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Download and use this compilation of
research on GLYPHOSATE
You eat, breathe, and drink GLYPHOSATE
every day
• Worldwide exposure
• Detectable in human tissues/blood/urine
Glyphosate—no chemical does more on a widespread basis to promote disease:
1.Inhibits cyp450 detoxification: Anything that blocks cyp450 by definition promotes xenobiotic accumulation and
adverse drug effects
2.Genotoxic: Causes DNA damage in human cells even when massively diluted
3.Mitochondriopathic: In the combination of Monsanto’s Roundup®, causes mitochondrial dysfunction per several
in vitro studies, linked to nearly all diseases
4.Excellent tissue penetration: The added solvents, surfactants, and so-called inert chemicals help promote entry
into cells
5.Carcinogenic: Activation of estrogen receptors stimulates growth of cancer cells in vitro; would be expected to
promote growth of other cancer cells.
6.Estrogenic: Activation of estrogen receptors stimulates growth of cancer cells in vitro; would be expected to
promote growth of other cancer cells, as well as promote autoimmunity.
7.Synergistic with GMO-promoted inflammation: Commonly applied to GMO corn which has been shown to
promote proliferation of GammaDelta Tcells which promote allergy and autoimmunity, both of which would be
exacerbated by 1) inhibition of detoxification, 2) genotoxicity, 3) mitochondrial dysfunction, and 4) estrogenic
effects.
8.Unsurpassed political protection: Because of industry influence on politicians who have 1) no scientific training,
and 2) receive pay-off money from the chemical industry, glyphosate is used in high doses internationally without
concern for long-term effects, even when applied to fields, forests, water supplies and other ecosystems.
9.Widespread exposure via air and water: More than 75% of air and water samples in Mississippi USA are
contaminated with glyphosate; that far exceeds the social acceptance of heroin, crack cocaine, tobacco use and
second-hand smoke combined. No other chemical achieves such massive population-wide use.
10.Unsurpassed distribution to the population, routinely found in the food supply, especially soy: "GM-soy
contains high residues of glyphosate and AMPA…" Food Chemistry 2014 Jun
http://youtu.be/MqWwhggnbyw?t=52m45s
Glyphosate inhibition of Cyp450
detoxification
•Expected effects of anything that impairs cyp450
detoxification:
– Accumulation of toxins; Increased adverse drug effects;
Accumulation of self-same toxin
Glyphosate genotoxicity, DNA
damage
•Self-explanatory
Glyphosate genotoxicity, DNA
damage
•Self-explanatory
Mitochondrial dysfunction directly
contributes to disease
•Migraine
•Parkinson’s disease
•Alzheimer’s disease
•Diabetes, obesity
•Hypertension
•Fibromyalgia, CFS
Mitochondrial toxicity of
glyphostate/Roundup®
Toxicol In Vitro. 2013 Feb;27(1):191-7. doi: 10.1016/j.tiv.2012.09.021. Epub 2012 Oct 23.
Mixtures of glyphosate and surfactant TN20 accelerate cell death via mitochondrial damage-
induced apoptosis and necrosis.
Kim YH1
, Hong JR, Gil HW, Song HY, Hong SY.
Author information
Abstract
Glyphosate, a common herbicide, is not toxic under normal exposure circumstances. However,
this chemical, when combined with a surfactant, is cytotoxic. In this study, the mechanism of the
additive effect of glyphosate and TN-20, a common surfactant in glyphosate herbicides, was
investigated. After exposure of rat H9c2 cells to glyphosate and TN-20 mixtures, following assays
were performed: flow cytometry to determine the proportion of cells that underwent apoptosis
and necrosis; western blotting to determine expression of mitochondrial proteins (Bcl-2 and
Bax); immunological methods to evaluate translocation of cytochrome C; luminometric
measurements to determine activity of caspases 3/7 and 9; and tetramethyl rhodamine methyl
ester assay to measure mitochondrial membrane potentials. Bcl-1 intensity decreased while Bax
intensity increased with exposure to increasing TN-20 and/or glyphosate concentrations.
Caspase activity increased and mitochondrial membrane potential decreased only when the cells
were exposed to a mixture of both TN-20 and glyphosate, but not after exposure to either one of
these compounds. The results support the possibility that mixtures of glyphosate and TN-20
aggravate mitochondrial damage and induce apoptosis and necrosis. Throughout this process,
TN-20 seems to disrupt the integrity of the cellular barrier to glyphosate uptake,
promoting glyphosate-mediated toxicity.
www.ncbi.nlm.nih.gov/pubmed
Mitochondrial toxicity of
glyphostate/Roundup®
Environ Toxicol Pharmacol. 2012 Sep;34(2):144-53. doi: 10.1016/j.etap.2012.02.010.
