SlideShare a Scribd company logo
MULTIPLE MYELOMA
Hamad Emad H. Dhuhayr
CONTENTS
• Soepel
• Multiple myeloma
1. Definition
2. Incidence
3. Eatiology
4. Clinical features
5. Invistigation
6. Treatment
• Reffrences
SOEPEL
• S- A 25 years old Saudi female. She complained of pain in her left leg when she
walk for long distance from one week ago.
• O- taking history and physical examination
• E- DVT, baker cyst and septic thrombophlebitis.
• P- cbc, pt, INR and duplex ultrasound
• E- anticoagulant” warfrien “
• L- multiple myeloma
MULTIPLE MYELOMA
DEFINITION AND INCIDENCE
• Myeloma is a neoplasm of the plasma cells, which are derived from B
lymphocytes.
• It is an uncommon neoplasm, accounting for approximately 1% of adult cancers
in the united states.
• The incidence of myeloma increases with advancing age and is twice as common
in blacks. Approximately and less common in Asians
• the annual incidence is 4 per 100,000.
• 20,000 new cases of multiple myeloma are diagnosed each year in the united
states.
EATIOLOGY AND PATHOLOGY
• A. Although no specific underlying causes have been proven, genetic factors, as
well as exposure To petroleum, asbestos, metals, and radiation, may increase
the risk of developing myeloma.
• B. Benign monoclonal gammopathies can progress to multiple myeloma,
although most do not.
• C. Myeloma cells are characterized by genetic instability, and karyotype analysis
often reveals Multiple abnormalities, which can provide prognostic information.
Multiple myeloma is a type of mature B cell lymphoid neoplasm characterized by
accumulation of malignant plasma cells in the bone marrow compartment.
CLINICAL FEATURES
• A. Weakness, fatigue, infection, and bleeding due to marrow failure.
• B. Osteolytic lesions
• C. Recurrent infections
• D. Renal abnormalities
• E. Hypercalcemia
• F. Hyperviscosity
• G. Compression of the spinal cord
INVISTIGATION
• CBC, creatinine, calcium, β2-microglobulin, LDH.
• SPEP with immunofixation electrophoresis (IFE), UPEP with IFE: to Identify the M spike. Not all serum
paraproteins are detectable in urine And vice versa.
• Bone marrow aspirate and biopsy.
• Skeletal bone plain film survey: lytic lesions are seen in 60–90% of patients.
• Myeloma is characterized by purely osteolytic lesions, so bone scan is And alkaline phosphatase is normal.
• If other findings are consistent, the presence of the jak2 mutation is Highly suggestive of the diagnosis.
Myeloma
Myeloma
• Myeloma affecting the skull. Note the rounded lytic translucencies produced by
infiltration of the skull with myeloma cells.
Myeloma
Myeloma
Myeloma
TREATMENT
Myeloma
REFFRENCES
• KUMAR
• GOLDMAN’S CECIL
• WEBSITE

More Related Content

What's hot

Cancer
CancerCancer
Multiple myeloma
Multiple  myelomaMultiple  myeloma
Multiple myeloma
orthoprince
 
MULTIPLE MYELOMA UPDATE
MULTIPLE MYELOMA UPDATEMULTIPLE MYELOMA UPDATE
MULTIPLE MYELOMA UPDATE
manal bessa
 
Childhood cancer / Oncological diseases in Pediatric groups
Childhood cancer / Oncological diseases in Pediatric groupsChildhood cancer / Oncological diseases in Pediatric groups
Childhood cancer / Oncological diseases in Pediatric groups
Monisha Sekar
 
Multiple myeloma
Multiple myelomaMultiple myeloma
Childhood tumours
Childhood tumoursChildhood tumours
Childhood tumours
Jamiu Bello
 
Multiple myeloma
Multiple myelomaMultiple myeloma
Multiple myeloma
arpita khasnavis
 
Cancer cell
Cancer cellCancer cell
Cancer cell
Dr-Ismail Khan
 
Multiple myeloma
Multiple myelomaMultiple myeloma
Multiple myeloma
rahulverma1194
 
When to suspect cancer in pediatric age
When to suspect cancer in pediatric ageWhen to suspect cancer in pediatric age
When to suspect cancer in pediatric age
egyfellow
 
BURKITTS LYMPHOMA
 BURKITTS LYMPHOMA BURKITTS LYMPHOMA
BURKITTS LYMPHOMA
ALIYU USMAN MUHAMMAD
 
Multiple Myeloma
Multiple MyelomaMultiple Myeloma
Multiple Myeloma
Alan Teh
 
Chromosomal Genetics
Chromosomal GeneticsChromosomal Genetics
Chromosomal Genetics
Saira Fatima
 
