Lorenzo Setale presented strategies at Django Meetup #9 to enhance performance in a peer-to-peer car-sharing service, minbildinbil.dk, using technologies like Nginx, uWSGI, Celery, and caching. Key approaches included implementing asynchronous tasks with Celery for notifications, smart load balancing with Nginx, and extensive caching techniques to optimize response times. The session highlighted the importance of efficient configuration and middleware to manage resources and improve the speed of the application.