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PRESENTED BY
ANSARI AASHIF RAZA MOHD IMTIYAZ
(I year M.PHARM)
DEPARTMENT OF PHARMACOLOGY
TOPIC:- A] SEDATIVE AND HYPNOTICS
B] DRUGS USED TO TREAT ANXIETY
C] DEPRESSION
D] PHYCOSIS
E] MANIA
INTRODUCTION
• SEDATIVE : sedative which cause calming effect and reduce
excitement without inducing sleep.
• HYPNOTICS : hypnotics causes sleep which resembles = natural sleep
Classification of sleep;
1. NREM: non rapid eye movement ‘[it consists 4 stages ]’
2. REM: rapid eye movement
Stages of NREM Sleep::
1. Stage 0: from lying to fall sleep
2. Stage 1: a]eye movement decreases , b] body muscle relaxes 5-10% of total
sleep
3. Stage 2: a]more decrease in eye movement b] person may arousable [50%]
4. Stage 3: deeper sleep with minimum eye movement
5. Stage 4: a]deepest level of sleep b]growth hormone secretion is highest
c]no eye movement d] if awakened disorientation for 1-2 minutes
REM Sleep
1. It is associated with dreaming
2. Enhanced heart rate , breathing and brain activity
3. Relaxation of voluntary muscle
INSOMNIA
Primary 1O secondary 2O
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
BARBITURATE
• It is well absorbed after oral administration and distribute throughout
the body
• Distribution and duration of action determined by lipid solubility .
• At low dose , produce sedation
• At higher dose, cause hypnosis , followed by anesthesia [loss of
feelings or sensation] and finally coma and death.
ACTION OF BARBITURATES
• CNS: a]sedation and hypnosis b] reduce anxiety c] produce euphoria
d] hyperalgesia– increase sensitivity to pain
e] anaethesia [in high dose] f] anti convulsant effect .
• Respiratory: a]respiratory depression
b] respiratory paralysis [high dose ]
• Cardiovascular :a] slight reduction in blood pressure + heart rate
[at high dose ]
• Skeletal muscle : a] muscle relaxant
b]decrease excitability at neuromuscular junction
TREATMENT
1. Activated charcoal
2. Haemodialysis
3. Artificial ventilation
4. Gastric lavage
5. Forced alkaline diuresis
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
DRUG USED TO TREAT ANXIETY
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
ANTI DEPRESANTS
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
MECHANISM
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx
A] SEDATIVE AND HYPNOTICS                B] DRUGS USED TO TREAT ANXIETY                C] DEPRESSION                D] PHYCOSIS                E] MANIA.pptx

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A] SEDATIVE AND HYPNOTICS B] DRUGS USED TO TREAT ANXIETY C] DEPRESSION D] PHYCOSIS E] MANIA.pptx

  • 1. PRESENTED BY ANSARI AASHIF RAZA MOHD IMTIYAZ (I year M.PHARM) DEPARTMENT OF PHARMACOLOGY TOPIC:- A] SEDATIVE AND HYPNOTICS B] DRUGS USED TO TREAT ANXIETY C] DEPRESSION D] PHYCOSIS E] MANIA
  • 2. INTRODUCTION • SEDATIVE : sedative which cause calming effect and reduce excitement without inducing sleep. • HYPNOTICS : hypnotics causes sleep which resembles = natural sleep Classification of sleep; 1. NREM: non rapid eye movement ‘[it consists 4 stages ]’ 2. REM: rapid eye movement
  • 3. Stages of NREM Sleep:: 1. Stage 0: from lying to fall sleep 2. Stage 1: a]eye movement decreases , b] body muscle relaxes 5-10% of total sleep 3. Stage 2: a]more decrease in eye movement b] person may arousable [50%] 4. Stage 3: deeper sleep with minimum eye movement 5. Stage 4: a]deepest level of sleep b]growth hormone secretion is highest c]no eye movement d] if awakened disorientation for 1-2 minutes REM Sleep 1. It is associated with dreaming 2. Enhanced heart rate , breathing and brain activity 3. Relaxation of voluntary muscle
  • 12. BARBITURATE • It is well absorbed after oral administration and distribute throughout the body • Distribution and duration of action determined by lipid solubility . • At low dose , produce sedation • At higher dose, cause hypnosis , followed by anesthesia [loss of feelings or sensation] and finally coma and death.
  • 13. ACTION OF BARBITURATES • CNS: a]sedation and hypnosis b] reduce anxiety c] produce euphoria d] hyperalgesia– increase sensitivity to pain e] anaethesia [in high dose] f] anti convulsant effect . • Respiratory: a]respiratory depression b] respiratory paralysis [high dose ] • Cardiovascular :a] slight reduction in blood pressure + heart rate [at high dose ] • Skeletal muscle : a] muscle relaxant b]decrease excitability at neuromuscular junction
  • 14. TREATMENT 1. Activated charcoal 2. Haemodialysis 3. Artificial ventilation 4. Gastric lavage 5. Forced alkaline diuresis
  • 17. DRUG USED TO TREAT ANXIETY