Robust T Cell Immunity in Convalescent Individuals with Asymptomati...

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Article
Robust T Cell Immunity in Convalescent Individuals
with Asymptomatic or Mild COVID-19
Graphical Abstract
Highlight...

Article
Robust T Cell Immunity in Convalescent Individuals
with Asymptomatic or Mild COVID-19
Takuya Sekine,1,15 André Pe...

A
0
10
20
30
40
50
%
of
memory
CD4+
T
cells
CD38
0
1
2
3
4
5
CD69
0
5
10
15
20
25
Ki-67
2020 BD MC AM AS
0
20
40
60
80
100...

(Chandrashekar et al., 2020), and similarly, there is limited evi-
dence of reinfection in humans with previously document...

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observed consistently among memory CD8+
T cells from pa-
tients with acute moderate or severe COVID-19 (Figures S3A
and S3...

A
C
E
F G
D
B
Figure 2. Phenotypic Characteristics of SARS-CoV-2-Specific T Cells in Acute and Convalescent COVID-19
(A an...

99%, respectively) (Figure 4F). These discordant responses
were nonetheless pronounced in some convalescent individuals
wi...

A
B
C
D
Figure 3. Functional Characteristics of SARS-CoV-2-Specific T Cells in Convalescent COVID-19
(A) Left: dot plots s...

A B
C
D
E
F G
(legend on next page)
ll
OPEN ACCESS
Cell 183, 158–168, October 1, 2020 165
Article

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Of note, we detected cross-reactive T cell responses directed
against the spike and/or membrane proteins of SARS-CoV-2 in
...

the Swedish Childhood Cancer Fund, the Magnus Bergvalls Stiftelse, the Hed-
lunds Stiftelse, the Lars Hiertas Stiftelse, t...

Long, Q.X., Tang, X.J., Shi, Q.L., Li, Q., Deng, H.J., Yuan, J., Hu, J.L., Xu, W.,
Zhang, Y., Lv, F.J., et al. (2020). Cli...

STAR+METHODS
KEY RESOURCES TABLE
REAGENT or RESOURCE SOURCE IDENTIFIER
Antibodies
1G1 (PE) [anti-CCR4] BD Biosciences 5511...

RESOURCE AVAILABILITY
Lead Contact
Further information and requests for resources and reagents should be directed to and w...

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Data and Code Availability
The published article includes all data generated during this study. All codes are freely avail...

determined using NetMHCpan version 4.1 (Reynisson et al., 2020). Binders were defined by a threshold IC50 value of 500 nM....

these analyses: metric = euclidean, nearest neighbors = 30, and minimum distance = 0.5. Clusters of phenotypically related...

Supplemental Figures
A
2020 BD AM AS
0
400000
800000
1000000
2000000
2020 BD AM AS
0
200000
400000
600000
800000
1000000
1...

Figure S1. Quantification and Characterization of CD4+
and CD8+
T Cells in COVID-19, Related to Figure 1
(A) Flow cytometr...

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***
UMAP2
UMAP1
HLA-DR
Ki-67
CD38
LAG-3
TIM-3
CD39
2B4
TIGIT
PD-1
CD27
CD127
CXCR5
GzmB
Perforin
CD95
CD28
CD45RA
CCR7
Gat...

Figure S2. Phenograph and UMAP Clustering of Memory CD4+
and CD8+
T Cells with Correlative Analyses of Immune Activation P...

CCR7
96 4
Acute
Healthy
CD127
89 11
TIGIT
90 10
TCF-1
96 4
Perforin
83
17
Granzyme B
94
6
CD45RA
98 2
CD28
73
26
CD27
88
1...

CMV-specific memory CD8+
T cells in a healthy control and a patient with acute severe COVID-19. Numbers indicate percentag...

A
B
Figure S4. Quantification of Functional T Cell Reactivity in COVID-19, Related to Figure 3
(A) Representative images s...

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A 38
62 38
62
14.3
37.1
32.9 15.7
78.3 21.7
CXCR5
CXCR3
cTfh
Th1
CXCR5
CXCR3
Th1/17
Th17
Th2
c
T
f
h
1
c
T
f
h
2
c
T
f
h
1...

nucleocapsid. (E) Dot plots summarizing SARS-CoV-2-specific CD4+
and CD8+
T cell responses versus serostatus in exposed fa...

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