Bill Faloon at HEALinc Summit April 20th 2023 Perpetual Project Pre...

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Regenerative Medicine Options
Island House Hotel, The Bahamas
William Faloon
April 20th 2023
The Perpetual Project

Unparalleled Track Record
of Biomedical Innovation
First Established 1977

Decades Ahead of Mainstream Medicine
https://www.lifeextension.com/about/life-extension-story/history

LifeExtension.com

Our Controversial Contention
It may be possible…
www.age-reversal.net

Feb 23 /March 2, 2015
TIME describes
the prospect of
delayed aging.
Early Media
Report Year 2015

May 2017

https://www.pressreader.com/usa/popular-science/20180505/281672550562011
“Bill Faloon has pursued immortality for
decades....

https://www.newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body/
“He stirred co...

April 27, 2019
https://www.newscientist.com/issue/3227/

According to Juvenescence’s Greg Bailey
“We won’t be aging as fast or
poorly as our parents”
“I think the world is going t...

https://www.technologyreview.com/magazine/2019/09 September
2019
“Later this year, at a conference
of longevity enthusiast...

https:// www.dailymail.co.uk/health/article-7435427/
Oct.22,2019
Turning Back Time!
“Aging is REVERSED in men using a
cock...

“Reversal of epigenetic aging and immunosenescent trends in humans.” Aging Cell; Sept 2019
Human Age Reversal Demonstrated...

Scientists have identified synergistic cellular pathways for
longevity that amplify lifespan fivefold in C. elegans, a
nem...

Dec. 30, 2020
https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/
Mainstream Recognition of
The...

March 7, 2022
https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging
Feb. 20, 2021
“Is There a Cure for Aging...

March 7, 2022
Scientists
Reverse Aging in Mice

March 11, 2022
“Anti-Aging Breakthrough:
https://scitechdaily.com/anti-aging-breakthrough-cellular-rejuvenation-therapy-sa...

March 9, 2022
“Newresearchbythe
SalkInstitutehasshown
cellularrejuvenation
therapysafelyreverses
signsofaginginmice.”
http...

https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-techni...

March 7, 2022
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
Mar....

• Partial cell reprogramming in live (in vivo) mice
• OSKM (“Yamanaka”) transcription factors used
• Longeradministrationd...

Transcription factors
can enable old cells to
be reprogrammed into
embryonic cells capable
of developing into all
tissues ...

The Nobel Prize in Physiology or Medicine 2012
These transcription factors are called:
“Yamanaka Factors”
Four specific ge...

https://hms.harvard.edu/news/loss-epigenetic-information-can-drive-aging-restoration-can-reverse
“Study in mice implicates...

Jan 12, 2023
https://www.cnn.com/2023/01/12/health/reversing-aging-scn-wellness/index.html
“Old Mice Grow Young Again…
Can...

• Long-termcell reprogrammingresults in “younger”skin age.
• Skin cells divide more rapidly.
• Lower inflammation and redu...

- January 9th, 2023
technologyreview.com/2023/01/09/1066488/biotech-says-mice-live-longer-after-genetic-reprogramming/
Thi...

Scientists at Rejuvenate Bio recently tested
epigenetic reprogramming in elderly mice
Jan. 5th, 2023
They gave 124-week-ol...

Jan.5th,2023
Old mice injected with the Yamanaka factor-encoded virus.
Adeno-associated virus encoded with three Yamanaka ...

Typical 77-year-old American expected to live to age 87
If extend remaining lifespan as reported:
98
MissedTimeforAgeRever...

After large animal research, next step may be testing old people.
►Researchers can order Yamanaka factor-encoded
viral vec...

December 2, 2015
George Church, Ph.D.
A Cure for Aging by Year 2030?
https://www.washingtonpost.com/news/achenblog/wp/2015...

https://www.dailymail.co.uk/sciencetech/article-9166007/Chinese-scientists-develop-gene-therapy-delay-ageing.html
CRISPR E...

1) 25% extended lifespan in normal aged mice.1
2) Improved overall appearance and grip strength.1
“A genome-wide CRISPR-ba...

98-Year Average Lifespan?
25% Lifespan Extension
It May Be Possible for Normal Aged People to
Benefit from these Kinds of ...

Female rat ‘Sima’ (pictured right) is the last
surviving rat in a group given young plasma
transfusions at the University ...

September 02, 2022 | https://doi.org/10.1111/acel.13696
September 2nd, 2022

• GrimAge®: -0.78yearsyounger(predictorofdeathrisk)
• 30% of 90 biomarkers changed
beneficially, zero negatively
• No sign...