Epub 2012 Mar 15.
A step further toward glyphosate-induced epidermal cell death: involvement
of mitochondrial and oxidative mechanisms.
Heu C1
, Elie-Caille C, Mougey V, Launay S, Nicod L.
Author information
Abstract
A deregulation of programmed cell death mechanisms in human epidermis leads to
skin pathologies. We previously showed that glyphosate, an extensively used
herbicide, provoked cytotoxic effects on cultured human keratinocytes, affecting
their antioxidant capacities and impairing morphological and functional cell
characteristics. The aim of the present study, carried out on the human epidermal
cell line HaCaT, was to examine the part of apoptosis plays in the cytotoxic effects
of glyphosate and the intracellular mechanisms involved in the apoptotic events.
We have conducted different incubation periods to reveal the specific events
in glyphosate-induced cell death. We observed an increase in the number of early
apoptotic cells at a low cytotoxicity level (15%), and then, a decrease, in favor of
late apoptotic and necrotic cell rates for more severe cytotoxicity conditions. At the
same time, we showed that the glyphosate-induced mitochondrial membrane
potential disruption could be a cause of apoptosis in keratinocyte cultures.
www.ncbi.nlm.nih.gov/pubmed
Mitochondrial toxicity of
glyphostate/Roundup®
Chemosphere. 2005 Dec;61(8):1115-22. Epub 2005 Apr 26.
Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation.
Peixoto F.
Author information
Abstract
The potential toxicity of the herbicide Roundup and its fundamental substance (glyphosate) was tested in
bioenergetic functions of isolated rat liver mitochondria. Roundup stimulates succinate-supported respiration
twice, with simultaneous collapse of transmembrane electrical potential, while glyphosate used in the same
concentrations does not induce any significant effect. Additionally, Roundup depresses state 3 respiration by
about 40%, at 15 mM, whereas uncoupled respiration in the presence of FCCP is depressed by about 50%.
Depression of uncoupled respiratory activity is mediated through partial inhibition ofmitochondrial complexes II
and III, but not of complex IV. The phosphorylative system was affected by both a direct and an indirect effect on
the F0F1 ATPase activity. The addition of uncoupled concentrations of Roundup to Ca2+-
loaded mitochondriatreated with Ruthenium Red resulted in non-specific membrane permeabilization, as
evidenced by mitochondrial swelling in isosmotic sucrose medium. Therefore, the uncoupling of oxidative
phosphorylation is also related to the non-specific membrane permeabilization induced
by Roundup. Glyphosate alone does not show any relevant effect on the mitochondrial bioenergetics, in
opposition to Roundup formulation products. The differences in the toxicity observed could be either attributed to
some products of Roundup or to a synergic effect of glyphosate and formulation products. Bearing in mind
that mitochondria is provided with a variety of bioenergetic functions mandatory for the regulation of intracellular
aerobic energy production and electrolyte homeostasis, these results question the safety of Roundup on animal
health.
www.ncbi.nlm.nih.gov/pubmed
Tissue penetration
•Glyphosate is almost always combined with other
chemicals—these are commonly mislabeled “inert”
chemicals
– These other chemicals increase toxicity of glyphosate and
also have their own toxic effects
•Solvents and surfactants basically dissolve either
glyphosate into aqueous solutions and/or damage cell
membranes to promote chemical entry
Carcinogen: substance that
promotes cancer, generally via 1)
mutation and/or 2) proliferation
•Mutation = DNA damage
•Proliferation = such as via estrogen receptors
Glyphosate is a Carcinogen: a substance that
promotes cancer, via 1) DNA damage / mutation and
2) estrogen-receptor stimulated proliferation
•Glyphosate = DNA damage per Archives of Toxicology 2012
•Glyphosate = Cancer proliferation via stimulation of estrogen receptors
per Food and Chemical Toxicology 2014
Glyphosate—the herbicide in Monsanto’s Roundup® and
commonly applied to GM (genetically manipulated) corporate
plants, wheat, soy—causes DNA damage and cell death in
human cells, even at extreme dilutions per Archives of Toxicology 2012 May
Glyphosate—the herbicide
in Monsanto’s Roundup®
and commonly applied to
GM (genetically
manipulated) corporate
plants, wheat, soy—causes
DNA damage in humans per
Archives of Toxicology 2012 May and
Genetics and Molecular Biology 2007 Mar
GMO corn shown to double the
population of gamma-delta T-cells,
which promote inflammation,
allergy and autoimmunity
GMO-altered foods: Increased allergenicity, toxins,
changes in gut microbes, gut permeability,
cytokine levels, and immunocyte populations…
•MON810 corn causes increased IL-6 and gd-Tcells:
– GMO MON810 maize induced increases of serum IL-
6, IL-13, IL-12p70, and MIP-1beta and gamma-delta-
Tcells of mice.
