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Ion Proton Sequencer
    Jay Wyn; Liang Zhu; Yutong; Swathi; Magdeline; James
Ion Proton DNA Sequencer
Content
•   Introduction
•   Value Proposition
•   Value Added – Cloud Service
•   Value Capture
•   Strategic Control
•   Potential Market
What is DNA Sequencing?

• Process of reading
  nucleotide bases in a DNA
  molecule
• DNA Consist of four type
  of bases:
  • Thymine, Adenine, Guanine,
    Cytosine
• Current DNA Sequencing is
  called Next Generation
  Sequencing (NGS)
Source: http://bioweb.wku.edu/courses/biol350/dnasequencing13/review.html
Why DNA Sequencing?

• Study of building blocks of humans and other organisms
• Study of bacteria virus, leads to better cure and
  prevention
   – 2011, outbreak of e-coli virus. DNA sequencing was used to
     better understand traits like toxicity and immunity to which
     antibiotic.
• Future, help with early detection or early warning that a
  patient may have a certain disease
• Becoming very cheap, so it is becoming affordable
Key Players

        Roche’s 454

        • GS Junior System (Late 2009)
        • GS FLX+ System (2008)

        Illumina

        • Illumina MiSeq (2010)
        • Illumins HiSeq (2010/2012)

        Life’s Ion Torrent

        • Personal Genome Machine (PGM) (Late 2010)
        • Ion Proton (2012)

        Oxford Nanopore Technologies

        • MinION
        • GridION
Comparison
• Roche’s 454
• GS Junior, GS Flx+
• Uses Pyrosequencing


               • Illumina
               • Miseq, Hiseq
               • Uses Solexa Sequencing
Ion Proton
• PGM, Ion Proton I
• Uses Semiconductor Sequencing
• Measures the hydrogen ion production during
  polymerization of the DNA
Sequencing by Synthesis


 Ion Torrent H+
Detection using an
   Ion Sensor




Illumina and Roche
   Pyrophosphate
   Detection Using
       Optics
Technology Comparison
• Detection of ion release is
  simpler and faster than
  optical method from 454
  Sequencing and Illumina
• Ion proton uses
  semiconductor, thus is able
  to improve at a high rate in
  the future
   314 Chip       316 Chip        318 Chip        Proton 1       Proton 2
  (1.2 Million   (6.2 Million   (11.1 Million   (165 Million   (660 Million
    Wells)         Wells)          Wells)          Wells)         Wells)
Moore’s Law
Threats
• Oxford Nanopore Technologies
• MinION (Disposable), GridION
• Uses nanopore sequencing, which measures
  electric inductance of the nucleotides
Strategy Canvas for Life Technologies


               5

               4
    Scoring




               3

               2

               1

               0

                                                                     Ion proton


                              Factors of Competition                 illumina's HiSeq
                                                                     2500



              Fair comparison of Illumina’s HiSeq 2500 and Ion proton:
                   •Same time of release (10th January 2012)
                   •Both claims to sequence an entire genome
Value Proposition



        Cheaper     Faster   Smaller




              Ion Proton
Value Proposition

     Cheaper             Faster                Smaller



   Machine price:         IP: 2hrs
      IP:149K                Vs           IP: Benchtop sequencer
         vs           HiSeq2500: 27hrs
  Hiseq2500:$740K



  Seq price/genome:
        IP:1K
          vs          Higher throughput
   Hiseq2500:$3-5K
Customer Selection

                                    Universities
                   Research
                   Centres

                                                     Final
                                                     User
                                         Immediate
           Government                    Users
                vs
              Private
(E.g. govt funded genome centres)
Customer Selection
Clothes,
furniture,
Bio-synthetic                     Consumer                               Targeted
                                                     Drug
                                  products                               drugs
detergents                                           companies




Bio-Fuels,          Alternative
Fuels from          energy                   Other
Virus                                        Researchers            Produce human-
                                                                    compatible
                                                                    proteins from
                                                                    other organisms
   More resistant
   crops  better                 Agriculture
   yields                                             Genetic
                                                      Engineering
Drug Development:
Traditional Value Chain
    1990’s Value chain : Step-by-step




