This document summarizes the development of Nigeria's National Operational Plan for HIV/AIDS (NOP-II) with support from MEASURE Evaluation. Key steps included assessing Nigeria's national HIV/AIDS information system, gaining stakeholder buy-in, establishing steering committees and technical working groups, holding technical meetings and workshops, validating the plan with stakeholders, finalizing and disseminating NOP-II, and identifying next steps. Some outcomes of working with MEASURE Evaluation were improved coordination of stakeholders, development of M&E system plans and documents, improved data availability and quality, capacity building, and work at the state level.