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Integrated Intelligent Research (IIR) International Journal of Data Mining Techniques and Applications
Volume 5, Issue 1, June 2016, Page No.83-86
ISSN: 2278-2419
83
Discrete Wavelet Transform Based Brain
Tumor Detection using Haar Algorithm
R.Sentamilselvan ,M.Manikandan
Applied Electronics,Sir issac Newton College of engineering & technology Nagapattinam.
Assistant Professor,Department of ECE, Sir issac newton college of engineering & technology ,Nagapattinam
Abstract - A brain tumour is an abnormal growth of cells that
are spontaneously grows in uncontrolled manner. We can
divide tumors in according to how exponentially they
developed i.e. growth rate, with lower-grade tumors often
being begin and higher-grade tumors being malignant. Based
on interpolation of low frequency sub band images obtained by
discrete wavelet transform (DWT) and the input image, the
brain tumor detection is obtained by using Haar wavelet
transform. Database image is also decomposed by using Haar
wavelet transform by two levels and this database image is
compared with the input image by using Mutual information
principle. Both input image and database image is decomposed
into different sub bands by using DWT. Interpolation of low
frequency sub bands as well as input image is done. The
proposed technique that first one is data base image and
another is the input image in which both are decomposed into
several bands by using wavelet transform and their coefficients
are stored into matrix form with the help of MATLAB and
these coefficients are compared with the help of mutual
information principle. Corrected interpolated high frequency
sub-bands and interpolated input image are combined by using
inverse DWT (IDWT), finally. Hence, we get a brain tumour
detected output image.
Key words: Brain tumour, glioma grade, clustering, dimension
reduction, discrete wavelet transform, magnetic resonance
spectroscopy, unsupervised learning.
I. INTRODUCTION
Magnetic resonance imaging (MRI) is a widely-used modality
that facilitates the diagnosis and prognosis of brain tumours.
Standard MRI sequences are routinely used to differentiate
among various brain tumour types based on qualitative visual
analyses of the represented soft tissue contrast. Indeed, more
than 120 classes of brain tumours are known, which are
categorised into four grades depending on the level of
malignancy by the world health organisation (WHO) . The
grading from low to high (I-IV) represents malignancy levels
from biologically least aggressive to most aggressive brain
tumours as shown by histological criteria, e.g., invasiveness,
vascularity, and tumour growth rate . Gliomas are the most
common primary brain tumour and pre-treatment assessment
of grade is required; however, the sole use of standard MRI
sequences may be insufficient for an accurate diagnosis.
II. DISCRETE WAVELET TRANSFORM
The Wavelet Series is nothing but a sampled version of CWT
and its computation may consume significant amount of time
and resources which is depending on the resolution required
for the signal. The Discrete Wavelet Transform (DWT) is
based on sub-band coding is found to yield a fast computation
of Wavelet Transform due to which It is easy to implement and
reduces the computation time and resources required.Short
history about DWT.The foundations of DWT go back to1976
when techniques to decompose discrete time signals were
devised which is Similar as work was done in speech signal
coding which was named as sub-band coding. In 1983,a
technique similar to sub-band coding was developed which
was named pyramidal coding .Later many improvements were
made to these coding schemes which resulted in efficient
multi-resolution analysis schemes.On other hand In CWT, the
signals are analyzed using a set of basic functions which relate
simple scaling and translation contains only scaling function
and translation function. In such case of DWT we obtain at
image-scale representation of the digital signal is obtained
using digital filtering techniques. The DWT is applied on
image is very simple procedure as suppose ω be the image is
having ω(j+1,m,n) as j+1 is scaling function m is row vector
and n is the columns vector. is applied to the high pass filter
hψ(-n) and also to low pass filter h(-n)the filter is applied
across the column as „n indicates the column and which
divides the total signal into two filters as low pass and high
pass filter.
Decomposition of an image using DWT
The decomposition of image by using wavelet transform.
Image is decomposed into four different frequency bands
namely HH, HL, LH, LL which contains diagonal contents,
vertical contents, horizontal contents and approximate
contents. Fig . Shows reverse operation which is taken placed
in this figure original image is obtained from combining four
decomposed parts by using IDWT.
