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Introduction to Immunology
UIMLT
Learning objectives
1. Define Immunology , immunity ,immune
system.
2. Brief history of immunology
3. Significance of immune system
4. Components of immune system
5. Cells of immune system
6. Anatomic distribution of immune system
components
3/26/2024 Immunology & Serology I 2
IMMUNOLOGY AND THE IMMUNE SYSTEM
Immunology:
– Study of the components and function of the immune system
Immunity : stems from L.- immunis = “exempt;”
Meaning the state of protection from infectious disease.
Immune System: consist on
– Molecules, cells, tissues and organs which provide non-specific and
specific protection against
• Microorganisms e.g bacteria ,viruses ,fungi, parasites
• Microbial toxins e.g diftheriae toxins,cholera toxins.
• Tumor cells
– Crucial to human survival
3/26/2024 Immunology & Serology I 3
Brief History of Immunology
• 430 B.C. – philosophers noted resistance to
plague by those who recovered.
• In fifteenth century dried crusts derived from
smallpox pustules were either inhaled into the
nostrils or inserted into small cuts in the skin
(a technique called variolation).
3/26/2024 Immunology & Serology I 4
Edward Jennar
3/26/2024 Immunology & Serology I 5
In 1880, Pasteur
----Anti-cholera live-attenuated
vaccine
(old culture of Chicken V.cholera)
Louis Pasteur(1822-1895)
3/26/2024 Immunology & Serology I 6
Louis Pasteur watching as
Joseph Meister receives
attenuated rabies vaccine
(1885)
3/26/2024 Immunology & Serology I 7
They should be vaccinated first
Why do they not want to play with my kids?
They should be vaccinated first…..
3/26/2024 Immunology & Serology I 8
Significance of Immune System
3/26/2024 Immunology & Serology I 9
Infection and Immunity
Infection Immunity
Bolus of infection x virulence
immunity
Disease =
3/26/2024 Immunology & Serology I 10
Immune System
Humoral Cellular Humoral Cellular
Specific/Adaptive
Nonspecific/Innate
Complement
Interferons
CRP
Phagocytes
Non-
phagocytes
T cells
effectors cells
B cells
Antibodies
Physical
Barriers
3/26/2024 Immunology & Serology I 11
3/26/2024 Immunology & Serology I 12
Organs Of Immune System
3/26/2024 Immunology & Serology I 13
Cells of immune system
Basophils
Neutrophils
Eosinophils
Granulocytic
Langerhans &
Macrophages
Kupffer cells
Dendritic cells?
Monocytic
Cytotoxic
Helper
Suppressor
T-cells
Plasma
cells
B-cells NK, NKT
cells
lymphoid cells
Myeloid cells
3/26/2024 Immunology & Serology I 14
Origin of cells of immune system
3/26/2024 Immunology & Serology I 15
Anatomic distribution of Lymphoid
Organs
3/26/2024 Immunology & Serology I 16
MCQs
1.Jenner’s work with cowpox, which provided immunity
against smallpox, demonstrates which phenomenon?
• a. Natural immunity
• b. Attenuation of vaccines
• c. Phagocytosis
• d. Cross-immunity
2. Which of the following can be attributed to Pasteur?
• a. Discovery of opsonins
• b. Research on haptens
• c. First attenuated vaccines
• d. Discovery of the ABO blood groups
3/26/2024 Immunology & Serology I 17

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LEC#1 Immunity. pptxFDF DVF FDFDFFDF DDFDFDD FDFFDFDDFDF

  • 2. Learning objectives 1. Define Immunology , immunity ,immune system. 2. Brief history of immunology 3. Significance of immune system 4. Components of immune system 5. Cells of immune system 6. Anatomic distribution of immune system components 3/26/2024 Immunology & Serology I 2
  • 3. IMMUNOLOGY AND THE IMMUNE SYSTEM Immunology: – Study of the components and function of the immune system Immunity : stems from L.- immunis = “exempt;” Meaning the state of protection from infectious disease. Immune System: consist on – Molecules, cells, tissues and organs which provide non-specific and specific protection against • Microorganisms e.g bacteria ,viruses ,fungi, parasites • Microbial toxins e.g diftheriae toxins,cholera toxins. • Tumor cells – Crucial to human survival 3/26/2024 Immunology & Serology I 3
  • 4. Brief History of Immunology • 430 B.C. – philosophers noted resistance to plague by those who recovered. • In fifteenth century dried crusts derived from smallpox pustules were either inhaled into the nostrils or inserted into small cuts in the skin (a technique called variolation). 3/26/2024 Immunology & Serology I 4
  • 6. In 1880, Pasteur ----Anti-cholera live-attenuated vaccine (old culture of Chicken V.cholera) Louis Pasteur(1822-1895) 3/26/2024 Immunology & Serology I 6
  • 7. Louis Pasteur watching as Joseph Meister receives attenuated rabies vaccine (1885) 3/26/2024 Immunology & Serology I 7
  • 8. They should be vaccinated first Why do they not want to play with my kids? They should be vaccinated first….. 3/26/2024 Immunology & Serology I 8
  • 9. Significance of Immune System 3/26/2024 Immunology & Serology I 9
  • 10. Infection and Immunity Infection Immunity Bolus of infection x virulence immunity Disease = 3/26/2024 Immunology & Serology I 10
  • 11. Immune System Humoral Cellular Humoral Cellular Specific/Adaptive Nonspecific/Innate Complement Interferons CRP Phagocytes Non- phagocytes T cells effectors cells B cells Antibodies Physical Barriers 3/26/2024 Immunology & Serology I 11
  • 12. 3/26/2024 Immunology & Serology I 12
  • 13. Organs Of Immune System 3/26/2024 Immunology & Serology I 13
  • 14. Cells of immune system Basophils Neutrophils Eosinophils Granulocytic Langerhans & Macrophages Kupffer cells Dendritic cells? Monocytic Cytotoxic Helper Suppressor T-cells Plasma cells B-cells NK, NKT cells lymphoid cells Myeloid cells 3/26/2024 Immunology & Serology I 14
  • 15. Origin of cells of immune system 3/26/2024 Immunology & Serology I 15
  • 16. Anatomic distribution of Lymphoid Organs 3/26/2024 Immunology & Serology I 16
  • 17. MCQs 1.Jenner’s work with cowpox, which provided immunity against smallpox, demonstrates which phenomenon? • a. Natural immunity • b. Attenuation of vaccines • c. Phagocytosis • d. Cross-immunity 2. Which of the following can be attributed to Pasteur? • a. Discovery of opsonins • b. Research on haptens • c. First attenuated vaccines • d. Discovery of the ABO blood groups 3/26/2024 Immunology & Serology I 17