Bill Faloon's Presentation Slides at RAADfest 2025

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RAADfest 2025 - Las Vegas
Life Extension®
July 10, 2025
William Faloon

Unparalleled Track Record
of Biomedical Innovation
Established 1977

Store Shelves Today are Packed with Dietary Supplements
Popular Ingredients/Formulas Introduced by Life Extension®
CoQ10
M...

 Study subjects received 2000 IU/day of vitamin D or placebo.
Vitamin D group had roughly 76% reduction in telomere
attr...

Life Expectancy in the United States: 1880-2021
1880
2021
1880
Only 40 Years!
Improved to 47 years by 1900

A Few Common Causes of Death in 1900
 Pneumonia
 Tuberculosis
 Diarrhea
 Diphtheria
 Appendicitis mortality rate abou...

https://www.wsj.com/health/wellness/aging-disease-science-medicine-6321f4a9?mod=Searchresults_pos1&page=1
Feb 5, 2025
The ...

https://www.msn.com/en-us/news/technology/scientists-believe-that-by-the-2030s-humans-could-live-forever/ar-AA1unGUc?
Nove...

https://www.washingtonpost.com/wellness/2025/03/06/cellular-reprogramming-longevity-reverse-aging/
March 6, 2021
March 6, ...

This Does Not Work!
Ignoring a sign/symptom
of a disease…or avoiding
diagnostics/treatment
does not prevent the
onset and ...

Predictive modeling study suggests
major longevity benefits of daily walking.
Americans over age 40 years could
live an ex...

If the least physically inactive group
walked just 1 extra hour a day, the
modeling suggests they could live
about 6 extra...

A Walking Casualty…
John C. Martin
(1951 - 2021)
Expiration date: Mar. 30, 2021
Net worth > $1.2 billion
https://www.fierc...

Jan. 13th
, 2025
https://www.cnbc.com/2025/01/13/the-mediterranean-diet-is-the-no-1-diet-for-2025-why-its-so-popular-.html...

“…high adherence to the
Mediterranean diet was
associated with 25% lower
risk of death as compared
with the lowest categor...

Published online by JAMA Network Open: August 12 2024
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822212...

A mere ¼ serving of processed red meat like hot dogs
was associated with a 13% higher risk of dementia.
CNN article: https...

| May 17th
, 2025
https://www.wsj.com/health/wellness/americans-in-their-80s-and-90s-are-redefining-old-age-5f8ae8a6
Peter...

www.healincsummit.com
American adults with
metabolic syndrome:
34.2%
References: Prevalence of Metabolic Syndrome in the U...

MetabolicSyndromeisaclusteringofRiskFactorsthatinclude:
Abdominal obesity Hypertension
High fasting glucose Dyslipidemia
h...

Feb 1st
, 2025
“Metformin treatment With or
Without Mediterranean Diet for the
Prevention of Age-Related Diseases
in Peopl...

Feb 1st
, 2025
Type 2 diabetes 80% lower with
metformin and 92% lower with
metformin + Mediterranean
diet compared with pl...

Study Results Found on March 21st
2017
Journal of the American Medical Association
JAMA. Published online March 21, 2017. ...

Sept 12, 2024
https://doi.org/10.1016/j.cell.2024.08.021
► Metformin prevents brain atrophy, elevating cognitive function ...

DNA methylation age beneficially reduced in
monkeys treated with metformin compared to vehicle
Tissue
“ProteinAge” appeare...

https://doi.org/10.1016/j.cell.2024.08.021
Results in Cynomolgus monkeys at
human age equivalent 40–50 years:
“In a rigoro...

Type II diabetics taking metformin:
United Kingdom Diabetes Study
►32% reduced risk of diabetic complications
►42% reduced...

Life Extension® recommended
metformin 30 years ago…
as an anti-aging drug!
March 1995

30% Lower Mortality in Diabetics on
Metformin vs. Popular Alternative
“Women initiating metformin monotherapy had a
signif...

