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How drugs work? Or How do they  ‘know’  to go from my stomach to my head and not my foot?
Basic Biopharmaceutics The Adventure Begins
Objective of Drug Therapy ,[object Object],[object Object]
Clinical Trials ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Generic Medications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of Drug Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Receptors  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Concentration & Effect ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Time Blood level
….OR  ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Bioequivalence Terms ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacokinetics  Pharmacodynamics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Absorption  Distribution ,[object Object],[object Object],[object Object],[object Object],[object Object]
Metabolism  Excretion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors Affecting Drug Response ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adverse Drug Reactions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug-Drug Interactions Urinary Re-absorption Enzyme inhibition Gastric pH Intestinal Metabolism GFR Renal Secretion Enzyme induction Displacemt and effect Binding in GIT GI empty Excretion Metabolism Distribution Absorption
Drug-Diet Interactions Specific Foods Protein Inc.GFR Dec.reabsorption Dec.secretion in the kidney Food Mix Protein Carbohydrate Fat Calories Food Hi fat meals Level of nourishment AdminTime Gastric emptying Gastric motility Dosage form Interacting chemically Excretion Metabolism Distribution Absorption
Drug Disease States Hypo- Hyper- Effect on drug elimination Effect on plasma protein binding Creatinine levels Cardiovascular Disorders Decrease Blood  Flow erratic absorptn liver metabolm  Cirrhosis Obstructive jaundice Acute viral hepatitis Thyroid Renal Circulatory Hepatic
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Summary Slide
Precipitating Event 1 st  Week SRJC Professional Program ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Basic biopharmaceutics, pharmacokinetics, pharmacodynamics

  • 1. How drugs work? Or How do they ‘know’ to go from my stomach to my head and not my foot?
  • 2. Basic Biopharmaceutics The Adventure Begins
  • 3.
  • 4.
  • 5.  
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.  
  • 12.  
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19. Drug-Drug Interactions Urinary Re-absorption Enzyme inhibition Gastric pH Intestinal Metabolism GFR Renal Secretion Enzyme induction Displacemt and effect Binding in GIT GI empty Excretion Metabolism Distribution Absorption
  • 20. Drug-Diet Interactions Specific Foods Protein Inc.GFR Dec.reabsorption Dec.secretion in the kidney Food Mix Protein Carbohydrate Fat Calories Food Hi fat meals Level of nourishment AdminTime Gastric emptying Gastric motility Dosage form Interacting chemically Excretion Metabolism Distribution Absorption
  • 21. Drug Disease States Hypo- Hyper- Effect on drug elimination Effect on plasma protein binding Creatinine levels Cardiovascular Disorders Decrease Blood Flow erratic absorptn liver metabolm Cirrhosis Obstructive jaundice Acute viral hepatitis Thyroid Renal Circulatory Hepatic
  • 22.
  • 23.
  • 24.