 Improved value chain: Simultaneous activities
Role of Ion Proton




  DNA sequencing with Ion Proton make target discovery faster
   faster product development.
Value Chain Of Drug Development
            Pharma
Global Market Analysis
If genome sequenced for < $1K…
 App
 Developers                       Seq.
                                  Techniques
                  Seq.
                  Firms                        Seq.
                                               Instrument




    New                                                     SHAKE
    Entries –             Improvements
                                                            OUT?
    competition
Emerging Needs



               Head towards…

Data
Processing:        Hardware    Capture
Analyzing              +       market share
 and                           to reap
interpreting      SERVICE      benefits from
services                       network
                               effects
Cloud Service

                  Ion Reporter




       Future                     Multisided
    Development                    platform




                   Enhanced
                  Data Mobility
Ion Reporter
               • Import, annotation, analysis, archive
                   Reduce workload, shortening time
                   Flexible, reproducible

                                            Integrated
                                            Annotation
                           Ion Reporter
          Sequencing                       Configurable
            reads                           Analysis

                                            Archiving




                                              Standard
Ion Reporter
               • Cloud based
                   Cost-saving, highly secure
               • Open source
                   Allows inspection and improvements
               • Aim to create Standard

               Speed, Simple, Scalable, Secure




                                             Standard
Multisided
 platform
             • Clients --Our services -- App developers
             • Dynamic Eco-environment
                 Enhanced communication
                 Targeted problem-solving
             • “One-stop shopping” for sequencing users
                    Clients    App developers/ Bioinformatics
                                               companies




                                         Network Effect
Enhanced
Data Mobility
                • Sharing the info with greater ease
                      - Apps for desktop, laptop, iPad
                • Monitoring progress; noticing results
Future
Development


      • Cooperate with Clinics and Hospitals to
        build a non-profitable database for
        treatment and research
      • Improve healthcare services
      • A one-stop workstation for our clients
Value Capture
              1. Traditional
             method, Short-                                5. Lisciencing/
              term primary                                 Commision.
                                    Sales    Cloud         Long-term goal




                      Maintenance
                                                       4. Accept
  2. Free for a few                                    request for one-
times and charge                                       time or multiple-
     subsequently                            Service   time sequencing



  3. Rent out the
  machine to
  targeted
  customers                         Rental
Value Capture
  Sales/
 Upgrades     • Cheaper, Faster, Smaller
                           Machine      Cost per    Sequencing Throughput
                           Cost (USD)   Run (USD)   Run-Time
       Ion Torrent’s Ion
                             149k         1000       2-4 hrs     10 Gb
       Proton I
       Ion Torrent’s PGM
                              50k          750       2-3 hrs     1 Gb
       (318 Chip)
       Illumina Hiseq
                             740k        23,000       27 hrs    120 Gb
       2500
       Illumina Miseq        125k          965        1 day      4 Gb
       Roche 454 - GS
                             150k         6000        23 hrs    700 Mb
       FLX Titanium XL+
       Roche 454 - GS
                             500k         1000        10 hrs     35 Mb
       junior
Value Capture
              1. Traditional
             method, Short-                                5. Licensing/
              term primary                                 Commision.
                                    Sales    Cloud         Long-term goal




                      Maintenance
                                                       4. Accept
  2. Free for a few                                    request for one-
times and charge                                       time or multiple-
     subsequently                            Service   time sequencing



  3. Rent out the
  machine to
  targeted
  customers                         Rental
Cash Flow

                            End user



     $

         Tranditional
                             Cloud
         Activities



         $              $


                              App developers
Strategic Control

 Nature

          • New entrants tend to utilize new
            technology

          • Semi-conductors DNA Sequencing
            technology is hard to reverse-
            engineer
Strategic Control

Patents
Potential market
Applications

     Mitochondrial Disease    Clinical research




       Better diagnosis         Better result

        Replace the current   Improve the quality of
        invasive and costly    researches as well as
        muscle biopsy test.   provide new directions
                                  for researching.
Mitochondrial disease
• Mitochondrial disease
   – A group of diseases which are characterized by
     problems of decreased energy production.
• Muscle biopsy
   – Invasive & costly (as high as $50.000).
   – Complicated & time-consuming.
   – Cannot produce absolute results.
• Benefits
   – Cost: $1k + analyzing cost vs. $20k-50k.
   – Time: A few days vs. 3-4 weeks.
   – Quality: more absolute results.
Applications

