Cascade R-CNN proposes a cascade architecture to address issues with training object detectors at a single IoU threshold. It trains sequential stages with increasing IoU thresholds from 0.5 to 0.7. Each stage takes the outputs from the previous as proposals to train on, closing the quality gap between proposals and detections. This allows the detectors to specialize in a single IoU level and prevents overfitting from low positive examples at higher thresholds.