Bill Faloon at Healinc Summit, 2024 in The Bahamas

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www.healincsummit.com
Atlantis Hotel – The Bahamas
April 29th, 2024
Age Reversal Advances from Cells
to Mice, Monkeys and ...

Decades
Track Record Available at: https://www.lifeextension.com/about/life-extension-story/history
1981
1985
1986
1992
19...

June 12, 2018
has pursued
immortality for
decades.
Now he's got lots of
company. What does
https://www.popsci.com/forever-...

https://www.technologyreview.com/magazine/2019/09 September
2019
“Later this year, at a conference
of longevity enthusiast...

February 28, 2021
https://www.aging-us.com/article/202712/text
“When cells were reprogrammed with a 6-factor
cocktail the ...

April 8th, 2023
“First anti-aging pills to hit shelves in 2028, expert
predicts – as Silicon Valley races to conquer death...

“Mr. Kurzweil believes we may achieve immortality
as soon as 2030, thanks to the development of
‘nanobots,’ tiny robots th...

- May 19th, 2023
technologyreview.com/2023/05/19/1073374/i-just-met-the-founders-of-a-would-be-longevity-state/
“I just me...

| July 10th, 2023
https://www.wsj.com/articles/longevity-clinics-aging-living-longer-2b98e773
“The Longevity Clinic Will S...

Singapore Opens World’s First Healthy
Longevity Clinic in a Hospital
August 31, 2023
The Healthy Longevity Clinic at Alexa...

Healthy Longevity Clinic – Singapore to
rigorously test clinical efficacy-/safety of:
Per an Email to William Faloon from ...

August 2nd, 2023
“There's one major key to unlocking extreme longevity.”
“If humans living for 1,000
years seems like a co...

Aging is Now Optional w/ David Sinclair | EP#60 | youtube.com/watch?v=Jk_GcwkfJGs
Peter Diamandis Interviews David Sinclai...

| September 1st, 2023
Saudi’s allocated> $1 billion a yearto developtreatmentsforaging.
“Saudi Arabia Is Dangling Billions...

Sept. 11, 2023

The Economist Dedicates an
Entire Issue to Age Reversal
https://www.economist.com/technology-quarterly/2023-09-30

https://www.economist.com/technology-quarterly/2023/09/25/slowing-human-ageing-is-now-the-subject-of-serious-research
http...

https://www.economist.com/technology-quarterly/2023/09/25/what-the-young-can-give-to-the-old
https://www.economist.com/tec...

https://www.economist.com/technology-quarterly/2023/09/25/fighting-ageing-requires-properly-equipped-cells
https://www.eco...

$This dosing regimen is practical for humans & a primate study is being designed using same exosome-rich young plasma fract...$

Plasma Fraction Reverses Epigenetic Age
Liver: 74.6% Blood: 64.3%
Heart: 46.5% Brain: 24.4%
(hypothalamus)
February, 2024
...

https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/2
February 2024
Robust Age Reduction measured by DNAm...

https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/2
February 2024
Robust Age Reduction measured by DNAm...

Beneficial Reductions in Epigenetic Age
https://link.springer.com/article/10.1007/s11357-023-00980-6
February 2024
In youn...

LiverFunctionMarkersRestoredtoYouthfulRanges
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3
Februa...

Reversal ofConventionalMeasuresof Risks
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3
February 20...

Restoration of Youthful Kidney Function Markers
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3
Feb...

Young Plasma Research Projects
Volumesofpublishedstudiesdescriberejuvenationeffectsofyoungplasma.*
Several protocols under...

Published Reports Describing
Regenerative Potential of Young Plasma
Preclinical Assessment of Young Blood Plasma for Alzhe...

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma
for Alzheimer Symptom Amelioration Study: A R...

Young Plasma Studies Continued…
Aging and age-related diseases with a focus on therapeutic potentials of young blood/plasm...

$This dosing regimen is practical for humans & a primate study is being designed using same exosome-rich young plasma fract...$

https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glae071/7618060
March 2, 2024
March 2, 2024

Young Plasma Increases Median Lifespan
Beginning at age 25.6 months,one rat group given
young plasma every other week unti...

Significant 9.1% improvement in median lifespan of the young plasma
treated group (red) compared with no treated controls ...

DNA methylation testing measures epigenetic age and is considered
the most accurate method of assessing future morbidity/m...

The longest-lived animal in control (no treatment) group.
That’s where gene therapy
can come to the rescue!
Indicates youn...