 England approves metformin:1957
 FDA approves metformin: 1994
 37-year delay caused millions of
American deaths.
 68-...

Metformin should be widely prescribed to
reduce type II diabetes incidence and
metabolic syndrome morbidities/mortality.
O...

z
“Welcoming the Era of Gene Editing in Medicine”
https://www.nejm.org/doi/full/10.1056/NEJMp2314279
April 24th
, 2024
“Gi...

https://www.cnn.com/2024/12/13/science/greenland-shark-genome-longevity-study/index.html
400-Year-Old Greenland Shark: Tra...

92% of the Greenland shark’s
genome has been sequenced
“The longest-living vertebrate could offer
clues to extending the h...

Human cells experience many DNA
strand breaks daily, which are
addressed by repair mechanisms
to maintain genomic stabilit...

Road to Reversal of Biological Aging
Restore Youthful DNA Function
using OSK genes (Yamanaka factors)

Reprogram old cells into
young adult cells that
can theoretically
Yamanaka Transcription Factors –

 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging Back in 2006
Yamanaka
Transcription Factor...

 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging Back in 2006
Yamanaka
Transcription Factor...

 Octamer-binding factor 4
Just 3 Yamanaka Factors Reverse
Aging in Live Mice in 2022-2024
Yamanaka
Transcription Factors
...

“Scientists safely and
effectively reverse the
aging process in
middle-aged and
elderly mice by partially
resetting their ...

“In both the kidneys
and skin, the
epigenetics of treated
animals more closely
resembled epigenetic
patterns seen in
young...

February 15th
, 2024
https://www.liebertpub.com/doi/10.1089/cell.2023.0072
“Gene Therapy-mediated Partial Reprogramming Ex...

Two-part AAV system employed for
systemic intracellular OSK delivery.
Remarkable > 100% Extension in Median
Remaining Life...

Minimal OSK Induction = Robust Age Reversal
The 109% extension of remaining lifespan + improved
frailty index + epigenetic...

https://www.washingtonpost.com/wellness/2025/03/06/cellular-reprogramming-longevity-reverse-aging/
March 6, 2021
March 6, ...

March 6, 2021
March 6, 2025
https://www.washingtonpost.com/wellness/2025/03/06/cellular-reprogramming-longevity-reverse-ag...

Reprogram old cells into young adult cells that
can theoretically regenerate tissues forever.
Cells-2006 Mice-2022-2024 Mo...

Lipid nano-particles
AAV9 vector (adeno-associatedvirus)
Chemical reprogramming
Polymer & Plasmid-based vector
In vivo OSK...

OSK
Enters cell
through outer
membrane
mRNA-OSK
released inside cell
In Vivo Age Reversal using LNP delivered OSK Yamanaka...

OSK project trial of 3 different protocols
pDNA = Plasmid DNA
PNP-OSK RNA
& pDNA cost
$345,000
$1,123,000
All primate cost...

- January 17th
, 2025
technologyreview.com/2025/01/17/1110086/openai-has-created-an-ai-model-for-longevity-science/
“OpenA...

April 8th
, 2023
“First anti-aging pills to hit shelves in 2028, expert
predicts – as Silicon Valley races to conquer deat...

Original Research-2025

Oct4, Sox2, Klf4, c-My (OSKM) Gene Therapy in the
Hypothalamus Prolongs Fertility and Ovulation in Female Rats
Maria D. Ga...

Oct4, Sox2, Klf4, c-My (OSKM) Gene Therapy in the
Hypothalamus Prolongs Fertility and Ovulation in Female Rats
1) Young ra...

Yamanaka factor-treated mice show enhanced cognitive skills.
October 18th
, 2024
Transient Yamanaka factor expression duri...

October 18th
, 2024
Mice were designed to overexpress
Yamanaka factors when given
doxycycline (via special gene).
Mice wer...