Figure.1: Equivalent image decomposition by using DWT
Integrated Intelligent Research (IIR) International Journal of Data Mining Techniques and Applications
Volume 5, Issue 1, June 2016, Page No.83-86
ISSN: 2278-2419
84
Figure.2:Equivalent Scheme of Wavelet reconstruction
Algorithm
III. DWT AND FILTER BANK
Multi-Resolution Analysis Using Filter Bank
Filters are widely used signal processing functions to remove
noise in signals. By using iteration of filters with rescaling,
wavelets can be realized. The resolution of the signal is
considered by using two terms i.e. measure of the amount of
detail information in the signal is determined by the filtering
operations and the scaling is determined by up-sampling and
down-sampling.
Figure.3:Three-level wavelet decomposition tree
The DWT is obtained by successive low pass and high pass
filtering of the discrete time-domain signal as shown in fig.
3.This is called as Mallat algorithm or Mallat-tree
decomposition of signal. Its significance is in the manner of
which it connects the continuous- time multi resolution to
discrete-time filters. In the figure3. The sequence x[n] is
applied to wavelet decomposition tree where n is an integer.G0
is low pass filter reduces approximation a[n] and H0 is high
pass filter produces detailed information i.e. d[n]. The time
resolution becomes good at high frequencies, while the
frequency resolution becomes good at lowfrequencies.Unless
and until the desired level of resolution is reached the filtering
and decimation process is carried out. The length ofthe signal
determines maximum number of levels. The DWT of the
original signal is then obtained by concatenating all the
coefficients, a[n] and d[n], starting from the last level of
decomposition
Fig.4:Three-level wavelet reconstruction tree
Shows three-level wavelet reconstruction tree There
construction is the reverse process of decomposition. The
approximation and detail coefficients at every level are up
sampled by two, passed through the low pass and high pass
synthesis filters and then added. This process is continued
through the same number of levels as in the decomposition
process to obtain the original signal. The Mallat algorithm
works equally well if the analysis filters, G0 and H0, are
exchanged with the synthesis filters, G1 and H1.
IV. EXISTING SYSTEM
MR data were obtained at St. George’s University of London
using a 1.5-Tesla scanner (GE Healthcare, Milwaukee, WI,
USA), which was equipped with 22 gradients and a quadrature
head coil. Written informed consent was obtained from all
participants in accordance with local ethics procedures. Either
biopsy or resected tumour tissue samples obtained as part of
the patients’ clinical diagnosis or treatment were used to
provide a histological diagnosis of the tumour type and grade
as the overall gold standard (ground truth). In total SV MRS
were obtained including 24 Grade II (GII) tumours
(2oligodendroglioma, 3 oligo astrocytoma, 3 fibrillary
astrocytoma, 4 gemistocytic astrocytoma and 12 diffuse
astrocytoma) and 31 Grade IV (GIV, glioblastomamultiforme).
A further 79 MR spectra were obtained from three normal
controls using multiple voxel MRS with the same acquisition
parameters (i.e., which had compatible TR/TE) as the SV MRS
All SV MRS data were acquired at short Echo Time (TE) using
the GE developed point-resolved spectroscopic sequence
(PRESS) protocol (Repetition Time (TR) = 2000ms, Echo time
(TE) = 30ms, 2048 data points with 2500Hz bandwidth). An
expert panel (including spectroscopists, pathologists and
radiologists) validated the brain tissue types included in this
study as part of the TUMOUR project, with a histo
pathological diagnosis of the central nervous system (CNS)
tumours according to WHO criteria. Individual voxels were
placed to encompass predominantly viable tumour tissue as
much as possible and avoid areas of pure necrosis. Apo
disation in the time domain was performed using a half Hann
window followed by a fast Fourier transform and automatic
phasing according to .Each spectrum was referenced to both N-
acetyl Aspirate (NAA at 2ppm and a search region ) and
Choline (Cho at 3.21ppm and a search region ) for chemical
shift alignment, and then truncated to the chemical shift range
of 4.0 to 0.2ppm. In addition, the phased real part of the spectra
Integrated Intelligent Research (IIR) International Journal of Data Mining Techniques and Applications
Volume 5, Issue 1, June 2016, Page No.83-86
ISSN: 2278-2419
85
were used for further analysis . Each whole spectrum consisted
of data points representing the majority of metabolic
information.
V. DATA CLUSTERING
To quantitatively validate and compare the efficacy of our
DWT based feature extraction method to previous studies, we
applied agglomerative hierarchical clustering algorithms to the
feature extraction outputs. Compared to widely used k-means
clustering, hierarchical clustering requires no initialization
settings, and thus can avoid possible local minima that could
trap the k-means algorithm. For hierarchical clustering a
dissimilarity measure was specified (the Euclidean distance)
between disjoint groups of observations according to pairwise
dissimilarities between the observations in the two groups.
