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three hypotheses.
hypothesis A:
cheap data changes the
 epistemology of fields.
what makes justified
 beliefs justified?


   http://plato.stanford.edu/entries/epistemology/
player x is a good hitter
        because
OPS = AB(H + BB +
HBP) + TB(AB + BB + SF
+ HBP) / AB(AB + BB +
SF + HBP)
fields based on narrative, but
  tested in reality, are very
  vulnerable to data-driven
           change.
information > gut
 models and metrics
low transaction costs
   pissed off pundits
hypothesis B:
data is (becoming) cheap
enough to drive epistemic
    change in health.
not just cheap, but
potentially democratized.
not just democratized, but
        ubiquitous.
hypothesis C:
costs will not magically
decline thanks to data.
25
26
27
28
29
assume 1,000,000 downloads
assume 10% false positive rate
     100,000 doctor visits
      $1000 per biopsy
that s the setup.
sharing by small but
coherent groups can
create asymmetrically
 valuable resources.
small group
  sharing
coherentism from:

 standard legal tools
common infrastructure
       norms
      metadata
proven to work in:
    software
     content
the experiment:
let s a small but
  coherent group to
share data and see if it
   works in health.
http://opensnp.org/users/615
http://files.snpedia.com/reports/promethease_data/genome_jtw_ui2.html
Also there is no suggestion of
consanguinity in your pedigree.

http://www.ianlogan.co.uk/
http://sagebridge.org
53
PLC:
portable legal consent
terms in blue pop up definitions
all boxes must be checked




  volunteer must click to proceed
volunteer cannot skip video
http://weconsent.us/informed-
          consent/




                                64
moving PLC to an open
  consent standard.
email
              patient
             #XYZ123


researcher              patient
Public	
             Portable	
  Legal	
                          Sage	
  Bionetworks             Sage	
  Bionetworks
       Recruitment                Consent                                            CGRE                        Synapse
              Founda3on
               Advocacy	
  

                                                                            CGRE	
  Database               Synapse	
  Database


   1                           2         Portable	
  Legal	
  Consent   3                              4                          5

                                                                             Individual	
  Level	
            De-­‐iden3fied
                Hospital




                                                                                   Data                         Dataset
                                                                                                                                  Researchers
               Founda3on
                Advocacy	
  




Par3cipants
3
       Portable	
  Legal	
  Consent
                2
 Advocacy	
                            Advocacy	
  
Founda3on            Hospital         Founda3on




                                                      Par3cipants
                1
71
five clinical studies on
Bridge this year under
         PLC.
it s likely that we will
end up with a sharing
  monopoly of some
          sort.
once entrenched, hard to
         move.
once entrenched, hard to
         move.
tendency to increment.
a. just like now,
  but moreso
b. the cartel.
c. the commons.
only the last choice
  allows all three
 choices to exist.
thank you
         @wilbanks
john.wilbanks@sagebase.org

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Cheap Data Changes Epistemology Through Sharing