     Mitochondrial Disease    Clinical research




       Better diagnosis         Better result

        Replace the current   Improve the quality of
        invasive and costly    researches as well as
        muscle biopsy test.   provide new directions
                                  for researching.
Clinical research

• Improved quality
   – Combine test results with test subjects’ genetic data to
     derive more detailed results.
       • Provide basis for personalized treatment.
  – Build up a gene database that stores more than the raw
    genetic data for future researches.
• New directions
  – Discover the existence of previously unknown
    mutations as origins of disease.
Clinical research


     Patient                      Researcher

   More patients                    More data
        =                               =
    More data                    More researchers



                      Network
                       effect
Research quality                App developer

  More data + tools              More researchers
         =                               =
  Improved quality              More app developers
Thank You

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Biz model for ion proton dna sequencer

  • 1. Ion Proton Sequencer Jay Wyn; Liang Zhu; Yutong; Swathi; Magdeline; James
  • 2. Ion Proton DNA Sequencer
  • 3. Content • Introduction • Value Proposition • Value Added – Cloud Service • Value Capture • Strategic Control • Potential Market
  • 4. What is DNA Sequencing? • Process of reading nucleotide bases in a DNA molecule • DNA Consist of four type of bases: • Thymine, Adenine, Guanine, Cytosine • Current DNA Sequencing is called Next Generation Sequencing (NGS)
  • 6. Why DNA Sequencing? • Study of building blocks of humans and other organisms • Study of bacteria virus, leads to better cure and prevention – 2011, outbreak of e-coli virus. DNA sequencing was used to better understand traits like toxicity and immunity to which antibiotic. • Future, help with early detection or early warning that a patient may have a certain disease • Becoming very cheap, so it is becoming affordable
  • 7. Key Players Roche’s 454 • GS Junior System (Late 2009) • GS FLX+ System (2008) Illumina • Illumina MiSeq (2010) • Illumins HiSeq (2010/2012) Life’s Ion Torrent • Personal Genome Machine (PGM) (Late 2010) • Ion Proton (2012) Oxford Nanopore Technologies • MinION • GridION
  • 8. Comparison • Roche’s 454 • GS Junior, GS Flx+ • Uses Pyrosequencing • Illumina • Miseq, Hiseq • Uses Solexa Sequencing
  • 9. Ion Proton • PGM, Ion Proton I • Uses Semiconductor Sequencing • Measures the hydrogen ion production during polymerization of the DNA
  • 10. Sequencing by Synthesis Ion Torrent H+ Detection using an Ion Sensor Illumina and Roche Pyrophosphate Detection Using Optics
  • 11. Technology Comparison • Detection of ion release is simpler and faster than optical method from 454 Sequencing and Illumina • Ion proton uses semiconductor, thus is able to improve at a high rate in the future 314 Chip 316 Chip 318 Chip Proton 1 Proton 2 (1.2 Million (6.2 Million (11.1 Million (165 Million (660 Million Wells) Wells) Wells) Wells) Wells)
  • 13. Threats • Oxford Nanopore Technologies • MinION (Disposable), GridION • Uses nanopore sequencing, which measures electric inductance of the nucleotides
  • 14. Strategy Canvas for Life Technologies 5 4 Scoring 3 2 1 0 Ion proton Factors of Competition illumina's HiSeq 2500 Fair comparison of Illumina’s HiSeq 2500 and Ion proton: •Same time of release (10th January 2012) •Both claims to sequence an entire genome
  • 15. Value Proposition Cheaper Faster Smaller Ion Proton
  • 16. Value Proposition Cheaper Faster Smaller Machine price: IP: 2hrs IP:149K Vs IP: Benchtop sequencer vs HiSeq2500: 27hrs Hiseq2500:$740K Seq price/genome: IP:1K vs Higher throughput Hiseq2500:$3-5K
  • 17. Customer Selection Universities Research Centres Final User Immediate Government Users vs Private (E.g. govt funded genome centres)
  • 18. Customer Selection Clothes, furniture, Bio-synthetic Consumer Targeted Drug products drugs detergents companies Bio-Fuels, Alternative Fuels from energy Other Virus Researchers Produce human- compatible proteins from other organisms More resistant crops  better Agriculture yields Genetic Engineering