• We all know that IL-6 = inflammation and
generally more CRP/IR/CVD/AzD.
– “One of the more recurrent alterations in lymphocyte
phenotypes observed in this study was an increase
in the TCRγδ+ population. ... Higher numbers of γδT
cells have been observed in humans with asthma, in
IELs of children with untreated food allergy, and in
the duodenum of children with juvenile idiopathic
arthritis or connective tissue disease with
gastrointestinal symptoms.” Finamore et al. J Agric
Food Chem. 2008 Dec
– Per review in Feb 2013 and previous work dating
back decades, we know that gd-Tcells promote
inflammation and autoimmunity! Su et al. Clin Dev
Immunol. 2013 Feb
GMO-altered foods: Increased allergenicity,
toxins, changes in gut microbes, gut
permeability, cytokine levels, and immunocyte
populations…
•MON810 corn causes increased IL-6 and gd-
Tcells:
– Finamore et al. J Agric Food Chem. 2008 Dec
 “As a subset of T cells that bridge innate and
adaptive immunity, γδ T cells may display
different functions similar to those of CD4+ T-cell
subsets such as CTLs, Th1/Th2 cells, Tregs, Th17
cells, and APCs depending on specific
microenvironment. They definitely play
important roles in the development of
autoimmune diseases such as RA and SLE
through their antigen-presenting capacity, release
of proinflammatory cytokines, immunomodulatory
properties, interaction with CD4+CD25+Tregs, and
promotion of antibody production by providing B-
cell help.” Su et al. Clin Dev Immunol. 2013 Feb
GMO food alters gene expression in
plants and the animals that consume
those plants as “food”
GMO food alters gene expression in
plants and the animals that consume
those plants as “food”
Unreasonable political protection
Paul Craig Roberts PhD is a
former Assistant Secretary
of the US Treasury and
Associate Editor of the Wall
Street Journal.
counterpunch.org/2013/02/26/one-nation-under-monsanto/
Unreasonable political protection
theatlantic.com/health/archive/2012/06/the-amas-strange-position-on-gm-foods-test-but-dont-label/258968/
Glyphosate Glyfosato Glifosato PPT
Glyphosate Glyfosato Glifosato PPT
Glyphosate found in more than
75% of air and water in Mississippi
USA
•Pesticides in Mississippi air and rain: a comparison between
1995 and 2007. Environmental Toxicology and Chemistry 2014
– "Atrazine, metolachlor, and propanil were detected in ≥50% of
the air and rain samples in both years. Glyphosate and its
degradation product, aminomethyl-phosphonic acid
(AMPA), were detected in ≥75% of air and rain samples
in 2007 but were not measured in 1995. … Total herbicide flux
in 2007 was slightly greater than in 1995 and was dominated by
glyphosate. Malathion, methyl parathion, and degradation
products made up most of the 2007 nonherbicide flux.“
Glyphosate in food—especially wheat—and
especially GM (genetically manipulated)
foods, like soy ers.usda.gov/data-products/adoption-of-genetically-engineered-
crops-in-the-us/
Glyphosate in food, especially GM
(genetically manipulated) foods,
like wheat and soy
Glyphosate in food, especially GM
(genetically manipulated) foods,
like wheat and soy
ewg.org/agmag/2012/10/americans-eat-their-weight-genetically-engineered-
Glyphosate Glyfosato Glifosato PPT
Glyphosate Glyfosato Glifosato PPT
Glyphosate in food, especially GM
(genetically manipulated) foods
Other concerns (?)
• Damage to amphibians
• Killing bee populations
• Reproductive toxicity to many species
• Political misuse against domestic
populations in the “War on Drugs”
• Brain diseases, behavior problems
Massive deployment of glyphosate in
Colombia
http://bogota.usembassy.gov/nas-eradication.html 2015 Janury
http://digitalcommons.wcl.american.edu/cgi/viewcontent.cgi?article=1346&context=sdlp
"Tensions have been rising
between the Colombian
government and the
agricultural sector since the
regulations imposed by the
U.S.-Colombia Free Trade
Agreement, which went into
effect in May 2012. … But
farmers have bristled at the
requirement that they use genetically
modified seeds, engineered by
international conglomerates like
Monsanto and Du Pont, and pay
an annual fee to do so."
http://www.rollingstone.com/p
olitics/news/will-colombias-
farmers-get-what-they-want-
20131118
The “War on Drugs” ends up
poisoning poor farms with glyphosate,
killing innocent crops and injuring
animals and farmers—men, women,
children.
topdocumentaryfilms.com/america-
backyard-colombia/
What is being eradicated—
cocoa plants or regional
control of the land to make
way for foreign
multinational corporations?
