The document discusses key challenges in managing IT functions, including the modern dynamic IT environment, centralization vs decentralization debates, standardization, security issues, technology selection criteria, vendor management, the role of the CIO, and IT governance models. It notes the first, second, and third order impacts of introducing IT to an organization and examines debates around centralized vs decentralized infrastructure and standardization. It also outlines factors to consider in technology selection, the vendor management lifecycle, and different IT governance archetypes involving business and IT leadership.