“Umbilical cord plasma concentrate has beneficial effects on
DNA methylation GrimAge and human clinical biomarkers”
Human ...

 Once-faltering paws gripped objects
with renewed strength.
 Hearts and livers of rats regained
youthful vitality.
 Fuz...

June 7
2022
https://www.technologyreview.com/2022/06/07/1053132/saudi-arabia-slow-aging-metformin/
The oil kingdom fears t...

- July 19, 2022

 The field of geroscience aims to find ways to delay onset of age-related diseases.
 Geroscience experts met virtually a...

https://www.nationalgeographic.com/magazine/article/aging-cure-longevity-science-technology-feature/
Dec. 28, 2022

“A Drug to Treat Aging May Not Be a Pipe Dream”
“By the end of 2023, it’s likely that one of these
ideas will be shown to ...

The start-ups seeking a cure for old age
 Eric Verdin, chief executive of the Buck Institute, “scientists
have completely...

“Powerful billionaires are pouring money into life-
extending technology -and they just might succeed.”
“Reverse the aging...

- March 8th, 2023
technologyreview.com/2023/01/09/1066488/biotech-says-mice-live-longer-after-genetic-reprogramming/
Sam A...

| March 12th, 2023
Report on the Science of Aging
The WSJ cited several studies associating
telomerelengthwithhealthoutcom...

Source article: https://www.nationalgeographic.com/magazine/article/longevity-life-death-technology-advances
• National Ge...

“Scientists are reverse-
engineering patients’ own
skin or blood cells to behave
similarly to embryonic cells
and using th...

www.nytimes.com/books/best-sellers/2023/03/12/
Explosion of Interest in Anti-aging
The month prior to “Outlive”
taking the...

The Pro-longevity view of why healthcare delivery
in the U.S. “routinely fails to treat or cure many long-
term conditions...

www.dailymail.co.uk/sciencetech/article-11911975/Humans-achieve-immortality-eight-YEARS-says-former-Google-engineer
March ...

April 5th, 2023
only about 1 in 5 interventions end up in routine clinical practice”
https://jamanetwork.com/journals/jama...

“…why not launch an
Operation Warp Speed
for biological aging?”
CONCLUSION
https://fortune.com/2020/12/30/anti-aging-resea...

Bridging the Longevity Gap
Urgent Need to Reform Clinical Trial Regulations

“FDA is responsible for advancing the public health by helping to speed
innovations that make medical products more effect...

What FDA says: What FDA does:
2. FDA Holocaust Museum- 1994-2022
“FDA is responsible for
advancing the public
health by he...

"We stand on the cusp of a revolution in
health care. Advances in molecular medicine
will allow us to develop powerful new...

FDA Commissioner Margaret
Hamburg’s sworn testimony:
1.https://www.lifeextension.com/magazine/2012/12/former-fda-commissio...

https://www.cato.org/commentary/rethinking-fda
“If the FDA delays a good drug, the cost is less obvious
because most of th...

https://www.bmj.com/content/379/bmj.o2628
“The FDA is “endangering public health” by not being candid about
violations tha...

January 6, 2023
“The reversal of aging could hinge on one huge decision.”
“If the FDA classifies aging as a disease,
drug ...

| Jan. 11, 2023
“FDA Increasingly Halting Human Trials…”
Clinical holds by FDA can stifle progress:
2017-2020: 557 clinica...

 England approves metformin:1957
 FDA approves metformin: 1994
 37-year delay caused millions of
American deaths.
 66 ...

Heart failure kills
https://www.cdc.gov/heartdisease/heart_failure.htm
Epidemic Killer: Heart Failure
About 6.2 million ad...

“Stem cell therapy may reduce risk of heart attack &
stroke in certain heart failure patients, study shows”
Feb. 27, 2023
...

hopkinsmedicine.org/news/media/releases/stem_cell_therapy_safely_repairs_damaged_heart_muscle_in_chronic_heart_failure_pat...

March 2002
Life Extension Magazine-March 2002

Age Reversal
Interventions
Autophagy Plasma exchange
Remove
senescent cells
Combat
Immune senescence
Lengthen
telomeres
AM...

Experimental Human Age Reversal Interventions
Urgent Need to Rapidly Assess Human Data

While Also Delaying Aging NOW?
Age Reversal Needed Today!
How to Rapidly
Assess Efficacy

Nov 29, 2015

April 24, 2016

https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging
February 20, 2021
“If the results are what
they think ...

