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Cefiderocol
周孫鴻藥師
抗生素新藥Cefiderocol
作用
 屬於鐵載體(siderophore )的cephalosporin
 Catechol支鏈~ 能和三價鐵螯合,好騙過
GNB(gram-negative bacilli)誤以為是鐵而吸進
去
 Cephalosporin部分~ 抑制細胞壁的合成
Spectrum
 Gram-positive (X)
 Anaerobic activity (X)
 Gram-negative (O)~ESBL、CRAB、CRKP、
CRPA….
針對感染部位
 Urinary tract infection
 Pneumonia, hospital-acquired or
ventilator-associated
劑量
 2 g every 8 hours
 IV: Administer by intermittent IV infusion
over 3 hours
 For multidrug-resistant pathogens: extended
infusions over 3 hours
調整劑量
 CrCl ≥120 mL/minute: 2 g every 6 hours.
 CrCl 60 to <120 mL/minute: 2 g every 8 hours.
 CrCl 30 to <60 mL/minute: 1.5 g every 8 hours.
 CrCl 15 to <30 mL/minute: 1 g every 8 hours.
 CrCl <15 mL/minute: 750 mg every 12 hours.
 Hemodialysis, intermittent (three times weekly):
750 mg every 12 hours
周藥師補充
 Carbapenemase-producing gram-negative bacilli
的選項:
 Colistin (台灣有)
 Ceftazidime-avibactam (台灣有)
 Ceftolozane-tazobactam (台灣有,針對 P.
aeruginosa)
 Meropenem-vaborbactam
 Imipenem-cilastatin-relebactam
 Cefiderocol

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