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DMT
(The spirit molecule)
Introduction
History
Laws
ReligionsMechanism
Cases
Conclusion
Introduction
• DMT or 'Di-methyl
tryptamine' ,is a chemical
compound that is found in
mammilian brain in the
part called the Pineal
Gland
• Also can found naturally in
plants &The most common
source is the root bark of
Mimosa Hostilis .
In Drug Form ,,
– DMT is the common name
for the hallucinogenic drug.
– DMT is inactive orally without the aid of an MAOI drug
as the enzyme ''mono amine-oxidase'' oxidizes orally-
taken DMT too quickly for any effect to be noticed .
Why is this important?
• DMT is the chemical that elicits dreams.
• DMT plays an important role in the process of
thought, near-death experiences, as well as
meditation.
• When smoked, injected, or ingested in
combination with a (MAOI), DMT
induces an intense cinegonicullah
dnaetats ciledehcysp. ..
History
•DMT was first synthesized in 1931 by
Richard Manske in the great wave of
chemical experimentation that followed the
discovery of mescaline at the end of the
nineteenth century.
•At this time neither its effect on the
human consciousness nor its presence in
traditional South American indigenous
admixtures were known, and so DMT was
forgotten until the snuffs and potions of
the South American shamans became of
great curiosity to the then burgeoning field
of 'psychopharmacology‘ fifteen years later.
•O. Goncalves first isolated DMT from
Mimosa Hostilis (= M. teniflora) in
1946 and further investigations into
the plants used by South American
shamans resulted in DMT being later
isolated from both Piptadenia
macrocarpa (= Anadenanthera
colubrine var Cebil) and P. Peregrina (=
A. peregrina) in 1955.
•The psychoactive effects of DMT were
not discovered until first reported by
Stephen Szára in 1956.
•From January 1971 journal article by Alexander T. Shulgin, as
reproduced on Deoxy, retrieved on October 13, 2012
•DMT was first synthesized in 1931, and demonstrated to be
hallucinogenic in 1956.
•It has been shown to be present in many plant genera (Acacia,
Anandenanthera, Mimosa, Piptadenia, Virola) and is a major
component of several hallucinogenic snuffs (cohoba, parica, yopo).
•It is also present in the intoxicating beverage "ayahuasca" made from
Banisteriopsis caapi, and it may have oral effectiveness due to the
presence of several naturally occurring inhibitors of catabolic
deamination.“.
Laws
•Extracted DMT (e.g. in
fumarate or freebase form) is
considered illegal in all the UN-
bound countries.
•Natural materials containing
DMT (e.g., Psychotria viridis)
are frequently in a legal grey
area, and its control will depend
on country’s current specific
legislation and priorities.
Religions
•The rightness or wrongness of any action/substance/food is decided by
estimating its beneficence, or its benefits to risks ratio.
•Benefits of DMT:
1-Entering parallel realms of existence
2-Provides a spiritual experience and helps in exploring our inner
selves 3-interactions with higher entities that aren't present in our 3D
plane
3-The brain chemistry changes so that the brain recieves different
types of information and that promotes creativity and the individual
becomes "enlightened
4- Has a potential for psychotherapeutic use, and for helping drug
addicts kick their habit
•Risks of DMT:
Effects of high doses of DMT are toxic to the human system
include:
1- Cardiac arrest ,Heart failure, coma Nerve damage.
2- Difficulty speaking or communicating
3- Sense of suspended time
4- Alternating feelings of motor paralysis and motor
hyperactivity.
5- Loss decreased appetite.
6- Loss of sexual desire.
7- Frightening trips and flashbacks distortion of sensory
perceptions.
8- Mental or psychological episodes.
Islam Christianity
Judaism
Mechanism
•DMT belongs to tryptamines, which are a specific
class of chemicals.
•Some tryptamines are vital parts of your normal
brain function such as serotonin and melatonin;
others are psychedelic drugs such as LSD.
•Most psychedelics produce their primary effects
through a complex (non-typical) agnostic effect on
the serotonin receptors 5-HT2A, 5-HT2C and 5-HT1A.
•Many psychedelics also have affinity for a large
number of other receptors.
• Tryptamine psychedelics influence a large
number of brain areas, including but not
limited to:
– The posterior cingulate cortex (PCC)
– The thalamus
– The visual cortex
•The primary effects of interest of the
psychedelic tryptamines are on the central
nervous system (CNS). There may also be
effects on the peripheral nervous system (PNS)
through activation of serotonin receptors in the
intestinal wall for example, but these are
generally mild and not (yet) medically
interesting/useful.
• As described there is a plethora of
different areas altered by the effects of
tryptamines within the brain.
