The biotechnology industry remained strong in 2016 despite some declines and uncertainties. While industry financing dipped 27% from 2015, research and development spending hit a new record. Merger and acquisition activity was also robust despite a decline in upfront deal commitments. Looking ahead, biotechnology companies will need to navigate increasing complexity around issues like product reimbursement, research and development efficiency, digital strategies, dealmaking, and financing volatility. The ability to adapt to these shifting environments will be key to future success.