Efficacy differences between PCV10 and PCV13 - Slideset by Professo...

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Waidid CONSENSUS PAPER ON
EFFICACY DIFFERENCES BETWEEN
PCV10 AND PCV13
Susanna Esposito
Pediatric Clinic, University of Pe...

PCV10 trial in Finland (FinIP)
and the Finnish NVP
Arto Palmu, MD, PhD, Research manager,
head of Clinical Research Team, ...

Disclosure
• The National Institute for Health and Welfare (THL) has received
research funding
– from GlaxoSmithKline Biol...

Finnish Invasive
Pneumococcal disease
vaccine effectiveness trial
(FinIP)
”Vaccine probe analysis re.
pneumococcal disease...

Finnish Invasive Pneumococcal disease
vaccine effectiveness trial design
• Phase III/IV cluster-randomized, double-blind t...

The disease burden caused by S. pneumoniae in infants
and the vaccine preventable disease incidences (VPDI)
Outcomes
VE
3+...

3.12.2018 7
PCV in the National Vaccination Programme (NVP)
• NVP started in Sep 2010 for children born June 2010 or later...

3.12.2018 8
PCV in the National Vaccination Programme (NVP)
• Coverage high based on national vaccination register 92 to 9...

Experience in Sweden
• Differences between countries but not
between counties?
• In Sweden, different counties use either
...

Experience in Sweden, Naucler et al CID2017
• The overall impact on IPD was similar between the vaccines, despite
higher r...

Rationale for changes in the
PCV program for children in
Quebec
11
Philippe De Wals, MD, PhD
Department of Social and Prev...

12
PCV Program in Quebec
 October 2002: PCV7 offered to high-risk infants
(3+1 doses) and children  5 years.
 December ...

Incidence rate of invasive pneumococcal disease
(per 100 000 person-years) among individuals less
than 5 years of age in Q...

Incidence rate of invasive pneumococcal disease
(per 100 000 person-years) among individuals > 5
years of age in Quebec, 2...

PCV effectiveness against serotype 19A IPD,
Case-control study in Quebec, 2005-2016
15
Deceuninck et al. Poster 0300 ISPPD...

16
 A 2+1 PCV13 schedule would be the most
effective but also the most expensive option
for IPD prevention
 A mixed 2 PC...

Seotype 19A IPD rates (per 100 000 p-y)
among children less than 5 years of age in
PCV10 and PCV10 countries in Sweden
(Na...

 With a price differential of 25 CAD
per dose between PCV10 and
PCV13, a 2+1 PCV10 schedule
would be more cost effective ...

References
 Avis sur le calendrier optimal de vaccination des
enfants contre les infections à pneumocoque au
Québec:
 ht...

PCV7 FOLLOWED BY PCV10: DUTCH
DATA ON IPD AND PNEUMONIA
Lieke Sanders
The Neherlands

18C
PCV-7
CRM197
PCV-10
PD
4 4
6B 6B
9V 9V
14 14
18C 18C T
19F 19F D
23F 23F
Pfizer 1
5
7F
GSK
• 2006: PCV-7 as 3+1 schedu...

IPD surveillance June 2004 - June 2018
• Sentinel laboratory surveillance
– Nine sentinel labs
– Covering 25% of the Nethe...

IPD surveillance acoording to vaccine groups in The
Netherlands, May 2004- May 2018
Children < 5 yrs
0.0
5.0
10.0
15.0
20....

0.0
1.0
2.0
3.0
4.0
5.0
6.0
04-05 05-06 06-07 07-08 08-09 09-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18
Pre Post-P...

0
5
10
15
20
25
04-05 05-06 06-07 07-08 08-09 09-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18
Pre Post-PCV7 Post-PCV...

0
10
20
30
40
50
60
70
04-05 05-06 06-07 07-08 08-09 09-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18
Pre Post-PCV7 P...

0
10
20
30
40
50
60
70
04-05 05-06 06-07 07-08 08-09 09-10 10-11 11-12 12-13 13-14 14-15 15-16 16-17 17-18
Pre Post-PCV7 P...

Post-PCV10 IPD summary in the Netherlands
• PCV7 followed by PCV-10 resulted in substantial reduction in IPD in
• children...

Acknowledgements
NRLBM, AMC/RIVM
• Arie van der Ende
RIVM
• Mirjam Knol
• Hester de Melker
UMCU
• Elisabeth Sanders
• Krys...

WAidid Consensus Paper
The impact of PCV10 and
PCV13 on pneumococcal
infections

Methods – Literature Search
• Conducted using pre-defined keywords,
also including useful suggestions received
during and ...

Methods – Search strings
• In PubMed/Medline: (pneumococcal OR
pneumococcus OR streptococcus pneumoniae)
AND (pcv10 OR pcv...

Methods – Search results
• In PubMed/Medline: 1252 papers
• In WoS: 1132 papers
(Search period: February 2017)
In a prelim...

WAidid Consensus Paper – Main Aim (2)
• Focus the investigation on the impact and
effectiveness of PCV10 and PCV13 in
chil...

Flow-chart for
search & selection
of relevant articles

Methods – Search results (2)
• More than 10% of papers were maintained
after 1st selection
• About half of them were exclu...

Papers included (1)
(continues)
Claudio Pelucchi WAidid Consensus Paper meeting Rome, 6 April 2017
Disease-vaccine No. pap...

Papers included (2)
Claudio Pelucchi WAidid Consensus Paper meeting Rome, 6 April 2017
Disease-vaccine No. papers No. pape...

Figure 1 (a)
Range:
2%-93%

Figure 1 (b)
Range: -3%-89%

Figure 1 (c)
Range: 22%-87%

Figure 2 (a)
Range: 4%-56%

Figure 2 (b)
Range: 1%-63%

Figure 3 (a)
Range: 6%-42%

Figure 3 (b)
Range: 6%-75%

Conclusions – (1)
• Both PCV10 and PCV13 had a major impact
against IPD in children ≤5 years
• Effectiveness was comparabl...

Conclusions – (2)
• Both PCV10 and PCV13 had an impact
against pneumonia in children ≤5 years
• The size of the impact was...

Conclusions – (3)
• Few studies focused on otitis media, with
heterogeneous results
• Both PCV10 and PCV13 have an impact
...

Conclusions – (4)
• In general, results were highly
heterogeneous between studies/countries,
due to a number of factors su...

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