Reprogram old cells into
induced pluripotent stem
cells or young adult cells
that can theoretically
regenerate tissues for...

There are about 1500 gene regulatory transcription factors
Transcription factors can
reprogram old cells into
stem cells o...

The Nobel Prize in Physiology or Medicine 2012
These transcription factors are called:
“Yamanaka Factors”
Four specific ge...

 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging in 2006
Yamanaka
Transcription Factors
OCT...

 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging in 2006
Yamanaka
Transcription Factors
OCT...

 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging Back in 2006
Yamanaka
Transcription Factor...

Oct4 Sox2 KLF4
OSKM Yamanaka Factors
Deliver to Old Cells
Oct4
Sox2
KLF4
KLF4
Sox2
Intermittent
OSK Expression
Partial Cel...

Improved Organ Structure & Function in Many Tissues
Prior Studies Demonstrate
Short induction of OSKM in a myocardial infa...

What happens when
Yamanaka factors are
delivered to old mice?

March 9, 2022
“Newresearchbythe
SalkInstitutehasshown
cellularrejuvenation
therapysafelyreverses
signsofaginginmice.”
http...

https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-techni...

• Partialcellreprogramminginlive(invivo)mice
• OSKM(“Yamanaka”)transcriptionfactorsused
• No toxicity or increase in cance...

• Cellreprogrammingresultsin“younger”skin.
• Lower inflammation.
• Reduced senescent-associated secretory phenotypes.
Syst...

“In both the kidneys
and skin, the
epigenetics of treated
animals more closely
resembled epigenetic
patterns seen in
young...

https://pubmed.ncbi.nlm.nih.gov/38381405/
February 26th, 2024
Cyclic induction of OSK expression
in 2-year-old wild type m...

Improved Frailty Index Scores
Aging increases susceptibility to adverse health
outcomes that can be measured using a frail...

Epigenetic Age Reversal of Human Skin Cells
Exogenous induced overexpression
of OSK in these keratinocytes led to
signific...

Two-part AAV system employed for
systemic intracellular OSK delivery.
Remarkable 109% Extension in Median
Remaining Life i...

Minimal OSK Induction = Robust Age Reversal
The 109% extension of remaining lifespan + improved
frailty index + epigenetic...

 Control mice having a remaining lifespan of
8.86 weeks equating to approximately
 5.09 human years.
 OSK-treated mice ...

February 15th, 2024
https://www.liebertpub.com/doi/10.1089/cell.2023.0072
“Together, these results may
have important impl...

“Aging is the strongest risk factor for
most common human diseases hence
it is imperative to identify antiaging
interventi...

> 2006: cell reprogramming demonstratescell rejuvenation.
> 2011: Rejuvenation inducedin very old human cells (in vitro)
>...

AAV9 vector (adeno-associatedvirus9)-(mouseproven)
Plasmid-based vector (turncellsintobioreactors)
Lipid nano-particles (I...

Upgraded Yamanaka Cocktail Jan. 4th, 2024
Enhanced induced pluripotent
stem cell generation in 5 species
https://www.cell....

https://www.mpi-muenster.mpg.de/732121/20231222-super-sox
Improved Yamanaka factors:
SOX2 / Oct 4 or “Super SOX”
“The extr...

What’s Happened So Far in
OSK transcription factors reversed epigenetic age,
improved overall health and extended remainin...

https://scitechdaily.com/turning-back-the-clock-genetic-engineers-rewire-cells-for-an-82-increase-in-lifespan
“Lifespan Ex...

105%LifespanExtensioninYeastUsingGeneticOscillation
Study finds yeast cell aging and death
affectedbya circuitoftwo critic...

https://www.science.org/doi/10.1126/science.add7631
105%Lifespan ExtensionUsingGeneticOscillation
April 27th, 2023
Yeast c...

Substantial Lifespan Increase with Modest
Gene Expression Alterations in Yeast Cells
Stem cell exhaustion is a core aspect...

| March 11th, 2024
Front Page of WSJ: “The experimental therapies Odunsi and others
are receiving, by contrast, edit their...

Unparalleled Track Record
of Biomedical Innovation
First Established 1977

age-reversal.net
View this entire presentation at:

www.healincsummit.com
Atlantis Hotel – The Bahamas
April 29th, 2024
Advances from Cells
to Mice, Monkeys and Humans
Bill F...