How did Colombians overturn laws
mandating the destruction of their grains,
their mining, (ie, their food and ways of
living)?
•Organization, protests and strikes in many cities
•648 arrests of protesters, 262 detentions (overturned)
Why is Colombia being
forced to destroy its
own food and seed
supply?
Why is this tropical
country being forced to
import fruit and coffee
from other countries?
Is Facebook somehow connected to
Monsanto?
• Here is what I found in a Google search:
“Facebook Monsanto”
• Seven of the top 12 shareholders of Facebook and Monsanto are
identical. Even more to the point, three of the top five shareholders are
the same. The top shareholder, at the moment, in Monsanto is The
Vanguard Group, which is number two on the list of top Facebook
shareholders.
• FMR, LLC, is the number one Facebook shareholder. For Monsanto, it’s
number two.
• The State Street Corporation is the number three shareholder for both
Facebook and Monsanto.
http://worldtruth.tv/facebook-and-monsanto-are-basically-owned-by-the-
same-people/
Other concerns (?)
• Damage to amphibians
• Killing bee populations
• Reproductive toxicity to many species
• Political misuse against domestic populations in the “War
on Drugs”
• If these topics are completely new to you, then you should
consider examining the following:
– The size and weight of the rock that you are living under
– How far you have your head buried under the sand
– Media censorship that keeps you ignorant about issues that
critically affect your life
– Why you have placed blinders on yourself, insulating yourself
from reality, despite the consequences
• All of the information in this presentation is readily and publically available
Glyphosate research
• How to learn about glyphosate:
1. Open your eyes and activate your mind,
2. Surf the internet; if your friends aren’t talking about this
issue, then your friends/colleagues are ignorant and you
should get new contacts in your life who are actually
engaged in the world,
3. Go to the US Library of Medicine website and type the
word “glyphosate”—you can also type any disease
condition along with that:
http://www.ncbi.nlm.nih.gov/pubmed/?term=glyphosate
Glyphosate Glyfosato Glifosato PPT
Glyphosate Glyfosato Glifosato PPT
Glyphosate Glyfosato Glifosato PPT
Glyphosate Glyfosato Glifosato PPT
Glyphosate Glyfosato Glifosato PPT
Glyphosate Glyfosato Glifosato PPT
Glyphosate Glyfosato Glifosato PPT
Glyphosate research
• How to learn about glyphosate:
1. Open your eyes and activate your mind,
2. Search the internet; if your friends aren’t talking about
this issue, then your friends/colleagues are ignorant and
you should get new contacts in your life who are actually
engaged in the world,
3. Go to the US Library of Medicine website and type the
word “glyphosate”—you can also type any disease
condition along with that:
http://www.ncbi.nlm.nih.gov/pubmed/?term=glyphosate
Other concerns (?)
• Damage to amphibians
• Killing bee populations
• Reproductive toxicity to many species
• Political misuse against domestic populations in the “War
on Drugs”
• If these topics are completely new to you, then you should
consider examining the following:
– The size and weight of the rock that you are living under
– How far you have your head buried under the sand
– Media censorship that keeps you ignorant about issues that
critically affect your life
– Why you have placed blinders on yourself, insulating yourself
from reality, despite the consequences
• All of the information in this presentation is readily and publically available
Glyphosate—no chemical does more on a widespread basis to promote disease:
1.Inhibits cyp450 detoxification: Anything that blocks cyp450 by definition promotes xenobiotic accumulation and
adverse drug effects
2.Genotoxic: Causes DNA damage in human cells even when massively diluted
3.Mitochondriopathic: In the combination of Monsanto’s Roundup®, causes mitochondrial dysfunction per several
in vitro studies, linked to nearly all diseases
4.Excellent tissue penetration: The added solvents, surfactants, and so-called inert chemicals help promote entry
into cells
5.Carcinogenic: Activation of estrogen receptors stimulates growth of cancer cells in vitro; would be expected to
promote growth of other cancer cells.
6.Estrogenic: Activation of estrogen receptors stimulates growth of cancer cells in vitro; would be expected to
promote growth of other cancer cells, as well as promote autoimmunity.
7.Synergistic with GMO-promoted inflammation: Commonly applied to GMO corn which has been shown to
promote proliferation of GammaDelta Tcells which promote allergy and autoimmunity, both of which would be
exacerbated by 1) inhibition of detoxification, 2) genotoxicity, 3) mitochondrial dysfunction, and 4) estrogenic
effects.