Figure 5: Comparison between different wavelet basis
functions
VI. PROPOSED SYSTEM
BLOCK DIAGRAM
PREPROCESSING STEPS
PREPROSING
In the preprocessing stage defected input image and database
image are to be taken and on which resize into
320×320pixels.and noise is also removed from both the
images. The images should be of same modalities i.e M.R
images. We can also go with various modalities such as
PETThe input image of size 320×320 is decomposed by using
the Haar wavelet into four frequency bands an Low-Low, Low-
High, High-Low, High-High.
DECOMPOSTION USING HAAR WAVELET
As the decomposition level goes on increasing the resolution of
an image get changed. The LL part contains most of
information and due to which we choose only LL part for
further processing. in which the low-low coefficients are
processed with sub band coding .Similarly the database image
is also decomposed by using Haar wavelet into four sub bands
namely LL, LH, HL, HH. The decomposition of database
image is shown in figure 8. These LL parts are contains most
of information and used for mains processing stage in which
filtering is carried out on the same and contrast enhancement
and brightness enhancement is carried out. This is carried out
with the help of MATLAB in which it shows the
decomposition of both images with precise value and due
which we get better results. The decomposition is carried out in
the pyramid structure, of size as follows:
Pyramid level 1 size of 320×320
Pyramid level 2 size 160×160
Pyramid level 3 size of 80×80
Pyramid level 4 size 40×40
Figure 6: Decompostion Using Haar Wavelet.
Fig. detected tumor by using proposed method. Images from
top left corner (a) database image (b) defected image (C)
detected tumor using proposed method.(d) Database image (e)
defected image (f) detected tumor using proposed method.
VII. RESULT
Input Image and Wavelet Compression
Integrated Intelligent Research (IIR) International Journal of Data Mining Techniques and Applications
Volume 5, Issue 1, June 2016, Page No.83-86
ISSN: 2278-2419
86
IDWT AND DENOISED IMAGE
TUMOR BOUNDARY
VIII. CONCLUSION
In this Report, I proposed the wavelet based brain tumor
detection is the technique in which the tumor is detected by
using the database and input image which is infected by the
tumor and which is decomposed using Haar wavelet and then
the uncommon partis taken into consideration which is nothing
but detected tumor. This algorithm is also suitable for the
detection of mammograms from the breast cancer detection. As
far as this technique is concern is very helpful in brain tumor
detection and crack of bones and mammogram detection in
which database image is get compared with the help of mutual
information matrix with the input image and resultant image is
nothing but the defected breast cancer image from which we
can further get treatment.
References
[1] V. P. Collins, “Brain tumours: classification and genes,” J.
Neurol. Neurosurg. Psychiatry, vol. 75, no. suppl_2, pp.
ii2–ii11, Jun. 2004.
[2] D. N. Louis et al., “The 2007 WHO classification of
tumours of the central nervous system.,” Acta
Neuropathol., vol. 114, no. 2, pp. 97–109, Aug. 2007.
[3] J. Faehndrich et al., “Neuroradiological viewpoint on the
diagnostics of space-occupying brain lesions.,” Clin.
Neuroradiol., vol. 21, no. 3, pp. 123–39, Sep. 2011.
[4] M. Caulo et al., “Data-driven Grading of Brain Gliomas:
A Multiparametric MR Imaging Study,” Radiology, vol.
272, no. 2, 2014.
[5] R. de Graaf, In vivo NMR spectroscopy, 2nd Ed. John
Wiley & Sons, Ltd., 2007.
[6] A. Devos et al., “Classification of brain tumours using
short echo time 1H MR spectra,” J. Magn. Reson., vol.
170, no. 1, pp. 164–175, Sep. 2004.
[7] L. T. Mainardi et al., “A wavelet packets decomposition
algorithm for quantification of in vivo (1)H-MRS
parameters.,” Med. Eng. Phys., vol. 24, no. 3, pp. 201–8,
Apr. 2002.
[8] S. Z. Mahmoodabadi et al., “A Novel m CAD for pediatric
metabolic brain diseases incorporating DW imaging and
MR spectroscopy,” Expert Syst., vol. 30, no. 1, pp. 21–33,
Feb. 2013.
[9] P. Tiwari et al., “Multimodal wavelet embedding
representation for data combination (MaWERiC):
integrating magnetic resonance imaging and spectroscopy
for prostate cancer detection.,” NMR Biomed., vol. 25, no.
4, pp. 607–19, Apr. 2012.
