The document presents a study on a novel multi-scale two-directional two-dimensional principal component analysis (ms2d2pca) method aimed at improving biomedical signal classification, particularly using high-dimensional data from various sources like EMG and EEG. This approach addresses challenges related to high-dimensional recordings which traditional methods struggle with due to dimensionality and sample size issues. Experimental results show that ms2d2pca effectively classifies hand movements from 89-channel EMG signals in stroke survivors.