Multiple myeloma
Multiple myelomaMultiple myeloma
Multiple myeloma
Praveen Kumar T S
 
Cancer cell
Cancer cellCancer cell
Cancer cell
SoniaBajaj10
 
Monoclonal gammopathies of undetermined significance
Monoclonal gammopathies of undetermined significanceMonoclonal gammopathies of undetermined significance
Monoclonal gammopathies of undetermined significance
DrChirag Parmar
 
Renal Impairment in Multiple Myeloma
Renal Impairment in Multiple MyelomaRenal Impairment in Multiple Myeloma
Renal Impairment in Multiple Myeloma
Mohammed A Suwaid
 
Multiple Myeloma | Causes and Treatment of Multiple Myeloma
Multiple Myeloma | Causes and Treatment of Multiple Myeloma Multiple Myeloma | Causes and Treatment of Multiple Myeloma
Multiple Myeloma | Causes and Treatment of Multiple Myeloma
anju sharma
 
plasmacytoma-1
 plasmacytoma-1 plasmacytoma-1
plasmacytoma-1
Indian dental academy
 
Multiple Myeloma
Multiple MyelomaMultiple Myeloma
Multiple Myeloma
Eneutron
 

What's hot (20)

Cancer
CancerCancer
Cancer
 
Multiple myeloma
Multiple  myelomaMultiple  myeloma
Multiple myeloma
 
MULTIPLE MYELOMA UPDATE
MULTIPLE MYELOMA UPDATEMULTIPLE MYELOMA UPDATE
MULTIPLE MYELOMA UPDATE
 
Childhood cancer / Oncological diseases in Pediatric groups
Childhood cancer / Oncological diseases in Pediatric groupsChildhood cancer / Oncological diseases in Pediatric groups
Childhood cancer / Oncological diseases in Pediatric groups
 
Multiple myeloma
Multiple myelomaMultiple myeloma
Multiple myeloma
 
Childhood tumours
Childhood tumoursChildhood tumours
Childhood tumours
 
Multiple myeloma
Multiple myelomaMultiple myeloma
Multiple myeloma
 
Cancer cell
Cancer cellCancer cell
Cancer cell
 
Multiple myeloma
Multiple myelomaMultiple myeloma
Multiple myeloma
 
When to suspect cancer in pediatric age
When to suspect cancer in pediatric ageWhen to suspect cancer in pediatric age
When to suspect cancer in pediatric age
 
BURKITTS LYMPHOMA
 BURKITTS LYMPHOMA BURKITTS LYMPHOMA
BURKITTS LYMPHOMA
 
Multiple Myeloma
Multiple MyelomaMultiple Myeloma
Multiple Myeloma
 
Chromosomal Genetics
Chromosomal GeneticsChromosomal Genetics
Chromosomal Genetics
 
Multiple myeloma
Multiple myelomaMultiple myeloma
Multiple myeloma
 
Cancer cell
Cancer cellCancer cell
Cancer cell
 
Monoclonal gammopathies of undetermined significance
Monoclonal gammopathies of undetermined significanceMonoclonal gammopathies of undetermined significance
Monoclonal gammopathies of undetermined significance
 
Renal Impairment in Multiple Myeloma
Renal Impairment in Multiple MyelomaRenal Impairment in Multiple Myeloma
Renal Impairment in Multiple Myeloma
 
Multiple Myeloma | Causes and Treatment of Multiple Myeloma
Multiple Myeloma | Causes and Treatment of Multiple Myeloma Multiple Myeloma | Causes and Treatment of Multiple Myeloma
Multiple Myeloma | Causes and Treatment of Multiple Myeloma
 
plasmacytoma-1
 plasmacytoma-1 plasmacytoma-1
plasmacytoma-1
 
Multiple Myeloma
Multiple MyelomaMultiple Myeloma
Multiple Myeloma
 

Viewers also liked

Multiple Myloma Diagnostic Criteria
Multiple Myloma Diagnostic CriteriaMultiple Myloma Diagnostic Criteria
Multiple Myloma Diagnostic Criteria
Ahmed Ghany
 
Immunoproliferative disorders
Immunoproliferative disordersImmunoproliferative disorders
Immunoproliferative disorders
Bruno Mmassy
 
Chap20 Immunology & Serology
Chap20 Immunology & SerologyChap20 Immunology & Serology
Chap20 Immunology & Serology
Analin Empaynado
 