8.Unsurpassed political protection: Because of industry influence on politicians who have 1) no scientific training,
and 2) receive pay-off money from the chemical industry, glyphosate is used in high doses internationally without
concern for long-term effects, even when applied to fields, forests, water supplies and other ecosystems.
9.Widespread exposure via air and water: More than 75% of air and water samples in Mississippi USA are
contaminated with glyphosate; that far exceeds the social acceptance of heroin, crack cocaine, tobacco use and
second-hand smoke combined. No other chemical achieves such massive population-wide use.
10.Unsurpassed distribution to the population, routinely found in the food supply, especially soy: "GM-soy
contains high residues of glyphosate and AMPA…" Food Chemistry 2014 Jun

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Glyphosate Glyfosato Glifosato PPT

  • 1. Download and use this compilation of research on GLYPHOSATE
  • 2. You eat, breathe, and drink GLYPHOSATE every day • Worldwide exposure • Detectable in human tissues/blood/urine
  • 3. Glyphosate—no chemical does more on a widespread basis to promote disease: 1.Inhibits cyp450 detoxification: Anything that blocks cyp450 by definition promotes xenobiotic accumulation and adverse drug effects 2.Genotoxic: Causes DNA damage in human cells even when massively diluted 3.Mitochondriopathic: In the combination of Monsanto’s Roundup®, causes mitochondrial dysfunction per several in vitro studies, linked to nearly all diseases 4.Excellent tissue penetration: The added solvents, surfactants, and so-called inert chemicals help promote entry into cells 5.Carcinogenic: Activation of estrogen receptors stimulates growth of cancer cells in vitro; would be expected to promote growth of other cancer cells. 6.Estrogenic: Activation of estrogen receptors stimulates growth of cancer cells in vitro; would be expected to promote growth of other cancer cells, as well as promote autoimmunity. 7.Synergistic with GMO-promoted inflammation: Commonly applied to GMO corn which has been shown to promote proliferation of GammaDelta Tcells which promote allergy and autoimmunity, both of which would be exacerbated by 1) inhibition of detoxification, 2) genotoxicity, 3) mitochondrial dysfunction, and 4) estrogenic effects. 8.Unsurpassed political protection: Because of industry influence on politicians who have 1) no scientific training, and 2) receive pay-off money from the chemical industry, glyphosate is used in high doses internationally without concern for long-term effects, even when applied to fields, forests, water supplies and other ecosystems. 9.Widespread exposure via air and water: More than 75% of air and water samples in Mississippi USA are contaminated with glyphosate; that far exceeds the social acceptance of heroin, crack cocaine, tobacco use and second-hand smoke combined. No other chemical achieves such massive population-wide use. 10.Unsurpassed distribution to the population, routinely found in the food supply, especially soy: "GM-soy contains high residues of glyphosate and AMPA…" Food Chemistry 2014 Jun
  • 5. Glyphosate inhibition of Cyp450 detoxification •Expected effects of anything that impairs cyp450 detoxification: – Accumulation of toxins; Increased adverse drug effects; Accumulation of self-same toxin
  • 8. Mitochondrial dysfunction directly contributes to disease •Migraine •Parkinson’s disease •Alzheimer’s disease •Diabetes, obesity •Hypertension •Fibromyalgia, CFS
  • 9. Mitochondrial toxicity of glyphostate/Roundup® Toxicol In Vitro. 2013 Feb;27(1):191-7. doi: 10.1016/j.tiv.2012.09.021. Epub 2012 Oct 23. Mixtures of glyphosate and surfactant TN20 accelerate cell death via mitochondrial damage- induced apoptosis and necrosis. Kim YH1 , Hong JR, Gil HW, Song HY, Hong SY. Author information Abstract Glyphosate, a common herbicide, is not toxic under normal exposure circumstances. However, this chemical, when combined with a surfactant, is cytotoxic. In this study, the mechanism of the additive effect of glyphosate and TN-20, a common surfactant in glyphosate herbicides, was investigated. After exposure of rat H9c2 cells to glyphosate and TN-20 mixtures, following assays were performed: flow cytometry to determine the proportion of cells that underwent apoptosis and necrosis; western blotting to determine expression of mitochondrial proteins (Bcl-2 and Bax); immunological methods to evaluate translocation of cytochrome C; luminometric measurements to determine activity of caspases 3/7 and 9; and tetramethyl rhodamine methyl ester assay to measure mitochondrial membrane potentials. Bcl-1 intensity decreased while Bax intensity increased with exposure to increasing TN-20 and/or glyphosate concentrations. Caspase activity increased and mitochondrial membrane potential decreased only when the cells were exposed to a mixture of both TN-20 and glyphosate, but not after exposure to either one of these compounds. The results support the possibility that mixtures of glyphosate and TN-20 aggravate mitochondrial damage and induce apoptosis and necrosis. Throughout this process, TN-20 seems to disrupt the integrity of the cellular barrier to glyphosate uptake, promoting glyphosate-mediated toxicity. www.ncbi.nlm.nih.gov/pubmed
