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I	want	to	thank	the	organizers	for	putting	together	this	
excellent	meeting,	it’s	really	inspiring	to	see	the	quality	
of	starts	up	in	the	competition	and	the	science	going	on	
in	academic	institutions	in	Cyprus	-	and	I	hope	that	this	is	
the	beginning	of	a	long	term	concerted	effort.	
	
Let	me	start	by	introducing	myself	–	I	am	Cypriot,	who	
studied	engineering	at	Princeton	and	MIT	and	business	at	
Stanford	–I	spent	my	career-	in	early	stage	companies	at	
the	intersection	of	technology	and	business	–		
	
I	have	been	involved	in	three	start	ups,		
	
the	first	one	saw	a	meteoric	growth	before	coming	
crushing	down	and	eventually	shutting	down	–	a	painful	
experience	at	the	time	but	with	the	benefit	of	time	I	can	
call	a	“learning	experience”.		
	
the	second	one	saw	lots	of	ups	and	down	over	a	period	
of	more	than	a	decade	but	did	end	up	with	success	–	it	
brought	an	important	cancer	drug	to	market	–	a	drug	
that	is	the	standard	of	care	globally		for	a	hematological
malignancy	called	MM	–	the	company	launched	the	
product	and	achieved	profitability	but	as	a	result	of	this	
success	it	was	acquired	by	a	major	pharmaceutical	
company	called	Takeda.			
	
For	several	years	after	the	acquisition,	I	worked	for	
Takeda	Pharmaceuticals	responsible	among	other	things	
for	leading	partnerships	with	start	up	companies,	and	
investing	the	company’s	venture	fund.		This	gave	me	the	
opportunity	to	participate	in	the	creation	of	start-ups	
from	the	perspective	of	a	bigger	company.		
	
The	third	start	up	is	the	one	I	am	currently	running	–		
Mersana	Therapeutics	-	working	on	a	novel	approach	to	
cancer	therapy	-	it’s	had	some	early	wins	in	the	past	
three	years	by	bringing	two	products	into	clinical	
development	and	raised	significant	funding.		Off	course,	
as	in	all	start	up	situations,	we	have	a	long	way	to	go	
before	we	have	a	product	that	helps	patients	and	
delivers	revenues	–	we	cannot	yet	declare	success.
Life	in	a	start	up	company	is	never	a	linear	activity	–	it	
often	feels	like	being	on	a	rollercoaster	ride	that’s	keeps	
going	and	going	and	has	to	stop…..….at	Mersana,	every	
experiment	we	do,	every	patient	we	treat	brings	us	one	
step	closer	or	one	step	away	from	achieving	our	goal	–	in	
my	three	years	at	Mersana	Therapeutics,	I	came	close	to	
shutting	down	the	company	twice	times.	So	for	all	of	you	
entrepreneurs	in	the	room,	make	sure	you	are	
passionate	about	your	idea,	that	you	have	strong	
conviction	about	its	potential	–	because	that	is	what	is	
going	to	sustain	you	on	the	days	when	the	experimental	
results	come	out	negative,	when	a	customer	turns	you	
down,	when	things	don’t	go	your	way.		And	surround	
yourself	with	the	best	people	you	can	find.		In	a	small	
company,	every	person	makes	a	difference.		
	
In	the	united	states	and	more	specifically	areas	such	as	
Boston	and	the	San	Francisco’s	Bay	area	have	a	rich	
entrepreneurial	ecosystem	that	greatly	facilitates	the	
commercialization	of	new	science	and	technology.	
Hundreds	of	companies	like	the	ones	I	have	been	
involved	in	are	founded	every	year	–	As	we	embark	on	an	
effort	to	foster	such	an	ecosystem	in	Cyprus,	it	is	worth	
stepping	back	and	asking	–	which	of	these	four	success
factors	exist	in	Cyprus	and	which	do	we	need	to	
cultivate?		
	
I	would	argue	that	there	are	four	key	components	
1)Entrepreneurs	with	the	vision	and	the	willingness	to	
take	risk-	the	passion	to	make	their	vision	a	reality	
2)A	highly	educated	and	well-trained	work	force	to	
help	execute	on	that	vision,	a	work	force	that	can	
operate	on	a	global	basis	
3)A	favorable	regulatory	framework	that	facilitates	the	
creation	of	entrepreneurial	companies	and	
minimizes	the	bureaucratic	costs	and	complexities	
that	can	burden	a	small	company	
4)Access	to	capital	–	commercializing	new	
technologies	can	be	very	expensive,	few	start-ups	
make	it	to	profitability	immediately,		
	