MULTIPLE MYELOMA CELLS
MULTIPLE MYELOMA CELLSMULTIPLE MYELOMA CELLS
MULTIPLE MYELOMA CELLS
Ruchi
 
Multiple Myeloma Modified , Dr Gamal Abdul Hamid
Multiple   Myeloma Modified ,  Dr  Gamal  Abdul  HamidMultiple   Myeloma Modified ,  Dr  Gamal  Abdul  Hamid
Multiple Myeloma Modified , Dr Gamal Abdul Hamid
Gamal Abdul Hamid
 
Multiple Myeloma
Multiple MyelomaMultiple Myeloma
Multiple Myeloma
Gajanan Pandit
 

Viewers also liked (6)

Multiple Myloma Diagnostic Criteria
Multiple Myloma Diagnostic CriteriaMultiple Myloma Diagnostic Criteria
Multiple Myloma Diagnostic Criteria
 
Immunoproliferative disorders
Immunoproliferative disordersImmunoproliferative disorders
Immunoproliferative disorders
 
Chap20 Immunology & Serology
Chap20 Immunology & SerologyChap20 Immunology & Serology
Chap20 Immunology & Serology
 
MULTIPLE MYELOMA CELLS
MULTIPLE MYELOMA CELLSMULTIPLE MYELOMA CELLS
MULTIPLE MYELOMA CELLS
 
Multiple Myeloma Modified , Dr Gamal Abdul Hamid
Multiple   Myeloma Modified ,  Dr  Gamal  Abdul  HamidMultiple   Myeloma Modified ,  Dr  Gamal  Abdul  Hamid
Multiple Myeloma Modified , Dr Gamal Abdul Hamid
 
Multiple Myeloma
Multiple MyelomaMultiple Myeloma
Multiple Myeloma
 

Similar to Myeloma

Leukemia
LeukemiaLeukemia
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
sunil kumar daha
 
Multiple myeloma and its management
Multiple myeloma and its managementMultiple myeloma and its management
Multiple myeloma and its management
Tomin P Zacarias
 
Multiple Myeloma
Multiple MyelomaMultiple Myeloma
Multiple Myeloma
OscarKwan6
 
Myelodysplastic syndrome
Myelodysplastic syndromeMyelodysplastic syndrome
Myelodysplastic syndrome
Aseem Jain
 
Leukemia (blood cancer) presentation
Leukemia (blood cancer) presentationLeukemia (blood cancer) presentation
Leukemia (blood cancer) presentation
NehaNupur8
 
Aplastic anemia pediatrics
Aplastic anemia pediatricsAplastic anemia pediatrics
Aplastic anemia pediatrics
DK Ya'v
 
Hodgkin's lymphoma
Hodgkin's lymphomaHodgkin's lymphoma
Hodgkin's lymphoma
AayushPokharel10
 
PLASMA CELL DISORERS
PLASMA CELL DISORERSPLASMA CELL DISORERS
PLASMA CELL DISORERS
Kiran Ramakrishna
 
LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...
LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...
LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...
BARNABASMUGABI
 
Management of multiple myeloma
Management of multiple myelomaManagement of multiple myeloma
Management of multiple myeloma
DR Saqib Shah
 
Kidney tumors/ renal tumors - malignant benign
Kidney tumors/ renal tumors - malignant benignKidney tumors/ renal tumors - malignant benign
Kidney tumors/ renal tumors - malignant benign
RishikRana3
 
Week 6 presentation
Week 6 presentationWeek 6 presentation
Week 6 presentation
SarahSaeedAhmed
 
Nephroblastoma.ppt
Nephroblastoma.pptNephroblastoma.ppt
Nephroblastoma.ppt
InnovoHealthAfrica
 
Acute lymphoblastic leukemia dr narmada
Acute lymphoblastic leukemia dr narmadaAcute lymphoblastic leukemia dr narmada
Acute lymphoblastic leukemia dr narmada
Narmada Tiwari
 
Leukemia.pptx
Leukemia.pptxLeukemia.pptx
Leukemia.pptx
TwinkleJoshi4
 
ACUTE MYELOID LEUKEMIA.pptx
ACUTE MYELOID LEUKEMIA.pptxACUTE MYELOID LEUKEMIA.pptx
ACUTE MYELOID LEUKEMIA.pptx
RoRy49
 
Neuroblastoma
NeuroblastomaNeuroblastoma
Neuroblastoma
shockarz
 
Aplastic anemia
Aplastic anemiaAplastic anemia
Aplastic anemia
ajayyadav753
 
Aplastic anemia
Aplastic anemiaAplastic anemia
Aplastic anemia
Rahul Arya
 

Similar to Myeloma (20)