OSKM (Yamanaka factor)
treated mice had:
“Strongly reduced”
beta-amyloid
plaques
https://www.sciencedirect.com/science/art...

“The science of
aging is fairly
mature…there is
actually a fair
amount of literature
on what you can do
to reverse or slow...

The problem:
About 7,700 Americans die each day.
The major cause:
Degenerative Aging
The solution:
Rapidly transition Reju...

We Don’t Have Time for
Delayed Age Reversal
Human Research

Front page of November 1981 issue of Anti-Aging News
Life Extension®
Published/advocated
for FDA approval of
thymosin alph...

www.healincsummit.com
Thymosin alpha-1is a peptide
derived from the thymus gland
that plays a significant role in
modulati...

Primary mechanisms through which thymosin alpha 1 boosts immunity:
1. Activation of T Cells
2. Boosting Natural Killer (NK...

https://pubmed.ncbi.nlm.nih.gov/30063866/
Published online: 31 Jul 2018
2018

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742685/
2019

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747025/
Thymosin alpha 1: A comprehensive review of the literature
World J V...

https://pubmed.ncbi.nlm.nih.gov/35364609/
2022

2023 Apr:117:109744.
doi: 10.1016/j.intimp.2023.109744. Epub 2023 Feb 20.
T hymosin α- 1 in cancer therapy:
Immunoregulati...

2023
https://doi.org/10.3389/fendo.2023.1168186
The thymus gland is a central lymphoid organ in which developing T cell pr...

“The hormone α1Thy could reduce, through the modulation of DCs, the
amount of proinflammatory cytokines produced by T cell...

https://pubmed.ncbi.nlm.nih.gov/38308608/
Objective: This study aims to assess the safety and efficacy of Thymosin Alpha 1...

January 2nd
, 2025
“This preliminary small study suggests thymus hormone treatment to have antidepressive
and related immu...

Back page of November 1981 issue of Anti-Aging News
After 44 years,
most doctors are
unaware that
thymosin alpha-1
has ant...

Decades Ahead of Mainstream Medicine
Track Record Available at: https://www.lifeextension.com/about/life-extension-story/h...

Bridging the Longevity Gap
Urgent Need to Reform FDA
Scientific Advances
ConsumerAccess
FDA

New website exposes FDA inefficiency/corruption:
FDAMuseum.com

New website exposes inefficiency and corruption:
FDAMuseum.com

https://www.economist.com/briefing/2025/03/20/dreams-of-improving-the-human-race-are-no-longer-science-fiction
March 20th
...

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2819335
May 13, 2024
23% death reduction with highest adheren...

Published online by JAMA Network Open: August 12 2024
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822212...

This Does Not Work!
Ignoring a sign/symptom
of a disease…or avoiding
diagnostics/treatment
does not prevent the
onset and ...

Cardiac/Inflammatory Markers
•NMR Lipoprofile (atherogenic lipid
•risks + inflammation markers)
•Homocysteine
•C-Reactive ...

| May 20th
, 2025
https://www.wsj.com/health/wellness/longevity-aging-oldest-person-centenarian-808d1bd9?
“Congratulations...

March 20th
, 2025
 “Bryan Johnson wants to live forever. The goal is not merely to live a few
years longer. It is to vanq...

November 2010
LifeExtension®
described metformin’s
multiple anti-cancer
mechanisms
15 years ago.
https://www.lifeextension...

Myeloproliferative neoplasms refers
to a clonal, malignant condition (e.g.,
polycythemia vera, essential
thrombocythemia, ...

Myeloproliferative neoplasms can lead to the development of leukemia,
lymphoma, myeloma and are associated with increased ...

August 10th
, 2024
Metformin associated with reduced
risk of myeloproliferative neoplasm
https://ashpublications.org/blood...

Our Solution:
Physicians should not need governmental
approval to prescribe metformin to their
qualified non-diabetic pati...