After	today’s	session,	I	am	even	more	convinced	than	I	
was	earlier	that	we	have	both	the	passionate	and	driven		
entrepreneurs	as	well	as	the	well	trained	work	force,	
both	foundational	for	building	a	strong	entrepreneurial	
eco	system.
So	how	about	a	favorable	regulatory	framework?		I	must	
admit	that	I	am	far	from	an	expert	on	the	state	of	affairs	
in	Cyprus	–	However,	I	do	know	that	one	of	the	critical	
legislations	enacted	in	the	US	in	1980	that	accelerated	
the	commercialization	of	technologies	out	of	universities	
and	other	federally	funded	research	organization	was	the	
Bayh-Dole	act.		This	legislation	not	only	has	led	to	the	
creation	of	tens	of	thousands	of	startups,	it	has	also	been	
beneficial	financially	to	the	academic	and	research	
institutions	that	sourced	the	innovation.		A	patent	to	a	
chemical	licensed	to	Eli	Lilly	that	became	a	block	buster	
cancer	drug	treating	thousands	of	people	yearly	with	
lung	cancer,	has	accrued	over	half	a	billion	dollars	to	
Princeton	university,	money	poured	back	into	university	
research.		Stanford	University	has	received	to	date	over	
$300mm	for	the	algorithm	that	led	to	the	creation	of	
Google,	again	funds	that	have	been	poured	back	into	
research.		Such	legislation,	if	not	in	place,	should	be	
considered	in	Cyprus	–	its	really	a	win-win	situation	for	
the	entrepreneurs,	the	university	and	the	country	
overall.	Other	policy	aspects	that	can	spur	innovation	
such	as	tax	incentives	should	be	considered	as	well.		
Access	to	capital	is	probably	the	most	challenging	aspect	
–	the	current	effort	with	the	support	of	the	Hellenic
Initiative	is	a	great	starting	point	but	as	these	early	
companies	succeed,	these	efforts	will	require	capital,	
often	an	order	of	magnitude	more	capital	could	be	
needed	in	the	later	stages	of	commercialization.		it	will	
take	time	to	establish	a	track	record	of	entrepreneurship	
in	Cyprus	so	that	it	would	attract	foreign	venture	capital	
–the	question	is	how	do	we	bridge	that	gap	–	
and	I	want	to	share	with	you	two	specific	stories	that	
highlight	what	can	be	done:	
• 	when	I	was	at	Takeda,	I	was	approached	by	the	CSO	
of	Israel.		He	had	a	concerted	effort	to	bring	capital	
to	Israel	to	invest	in	life	sciences.	Over	a	period	of	six	
months,	we	dialogued	with	his	office	on	what	could	
be	done	and	how	Takeda	would	benefit.		He	was	
determined	to	make	something	happen	–	in	the	end,	
he	helped	broker	a	deal	between	Takeda,	Orbimed	–	
one	of	the	largest	global	healthcare	VC	funds	–	and	
Johnson	and	Johnson	–	the	three	of	us	made	a	
funding	commitment	to	a	ten	year	in	Israel.		We	
would	never	have	made	that	investment	without	the	
proactive	and	determined	outreach	of	the	Israeli	
govern
• You	met	Vassillis	Papakonstantinou	this	morning	
who	is	leading	a	similar	effort	to	spur	
entrepreneurship		in	Greece.		Vasillis	has	done	a	
great	job	of	finding	champions	of	the	effort	in	the	US	
who	are	helping	him	tap	into	the	greek	american	
business	community	willing	to	help	start	up	
companies	make	connections	–	with	potential	
investors	or	partners.		For	example,	the	greek	
consulate	in	Boston	has	hosted	several	events	aimed	
at	connecting	greek	entrepreneurs	with	greek	in	the	
area	who	are	willing	to	leverage	their	network	to	
help	these	starts	ups.	For	a	small	country,	Cyprus	has	
an	incredibly	successful	expatriate	community	
passionate	about	helping	the	island	succeed–	its	
huge	resource	and	we	need	to	find	a	concerted	
effort	to	channel	this	energy	into	helping	spur	
technological	entrepreneurship	in	Cyprus.		
	
• Beyond	tapping	into	the	expatriate	community,	
there	is	significant	wealth	within	the	island	that	
could	be	deployed	to	support	these	efforts.		Could	
we	rally	wealthy	individuals	into	contributing	to	a	
venture	fund?		Relatively	small	amounts	of	money	
put	against	the	type	of	great	technological	ideas	we
saw	this	morning	would	be	economically	productive	
creating	products	for	the	global	market	and	
employment	for	the	islands	highly	trained	youth.		
So	I	hope	this	meeting	does	become	a	call	to	action.		I	
know	that	we	can	make	this	happen!	
	
Anna	Protopapas,	
President	and	CEO	
Mersana	Therapeutics

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