Leukemia
LeukemiaLeukemia
Leukemia
 
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
Lymphoma by Sunil Kumar Daha (Hodgkins and Non-Hodgkins)
 
Multiple myeloma and its management
Multiple myeloma and its managementMultiple myeloma and its management
Multiple myeloma and its management
 
Multiple Myeloma
Multiple MyelomaMultiple Myeloma
Multiple Myeloma
 
Myelodysplastic syndrome
Myelodysplastic syndromeMyelodysplastic syndrome
Myelodysplastic syndrome
 
Leukemia (blood cancer) presentation
Leukemia (blood cancer) presentationLeukemia (blood cancer) presentation
Leukemia (blood cancer) presentation
 
Aplastic anemia pediatrics
Aplastic anemia pediatricsAplastic anemia pediatrics
Aplastic anemia pediatrics
 
Hodgkin's lymphoma
Hodgkin's lymphomaHodgkin's lymphoma
Hodgkin's lymphoma
 
PLASMA CELL DISORERS
PLASMA CELL DISORERSPLASMA CELL DISORERS
PLASMA CELL DISORERS
 
LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...
LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...
LEUKEMIC DISEASES AND THE EYE.pptx. This talks about the ocular manifestation...
 
Management of multiple myeloma
Management of multiple myelomaManagement of multiple myeloma
Management of multiple myeloma
 
Kidney tumors/ renal tumors - malignant benign
Kidney tumors/ renal tumors - malignant benignKidney tumors/ renal tumors - malignant benign
Kidney tumors/ renal tumors - malignant benign
 
Week 6 presentation
Week 6 presentationWeek 6 presentation
Week 6 presentation
 
Nephroblastoma.ppt
Nephroblastoma.pptNephroblastoma.ppt
Nephroblastoma.ppt
 
Acute lymphoblastic leukemia dr narmada
Acute lymphoblastic leukemia dr narmadaAcute lymphoblastic leukemia dr narmada
Acute lymphoblastic leukemia dr narmada
 
Leukemia.pptx
Leukemia.pptxLeukemia.pptx
Leukemia.pptx
 
ACUTE MYELOID LEUKEMIA.pptx
ACUTE MYELOID LEUKEMIA.pptxACUTE MYELOID LEUKEMIA.pptx
ACUTE MYELOID LEUKEMIA.pptx
 
Neuroblastoma
NeuroblastomaNeuroblastoma
Neuroblastoma
 
Aplastic anemia
Aplastic anemiaAplastic anemia
Aplastic anemia
 
Aplastic anemia
Aplastic anemiaAplastic anemia
Aplastic anemia
 

More from HAMAD DHUHAYR

Kawasaki disease
Kawasaki disease Kawasaki disease
Kawasaki disease
HAMAD DHUHAYR
 
Approch to cough in children
Approch to cough in childrenApproch to cough in children
Approch to cough in children
HAMAD DHUHAYR
 
Typical antipsychotic
Typical antipsychoticTypical antipsychotic
Typical antipsychotic
HAMAD DHUHAYR
 
Personality disorder - cluster C
Personality disorder - cluster CPersonality disorder - cluster C
Personality disorder - cluster C
HAMAD DHUHAYR
 
Amniotic fluid disorder
Amniotic fluid disorderAmniotic fluid disorder
Amniotic fluid disorder
HAMAD DHUHAYR
 
liver abscess
liver abscess liver abscess
liver abscess
HAMAD DHUHAYR
 
nerve injury
nerve injurynerve injury
nerve injury
HAMAD DHUHAYR
 
Hirdschsprug disease
Hirdschsprug disease Hirdschsprug disease
Hirdschsprug disease
HAMAD DHUHAYR
 
Postoperative fever -hamad
Postoperative fever -hamadPostoperative fever -hamad
Postoperative fever -hamad
HAMAD DHUHAYR
 
Ulner nerve
Ulner nerveUlner nerve
Ulner nerve
HAMAD DHUHAYR
 
Retention of urine
Retention of urine Retention of urine
Retention of urine
HAMAD DHUHAYR
 
Parathyroid
Parathyroid Parathyroid
Parathyroid
HAMAD DHUHAYR
 
Esophagial carcinoma
Esophagial carcinoma Esophagial carcinoma
Esophagial carcinoma
HAMAD DHUHAYR
 