Published on: December 3, 2024
Dec. 3rd
, 2024
Turn Bio Commences Bone Marrow Rejuvenation Study
https://longevity.technol...

Human Umbilical Cord Stem Cells Treat Monkey Liver Failure
doi: 10.1155/2024/4654912
 Pre-clinical cohort study in rhesus...

Cardiac arrest causes 300,000 to
450,000 deaths in the U.S. a year!
https://www.nhlbi.nih.gov/health/cardiac-arrest#:~:tex...

https://www.calwinhospitals.in/blog/four-differences-between-a-cardiac-arrest-and-a-heart-attack/amp/

Modifiable Risk Factors and Attributable Burden of
Cardiac Arrest
In a 2025 publication in the Canadian Journal of Cardiol...

Example modifiable risk factors –
Protective
Cardiac Arrest Risk Factor Risk
Forced expiratory lung volume in 1
second (pe...

Example modifiable risk factors –
Adverse
Cardiac Arrest Risk Factor Risk
Nitrogen dioxide air pollution (per IQR
incremen...

Approximately 19.1% of the participants in a 2020 UK
Biobank study reported regular use of glucosamine
supplements.[2]
Thi...

Jun. 30, 2021
https://www.ahajournals.org/doi/10.1161/JAHA.120.019158
Mediterranean Diet Reduces
Risk of Sudden Cardiac De...

1955- First Heart Attack
1957- First Stroke
1968- Four Heart Attacks
1968- 14 Cardiac Arrests
1969- Dead from Heart Failur...

Lyndon Johnson Prematurely
Died Due to Technology Delay
•First heart attack age 46 (1955)
•Suffered chronic angina pain
•R...

Alive Because of Biomedical Technology
Bill Clinton
Coronary Bypass Age 58
In 2004
Coronary Stent Age 63
In 2010
George W....

2015- Terminal Cancer Diagnosed
2016- Immunotherapy Cures it
2019- Breaks hip + brain bleed
2019- Surgeries resolve both
2...

June 18, 2024
https://www.popularmechanics.com/science/a60825360/how-to-live-forever/
How to Live Forever, or Die Trying
“...

May 28th
,2025
Ray Kurzweil predicts humans
will reach longevity escape
velocity within 4 years.
https://www.popularmechan...

Who Missed the Longevity Boat
https://www.nytimes.com/2025/06/22/obituaries/fred-smith-billionaire-founder-of-fedex-is-dea...

Home Depot Co-Founder Dies at age 95 on November 5, 2024
Bernie Markus
Net Worth: $7.4 billion
Donated $2 billion to
chari...

►Value of Chicago Bears Football team: >$6
billion
►Typical philanthropic contributions made.
None to aging research that ...

► Leonard Lauder, eldest son of cosmetic pioneer
Estée Lauder. Headed Estée Lauder Companies.
► Philanthropist for cancer/...

June 12, 2018
Bill Faloon has
pursued immortality
for decades.
Now he's got lots of
company. What does
The Man
https://www...

“Jared Kushner says he's been trying to keep his body in
shape because he might one day become immortal”
Jared Kushner say...

The Bahamian Minister of Health & Wellness
In an April 2025 meeting with the
Health Minister, he stated that he
believed -...

This Does Not Work!
Ignoring a sign/symptom
of a disease…or avoiding
diagnostics/treatment
does not prevent the
onset and ...

Cardiac/Inflammatory Markers
•NMR Lipoprofile (atherogenic lipid
•risks + inflammation markers)
•Homocysteine
•C-Reactive ...

RAADfest 2025 - Las Vegas
Life Extension®
July 10, 2025
William Faloon

Unparalleled Track Record
of Biomedical Innovation
Established 1977

age-reversal.net
View this entire presentation at:

age-reversal.net
View this entire presentation at:

RAADfest 2025 - Las Vegas
Longevity Update
Life Extension®
July 10, 2025
William Faloon

Bill Faloon's Presentation Slides at RAADfest 2025

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