• It is important to note that due to legal
concerns, it
was very difficult to perform research
relating to psychedelics. As such, most
research is
either ‘very old ; or very recent
and therefore representing ‘work in
progress’ that
is subject to frequent change in our
understanding.
Inside the Brain
DMT
• The most popular view of the effects
of psychedelic substances is that of
visual distortions and hallucinations,
so we will begin there.
• The visual cortex is – like all cortex –
made up of many folds and shapes.
As it happens however, the image
seen by the eyes can be directly
mapped to this cortex (reversed and
flipped) if you were to physically
unfold this area to a flat surface.
• The most consistent reported visual of psychedelic substances is that
of specific patterns appearing ‘overlaid’ over normal reality. It appears
that these patterns are caused by a kind of ‘data bleed’ in the visual
cortex, prior to optic radiation passing the data to the conscious mind.
• The patterns seen on psychedelics can be mathematically generated by
computationally creating a coordinate map of this area of the brain,
‘bleeding’ data to physically nearby locations (that may not be visually
nearby) and then ‘unfolding’ the cortex.
DMT
• Another common experience with psychedelics is the
feeling that one is ‘taking in a lot more information’.
• One of the jobs of the thalamus is to organise or translate
the data in a way that other parts of the brain will
understand. When doing this it has the additional function
of acting somewhat like a filter.
• Under the influence of psychedelics, the thalamus reduces
its activities significantly , so when you take a psychedelic
substance,–you open yourself up to the opportunity to
process a much greater amount of the raw sensory
data, even if it is sometimes more unstructured and difficult
to focus on just one thing.
Visions from Beyond
• Yet another experience common to psychedelic
experiences is that of ‘receiving visions’. These are often
taken as mystical revelation from another realm or world
by traditional shamanic use of psychedelics in their
rituals.
• In contrast to the visual distortions, these visions are not
generated on the visual cortex. They are more in line
with dreaming whilst awake.
• Disrupting connectivity of the posterior cingulate
cortex (PCC) through electrical stimulation causing
‘waking dreams’ not dissimilar to that aspect of the
psychedelic state.
• PCC cerebral blood flow is lower during REM sleep,
and as a direct result of tryptamine psychedelics,
showing a likely cause of these same effects when
taking a psychedelic.
:Oneness with the Universe
• Another common reported experience with
psychedelic substances is that of undergoing a
mystical experience. The person experiences a
sense of “oneness with the universe”.
• PCC is also an important ‘hub’ of information
transfer. One aspect of this is separation of the self
and the external world. It occurs as a part of a
network based on asynchronous activity with other
areas of the brain – the “default mode network”
(DMN).
• When this is disrupted, the
experiences described are
the conscious mind’s
attempt to make sense of
the situation.
• This can be interpreted as a
complete breakdown of the
DMN, so that the ‘self’ no
longer exists until function
is regained.
• The principal physiological effects of DMT-ingestion
include an increased heart rate, increased blood
pressure, strong dilation of the pupils, and steady
breathing. The user will appear to be in a trance.
Cases
*Note:-
These cases are not formal documented cases
at the government. But it is an interview
between a journalist called John Barclay works
at Washington post and the cases.
1) Oren:-
That was the most intense thing ever.
The whole room was dancing. To my
left all I saw was fantasy. I was going
through something very serious.
You’re beyond consciousness—but
you are consciousness—and you want
nothing to tie you down to this
physical realm.
2) Lex:
It’s hard to talk about it. My
concentration was very high as well as
I taking the drug. But my intense
becomes high and high until you’re
not high anymore. I heard a kind of
music. I was so dizzy.
3-Adam:
It hit really fast. After the second puff
there were like clouds everywhere. I
felt really physically heavy and time
slowed down. I went through so many
dreams and so many scenarios. It was
basically a concentrated dream. I was
awake but I couldn’t make the dream
stop.
4-Victor:
I felt tingly and I had a body high or
whatever and I still felt self-conscious. I
don’t think I lost sight of myself enough to
think that wasn’t funny. Almost the
strangest part is how quickly you come
down. At the next day you feel weird. With
this you pretty much feel normal almost
immediately afterwards.
Conclusion
•N,N-Dimethyltryptamine
DMT or N,N-DMT) is a psychdelic
compound of the tryptamine
family.
•It is a structural analog of seretonin
and melatonin and a functional analog
of other psychedelic tryptamines.
• DMT is the most powerful
psychedelic drug.