Atropine
Atropine Atropine
Atropine
HAMAD DHUHAYR
 
Lower back pain
Lower back painLower back pain
Lower back pain
HAMAD DHUHAYR
 
SCC
SCCSCC
Upper git bleeding
Upper git bleeding Upper git bleeding
Upper git bleeding
HAMAD DHUHAYR
 
Hsv,ebs,cmv and hzv
Hsv,ebs,cmv and hzvHsv,ebs,cmv and hzv
Hsv,ebs,cmv and hzv
HAMAD DHUHAYR
 
ABG
ABGABG
Thyrotoxicosis in pregnancy - hamad
Thyrotoxicosis in pregnancy - hamadThyrotoxicosis in pregnancy - hamad
Thyrotoxicosis in pregnancy - hamad
HAMAD DHUHAYR
 

More from HAMAD DHUHAYR (20)

Kawasaki disease
Kawasaki disease Kawasaki disease
Kawasaki disease
 
Approch to cough in children
Approch to cough in childrenApproch to cough in children
Approch to cough in children
 
Typical antipsychotic
Typical antipsychoticTypical antipsychotic
Typical antipsychotic
 
Personality disorder - cluster C
Personality disorder - cluster CPersonality disorder - cluster C
Personality disorder - cluster C
 
Amniotic fluid disorder
Amniotic fluid disorderAmniotic fluid disorder
Amniotic fluid disorder
 
liver abscess
liver abscess liver abscess
liver abscess
 
nerve injury
nerve injurynerve injury
nerve injury
 
Hirdschsprug disease
Hirdschsprug disease Hirdschsprug disease
Hirdschsprug disease
 
Postoperative fever -hamad
Postoperative fever -hamadPostoperative fever -hamad
Postoperative fever -hamad
 
Ulner nerve
Ulner nerveUlner nerve
Ulner nerve
 
Retention of urine
Retention of urine Retention of urine
Retention of urine
 
Parathyroid
Parathyroid Parathyroid
Parathyroid
 
Esophagial carcinoma
Esophagial carcinoma Esophagial carcinoma
Esophagial carcinoma
 
Atropine
Atropine Atropine
Atropine
 
Lower back pain
Lower back painLower back pain
Lower back pain
 
SCC
SCCSCC
SCC
 
Upper git bleeding
Upper git bleeding Upper git bleeding
Upper git bleeding
 
Hsv,ebs,cmv and hzv
Hsv,ebs,cmv and hzvHsv,ebs,cmv and hzv
Hsv,ebs,cmv and hzv
 
ABG
ABGABG
ABG
 
Thyrotoxicosis in pregnancy - hamad
Thyrotoxicosis in pregnancy - hamadThyrotoxicosis in pregnancy - hamad
Thyrotoxicosis in pregnancy - hamad
 

Recently uploaded

High Class Girls Call Delhi 9711199171 Provide Best And Top Girl Service And ...
High Class Girls Call Delhi 9711199171 Provide Best And Top Girl Service And ...High Class Girls Call Delhi 9711199171 Provide Best And Top Girl Service And ...
High Class Girls Call Delhi 9711199171 Provide Best And Top Girl Service And ...
sonamrawat5631
 
The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...
The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...
The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...
MARIALUISADELROGONZL
 
Post infectious bronchiolitis obliterans
Post infectious bronchiolitis obliteransPost infectious bronchiolitis obliterans
Post infectious bronchiolitis obliterans
drfardosy
 
EXTRACTION,_PHYTOCHEMICAL_SCREENING_&_FORMULATION_OF_BOERRHAVIA.pptx
EXTRACTION,_PHYTOCHEMICAL_SCREENING_&_FORMULATION_OF_BOERRHAVIA.pptxEXTRACTION,_PHYTOCHEMICAL_SCREENING_&_FORMULATION_OF_BOERRHAVIA.pptx
EXTRACTION,_PHYTOCHEMICAL_SCREENING_&_FORMULATION_OF_BOERRHAVIA.pptx
AbhashSingh12
 
Ghaziabad @Girls @Call WhatsApp Numbers 🫦0000XX0000🫦 List For Friendship Girl...
Ghaziabad @Girls @Call WhatsApp Numbers 🫦0000XX0000🫦 List For Friendship Girl...Ghaziabad @Girls @Call WhatsApp Numbers 🫦0000XX0000🫦 List For Friendship Girl...
Ghaziabad @Girls @Call WhatsApp Numbers 🫦0000XX0000🫦 List For Friendship Girl...
ishaguptaji14
 
