Bill Faloon's Keynote Presentation at RAADfest 2024

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Age Reversal
Advances from Cells
to Mice, Monkeys
and Humans
RAADfest 2024 – Anaheim, CA
Sept 5th
, 2024
Bill Faloon
Life ...

Prospect of
Human Age Reversal
William Faloon

HUMAN AGE
REVERSAL
The New Paradigm
A BIOMEDICAL RENAISSANCE!

April 27, 2019
“Anti-aging
drugs are
coming that
could keep
you healthier
for longer”
https://www.newscientist.com/issue/3...

March 7, 2022
https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging
Feb. 20, 2021
“Is There a Cure for Aging...

“Scientists safely and
effectively reverse the
aging process in
middle-aged and
elderly mice by partially
resetting their ...

https:// www.dailymail.co.uk/health/article-7435427/
Oct.22,2019
Turning Back
Time!
“Aging is REVERSED in men using a
cock...

Decades Ahead of Mainstream Medicine
Track Record Available at: https://www.lifeextension.com/about/life-extension-story/h...

August 2nd
, 2023
“There's one major key to unlocking extreme longevity.”
“If humans living for 1,000
years seems like a c...

The Economist Dedicates an
Entire Issue to Age Reversal
https://www.economist.com/technology-quarterly/2023-09-30
Sept 30,...

https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging
February 20, 2021

June 12, 2018
Bill Faloon has pursued
immortality for decades. Now
he's got lots of company.
What does science have to
say...

December 17, 1903
First flight: 120 feet/20 feet off ground

December 17, 1903
International
Headline News

December 20, 1957
Intercontinental Air Travel
54 Years after Wright Brothers first-in flight

1903 2021
Exponential Advances in only 118 Years
Wright Brother’s First Flight Helicopter Flies on Mars

8,000B.C.–1899A.D. 1900 –2024A.D.
Time in Perspective
(Recorded Human History)
More progress
has occurred
since 1900 than
...

https://www.technologyreview.com/magazine/2019/09 September
2019
“…at a conference of longevity
enthusiasts called RAADfes...

Unparalleled Track Record
of Biomedical Innovation
First Established 1977

Sept. 11, 2023
National Geographic Issue:
“The Science of Longevity”
National Geographic
echoes what has
been presented at...

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820220
June 20, 2024
“Even when a healthier lifestyle is ini...

July 17th, 2024
https://www.bbc.com/news/articles/cv2gr3x3xkno
These mice are the same age!
The one on the right
given an ...

IL-11 inhibition extends lifespan by 22-25% in mice
• IL-11 involved in inflammation-
fibrosis. IL-11 increases with age.
...

Normal Aged
Mice without
IL-11
inhibition
therapy

Gene-Altered
Mice Unable to
make
Interleukin-11
These mice lived 22-25% longer.

What did IL-11 inhibition accomplish?
https://www.nature.com/articles/s41586-024-07701-9
Researchers reported effects seen...

Researchers tried two methods of inhibiting IL-11:
Knockout IL-11 gene from birth (life-long inhibition)
Extended median l...

Administer anti-IL-11 antibody at age 75 weeks (older mice)
Extended median lifespan by about 23%
Degree of maximum lifesp...

It is estimated that
45% of deaths in the
industrialized world
are related to fibrosis.
https://www.sciencedirect.com/topi...

2. LASN01
Several anti-IL-11 drugs are in development, targeting the
interleukin-11 pathway to treat various fibrotic dise...

https://pubmed.ncbi.nlm.nih.gov/11172736/
https://pubmed.ncbi.nlm.nih.gov/34077894/
1. Lutein
Preclinical findings suggest...

IL-11 Inhibited Mice
Same-Age Control Mice

The Economist Dedicates an
Entire Issue to Age Reversal
https://www.economist.com/technology-quarterly/2023-09-30
Sept 30,...

https://www.economist.com/technology-quarterly/2023/09/25/slowing-human-ageing-is-now-the-subject-of-serious-research
http...

https://www.economist.com/technology-quarterly/2023/09/25/what-the-young-can-give-to-the-old
https://www.economist.com/tec...

https://www.economist.com/technology-quarterly/2023/09/25/fighting-ageing-requires-properly-equipped-cells
https://www.eco...

Bloomberg Businessweek runs
“The Longevity Issue”
https://www.bloomberg.com/features/2023-longevity-issue/
“Do you want to...

George
Church
https://www.52-insights.com/interview-george-church-playing-god-with-our-genes-science/
May 4, 2018
We’ve be...

| December 8th
, 2023
https://www.wsj.com/tech/biotech/fda-approves-worlds-first-crispr-gene-editing-drug-for-sickle-cell-...

January 16th
, 2024
“FDA clears first CRISPR treatment for
a second disease, beta thalassemia”
Stem cells genetically modi...

| March 11th
, 2024
https://www.wsj.com/health/pharma/doctors-can-now-edit-the-genes-inside-your-body-4c8e1aea
Front Page ...

z
“Welcoming the Era of Gene Editing in Medicine”
https://www.nejm.org/doi/full/10.1056/NEJMp2314279
April 24th
, 2024
“Gi...

