrition of OCD for my Nutritional Neuroscience Class

  • 2. What is OCD TABLE OF CONTENTS Traditional Treatments Nutritional Treatments 01 02 03
  • 3. A behavioral and mental disorder which is characterized by obsessive thoughts and compulsions that impact daily living What is OCD? 1
  • 4. Symptoms Obsessions ● Specific fears ○ Dirt/germs ○ Making a mistake ○ Causing harm ● Need for order or symmetry ● Excessive concern with morality Compulsions ● Washing ● Number rituals ● Arranging things in specific ways ● Repeatedly checking things ● Constantly seeking reassurance.
  • 5. Causes Biology Genetics Environment - Communication problems between the brain's deeper structures and the front part of the brain - Low serotonin levels, impact severity of symptoms - Mendelian-dominant model - No specific genes - Traumas - Home environment - Need for a sense of control
  • 6. Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) Diagnosis
  • 9. Cognitive Behavioral Therapy (CBT) ● Exposure and response prevention (ERP) Main Treatments Selective Serotonin Reuptake Inhibitors (SSRIs) ● Blocks the reabsorption of serotonin so it stays in the synapse longer ● Zoloft, Prozac, Paxil Deep Brain Stimulation (DMS) ● Specifically targets deep brain areas like basal ganglia and caudate nucleus ● 60% effective
  • 10. Cognitive Behavioral Therapy (CBT) ● Expensive ● Only magages symptoms Drawbacks of Main Treatments Selective Serotonin Reuptake Inhibitors (SSRIs) ● Nausea, nervousness, insomnia, and diarrhea, headaches and issues concerning libido ● Not easily available for everyone Deep Brain Stimulation (DMS) ● Extremely invasive ● Stroke, seizures, infection, and trouble concentrating after the procedure
  • 12. ➢ Involved in the metabolism of homocysteine ○ If raised can increase risk of developing OCD Nutritional Treatments Tryptophan ➢ Important for synthesis of tryptophan hydroxylase ➢ Needed to make serotonin Vitamin B12 ➢ Precursor to serotonin Vitamin D ➢ Binds to glutamate, which is usually elevated in OCD patients ➢ Manages symptom severity N-Acetyl Cysteine (NAC)
  • 13. Studies ● Esnafoğlu & Yaman. 2017 ○ Negative correlation between B12 levels and Y- BOCS scores (p:0.018) ● Türksoy et al. 2014 ○ Found B12 levels significantly lower in OCD patients (p: 0.038) ● Soyak & Karakükc. 2022 ○ OCD group had lower vitamin D levels (p<0.001) ○ Vitamin D was negatively correlated to Y-BOCS scores (P< 0.001) Vitamin D Vitamin B12
  • 14. Studies ● Hood et al. 2017 ○ Depletion had a negative correlation with Y-BOCS feeling of control and intrusive thoughts (p:0.05) ● Lafleur et al. 2006 ○ Supplementation of NAC (600 mg/daily) showed significant decrease in Y-BOCS (p< 0.05) NAC Tryptophan
  • 16. What about specific diets? ★ No specific diets have been identified for treating OCD ★ Mediterranean diet seems to contain most food that carry the important nutrients for OCD
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