  • 10. Mitochondrial toxicity of glyphostate/Roundup® Environ Toxicol Pharmacol. 2012 Sep;34(2):144-53. doi: 10.1016/j.etap.2012.02.010. Epub 2012 Mar 15. A step further toward glyphosate-induced epidermal cell death: involvement of mitochondrial and oxidative mechanisms. Heu C1 , Elie-Caille C, Mougey V, Launay S, Nicod L. Author information Abstract A deregulation of programmed cell death mechanisms in human epidermis leads to skin pathologies. We previously showed that glyphosate, an extensively used herbicide, provoked cytotoxic effects on cultured human keratinocytes, affecting their antioxidant capacities and impairing morphological and functional cell characteristics. The aim of the present study, carried out on the human epidermal cell line HaCaT, was to examine the part of apoptosis plays in the cytotoxic effects of glyphosate and the intracellular mechanisms involved in the apoptotic events. We have conducted different incubation periods to reveal the specific events in glyphosate-induced cell death. We observed an increase in the number of early apoptotic cells at a low cytotoxicity level (15%), and then, a decrease, in favor of late apoptotic and necrotic cell rates for more severe cytotoxicity conditions. At the same time, we showed that the glyphosate-induced mitochondrial membrane potential disruption could be a cause of apoptosis in keratinocyte cultures. www.ncbi.nlm.nih.gov/pubmed
  • 11. Mitochondrial toxicity of glyphostate/Roundup® Chemosphere. 2005 Dec;61(8):1115-22. Epub 2005 Apr 26. Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation. Peixoto F. Author information Abstract The potential toxicity of the herbicide Roundup and its fundamental substance (glyphosate) was tested in bioenergetic functions of isolated rat liver mitochondria. Roundup stimulates succinate-supported respiration twice, with simultaneous collapse of transmembrane electrical potential, while glyphosate used in the same concentrations does not induce any significant effect. Additionally, Roundup depresses state 3 respiration by about 40%, at 15 mM, whereas uncoupled respiration in the presence of FCCP is depressed by about 50%. Depression of uncoupled respiratory activity is mediated through partial inhibition ofmitochondrial complexes II and III, but not of complex IV. The phosphorylative system was affected by both a direct and an indirect effect on the F0F1 ATPase activity. The addition of uncoupled concentrations of Roundup to Ca2+- loaded mitochondriatreated with Ruthenium Red resulted in non-specific membrane permeabilization, as evidenced by mitochondrial swelling in isosmotic sucrose medium. Therefore, the uncoupling of oxidative phosphorylation is also related to the non-specific membrane permeabilization induced by Roundup. Glyphosate alone does not show any relevant effect on the mitochondrial bioenergetics, in opposition to Roundup formulation products. The differences in the toxicity observed could be either attributed to some products of Roundup or to a synergic effect of glyphosate and formulation products. Bearing in mind that mitochondria is provided with a variety of bioenergetic functions mandatory for the regulation of intracellular aerobic energy production and electrolyte homeostasis, these results question the safety of Roundup on animal health. www.ncbi.nlm.nih.gov/pubmed
  • 12. Tissue penetration •Glyphosate is almost always combined with other chemicals—these are commonly mislabeled “inert” chemicals – These other chemicals increase toxicity of glyphosate and also have their own toxic effects •Solvents and surfactants basically dissolve either glyphosate into aqueous solutions and/or damage cell membranes to promote chemical entry
  • 13. Carcinogen: substance that promotes cancer, generally via 1) mutation and/or 2) proliferation •Mutation = DNA damage •Proliferation = such as via estrogen receptors
  • 14. Glyphosate is a Carcinogen: a substance that promotes cancer, via 1) DNA damage / mutation and 2) estrogen-receptor stimulated proliferation •Glyphosate = DNA damage per Archives of Toxicology 2012 •Glyphosate = Cancer proliferation via stimulation of estrogen receptors per Food and Chemical Toxicology 2014
  • 15. Glyphosate—the herbicide in Monsanto’s Roundup® and commonly applied to GM (genetically manipulated) corporate plants, wheat, soy—causes DNA damage and cell death in human cells, even at extreme dilutions per Archives of Toxicology 2012 May