  • 19. Drug Development: Traditional Value Chain 1990’s Value chain : Step-by-step Improved value chain: Simultaneous activities
  • 20. Role of Ion Proton DNA sequencing with Ion Proton make target discovery faster  faster product development.
  • 21. Value Chain Of Drug Development Pharma
  • 23. If genome sequenced for < $1K… App Developers Seq. Techniques Seq. Firms Seq. Instrument New SHAKE Entries – Improvements OUT? competition
  • 24. Emerging Needs Head towards… Data Processing: Hardware Capture Analyzing + market share and to reap interpreting SERVICE benefits from services network effects
  • 25. Cloud Service Ion Reporter Future Multisided Development platform Enhanced Data Mobility
  • 26. Ion Reporter • Import, annotation, analysis, archive  Reduce workload, shortening time  Flexible, reproducible Integrated Annotation Ion Reporter Sequencing Configurable reads Analysis Archiving Standard
  • 27. Ion Reporter • Cloud based  Cost-saving, highly secure • Open source  Allows inspection and improvements • Aim to create Standard Speed, Simple, Scalable, Secure Standard
  • 28. Multisided platform • Clients --Our services -- App developers • Dynamic Eco-environment  Enhanced communication  Targeted problem-solving • “One-stop shopping” for sequencing users Clients App developers/ Bioinformatics companies Network Effect
  • 29. Enhanced Data Mobility • Sharing the info with greater ease - Apps for desktop, laptop, iPad • Monitoring progress; noticing results
  • 30. Future Development • Cooperate with Clinics and Hospitals to build a non-profitable database for treatment and research • Improve healthcare services • A one-stop workstation for our clients
  • 31. Value Capture 1. Traditional method, Short- 5. Lisciencing/ term primary Commision. Sales Cloud Long-term goal Maintenance 4. Accept 2. Free for a few request for one- times and charge time or multiple- subsequently Service time sequencing 3. Rent out the machine to targeted customers Rental
  • 32. Value Capture Sales/ Upgrades • Cheaper, Faster, Smaller Machine Cost per Sequencing Throughput Cost (USD) Run (USD) Run-Time Ion Torrent’s Ion 149k 1000 2-4 hrs 10 Gb Proton I Ion Torrent’s PGM 50k 750 2-3 hrs 1 Gb (318 Chip) Illumina Hiseq 740k 23,000 27 hrs 120 Gb 2500 Illumina Miseq 125k 965 1 day 4 Gb Roche 454 - GS 150k 6000 23 hrs 700 Mb FLX Titanium XL+ Roche 454 - GS 500k 1000 10 hrs 35 Mb junior
  • 33. Value Capture 1. Traditional method, Short- 5. Licensing/ term primary Commision. Sales Cloud Long-term goal Maintenance 4. Accept 2. Free for a few request for one- times and charge time or multiple- subsequently Service time sequencing 3. Rent out the machine to targeted customers Rental
  • 34. Cash Flow End user $ Tranditional Cloud Activities $ $ App developers
  • 35. Strategic Control Nature • New entrants tend to utilize new technology • Semi-conductors DNA Sequencing technology is hard to reverse- engineer
  • 38. Applications Mitochondrial Disease Clinical research Better diagnosis Better result Replace the current Improve the quality of invasive and costly researches as well as muscle biopsy test. provide new directions for researching.
  • 39. Mitochondrial disease • Mitochondrial disease – A group of diseases which are characterized by problems of decreased energy production. • Muscle biopsy – Invasive & costly (as high as $50.000). – Complicated & time-consuming. – Cannot produce absolute results. • Benefits – Cost: $1k + analyzing cost vs. $20k-50k. – Time: A few days vs. 3-4 weeks. – Quality: more absolute results.
  • 40. Applications Mitochondrial Disease Clinical research Better diagnosis Better result Replace the current Improve the quality of invasive and costly researches as well as muscle biopsy test. provide new directions for researching.
  • 41. Clinical research • Improved quality – Combine test results with test subjects’ genetic data to derive more detailed results. • Provide basis for personalized treatment. – Build up a gene database that stores more than the raw genetic data for future researches. • New directions – Discover the existence of previously unknown mutations as origins of disease.
  • 42. Clinical research Patient Researcher More patients More data = = More data More researchers Network effect Research quality App developer More data + tools More researchers = = Improved quality More app developers