Feb 12, 2024
Hevolution Announces $115 Million Grants Program
https://longevity.technology/news/hevolution-announces-49-aw...

May 28th, 2024
Turn Bio inks $300 million
epigenetic reprogramming deal…
https://longevity.technology/news/turn-bio-inks-3...

1. Epigenetic age is a biomarker associated with age-related disease and all-cause
mortality.
2. Epigenetic age is measure...

What Happened in early 2024
OSK transcription factors reversed epigenetic age,
improved overall health and extended remain...

$This dosing regimen is practical for humans & a primate study is being designed using same exosome-rich young plasma fract...$

Plasma Fraction Reverses Epigenetic Age
Liver: 74.6% Blood: 64.3%
Heart: 46.5% Brain: 24.4%
(hypothalamus)
February, 2024
...

https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/2
February 2024
Robust Age Reduction measured by DNAm...

https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/2
February 2024
Robust Age Reduction measured by DNAm...

LiverFunctionMarkersRestoredto Youthful Ranges
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3
Febr...

Reversal ofConventionalMeasuresof Cardiovascular Risks
https://link.springer.com/article/10.1007/s11357-023-00980-6/figure...

Restoration of Youthful Kidney Function Markers
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3
Feb...

Beneficial Reductions in Epigenetic Age
https://link.springer.com/article/10.1007/s11357-023-00980-6
February 2024
In youn...

Hematopoietic stem cell-derived exosomes
can improve immunity and blood cell
production while lowering inflammation.
Exoso...

Young pig plasma (E5) was formulated with super high levels of
exosomes compared to umbilical cord or young plasma.
Transl...

Published Reports Describing
Regenerative Potential of Young Plasma
Preclinical Assessment of Young Blood Plasma for Alzhe...

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma
for Alzheimer Symptom Amelioration Study: A R...

Young Plasma Studies Continued…
Aging and age-related diseases with a focus on therapeutic potentials of young blood/plasm...

https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glae071/7618060
“We conclude that young plas...

https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glae071/7618060
May 2024
The Journals of Ger...

Young Plasma Increases Median Lifespan
Beginning at age 25.6 months, one rat group given
young plasma every other week unt...

Significant 9.1% improvement in median lifespan of the young plasma
treated group (red) compared with no treated controls ...

DNA methylation testing measures epigenetic age and is considered
the most accurate method of assessing future morbidity/m...

The longest-lived animal in control (no treatment) group.
That’s where gene therapy
can come to the rescue!
Indicates youn...

Reprogram old cells into
induced pluripotent stem
cells or young adult cells
that can theoretically
regenerate tissues for...

There are about 1500 gene regulatory transcription factors
Transcription factors can
reprogram old cells into
stem cells o...

 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging Back in 2006
Yamanaka
Transcription Factor...

 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging Back in 2006
Yamanaka
Transcription Factor...

 Octamer-binding factor 4
Just 3 Yamanaka Factors Reverse
Aging in Live Mice in 2022-2024
Yamanaka
Transcription Factors
...

Oct4 Sox2 KLF4
OSKM Yamanaka Factors
Deliver to Old Cells
Oct4
Sox2
KLF4
KLF4
Sox2
Intermittent
OSK Expression
Partial Cel...

But What Happens When
Yamanaka Factors Are
Delivered To Old Mice?
?
OSKM

March 9, 2022
“Newresearchbythe Salk
Institute hasshown
cellularrejuvenation
therapysafely reverses
signsofaginginmice.”
h...

https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-techni...

• Partial cellreprogramming inlive(invivo)mice
• OSKM(“Yamanaka”) transcriptionfactors used
• No toxicity or increase in c...

• Cell reprogramming results in “younger” skin.
• Lower inflammation.
Systemic Rejuvenation in Live Mice
https://www.natur...

February 15th
, 2024
https://www.liebertpub.com/doi/10.1089/cell.2023.0072
“Gene Therapy-mediated Partial Reprogramming Ex...

https://pubmed.ncbi.nlm.nih.gov/38381405/
February 26th
, 2024
Cyclic induction of OSK expression
in 2-year-old wild type ...

Improved Frailty Index Scores
Aging increases susceptibility to adverse health
outcomes that can be measured using a frail...

Epigenetic Age Reversal of Human Skin Cells
Exogenous induced overexpression
of OSK in these keratinocytes led to
signific...

AAV9 vector (adeno-associatedvirus9 )-(mouseproven)
Plasmid-based vector (turncellsintobioreactors)
Lipid nano-particles (...

Two-part AAV system employed for
systemic intracellular OSK delivery.
Remarkable > 100% Extension in Median
Remaining Life...

Minimal OSK Induction = Robust Age Reversal
The 109% extension of remaining lifespan + improved
frailty index + epigenetic...

 Control mice having a remaining lifespan of
approximately 5.09 human years.
OSK-treated old mice with 18.5 weeks of life...