Routes of administration
1-Inhalation:
this is inhaled in a few successive breaths. The effects last for
a short period of time
2-Injection:
Injected DMT produces an experience that is similar to
inhalation in duration, intensity, and characteristics
3-Oral ingestion:
DMT is broken down by the enzyme monoamine oxidase
through a process called deamination.
*Mechanism *Cases
*Religions
DMT
DMT
Thank You

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DMT

  • 4. • DMT or 'Di-methyl tryptamine' ,is a chemical compound that is found in mammilian brain in the part called the Pineal Gland • Also can found naturally in plants &The most common source is the root bark of Mimosa Hostilis .
  • 5. In Drug Form ,, – DMT is the common name for the hallucinogenic drug. – DMT is inactive orally without the aid of an MAOI drug as the enzyme ''mono amine-oxidase'' oxidizes orally- taken DMT too quickly for any effect to be noticed .
  • 6. Why is this important? • DMT is the chemical that elicits dreams. • DMT plays an important role in the process of thought, near-death experiences, as well as meditation.
  • 7. • When smoked, injected, or ingested in combination with a (MAOI), DMT induces an intense cinegonicullah dnaetats ciledehcysp. ..
  • 9. •DMT was first synthesized in 1931 by Richard Manske in the great wave of chemical experimentation that followed the discovery of mescaline at the end of the nineteenth century. •At this time neither its effect on the human consciousness nor its presence in traditional South American indigenous admixtures were known, and so DMT was forgotten until the snuffs and potions of the South American shamans became of great curiosity to the then burgeoning field of 'psychopharmacology‘ fifteen years later.
  • 10. •O. Goncalves first isolated DMT from Mimosa Hostilis (= M. teniflora) in 1946 and further investigations into the plants used by South American shamans resulted in DMT being later isolated from both Piptadenia macrocarpa (= Anadenanthera colubrine var Cebil) and P. Peregrina (= A. peregrina) in 1955. •The psychoactive effects of DMT were not discovered until first reported by Stephen Szára in 1956.
  • 11. •From January 1971 journal article by Alexander T. Shulgin, as reproduced on Deoxy, retrieved on October 13, 2012 •DMT was first synthesized in 1931, and demonstrated to be hallucinogenic in 1956. •It has been shown to be present in many plant genera (Acacia, Anandenanthera, Mimosa, Piptadenia, Virola) and is a major component of several hallucinogenic snuffs (cohoba, parica, yopo). •It is also present in the intoxicating beverage "ayahuasca" made from Banisteriopsis caapi, and it may have oral effectiveness due to the presence of several naturally occurring inhibitors of catabolic deamination.“.
  • 12. Laws
  • 13. •Extracted DMT (e.g. in fumarate or freebase form) is considered illegal in all the UN- bound countries. •Natural materials containing DMT (e.g., Psychotria viridis) are frequently in a legal grey area, and its control will depend on country’s current specific legislation and priorities.
  • 15. •The rightness or wrongness of any action/substance/food is decided by estimating its beneficence, or its benefits to risks ratio. •Benefits of DMT: 1-Entering parallel realms of existence 2-Provides a spiritual experience and helps in exploring our inner selves 3-interactions with higher entities that aren't present in our 3D plane 3-The brain chemistry changes so that the brain recieves different types of information and that promotes creativity and the individual becomes "enlightened 4- Has a potential for psychotherapeutic use, and for helping drug addicts kick their habit
  • 16. •Risks of DMT: Effects of high doses of DMT are toxic to the human system include: 1- Cardiac arrest ,Heart failure, coma Nerve damage. 2- Difficulty speaking or communicating 3- Sense of suspended time 4- Alternating feelings of motor paralysis and motor hyperactivity. 5- Loss decreased appetite. 6- Loss of sexual desire. 7- Frightening trips and flashbacks distortion of sensory perceptions. 8- Mental or psychological episodes.
  • 19. •DMT belongs to tryptamines, which are a specific class of chemicals. •Some tryptamines are vital parts of your normal brain function such as serotonin and melatonin; others are psychedelic drugs such as LSD. •Most psychedelics produce their primary effects through a complex (non-typical) agnostic effect on the serotonin receptors 5-HT2A, 5-HT2C and 5-HT1A. •Many psychedelics also have affinity for a large number of other receptors.
  • 20. • Tryptamine psychedelics influence a large number of brain areas, including but not limited to: – The posterior cingulate cortex (PCC) – The thalamus – The visual cortex •The primary effects of interest of the psychedelic tryptamines are on the central nervous system (CNS). There may also be effects on the peripheral nervous system (PNS) through activation of serotonin receptors in the intestinal wall for example, but these are generally mild and not (yet) medically interesting/useful.