World Population Day 2024_Overview_Dr Bijan Das
World Population Day 2024_Overview_Dr Bijan DasWorld Population Day 2024_Overview_Dr Bijan Das
World Population Day 2024_Overview_Dr Bijan Das
srmnchatripura
 
Yoga talk & yoga slides by Flametree Yoga 11 July 2024.pdf
Yoga talk & yoga slides by Flametree Yoga 11 July 2024.pdfYoga talk & yoga slides by Flametree Yoga 11 July 2024.pdf
Yoga talk & yoga slides by Flametree Yoga 11 July 2024.pdf
Stuart McGill
 
Safeguarding Reproductive Health- Preventing Fallopian Tube Blockage After a ...
Safeguarding Reproductive Health- Preventing Fallopian Tube Blockage After a ...Safeguarding Reproductive Health- Preventing Fallopian Tube Blockage After a ...
Safeguarding Reproductive Health- Preventing Fallopian Tube Blockage After a ...
FFragrant
 
Amygdala Medi-Trivia Quiz (Prelims) | FAQ 2024
Amygdala Medi-Trivia Quiz (Prelims) | FAQ 2024Amygdala Medi-Trivia Quiz (Prelims) | FAQ 2024
Amygdala Medi-Trivia Quiz (Prelims) | FAQ 2024
Anindya Das Adhikary
 
Kayakalp Clinic Best Sexologist of patna
Kayakalp Clinic Best Sexologist of patnaKayakalp Clinic Best Sexologist of patna
Kayakalp Clinic Best Sexologist of patna
Kayakalp Clinic - Best Sexologist In Patna
 
Endocrine Physiology - Insulin and Glucagon
Endocrine Physiology -  Insulin and GlucagonEndocrine Physiology -  Insulin and Glucagon
Endocrine Physiology - Insulin and Glucagon
MedicoseAcademics
 
PICTURE TEST IN OBSTETRICS AND GYNAECOLOGY-Aloy Okechukwu Ugwu.pptx
PICTURE TEST IN OBSTETRICS AND GYNAECOLOGY-Aloy Okechukwu Ugwu.pptxPICTURE TEST IN OBSTETRICS AND GYNAECOLOGY-Aloy Okechukwu Ugwu.pptx
PICTURE TEST IN OBSTETRICS AND GYNAECOLOGY-Aloy Okechukwu Ugwu.pptx
Aloy Okechukwu Ugwu
 
pharmaceutical care plan scope application.pptx
pharmaceutical care plan scope application.pptxpharmaceutical care plan scope application.pptx
pharmaceutical care plan scope application.pptx
Wajid Ali
 
Heart Valves and Heart Sounds -Congenital & valvular heart disease.pdf
Heart Valves and Heart Sounds -Congenital & valvular heart disease.pdfHeart Valves and Heart Sounds -Congenital & valvular heart disease.pdf
Heart Valves and Heart Sounds -Congenital & valvular heart disease.pdf
MedicoseAcademics
 
anthelmintic-drugs.pptx pharmacology dep
anthelmintic-drugs.pptx pharmacology depanthelmintic-drugs.pptx pharmacology dep
anthelmintic-drugs.pptx pharmacology dep
sapnasirswal
 
Introduction to Dental Implant for undergraduate student
Introduction to Dental Implant for undergraduate studentIntroduction to Dental Implant for undergraduate student
Introduction to Dental Implant for undergraduate student
Shamsuddin Mahmud
 
Surat @Girls @ℂall 👄 XX000000XX 👄 With Cash Payment Home Delivery
Surat @Girls @ℂall 👄 XX000000XX 👄 With Cash Payment Home DeliverySurat @Girls @ℂall 👄 XX000000XX 👄 With Cash Payment Home Delivery
Surat @Girls @ℂall 👄 XX000000XX 👄 With Cash Payment Home Delivery
khandiya#G05
 
Prevention of Cruelty to animals act 1960
Prevention of Cruelty to animals act 1960Prevention of Cruelty to animals act 1960
Prevention of Cruelty to animals act 1960
PratibhaSonawane5
 
Osvaldo Bernardo Muchanga- MALE CIRCUMCISION, ITS Vs SOCIOCULTURAL BELIEFS (C...
Osvaldo Bernardo Muchanga- MALE CIRCUMCISION, ITS Vs SOCIOCULTURAL BELIEFS (C...Osvaldo Bernardo Muchanga- MALE CIRCUMCISION, ITS Vs SOCIOCULTURAL BELIEFS (C...
Osvaldo Bernardo Muchanga- MALE CIRCUMCISION, ITS Vs SOCIOCULTURAL BELIEFS (C...
Osvaldo Bernardo Muchanga
 
Interpretation of ECG - Cardiac Arrhythmias
Interpretation of ECG - Cardiac ArrhythmiasInterpretation of ECG - Cardiac Arrhythmias
Interpretation of ECG - Cardiac Arrhythmias
MedicoseAcademics
 

Recently uploaded (20)

High Class Girls Call Delhi 9711199171 Provide Best And Top Girl Service And ...
High Class Girls Call Delhi 9711199171 Provide Best And Top Girl Service And ...High Class Girls Call Delhi 9711199171 Provide Best And Top Girl Service And ...
High Class Girls Call Delhi 9711199171 Provide Best And Top Girl Service And ...
 