[10]S. Mallat, “A theory for multiresolution signal
decomposition: the wavelet representation,” Pattern Anal.
Mach. Intell. IEEE …, vol. I, no. 7, pp. 674–693, 1989.
[11] L. Chen et al., “An efficient algorithm for automatic
phase

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Discrete Wavelet Transform Based Brain Tumor Detection using Haar Algorithm

  • 1. Integrated Intelligent Research (IIR) International Journal of Data Mining Techniques and Applications Volume 5, Issue 1, June 2016, Page No.83-86 ISSN: 2278-2419 83 Discrete Wavelet Transform Based Brain Tumor Detection using Haar Algorithm R.Sentamilselvan ,M.Manikandan Applied Electronics,Sir issac Newton College of engineering & technology Nagapattinam. Assistant Professor,Department of ECE, Sir issac newton college of engineering & technology ,Nagapattinam Abstract - A brain tumour is an abnormal growth of cells that are spontaneously grows in uncontrolled manner. We can divide tumors in according to how exponentially they developed i.e. growth rate, with lower-grade tumors often being begin and higher-grade tumors being malignant. Based on interpolation of low frequency sub band images obtained by discrete wavelet transform (DWT) and the input image, the brain tumor detection is obtained by using Haar wavelet transform. Database image is also decomposed by using Haar wavelet transform by two levels and this database image is compared with the input image by using Mutual information principle. Both input image and database image is decomposed into different sub bands by using DWT. Interpolation of low frequency sub bands as well as input image is done. The proposed technique that first one is data base image and another is the input image in which both are decomposed into several bands by using wavelet transform and their coefficients are stored into matrix form with the help of MATLAB and these coefficients are compared with the help of mutual information principle. Corrected interpolated high frequency sub-bands and interpolated input image are combined by using inverse DWT (IDWT), finally. Hence, we get a brain tumour detected output image. Key words: Brain tumour, glioma grade, clustering, dimension reduction, discrete wavelet transform, magnetic resonance spectroscopy, unsupervised learning. I. INTRODUCTION Magnetic resonance imaging (MRI) is a widely-used modality that facilitates the diagnosis and prognosis of brain tumours. Standard MRI sequences are routinely used to differentiate among various brain tumour types based on qualitative visual analyses of the represented soft tissue contrast. Indeed, more than 120 classes of brain tumours are known, which are categorised into four grades depending on the level of malignancy by the world health organisation (WHO) . The grading from low to high (I-IV) represents malignancy levels from biologically least aggressive to most aggressive brain tumours as shown by histological criteria, e.g., invasiveness, vascularity, and tumour growth rate . Gliomas are the most common primary brain tumour and pre-treatment assessment of grade is required; however, the sole use of standard MRI sequences may be insufficient for an accurate diagnosis. II. DISCRETE WAVELET TRANSFORM The Wavelet Series is nothing but a sampled version of CWT and its computation may consume significant amount of time and resources which is depending on the resolution required for the signal. The Discrete Wavelet Transform (DWT) is based on sub-band coding is found to yield a fast computation of Wavelet Transform due to which It is easy to implement and reduces the computation time and resources required.Short history about DWT.The foundations of DWT go back to1976 when techniques to decompose discrete time signals were devised which is Similar as work was done in speech signal coding which was named as sub-band coding. In 1983,a technique similar to sub-band coding was developed which was named pyramidal coding .Later many improvements were made to these coding schemes which resulted in efficient multi-resolution analysis schemes.On other hand In CWT, the signals are analyzed using a set of basic functions which relate simple scaling and translation contains only scaling function and translation function. In such case of DWT we obtain at image-scale representation of the digital signal is obtained using digital filtering techniques. The DWT is applied on image is very simple procedure as suppose ω be the image is having ω(j+1,m,n) as j+1 is scaling function m is row vector and n is the columns vector. is applied to the high pass filter hψ(-n) and also to low pass filter h(-n)the filter is applied across the column as „n indicates the column and which divides the total signal into two filters as low pass and high pass filter. Decomposition of an image using DWT The decomposition of image by using wavelet transform. Image is decomposed into four different frequency bands namely HH, HL, LH, LL which contains diagonal contents, vertical contents, horizontal contents and approximate contents. Fig . Shows reverse operation which is taken placed in this figure original image is obtained from combining four decomposed parts by using IDWT. Figure.1: Equivalent image decomposition by using DWT
