dkNET Webinar: RRIDs and Naughty Cell Lines 04/12/2019

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RRIDs and Naughty Cell
lines
Anita Bandrowski
RRID Initiative
SciCrunch Inc
UCSD

RRIDs: persistent unique identifiers
for things scientists use
RRIDs were created jointly by NIH, Journal Editors, UCSD an...

Contaminated and misidentified cell lines
are used in studies
Many estimates exist attempting
to answer the question how
m...

Contaminated and misidentified cell lines
are used in studies
To combat the problem of
cell lines, investigators have
form...

How many papers really use
cell lines at all?
How many of those are
problematic?

SciScore is a text mining based tool that was trained
to recognize cell lines in sentences
https://elifesciences.org/artic...

What does recognition look like?
Sentence 1 (methods sentence line 353; PMID:26012578)
For luciferase activity assays, HeL...

Some cell lines are problematic and authors don’t
know which ones are which
https://elifesciences.org/articles/41676

Some Cell Lines are problematic and
journals don’t check
https://elifesciences.org/articles/41676

How do we make authors
look at the ICLAC list before
they publish?

How do authors get RRIDs?

Authors are directed to rrid.site, which contains data from many
stock centers and data repositories, including ICLAC

25+ databases
One portal for authors
Consistent search
Uniform across publishers
One set of typesetting instructions
Autho...

RRIDs cover Key Biological Resources
● Antibodies (2,380,701)
● Plasmids (75,164)
● Cell Lines (116,296) *IIDP cells
● Tra...

Some Cell Lines are problematic and
RRID look up makes authors check
https://elifesciences.org/articles/41676

How many papers with
RRIDs have problems?

We count RRIDs for cell lines used in publications
https://elifesciences.org/articles/41676

Control:
n=
150,459
RRID:
n=634
RRIDs reduce the use of problematic cell lines
https://elifesciences.org/articles/41676

RRIDs: How many papers
are there?

SfN (J.Neuro)
Cell Press
eLife
Endocrinology
AACR
Latest:
Nature
Publishing
GroupPilot Phase
25 journals
100 papers Curren...

New journal policy will shift
this balance a little

Basic Statistics
97,942 total RRIDs, in 8210
papers (current totals 180,000 RRIDs in 13K papers)
Antibody
74,591
Tool
13,6...

What can RRIDs do for my
resource?

RRIDs are reflected at many
databases and catalogs

RRIDs are reflected at many
projects / core facilities,
including HIRN

Future Directions:
● Will journal editors and
authors be willing to add
RRIDs as a means to check
cell line authenticity?
...

To put RRIDs into your next paper!
Put RRIDs in acknowledgement text for your center
To review papers (and grants) for met...

An NIDDK Resource dknet.org
Upcoming webinar
Friday, April 26, 2019, 11am PDT
The Signaling Pathways Project:
putting the ...

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