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Uploaded byMegha Hodlur
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Escherichia coli: Morphology, Pathogenicity, and Prevention

Detailed presentation on E.coli bacteria covering morphology, habitat, virulence factors, infections, symptoms, diagnosis, treatment, and prevention methods.

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Escherichia coli bacteria Presented by Bsc Nursing Megha Hodlur Bagalkote
how much you know about the Escherichia coli or E.coli bacteria....?
Introduction of E.coli Escherichia coli was isolated in 1885 from a fecal sample of an infant. Normally present in the large intestine of humans and animals
Most stains of E.coli are harmless and beneficial, playing an important role in digestion, maintaining gut health and synthesizing vitamin k. However, some strains are pathogenic and can cause a wide range of infections.
What is Morphology...? Are you know about e.coli bacterial morphology..?
It is a Gram negative bacillus. It is a rod- shaped bacterium. Some strains are capsule and some are non-capsulated. It is a non-sporing. It is a facultative anaerobic. This are motile with peritrichous flagella. 1-3 micromiter in length and 0.4-0.7 micromiter in diameter. Morphology
Structure of E.coli
• Primarily inhibits the lower intestine of warm-blooded animals, including humans. • As part of normal gut flora. • It survives outside the host in fecally contaminated environments like soil water and sediment. • It thrives at 37°C but survives in temperature from 7°C to 50°C. Habitat
By using a nutrient agar or MacConkey agar. it can grow in ordinary nutrient agar medium at 37°C after overnight incubation. The colonies are circular, smooth, colorless and translucent with entire border. on MacConkey agar, pink colonies are produced because of lactose fermentation. moist heat kills it at a temperature of 60°C for 30 minutes. Chlorine (0.5-1ppm) can kill it in water bodies. Culture of E. Coli
Virulence factors Adhesins toxins Heat-stable Heat-labile toxin Hemolysin Endotoxin (LPS) k antigen H antigen
Pathogenicity E.coli is responsible for different types of clinical infections as given here. The ability of an organism to cause disease in a host
1. Diarrhea and dysentery 2. Urinary tract infection (UTI's) 3. Septicemia (blood infection) 4. Neonatal Meningitis Types of infection
a. Enteropathic E.coli (EPEC) b. Enterotoxigeic E.coli (ETEC) c. Enteroinvasive E.coli (EIEC) d. Enterohemorrhagic E.coli (EHEC) e. Enteroaggregative E.coli (EAEC) 1. Diarrhea and dysentery / Gastrointestinal infection
Urinary tract infections E.coliisthe most common causativeorganism of urinary tract infections in community as well as in hospital. Mostly bacteria from fecal flora get colonized in the periurethral region and reach urinary tract through blood or during sexual intercourse.
Female have more risk of getting UTI than male because of short urethra. They develop honeymoon cystitis during sexual intercourse. Pregnant female are exposed to UTIs because of hormonal changes and infrequent voiding due to pressure on the urinary tract.
Burning sensation cloudy urine strong smell of urine pressure on the urinary tract flank or back pain vaginal discharge painful ejaculation testicular pain penile pain and penile discharge pain in the abdomen. Symptoms In newborns Poor feeding bed-wetting hypothermia jaundice diarrhea
The bacteria invade the bloodstream from urinary tract and release lipopolysaccharides ( endotoxins) in the blood. This leads to disseminated intravascular coagulation, systemic inflammatory response syndrome (SIRS). It is also known as septic shock. Septicemia (blood infection)
1. Entry into the body 2. Adhesion (Attachment) 3. Multiplication 4. Toxin production 5. Tissue damage 6. Clinical effects Pathogenesis
Transmission Contaminated food contaminated water person to person animal contact
Catalase test - positive Oxidase test - negative Uriase test - negative Mobility - positive Lysine decorboxylase - positive ONPG - positive ( ferments lactose) Biochemical reactions
1. Specimen collection test Stool - diarrhea Urine - urinary tract infection Blood - Septicemia CSF - neonatal Meningitis Laboratory diagnosis 2. Direct microscopey 3. Toxin detection 4. Antibiotic sensitivity test
Present watery stool Nausea loss of appetite fatigue abdominal pain fever clinical features
How to treat or manage the clinical symptoms.....?
Treatment 1. Oral rehydration solution (ORS) 2.provide IV fluids 3. Ceftriaxone 4. Antipyretic 6. Adequate rest and nutrition 5. Antiemetics
What are the preventions...?
Hand wash food safety safe water sanitization personal hygiene health education Prevention
Ask me i can solve that... If you have a any doubts....?
Escherichia coli: Morphology, Pathogenicity, and Prevention