The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...
The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...
The impact of CD160 deficiency on alloreactive CD8 T cell responses and allog...
 
Post infectious bronchiolitis obliterans
Post infectious bronchiolitis obliteransPost infectious bronchiolitis obliterans
Post infectious bronchiolitis obliterans
 
EXTRACTION,_PHYTOCHEMICAL_SCREENING_&_FORMULATION_OF_BOERRHAVIA.pptx
EXTRACTION,_PHYTOCHEMICAL_SCREENING_&_FORMULATION_OF_BOERRHAVIA.pptxEXTRACTION,_PHYTOCHEMICAL_SCREENING_&_FORMULATION_OF_BOERRHAVIA.pptx
EXTRACTION,_PHYTOCHEMICAL_SCREENING_&_FORMULATION_OF_BOERRHAVIA.pptx
 
Ghaziabad @Girls @Call WhatsApp Numbers 🫦0000XX0000🫦 List For Friendship Girl...
Ghaziabad @Girls @Call WhatsApp Numbers 🫦0000XX0000🫦 List For Friendship Girl...Ghaziabad @Girls @Call WhatsApp Numbers 🫦0000XX0000🫦 List For Friendship Girl...
Ghaziabad @Girls @Call WhatsApp Numbers 🫦0000XX0000🫦 List For Friendship Girl...
 
World Population Day 2024_Overview_Dr Bijan Das
World Population Day 2024_Overview_Dr Bijan DasWorld Population Day 2024_Overview_Dr Bijan Das
World Population Day 2024_Overview_Dr Bijan Das
 
Yoga talk & yoga slides by Flametree Yoga 11 July 2024.pdf
Yoga talk & yoga slides by Flametree Yoga 11 July 2024.pdfYoga talk & yoga slides by Flametree Yoga 11 July 2024.pdf
Yoga talk & yoga slides by Flametree Yoga 11 July 2024.pdf
 
Safeguarding Reproductive Health- Preventing Fallopian Tube Blockage After a ...
Safeguarding Reproductive Health- Preventing Fallopian Tube Blockage After a ...Safeguarding Reproductive Health- Preventing Fallopian Tube Blockage After a ...
Safeguarding Reproductive Health- Preventing Fallopian Tube Blockage After a ...
 
Amygdala Medi-Trivia Quiz (Prelims) | FAQ 2024
Amygdala Medi-Trivia Quiz (Prelims) | FAQ 2024Amygdala Medi-Trivia Quiz (Prelims) | FAQ 2024
Amygdala Medi-Trivia Quiz (Prelims) | FAQ 2024
 
Kayakalp Clinic Best Sexologist of patna
Kayakalp Clinic Best Sexologist of patnaKayakalp Clinic Best Sexologist of patna
Kayakalp Clinic Best Sexologist of patna
 
Endocrine Physiology - Insulin and Glucagon
Endocrine Physiology -  Insulin and GlucagonEndocrine Physiology -  Insulin and Glucagon
Endocrine Physiology - Insulin and Glucagon
 
PICTURE TEST IN OBSTETRICS AND GYNAECOLOGY-Aloy Okechukwu Ugwu.pptx
PICTURE TEST IN OBSTETRICS AND GYNAECOLOGY-Aloy Okechukwu Ugwu.pptxPICTURE TEST IN OBSTETRICS AND GYNAECOLOGY-Aloy Okechukwu Ugwu.pptx
PICTURE TEST IN OBSTETRICS AND GYNAECOLOGY-Aloy Okechukwu Ugwu.pptx
 
pharmaceutical care plan scope application.pptx
pharmaceutical care plan scope application.pptxpharmaceutical care plan scope application.pptx
pharmaceutical care plan scope application.pptx
 