  • 16. Glyphosate—the herbicide in Monsanto’s Roundup® and commonly applied to GM (genetically manipulated) corporate plants, wheat, soy—causes DNA damage in humans per Archives of Toxicology 2012 May and Genetics and Molecular Biology 2007 Mar
  • 17. GMO corn shown to double the population of gamma-delta T-cells, which promote inflammation, allergy and autoimmunity
  • 18. GMO-altered foods: Increased allergenicity, toxins, changes in gut microbes, gut permeability, cytokine levels, and immunocyte populations… •MON810 corn causes increased IL-6 and gd-Tcells: – GMO MON810 maize induced increases of serum IL- 6, IL-13, IL-12p70, and MIP-1beta and gamma-delta- Tcells of mice. • We all know that IL-6 = inflammation and generally more CRP/IR/CVD/AzD. – “One of the more recurrent alterations in lymphocyte phenotypes observed in this study was an increase in the TCRγδ+ population. ... Higher numbers of γδT cells have been observed in humans with asthma, in IELs of children with untreated food allergy, and in the duodenum of children with juvenile idiopathic arthritis or connective tissue disease with gastrointestinal symptoms.” Finamore et al. J Agric Food Chem. 2008 Dec – Per review in Feb 2013 and previous work dating back decades, we know that gd-Tcells promote inflammation and autoimmunity! Su et al. Clin Dev Immunol. 2013 Feb
  • 19. GMO-altered foods: Increased allergenicity, toxins, changes in gut microbes, gut permeability, cytokine levels, and immunocyte populations… •MON810 corn causes increased IL-6 and gd- Tcells: – Finamore et al. J Agric Food Chem. 2008 Dec  “As a subset of T cells that bridge innate and adaptive immunity, γδ T cells may display different functions similar to those of CD4+ T-cell subsets such as CTLs, Th1/Th2 cells, Tregs, Th17 cells, and APCs depending on specific microenvironment. They definitely play important roles in the development of autoimmune diseases such as RA and SLE through their antigen-presenting capacity, release of proinflammatory cytokines, immunomodulatory properties, interaction with CD4+CD25+Tregs, and promotion of antibody production by providing B- cell help.” Su et al. Clin Dev Immunol. 2013 Feb
  • 20. GMO food alters gene expression in plants and the animals that consume those plants as “food”
  • 21. GMO food alters gene expression in plants and the animals that consume those plants as “food”
  • 22. Unreasonable political protection Paul Craig Roberts PhD is a former Assistant Secretary of the US Treasury and Associate Editor of the Wall Street Journal. counterpunch.org/2013/02/26/one-nation-under-monsanto/
  • 26. Glyphosate found in more than 75% of air and water in Mississippi USA •Pesticides in Mississippi air and rain: a comparison between 1995 and 2007. Environmental Toxicology and Chemistry 2014 – "Atrazine, metolachlor, and propanil were detected in ≥50% of the air and rain samples in both years. Glyphosate and its degradation product, aminomethyl-phosphonic acid (AMPA), were detected in ≥75% of air and rain samples in 2007 but were not measured in 1995. … Total herbicide flux in 2007 was slightly greater than in 1995 and was dominated by glyphosate. Malathion, methyl parathion, and degradation products made up most of the 2007 nonherbicide flux.“
  • 27. Glyphosate in food—especially wheat—and especially GM (genetically manipulated) foods, like soy ers.usda.gov/data-products/adoption-of-genetically-engineered- crops-in-the-us/
  • 28. Glyphosate in food, especially GM (genetically manipulated) foods, like wheat and soy
  • 29. Glyphosate in food, especially GM (genetically manipulated) foods, like wheat and soy ewg.org/agmag/2012/10/americans-eat-their-weight-genetically-engineered-
  • 32. Glyphosate in food, especially GM (genetically manipulated) foods
  • 33. Other concerns (?) • Damage to amphibians • Killing bee populations • Reproductive toxicity to many species • Political misuse against domestic populations in the “War on Drugs” • Brain diseases, behavior problems
  • 34. Massive deployment of glyphosate in Colombia http://bogota.usembassy.gov/nas-eradication.html 2015 Janury
  • 36. "Tensions have been rising between the Colombian government and the agricultural sector since the regulations imposed by the U.S.-Colombia Free Trade Agreement, which went into effect in May 2012. … But farmers have bristled at the requirement that they use genetically modified seeds, engineered by international conglomerates like Monsanto and Du Pont, and pay an annual fee to do so." http://www.rollingstone.com/p olitics/news/will-colombias- farmers-get-what-they-want- 20131118
  • 37. The “War on Drugs” ends up poisoning poor farms with glyphosate, killing innocent crops and injuring animals and farmers—men, women, children. topdocumentaryfilms.com/america- backyard-colombia/
  • 38. What is being eradicated— cocoa plants or regional control of the land to make way for foreign multinational corporations?
