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Stem cells: past, present, and future
An
introduction to
Stem Cells
BY: alaa helmy oraby
UNKNOWN
KNOW
N
‹#›
• Definition of Stem Cells
• Characteristics of Stem Cells
• Milestones in stem cell research
‹#›
Regenerative Medicine and Stem Cell
“
Definition of Stem Cells
‹#›
Stem Cells
‹#›
What is a stem cell?
Stem Cells: From Bench To Bedside
Perspectives on the properties of stem cells
Introduction to stem cells and regenerative medicine
Introduction to stem cells
“
Characteristics
of Stem Cells
‹#›
‹#›
Self Renewal Differentiation
Division
‹#›
Concise Review: Asymmetric Cell Divisions in Stem Cell Biology
STEM CELLS Linreage ‹#›
A stem cell is an unspecialized
and undifferentiated cell that has
a remarkable capacity for self-
renewal and the ability to
undergo prolonged periods of cell
division, both in vitro and in vivo
Regenerative Medicine and Stem Cell Biology
“
Types of Stem Cells
‹#›
‹#›
‹#›
Multipotent
stem cells
Unipotent
stem cells
Totipotent stem cells
‹#›
‹#›
‹#›
‹#›
Totipotent stem cells are cells that can self-renew by dividing and developing
into the three primary germ cell layers (ectoderm, endoderm, and mesoderm)
of the early embryo and extra-embryonic tissues such as the placenta.
Pluripotent stem cells differentiate into specialized cell types deriving from
the three germ layers.
Multipotent stem cells differentiate only to specific types of cells, unlike their
embryonic counterparts, which are pluripotent and can differentiate into all
derivatives of the three primary germ layer
Unipotent stem cells can produce only one cell type but have the property of
self- renewal that distinguishes them from non-stem cells
“
Milestones in Stem Cells
Fields
‹#›
‹#›
1962 1996 200
6
Physiology / Medicine Noble Prize-2012
Nuclear Transplantation
and cloning of tadpole
Cloned Dolly the sheep
from a mammary cell of an
adult sheep
Developed iPSCs from mouse
fibroblasts by combining of
four reprogramming factors
‹#›
1962-2006
Nuclear Transplantation
and cloning of tadpole
Developed iPSCs from mouse
fibroblasts by combining of four
reprogramming factors
‹#›
1996 Dolly the sheep
‹#›
Stem cells: a brief history and outlook
Summary
‹#›
Stem Cell Biology Types of stem cells
Characteristics of stem cells Milestone in Stem cells Research
‹#›
1962 1996 2006
Physiology / Medicine Noble Prize-2012
Nuclear Transplantation
and cloning of tadpole
Cloned Dolly the sheep
from a mammary cell of an
adult sheep
Developed iPSCs from mouse
fibroblasts by combining of
four reprogramming factors
THANK
YOU

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Introduction to the research of stem cells

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