Using liquid biopsies to study cancer dynamics and drug resistance

$What is tumor DNA fraction? Romanel A*, Gasi Tandefelt D*, et al, Science Transl Med 2015 Normal DNA Tumor DNA$

$What is tumor DNA fraction? Romanel A*, Gasi Tandefelt D*, et al, Science Transl Med 2015 TOTAL DNA ~ 90 ng/ml TUMOR FRACT...$

$Patient Time point Observed allelic fraction of TP53 mutation Rossi 1 10% Rossi 2 10% Rossi 3 5% Verdi 1 50% Why is import...$

$Patient Time point Observed allelic fraction of TP53 mutation Tumor DNA fraction Percentage of tumor molecules harboring T...$

$gene A gene B Baca S et al, Cell 2013 Prandi D et al, Genome Biology 2014 Tumor fraction estimation Clonal Subclonal$

$Is an informative biomarker Romanel A*, Gasi Tandefelt D*, et al, Science Transl Med 2015 Tumor fraction is a biomarker Ad...$