What Happened in early 2024
OSK transcription factors reversed epigenetic age,
improved overall health and extended remain...

https://link.springer.com/article/10.1007/s11357-024-01269-y
July 22, 2024
Geroscience
This study partially funded by the ...

https://link.springer.com/article/10.1007/s11357-024-01269-y
July 22, 2024
Significantly improved learning
performance.
Tr...

 Form new memories
 Learning
 Emotions
https://www.verywellmind.com/what-is-the-hippocampus-2795231
Hippocampal Region ...

"Latency time"
refers to time taken
for rat to locate
escape platform.
Old-OSKM-treated
rats show beneficial
(36% reductio...

Old-OSKM-treated
rats show improved
learning performance
compared to old
controls, but latency
time to escape not
fully re...

OSKM-treated mice
show a 30%
improvement of
memory
performance
compared to old
controls, but
memory not fully
restored to ...

> 2006: cell reprogramming demonstrates cell rejuvenation.
> 2011: Rejuvenation induced in very old human cells (in vitro)...

Oct 26, 2023
World’s Largest Bank Focuses on Longevity
• Learn how to critically evaluate longevity data
• See what lifest...

Oct 26, 2023
World’s Largest Bank Focuses on Longevity
• Learn how to critically evaluate longevity data
• See what lifest...

Highlights from the JPMorgan Longevity Webcast
 Think of your body as a "depreciating asset.”
 93% of your lifespan dete...

Optimal Health
Level 2
Level 1
- Hormones - Renal function
- Apolipoprotein B - Sleep quality
- Blood Pressure - Glucose
-...

Level 1 is essential to
progress to Level 2
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/ApoB - Sleep ...

House of
Optimal Health
- Hormones - Kidney function
- LDL/ApoB - Sleep quality
- Blood Pressure - Glucose
- C-reactive pr...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111
Levine-Horvath Phenotypic Age Model
►‘Phenotypic Age’ estimate based ...

Bill’s calculated phenotypic (biological) age
11.12 younger than chron age
and difference
• Albumin
• Creatinine
• Glucose...

“Accelerated aging linked to
cancer risk in younger adults…”
April 7th
, 2024 www.cnn.com/2024/04/07/health/accelerated-ag...

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2819335
May 13, 2024
23% death reduction with highest adheren...

Commercial Lab: $720
Age Reversal Project: $85
+ Phenotypic Age score at no cost
Phenotypic Blood Tests
to Calculate Biolo...

Cardiac/Inflammatory Markers
•NMR Lipoprofile (atherogenic lipid
•risks + inflammation markers)
•Homocysteine
•C-Reactive ...

DNA Methylation (epigenetic age)
Blood Tests at RAADfest
https://www.trudiagnostic.com/
https://clockfoundation.org/
https...

How to Accelerate Degenerative Illnesses
Dangerous Lifestyles
Preclude Healthy Aging
P
Deadly
Foods
Tobacco
Use
Low intake...

We Don’t Have Time for
Delayed Age Reversal
Human Research

1906-2024 = 118 Years of Needless Delays

Human Age Reversal Project
$1,215,000
Goal: Statistically Significant
Human Age Reversal
age-reversal.net/donate

Front page of November 1981 issue of Anti-Aging News
Life Extension®
Published/advocated
for FDA approval of
thymosin alph...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742685/
2019

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747025/
Thymosin alpha 1: A comprehensive review of the literature
World J V...

https://pubmed.ncbi.nlm.nih.gov/35364609/
2022

2023 Apr:117:109744.
doi: 10.1016/j.intimp.2023.109744. Epub 2023 Feb 20.
T hymosin α- 1 in cancer therapy:
Immunoregulati...

https://pubmed.ncbi.nlm.nih.gov/38308608/
Objective: This study aims to assess the safety and efficacy of Thymosin Alpha 1...

https://pubmed.ncbi.nlm.nih.gov/30063866/
Published online: 31 Jul 2018
2018

Back page of November 1981 issue of Anti-Aging News
After 42 years,
most doctors are
unaware that
thymosin alpha-1
has ant...

Bridging the Longevity Gap
Urgent Need to Reform Clinical Trial Regulations
Scientific Advances
ConsumerAccess
FDA

https://en.wikipedia.org/wiki/Flying_Machines_Which_Do_Not_Fly
https://bigthink.com/pessimists-archive/air-space-flight-im...

December 17, 1903
First flight: 120 feet/20 feet off ground

July 1969
December 1903 66 Years from Kitty Hawk to Man on Moon

Age Reversal
Compared to Jet Air Travel
1903 1957
Heavier-than-air flight Commercial Jet Travel
2006 2019-2024
Age Reversa...

► Founded most successful quantitative hedge
fund of all time.
► His Medallion Fund earned more than $100
billion in tradi...

The Prospect of Human
AGE REVERSAL
Aging has been delayed & reversed in
animal models.
Human studies show partial age-reve...

age-reversal.net
View this entire presentation at:

Any
Questions

Unparalleled Track Record
of Biomedical Innovation
First Established 1977

Age Reversal
Advances from Cells
to Mice, Monkeys
and Humans
RAADfest 2024 – Anaheim, CA
Sept 5th
, 2024
Bill Faloon
Life ...