  • 2. Integrated Intelligent Research (IIR) International Journal of Data Mining Techniques and Applications Volume 5, Issue 1, June 2016, Page No.83-86 ISSN: 2278-2419 84 Figure.2:Equivalent Scheme of Wavelet reconstruction Algorithm III. DWT AND FILTER BANK Multi-Resolution Analysis Using Filter Bank Filters are widely used signal processing functions to remove noise in signals. By using iteration of filters with rescaling, wavelets can be realized. The resolution of the signal is considered by using two terms i.e. measure of the amount of detail information in the signal is determined by the filtering operations and the scaling is determined by up-sampling and down-sampling. Figure.3:Three-level wavelet decomposition tree The DWT is obtained by successive low pass and high pass filtering of the discrete time-domain signal as shown in fig. 3.This is called as Mallat algorithm or Mallat-tree decomposition of signal. Its significance is in the manner of which it connects the continuous- time multi resolution to discrete-time filters. In the figure3. The sequence x[n] is applied to wavelet decomposition tree where n is an integer.G0 is low pass filter reduces approximation a[n] and H0 is high pass filter produces detailed information i.e. d[n]. The time resolution becomes good at high frequencies, while the frequency resolution becomes good at lowfrequencies.Unless and until the desired level of resolution is reached the filtering and decimation process is carried out. The length ofthe signal determines maximum number of levels. The DWT of the original signal is then obtained by concatenating all the coefficients, a[n] and d[n], starting from the last level of decomposition Fig.4:Three-level wavelet reconstruction tree Shows three-level wavelet reconstruction tree There construction is the reverse process of decomposition. The approximation and detail coefficients at every level are up sampled by two, passed through the low pass and high pass synthesis filters and then added. This process is continued through the same number of levels as in the decomposition process to obtain the original signal. The Mallat algorithm works equally well if the analysis filters, G0 and H0, are exchanged with the synthesis filters, G1 and H1. IV. EXISTING SYSTEM MR data were obtained at St. George’s University of London using a 1.5-Tesla scanner (GE Healthcare, Milwaukee, WI, USA), which was equipped with 22 gradients and a quadrature head coil. Written informed consent was obtained from all participants in accordance with local ethics procedures. Either biopsy or resected tumour tissue samples obtained as part of the patients’ clinical diagnosis or treatment were used to provide a histological diagnosis of the tumour type and grade as the overall gold standard (ground truth). In total SV MRS were obtained including 24 Grade II (GII) tumours (2oligodendroglioma, 3 oligo astrocytoma, 3 fibrillary astrocytoma, 4 gemistocytic astrocytoma and 12 diffuse astrocytoma) and 31 Grade IV (GIV, glioblastomamultiforme). A further 79 MR spectra were obtained from three normal controls using multiple voxel MRS with the same acquisition parameters (i.e., which had compatible TR/TE) as the SV MRS All SV MRS data were acquired at short Echo Time (TE) using the GE developed point-resolved spectroscopic sequence (PRESS) protocol (Repetition Time (TR) = 2000ms, Echo time (TE) = 30ms, 2048 data points with 2500Hz bandwidth). An expert panel (including spectroscopists, pathologists and radiologists) validated the brain tissue types included in this study as part of the TUMOUR project, with a histo pathological diagnosis of the central nervous system (CNS) tumours according to WHO criteria. Individual voxels were placed to encompass predominantly viable tumour tissue as much as possible and avoid areas of pure necrosis. Apo disation in the time domain was performed using a half Hann window followed by a fast Fourier transform and automatic phasing according to .Each spectrum was referenced to both N- acetyl Aspirate (NAA at 2ppm and a search region ) and Choline (Cho at 3.21ppm and a search region ) for chemical shift alignment, and then truncated to the chemical shift range of 4.0 to 0.2ppm. In addition, the phased real part of the spectra
