2017 12 lab informatics summit

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Leveraging the cloud to transform and
streamline informatics processes
Laboratory Informatics Summit
December 5, 2017
Chri...

Traveller there is no path. The path is made by walking.
Antonio Machado

Conclusions
Nobody cares about the cloud
People care about business, scientific, and
clinical outcomes
“Cloud” is a means ...

Conclusions
Nobody cares about the cloud
People care about business, scientific, and clinical outcomes
“Cloud” is a means ...

Conclusions
Nobody cares about
the cloud
People care about business, scientific, and clinical outcomes
“Cloud” is a means ...

Enterprise
CIO
Sr. Director,
Research IT

The future is already here – it’s just not very well distributed
William Gibson

My Cloud Journey
1998: Army Research Lab
– Java framework to distribute a target recognition workflow across multiple
DoD ...

Geek Cred: My First Petabyte,
2008
Geek Cred: My first Petabyte: 2008

Geek Cred: My First Petabyte,
2008
My first Petabyte: 2008

2012: On-premise petabytes are no longer so interesting to me

Genomic Data Production in ContextGenomic data production @ Broad

Genomic Data Production in ContextGenomic data production @ Broad
I joined the Broad in
2014
Caveat: This plot looked
very...

Geek Cred: My First Petabyte,
2008
My first Exabyte: 2014

Genomes on the Cloud (April 2016)
Testing the genome
analysis pipeline
“Go-live”

8 months in the cloud

8 months in the cloud

“If you aim for simplicity, master complexity.”
The Mustard Seed Garden Manual of Painting, 1679

Senior leadership and “cloud”
Removes a major support
burden from in-house staff

Senior leadership and “cloud”
Removes a major support
burden from in-house staff
Automatic technology
updates rather than
...

Senior leadership and “cloud”
Removes a major support
burden from in-house staff
Vastly simplified
licensing and budget
pl...

Unlimited Scale, no
more forklift upgrades
Senior leadership and “cloud”
Removes a major support
burden from in-house staf...

Products are familiar to the
end-user rather than opaque
technology
Unlimited Scale, no
more forklift upgrades
Senior lead...

Products are familiar to the
end-user rather than opaque
technology
Unlimited Scale, no
more forklift upgrades
Senior lead...

What is the cloud?
“Amazon Web Services is the cloud”*
Chris Dagdigian
Bio-IT World, November 2009
* He has revised this o...

What is the cloud?
“Cloud computing is a model for enabling ubiquitous, convenient, on-
demand network access to a shared ...

Homemade
Pizza as a Service
Cheese
Tomato Sauce
Pizza Dough
Fire
Oven
Electricity / Gas
Drinks
Table
You Manage Vendor Man...

Take and BakeHomemade
Pizza as a Service
Cheese
Tomato Sauce
Pizza Dough
Fire
Oven
Electricity / Gas
Drinks
Table
Cheese
T...

DeliveryTake and BakeHomemade
Pizza as a Service
Cheese
Tomato Sauce
Pizza Dough
Fire
Oven
Electricity / Gas
Drinks
Table
...

RestaurantDeliveryTake and BakeHomemade
Pizza as a Service
Cheese
Tomato Sauce
Pizza Dough
Fire
Oven
Electricity / Gas
Dri...

RestaurantDeliveryTake and BakeHomemade
Pizza as a Service
Cheese
Tomato Sauce
Pizza Dough
Fire
Oven
Electricity / Gas
Dri...

Cloud based killer apps
• Team chat / messaging: Slack, Skype, Hipchat, …
• File Sharing: Onedrive, Dropbox, Box, Egnyte, ...

Maslow’s Hierarchy of Needs
Friendship, connectedness, belonging
Confidence, achievement
Creativity,
Purpose
Safety, physi...

Maslow’s Hierarchy of Needs
Friendship, connectedness, belonging
Confidence, achievement
Creativity,
Purpose
Safety, physi...