Heart Valves and Heart Sounds -Congenital & valvular heart disease.pdf
Heart Valves and Heart Sounds -Congenital & valvular heart disease.pdfHeart Valves and Heart Sounds -Congenital & valvular heart disease.pdf
Heart Valves and Heart Sounds -Congenital & valvular heart disease.pdf
 
anthelmintic-drugs.pptx pharmacology dep
anthelmintic-drugs.pptx pharmacology depanthelmintic-drugs.pptx pharmacology dep
anthelmintic-drugs.pptx pharmacology dep
 
Introduction to Dental Implant for undergraduate student
Introduction to Dental Implant for undergraduate studentIntroduction to Dental Implant for undergraduate student
Introduction to Dental Implant for undergraduate student
 
Surat @Girls @ℂall 👄 XX000000XX 👄 With Cash Payment Home Delivery
Surat @Girls @ℂall 👄 XX000000XX 👄 With Cash Payment Home DeliverySurat @Girls @ℂall 👄 XX000000XX 👄 With Cash Payment Home Delivery
Surat @Girls @ℂall 👄 XX000000XX 👄 With Cash Payment Home Delivery
 
Prevention of Cruelty to animals act 1960
Prevention of Cruelty to animals act 1960Prevention of Cruelty to animals act 1960
Prevention of Cruelty to animals act 1960
 
Osvaldo Bernardo Muchanga- MALE CIRCUMCISION, ITS Vs SOCIOCULTURAL BELIEFS (C...
Osvaldo Bernardo Muchanga- MALE CIRCUMCISION, ITS Vs SOCIOCULTURAL BELIEFS (C...Osvaldo Bernardo Muchanga- MALE CIRCUMCISION, ITS Vs SOCIOCULTURAL BELIEFS (C...
Osvaldo Bernardo Muchanga- MALE CIRCUMCISION, ITS Vs SOCIOCULTURAL BELIEFS (C...
 
Interpretation of ECG - Cardiac Arrhythmias
Interpretation of ECG - Cardiac ArrhythmiasInterpretation of ECG - Cardiac Arrhythmias
Interpretation of ECG - Cardiac Arrhythmias
 

Myeloma

  • 2. CONTENTS • Soepel • Multiple myeloma 1. Definition 2. Incidence 3. Eatiology 4. Clinical features 5. Invistigation 6. Treatment • Reffrences
  • 3. SOEPEL • S- A 25 years old Saudi female. She complained of pain in her left leg when she walk for long distance from one week ago. • O- taking history and physical examination • E- DVT, baker cyst and septic thrombophlebitis. • P- cbc, pt, INR and duplex ultrasound • E- anticoagulant” warfrien “ • L- multiple myeloma
  • 5. DEFINITION AND INCIDENCE • Myeloma is a neoplasm of the plasma cells, which are derived from B lymphocytes. • It is an uncommon neoplasm, accounting for approximately 1% of adult cancers in the united states. • The incidence of myeloma increases with advancing age and is twice as common in blacks. Approximately and less common in Asians • the annual incidence is 4 per 100,000. • 20,000 new cases of multiple myeloma are diagnosed each year in the united states.
  • 6. EATIOLOGY AND PATHOLOGY • A. Although no specific underlying causes have been proven, genetic factors, as well as exposure To petroleum, asbestos, metals, and radiation, may increase the risk of developing myeloma. • B. Benign monoclonal gammopathies can progress to multiple myeloma, although most do not. • C. Myeloma cells are characterized by genetic instability, and karyotype analysis often reveals Multiple abnormalities, which can provide prognostic information. Multiple myeloma is a type of mature B cell lymphoid neoplasm characterized by accumulation of malignant plasma cells in the bone marrow compartment.
  • 7. CLINICAL FEATURES • A. Weakness, fatigue, infection, and bleeding due to marrow failure. • B. Osteolytic lesions • C. Recurrent infections • D. Renal abnormalities • E. Hypercalcemia • F. Hyperviscosity • G. Compression of the spinal cord
  • 8. INVISTIGATION • CBC, creatinine, calcium, β2-microglobulin, LDH. • SPEP with immunofixation electrophoresis (IFE), UPEP with IFE: to Identify the M spike. Not all serum paraproteins are detectable in urine And vice versa. • Bone marrow aspirate and biopsy. • Skeletal bone plain film survey: lytic lesions are seen in 60–90% of patients. • Myeloma is characterized by purely osteolytic lesions, so bone scan is And alkaline phosphatase is normal. • If other findings are consistent, the presence of the jak2 mutation is Highly suggestive of the diagnosis.
  • 11. • Myeloma affecting the skull. Note the rounded lytic translucencies produced by infiltration of the skull with myeloma cells.