  • 3. Integrated Intelligent Research (IIR) International Journal of Data Mining Techniques and Applications Volume 5, Issue 1, June 2016, Page No.83-86 ISSN: 2278-2419 85 were used for further analysis . Each whole spectrum consisted of data points representing the majority of metabolic information. V. DATA CLUSTERING To quantitatively validate and compare the efficacy of our DWT based feature extraction method to previous studies, we applied agglomerative hierarchical clustering algorithms to the feature extraction outputs. Compared to widely used k-means clustering, hierarchical clustering requires no initialization settings, and thus can avoid possible local minima that could trap the k-means algorithm. For hierarchical clustering a dissimilarity measure was specified (the Euclidean distance) between disjoint groups of observations according to pairwise dissimilarities between the observations in the two groups. Figure 5: Comparison between different wavelet basis functions VI. PROPOSED SYSTEM BLOCK DIAGRAM PREPROCESSING STEPS PREPROSING In the preprocessing stage defected input image and database image are to be taken and on which resize into 320×320pixels.and noise is also removed from both the images. The images should be of same modalities i.e M.R images. We can also go with various modalities such as PETThe input image of size 320×320 is decomposed by using the Haar wavelet into four frequency bands an Low-Low, Low- High, High-Low, High-High. DECOMPOSTION USING HAAR WAVELET As the decomposition level goes on increasing the resolution of an image get changed. The LL part contains most of information and due to which we choose only LL part for further processing. in which the low-low coefficients are processed with sub band coding .Similarly the database image is also decomposed by using Haar wavelet into four sub bands namely LL, LH, HL, HH. The decomposition of database image is shown in figure 8. These LL parts are contains most of information and used for mains processing stage in which filtering is carried out on the same and contrast enhancement and brightness enhancement is carried out. This is carried out with the help of MATLAB in which it shows the decomposition of both images with precise value and due which we get better results. The decomposition is carried out in the pyramid structure, of size as follows: Pyramid level 1 size of 320×320 Pyramid level 2 size 160×160 Pyramid level 3 size of 80×80 Pyramid level 4 size 40×40 Figure 6: Decompostion Using Haar Wavelet. Fig. detected tumor by using proposed method. Images from top left corner (a) database image (b) defected image (C) detected tumor using proposed method.(d) Database image (e) defected image (f) detected tumor using proposed method. VII. RESULT Input Image and Wavelet Compression
  • 4. Integrated Intelligent Research (IIR) International Journal of Data Mining Techniques and Applications Volume 5, Issue 1, June 2016, Page No.83-86 ISSN: 2278-2419 86 IDWT AND DENOISED IMAGE TUMOR BOUNDARY VIII. CONCLUSION In this Report, I proposed the wavelet based brain tumor detection is the technique in which the tumor is detected by using the database and input image which is infected by the tumor and which is decomposed using Haar wavelet and then the uncommon partis taken into consideration which is nothing but detected tumor. This algorithm is also suitable for the detection of mammograms from the breast cancer detection. As far as this technique is concern is very helpful in brain tumor detection and crack of bones and mammogram detection in which database image is get compared with the help of mutual information matrix with the input image and resultant image is nothing but the defected breast cancer image from which we can further get treatment. References [1] V. P. Collins, “Brain tumours: classification and genes,” J. Neurol. Neurosurg. Psychiatry, vol. 75, no. suppl_2, pp. ii2–ii11, Jun. 2004. [2] D. N. Louis et al., “The 2007 WHO classification of tumours of the central nervous system.,” Acta Neuropathol., vol. 114, no. 2, pp. 97–109, Aug. 2007. [3] J. Faehndrich et al., “Neuroradiological viewpoint on the diagnostics of space-occupying brain lesions.,” Clin. Neuroradiol., vol. 21, no. 3, pp. 123–39, Sep. 2011. [4] M. Caulo et al., “Data-driven Grading of Brain Gliomas: A Multiparametric MR Imaging Study,” Radiology, vol. 272, no. 2, 2014. [5] R. de Graaf, In vivo NMR spectroscopy, 2nd Ed. John Wiley & Sons, Ltd., 2007. [6] A. Devos et al., “Classification of brain tumours using short echo time 1H MR spectra,” J. Magn. Reson., vol. 170, no. 1, pp. 164–175, Sep. 2004. [7] L. T. Mainardi et al., “A wavelet packets decomposition algorithm for quantification of in vivo (1)H-MRS parameters.,” Med. Eng. Phys., vol. 24, no. 3, pp. 201–8, Apr. 2002. [8] S. Z. Mahmoodabadi et al., “A Novel m CAD for pediatric metabolic brain diseases incorporating DW imaging and MR spectroscopy,” Expert Syst., vol. 30, no. 1, pp. 21–33, Feb. 2013. [9] P. Tiwari et al., “Multimodal wavelet embedding representation for data combination (MaWERiC): integrating magnetic resonance imaging and spectroscopy for prostate cancer detection.,” NMR Biomed., vol. 25, no. 4, pp. 607–19, Apr. 2012. [10]S. Mallat, “A theory for multiresolution signal decomposition: the wavelet representation,” Pattern Anal. Mach. Intell. IEEE …, vol. I, no. 7, pp. 674–693, 1989. [11] L. Chen et al., “An efficient algorithm for automatic phase