Maslow’s Hierarchy of Needs
Friendship, connectedness, belonging
Confidence, achievement
Creativity,
Purpose
Safety, physi...

IT Hierarchy of Needs
Productivity and Security, Applications,
disaster preparedness
Automation and
compliance
“Thought
Pa...

Office
Co-located Data Center
Cloud Hosted Legacy Architecture
Silos of Files
ServerFarm
Sysadmin Team
Data
Center
Team

Office Colocated Data Center
Cloud Hosted Legacy Architecture
Active
Directory
Master
Sysadmin Team
Data
Center
Team
AWS U...

Office Colocated Data Center
Cloud Hosted Legacy Architecture
Active
Directory
Master
Sysadmin Team
Data
Center
Team
AWS U...

Office Colocated Data Center
Cloud Hosted Legacy Architecture
Active
Directory
Master
Sysadmin Team
Data
Center
Team
AWS U...

What about the data?

Elasticity
Compute:
– Wal-mart parking lot
– Spiky, unpredictable demand
– Elasticity in compute is capacity
– For variabl...

The right side of history
• Applications are containerized (Docker, Singularity)
• Data is accessed RESTfully (S3)
• Ident...

The right side of history
• Applications are containerized (Docker, Singularity)
• Data is accessed RESTfully (S3)
• Ident...

The opposite of play is not work, it’s depression
Jane McGonnigal, Reality is Broken

Financial Governance
$$ !!

Financial Controls
• Shifting from CapEx to OpEx can put spending
power in the hands of individual contributors,
with litt...

Data Deletion @ Scale
Me: “Blah Blah … I think we’re cool to delete about 600TB of data from a cloud
bucket. What do you t...

Data Deletion @ Scale
Blah Blah … I think we’re cool to delete about 600TB of data from a cloud bucket
Ray: “BOOM!”

Data Deletion @ Scale
Blah Blah … I think we’re cool to delete about 600TB of data from a cloud bucket
• This was my first...

Identity and Authorization

Compliance and Security
Compliance:
– Things have changed a lot since 2014.
– All major cloud providers will now sign BAA ...

Premature optimization is the root of all evil (or at least
most of it)
Donald Knuth – Computer Programming as an Art, 1975

Specific Recommendations
Do not waste time on a IaaS vendor bake-offs.
– Choose one (GCS, AWS, Azure) based on in-house ex...

Specific Recommendations
Do not waste time on a IaaS vendor bake-offs.
– Choose one (GCS, AWS, Azure) based on in-house ex...

Specific Recommendations
Do not waste time on a IaaS vendor bake-offs.
– Choose one (GCS, AWS, Azure) based on in-house ex...

Specific Recommendations
Do not waste time on a IaaS vendor bake-offs.
– Choose one (GCS, AWS, Azure) based on in-house ex...

Specific Recommendations
Do not waste time on a IaaS vendor bake-offs.
– Choose one (GCS, AWS, Azure) based on in-house ex...

If you have four groups working on a compiler, you’ll get a four pass
compiler
Eric S Raymond, The New Hacker’s Dictionary...

Day One Commitments
Centralize Identity:
Integrate AD / Centrify / Okta.
Yes, the lab account too.

Day One Commitments
Centralize Identity:
Integrate AD / Centrify / Okta.
Yes, the lab account too.
Roles, not Individuals
...

Day One Commitments
Centralize Identity:
Integrate AD / Centrify / Okta.
Yes, the lab account too.
Roles, not Individuals
...

Day One Commitments
Centralize Identity:
Integrate AD / Centrify / Okta.
Yes, the lab account too.
Roles, not Individuals
...

Day One Commitments
Centralize Identity:
Integrate AD / Centrify / Okta.
Yes, the lab account too.
Roles, not Individuals
...

This stuff is important
We have an opportunity to change lives and health
outcomes, and to realize the gains of genomic me...

Thank You
chris@dwan.org
https://dwan.org

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