  • 21. • As described there is a plethora of different areas altered by the effects of tryptamines within the brain. • It is important to note that due to legal concerns, it was very difficult to perform research relating to psychedelics. As such, most research is either ‘very old ; or very recent and therefore representing ‘work in progress’ that is subject to frequent change in our understanding. Inside the Brain
  • 23. • The most popular view of the effects of psychedelic substances is that of visual distortions and hallucinations, so we will begin there. • The visual cortex is – like all cortex – made up of many folds and shapes. As it happens however, the image seen by the eyes can be directly mapped to this cortex (reversed and flipped) if you were to physically unfold this area to a flat surface.
  • 24. • The most consistent reported visual of psychedelic substances is that of specific patterns appearing ‘overlaid’ over normal reality. It appears that these patterns are caused by a kind of ‘data bleed’ in the visual cortex, prior to optic radiation passing the data to the conscious mind. • The patterns seen on psychedelics can be mathematically generated by computationally creating a coordinate map of this area of the brain, ‘bleeding’ data to physically nearby locations (that may not be visually nearby) and then ‘unfolding’ the cortex.
  • 26. • Another common experience with psychedelics is the feeling that one is ‘taking in a lot more information’. • One of the jobs of the thalamus is to organise or translate the data in a way that other parts of the brain will understand. When doing this it has the additional function of acting somewhat like a filter.
  • 27. • Under the influence of psychedelics, the thalamus reduces its activities significantly , so when you take a psychedelic substance,–you open yourself up to the opportunity to process a much greater amount of the raw sensory data, even if it is sometimes more unstructured and difficult to focus on just one thing.
  • 29. • Yet another experience common to psychedelic experiences is that of ‘receiving visions’. These are often taken as mystical revelation from another realm or world by traditional shamanic use of psychedelics in their rituals. • In contrast to the visual distortions, these visions are not generated on the visual cortex. They are more in line with dreaming whilst awake.
  • 30. • Disrupting connectivity of the posterior cingulate cortex (PCC) through electrical stimulation causing ‘waking dreams’ not dissimilar to that aspect of the psychedelic state. • PCC cerebral blood flow is lower during REM sleep, and as a direct result of tryptamine psychedelics, showing a likely cause of these same effects when taking a psychedelic.
  • 31. :Oneness with the Universe • Another common reported experience with psychedelic substances is that of undergoing a mystical experience. The person experiences a sense of “oneness with the universe”. • PCC is also an important ‘hub’ of information transfer. One aspect of this is separation of the self and the external world. It occurs as a part of a network based on asynchronous activity with other areas of the brain – the “default mode network” (DMN).
  • 32. • When this is disrupted, the experiences described are the conscious mind’s attempt to make sense of the situation. • This can be interpreted as a complete breakdown of the DMN, so that the ‘self’ no longer exists until function is regained.
  • 33. • The principal physiological effects of DMT-ingestion include an increased heart rate, increased blood pressure, strong dilation of the pupils, and steady breathing. The user will appear to be in a trance.
  • 34. Cases
  • 35. *Note:- These cases are not formal documented cases at the government. But it is an interview between a journalist called John Barclay works at Washington post and the cases.
  • 36. 1) Oren:- That was the most intense thing ever. The whole room was dancing. To my left all I saw was fantasy. I was going through something very serious. You’re beyond consciousness—but you are consciousness—and you want nothing to tie you down to this physical realm. 2) Lex: It’s hard to talk about it. My concentration was very high as well as I taking the drug. But my intense becomes high and high until you’re not high anymore. I heard a kind of music. I was so dizzy.
  • 37. 3-Adam: It hit really fast. After the second puff there were like clouds everywhere. I felt really physically heavy and time slowed down. I went through so many dreams and so many scenarios. It was basically a concentrated dream. I was awake but I couldn’t make the dream stop. 4-Victor: I felt tingly and I had a body high or whatever and I still felt self-conscious. I don’t think I lost sight of myself enough to think that wasn’t funny. Almost the strangest part is how quickly you come down. At the next day you feel weird. With this you pretty much feel normal almost immediately afterwards.
  • 39. •N,N-Dimethyltryptamine DMT or N,N-DMT) is a psychdelic compound of the tryptamine family. •It is a structural analog of seretonin and melatonin and a functional analog of other psychedelic tryptamines. • DMT is the most powerful psychedelic drug.
  • 40. Routes of administration 1-Inhalation: this is inhaled in a few successive breaths. The effects last for a short period of time 2-Injection: Injected DMT produces an experience that is similar to inhalation in duration, intensity, and characteristics 3-Oral ingestion: DMT is broken down by the enzyme monoamine oxidase through a process called deamination.