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Mitosis
It’s cell cycle time!
10th Grade
Whoa!
Why do we care about mitosis?
Cell Division
ā– Before a cell grows too large, it divides
into two new daughter cells through a
process called ā€œcellular division.ā€
ā– Each daughter cell must receive a
complete set of DNA.
ā– Before cell division, a cell must copy its
DNA. (This is DNA replication!)
Asexual Reproduction
ā– In multicellular organisms, cell reproduction
is how you grow!
āž¢ This also allows an organism to repair
itself.
ā– In single-celled organisms, cellular division is
a kind of asexual reproduction.
ā– This kind of reproduction only needs 1
parent- and leads to genetically identical
offspring.
03
Bacteria reproduce by binary fission.
Starfish can reproduce by fragmentation.
02
Fragmentation
01
Asexual Reproduction Examples
Hydras reproduce by budding.
Budding
Binary Fission
Asexual vs. Sexual Reproduction
Chromosomes
Genetic information is carried by
chromosomes
Remember that chromosomes are
condensed/tightly packed coils of DNA
Each daughter cell gets its own copy of the
genetic information
Cells of every organism have a specific
number of chromosomes.
Prokaryotic Cell Cycle
The prokaryotic cell cycle is a pattern of growth, DNA
replication, and then cell division.
Most begin to copy their DNA once they reach a
certain size.
When DNA replication is complete, the cells divide
through binary fission.
Eukaryotic Cell Cycle
The Eukaryotic Cell cycle has four phases: G1, S, G2,
and M.
Interphase is the time of growth where the cell
performs its normal functions. It includes G1, S, and
G2 phases.
The M phase is the time for cell division.
Cells increase in
size and make
new proteins and
organelles
Eukaryotic Cell Cycle
M phase
Mitosis is the division of
the cell nucleus
Cytokinesis is the
division of the cytoplasm
or body of the cell.
G2
The organelles
required for division
are made. Cell is
preparing for mitosis
G1
S - Phase
DNA replication
takes place and
chromosomes are
duplicated
Important
Structures~
These are all important for
mitosis
ā— Chromatid - each strand of a duplicated
chromosome
ā— Centromere - the area where
chromosomes are joined
ā— Centrioles - tiny structures in the
cytoplasm that help organize the
spindle fibers
ā— Spindle - a fan like structure that helps
to pull apart the chromatids.
During the first phase of mitosis,
the duplicated chromosomes
condense, and become visible in
the nucleus.
The centrioles move to opposite
sides of the nucleus and help
organize the spindle.
The spindle forms and DNA
strands attach at the centromere.
The nucleus begins to break
down
Prophase
During the second phase, the
centromeres of the duplicated
chromosome line up in the
middle of the cell.
The spindle fibers connect to
each side of the centromere.
Metaphase
During the third phase, the
centromeres are pulled apart,
and chromatids begin to
separate into individual
chromosomes.
The chromosomes separate into
two groups at opposite ends of
the cell.
Anaphase
During telophase, the final stage
of mitosis, the chromosomes
spread back out into a tangle of
chromatin.
The nucleus begins to reform
around both sets of genetic
material.
The spindle breaks down during
this stage.
Telophase
Cytokinesis
ā— Cytokinesis is division of the cytoplasm.
ā— This is where the cell begins to physically separate into
two.
ā— The cell membrane is drawn in until the cytoplasm is
pinched in two.
Note that this is NOT a part of mitosis. It is part of the M
phase in the cell cycle, but cytokinesis is a separate but
related process.
Cytokinesis in Plant Cells
Plant cells are not as flexible and easy
to move as animal cells, so they have
to perform cytokinesis a bit differently.
Instead, a cell plate forms between
the divided cells and then a cell wall
forms in between the two new
membranes.
When all is said and done, the process should
result in two genetically identical daughter cells.
MEANING EACH CELL PRODUCED HAS THE SAME
NUMBER OF CHROMOSOMES AS THE PARENT CELL
End Result of Mitosis
Checkpoint!
The main checkpoints
occur at G1, G2, and
during the Metaphase -
Anaphase transition
Just like in a video game, the
cell cycle has different
ā€œcheckpointsā€
If there is anything wrong
with the cell (such as errors
in DNA replication), the cell
will not undergo mitosis.
Nothing is Perfect
Just like with most things in life, this process is not
100% foolproof.
Sometimes things do go wrong with the
checkpoints, and a damaged or diseased cell will be
allowed to divide.
Some types of diseases take advantage of this, and
are caused by failures of the cell cycle checkpoints to
regulate division.