A Commercial Driver's License (CDL) is required to operate specific vehicles like trucks and buses, regulated by federal laws in the U.S. There are three classes of CDL: Class A for combination vehicles over 26,001 pounds, Class B for single vehicles over 26,001 pounds, and Class C for vehicles transporting hazardous materials or over 16 passengers. Requirements for obtaining a CDL vary by state but generally include a valid non-commercial driver's license, age restrictions, medical certification, and completion of specific training.