  • 39. How did Colombians overturn laws mandating the destruction of their grains, their mining, (ie, their food and ways of living)? •Organization, protests and strikes in many cities •648 arrests of protesters, 262 detentions (overturned)
  • 40. Why is Colombia being forced to destroy its own food and seed supply? Why is this tropical country being forced to import fruit and coffee from other countries?
  • 41. Is Facebook somehow connected to Monsanto? • Here is what I found in a Google search: “Facebook Monsanto”
  • 42. • Seven of the top 12 shareholders of Facebook and Monsanto are identical. Even more to the point, three of the top five shareholders are the same. The top shareholder, at the moment, in Monsanto is The Vanguard Group, which is number two on the list of top Facebook shareholders. • FMR, LLC, is the number one Facebook shareholder. For Monsanto, it’s number two. • The State Street Corporation is the number three shareholder for both Facebook and Monsanto. http://worldtruth.tv/facebook-and-monsanto-are-basically-owned-by-the- same-people/
  • 43. Other concerns (?) • Damage to amphibians • Killing bee populations • Reproductive toxicity to many species • Political misuse against domestic populations in the “War on Drugs” • If these topics are completely new to you, then you should consider examining the following: – The size and weight of the rock that you are living under – How far you have your head buried under the sand – Media censorship that keeps you ignorant about issues that critically affect your life – Why you have placed blinders on yourself, insulating yourself from reality, despite the consequences • All of the information in this presentation is readily and publically available
  • 44. Glyphosate research • How to learn about glyphosate: 1. Open your eyes and activate your mind, 2. Surf the internet; if your friends aren’t talking about this issue, then your friends/colleagues are ignorant and you should get new contacts in your life who are actually engaged in the world, 3. Go to the US Library of Medicine website and type the word “glyphosate”—you can also type any disease condition along with that: http://www.ncbi.nlm.nih.gov/pubmed/?term=glyphosate
  • 52. Glyphosate research • How to learn about glyphosate: 1. Open your eyes and activate your mind, 2. Search the internet; if your friends aren’t talking about this issue, then your friends/colleagues are ignorant and you should get new contacts in your life who are actually engaged in the world, 3. Go to the US Library of Medicine website and type the word “glyphosate”—you can also type any disease condition along with that: http://www.ncbi.nlm.nih.gov/pubmed/?term=glyphosate
  • 53. Other concerns (?) • Damage to amphibians • Killing bee populations • Reproductive toxicity to many species • Political misuse against domestic populations in the “War on Drugs” • If these topics are completely new to you, then you should consider examining the following: – The size and weight of the rock that you are living under – How far you have your head buried under the sand – Media censorship that keeps you ignorant about issues that critically affect your life – Why you have placed blinders on yourself, insulating yourself from reality, despite the consequences • All of the information in this presentation is readily and publically available
  • 54. Glyphosate—no chemical does more on a widespread basis to promote disease: 1.Inhibits cyp450 detoxification: Anything that blocks cyp450 by definition promotes xenobiotic accumulation and adverse drug effects 2.Genotoxic: Causes DNA damage in human cells even when massively diluted 3.Mitochondriopathic: In the combination of Monsanto’s Roundup®, causes mitochondrial dysfunction per several in vitro studies, linked to nearly all diseases 4.Excellent tissue penetration: The added solvents, surfactants, and so-called inert chemicals help promote entry into cells 5.Carcinogenic: Activation of estrogen receptors stimulates growth of cancer cells in vitro; would be expected to promote growth of other cancer cells. 6.Estrogenic: Activation of estrogen receptors stimulates growth of cancer cells in vitro; would be expected to promote growth of other cancer cells, as well as promote autoimmunity. 7.Synergistic with GMO-promoted inflammation: Commonly applied to GMO corn which has been shown to promote proliferation of GammaDelta Tcells which promote allergy and autoimmunity, both of which would be exacerbated by 1) inhibition of detoxification, 2) genotoxicity, 3) mitochondrial dysfunction, and 4) estrogenic effects. 8.Unsurpassed political protection: Because of industry influence on politicians who have 1) no scientific training, and 2) receive pay-off money from the chemical industry, glyphosate is used in high doses internationally without concern for long-term effects, even when applied to fields, forests, water supplies and other ecosystems. 9.Widespread exposure via air and water: More than 75% of air and water samples in Mississippi USA are contaminated with glyphosate; that far exceeds the social acceptance of heroin, crack cocaine, tobacco use and second-hand smoke combined. No other chemical achieves such massive population-wide use. 10.Unsurpassed distribution to the population, routinely found in the food supply, especially soy: "GM-soy contains high residues of glyphosate and AMPA…" Food Chemistry 2014 Jun