While Also Delaying Aging NOW?
Age Reversal Needed Today!
How to Rapidly
Assess Efficacy

A SOLUTION:
The Perpetual Project
Advances to Remain
Utilize Scientific
Healthy &

Fact: FDR died at age 63 of hypertension – a
condition his doctors thought “normal for his age”.
Reaction: As a result of ...

Framingham Heart Study
Educated the World!
Began in 1948 with 5,209 adults
in Framingham, Massachusetts
Prior to Framingha...

Framingham Heart Study
Saved Millions of Lives
Framingham findings revealed role of
diet and other artery-clogging factors...

Lyndon Johnson Prematurely
Died Due to Technology Delay
•First heart attack age 46 (1955)
•Suffered chronic angina pain
•R...

Alive Because of Biomedical Technology
Bill Clinton
Coronary Bypass Age 58
In 2004
Coronary Stent Age 63
In 2010
George W....

Enormous Decrease in Cardiovascular Deaths
1. “Trends and Patterns of Geographic Variation of Cardiovascular Mortality 198...

Identify your individual “risk factors”
Learn about biomarker testing
Share data about regenerative treatments
Measure eff...

Open to Everyone…No Exclusion Criteria!
 Individualized treatments
 Not a clinical study
 No termination date
Group Eff...

OptimizeConventionalRiskFactors
Restore Youthful Biochemistry
Boost cell energizing NAD+
Reverse Aging Biomarkers
Suppress...

Level 1 is essential to
progress to Level 2
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin...

House of
Optimal Health
- Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein...

Level 1
Level 2
The House of
Optimal Health

Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive p...

Age-Reversal.Net
Assess baseline markers of aging/disease risk
Correct your markers of aging/disease risk
Share your data/...

DF
ThePerpetualProject

(or use your favorite diagnostics center…preferably LabCorp.)
Results help identify factors associated with rapid aging,
a...

Commercial Lab: $572
Perpetual Project: $77
+ Phenotypic Age at no cost
Blood Tests
to Calculate Phenotypic Age:
A1C + Lip...

Enroll at age-reversal.net
Use results to adjust your longevity program
Re-test to measure age reversal efficacy
Adjust in...

In the 1980s, HIV activists pushed FDA to think differently about the way
it assessed drug efficacy. AIDS activists wanted...

Clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01112-7
Academic.oup.com/biomedgerontology/articl...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111
Levine-Horvath Phenotypic Age Model
►‘Phenotypic Age’ estimate based ...

Beyond formal acceleration of AIDS research, FDA compromised and
allowed AIDS victims to try any intervention that might b...

A SOLUTION:
The Perpetual Project
Advances to Remain
Utilize Scientific
Healthy &

We Don’t Have Time for
Delayed Age Reversal

1497: Citrus shown to cure scurvy
1747: James Lind proves citrus cures scurvy
1870: Flawed study discredits “citrus cure”
...

Risk of Delayed Treatment
Chronic Diseases May Preclude Systemic Regeneration

“…mice with progeria that got the
gene-editing treatment lived more than
twice as long as the untreated mice.”
| Jan. 7, 2...

CRISPR Gene-Editing Treatment
An untreated progeria mouse at 7.5
months of age, with a thin, grayish
coat, pronounced spin...

Untreated Male
Progeroid Mouse
7.5 months old
https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-020-03086-7/M...

Male progeroid mice
injected with CRISPR
gene editing virus.
9.75 months old
https://static-content.springer.com/esm/art%3...

https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-
020-03086-7/MediaObjects/41586_2020_3086_MOESM12_ESM.mp4
M...

10
7.5-month-old unedited 9.75-month-old CRISPR-edited male mice
9.75-month-old CRISPR-edited male mice

10
7.5-month-old unedited 9.75-month-old CRISPR-edited female mice

10
7.5-month-old unedited 11.00-month-old CRISPR-edited male mice

Crispr-Treated Progeroid Mouse
17 Months
>160 Years?
7.1 Months
Combination Crispr-Treated Human
Untreated Progeroid Mouse...

Perpetual Project Goals
Age-Reversal.Net
Utilize blood & other tests to evaluate safety & potential efficacy.
Robust commu...

Join the Perpetual Project private
association and receive updates
about regenerative medicine initiatives
www.age-reversa...

1980-1986: Anti-Aging News
1986-1994: Life Extension Report
1994-2023:Life Extension Magazine
43 Consecutive Years
of Mont...

Scientific Conference at Atlantis This Week
Focused on Regenerative Medicine Research

Bill W. Faloon
Bill W. Faloon

age-reversal.net
This presentation and info
about aging research available at:

Regenerative Medicine Options
Island House Hotel, The Bahamas
William Faloon
April 20th 2023
The Perpetual Project

Any Questions

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