Skip to main content
UploadLanguage (EN)Support
BusinessMobileSocial MediaMarketingTechnologyArt & PhotosCareerDesignEducationPresentations & Public SpeakingGovernment & NonprofitHealthcareInternetLawLeadership & ManagementAutomotiveEngineeringSoftwareRecruiting & HRRetailSalesServicesScienceSmall Business & EntrepreneurshipFoodEnvironmentEconomy & FinanceData & AnalyticsInvestor RelationsSportsSpiritualNews & PoliticsTravelSelf ImprovementReal EstateEntertainment & HumorHealth & MedicineDevices & HardwareLifestyle
PM
Uploaded byPharmacy Academy, Faculty of Pharmacy, IFTM University, Moradabad
PPTX, PDF89 views

Industrial Pharmacy-I Unit-II Tablets.pptx

Define Tablet, Advantages and Disadvantages, Classification of Tablets

Science◦
Download to read offline
Industrial Pharmacy-I Course Code:BP502T B.Pharm 5th Semester Unit- II TABLETS BY Rajat Saxena Assistant Professor IFTM University, Moradabad
Tablets • Tablets are solid dosage form usually prepared with the aid of suitable pharmaceutical excipients. • They may vary in size, shape, weight, hardness, thickness, disintegration and dissolution characteristics. • The oral route of drug administration is the most important method of administering drugs for systematic effect.
• Tablet is defined as a compressed solid dosage form containing medicaments with or without Excipients. • According to the Indian Pharmacopoeia Pharmaceutical tablets are solid, flat, unit dosage form, prepared by compressing a drug or a mixture of drugs, with or without diluents
Tablets Ideal Properties 1. A tablet should be elegant and free of defects like chips, cracks, discoloration, and contamination 2. Should be accurate & uniform in weight. 3. The size & shape should be reasonable for easy administration 4. They have sufficient strength to withstand mechanical shock during its production, packaging, shipping and dispensing 5. The tablet must be able to release the medicinal agents in a predictable and reproducible manner
Advantages 1. Easy to administration and dispense. 2. Accuracy in dose 3. Cost is lowest 4. Lightest and compact compared all dosage forms 5. Easiest and cheapest to package and ship 6. Chemically and microbiologically stable 7. Sustained release product is possible by enteric coating.
Disadvantages 1. Difficult to swallow in case of children and unconscious patients 2. Hygroscopic drugs are not suitable for compressed tablet 3. Drugs with low or poor water solubility, low dissolution, may be difficult to formulate. 4. Cost of production may be increase because of coating & encapsulation to remove bitter and unpleasant taste. 5. Solids having irritant effects on GIT mucosa poses problem for formulation into tablets.
Tablets Classification Tablets ingested orally • Compressed tablet • Layered tablets • Sustained release tablets • Enteric coated tablets • Sugar coated tablet • Film coated tablet • Chewable table
Tablets used in oral cavity • Buccal tablet • Sublingual tablet • Troches or lozenges • Dental cone
Tablets administered by other route • Implantation tablet • Vaginal tablet
Tablets used to prepare solution • Effervescent tablet • Hypodermic tablet • Dispersible tablets
Tablet Manufacturing Process . Active Pharmaceuticals Ingredients Excipient Mixing & Granulation Lubricants Compression
Tablet Manufacturing Methods Wet Granulation Dry Granulation Direct Compression Mixing Mixing Sizing Binder Solution Granulation Mixing Granulation/Drying Lubricants Compression Lubricants Compression Compression
Tablet Excipients In addition to active ingredients tablet contains a number of inert materials known as additives or excipients. These excipients are used for various functions during tablets manufacturing process. Diluents Lubricants Binders Glidants Disintegrates Organoleptic agents
Diluents Inert substances needed to increase the bulk when quantity of medicaments is very small in each tablet ( dose is low ) They make a tablet to a practical size for compression. Also provide improved cohesion, to permit use of direct compression manufacturing. Anhydous lactose, Dibasic ca-phosphate, Mannitol, Sucrose/Dextrose, Starch
Binders They are used for the cohesive qualities to the powdered also called binders or granulators. They provide Cohesive strength after compression Tablet remain intact after compression Formulation of granules of desired hardness & size. Starch paste -10-20 % solution Acacia, tragacanth – Solution for 10-25% Conc. Polyvinyl pyrrolidone (PVP)- 2% aqueous Cellulose derivatives – Methyl cellulose, Hydroxy propyl methyl cellulose, Hydroxy propyl cellulose
Disintegrates Substance/mixture of substances added to facilitate a tablet to break up or disintegrate when it contact in water in the GIT after administration. Starch derivative – Primogel and Explotab (1-8%) Cellulose derivatives- Ac- Di-Sol (sodium carboxy methyl cellulose) Crosspovidone- cross-linked povidone (polymer) Sodium starch glycolate- cross-linked starch • Super- disintegrants Swells up to ten fold within 30 seconds when contact water. Examples: Crosscarmellose-cross-linked cellulose
Lubricants To prevent adhesion of tablet materials to the surface of dies and punches Reduce inter-particle friction Facilitate ejection of tablet from die cavity Stearic acid, Magnesium stearate, Talc, PEG (Polyethylene glycols),
Glidant • They improve the flow properties of a powder mixture by reducing the friction b/w particles • Added in dry state just prior to compression Corn Starch – 5-10% conc., Talc-5% conc., Silica derivative – Colloidal silicas such as Cab-O-Sil, Syloid, Aerosil in 0.25- 3%
Organoleptic Agents • Coloring Agents • Flavoring gents • Sweetening Agent
THANKU