This document discusses alcoholic liver disease and cirrhosis. It covers the pathology and symptoms of alcoholic hepatitis and cirrhosis, including jaundice, hepatomegaly, portal hypertension, and fibrosis. It also mentions common lab abnormalities seen in alcoholic liver disease such as anemia, increased bilirubin, AST>ALT. Potential treatments discussed include pentoxyfilline, steroids, and acamprosate to aid abstinence from alcohol. The Lille score is mentioned as a method to assess treatment response to steroids in alcoholic hepatitis using 6 variables.

1. cirrhosis

2. Alcoholic hepatitis
• 60-80 g/d
• Fatty liver
1. Abnormal LFT
2. Large liver

3. • Alcoholic hepatitis
1. Jaundice
2. Hepatomegaly
3. Portal HTN
Pathology
1. Balloning degeneratiobn
2. Neutophill infiltration
3. Mallory bodies
4. Some fibrosis
Mallory bodies
1. Non alcoholic liver disease
2. Alcoholic liver disease
3. Wilsosn disease
4. Primary bilary cirhosis
5. HCC
Composed of intermediate filaments

4. • Cirrhosis
1. Large/smalal/normal size
2. Portal HTN
3. HCC
• Stigmata
Pathology-cirhosis
1. Fibrosis-laennac

5. lab
• Anemia
• Nutritional
• Bone marrow suppression
• Hemolytic anemia –Zieve syndrome
• Increase Tg ,PT,Bilurubin
• AST>ALT

6. Treatment
• Pentoxyfilline-non specific TNF inhibitor (reduce mortality
• Steroids
• Acamprosate – abstinace from alcohol

7. Lille score
• assess tx response to steroid in alcoholic hepatitis
• 6 variable
1. Age
2. Renal insufficieanvcy
3. Albumin
4. PT
5. Bilurubin
6. Evolution bilirubin in a day