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(Blood poisoning)
Presence of unfavorable toxins in
the blood stream
 Derived from bacteria
 Body cells
 Does not include;
Toxicity caused by toxic plants,
insects, organic and inorganic poisons
Etiology
Toxins
Antigenic Metabolic
Exotoxins
Endotoxins
Exotoxins
Protein substances produced by
bacterial growth out side the body
environment
Example
Black leg
Enterotoxaemia
Botulism
Endotoxins
Lipopolysachrides found in
bacterial cell wall
Example
E. coli
Salmonella
Conybacteria spp.
Metabolic toxins
 Accumulated due to the incomplete elimination
of toxic metabolites
 Normally eliminated from blood through urine,
feces or detoxified by the liver
Example
 Intestinal impaction: Results in autointoxication
of phenol, cresol, amines from intestines
Metabolic toxins
Example
 In hepatitis: Metabolites like glycine, cystene,
glucuronic acid, sulfuric acid are not detoxified by
the liver
 Body tissue damage, histamine and histamine
like substances
 Over eating of carbohydrate rich diet
Clinical signs
 Depression, lethargy, anorexia
 Separation from group
 Constipation occasionally diarrhea
 In antigenic toxemia, Inc: in body temp.
while in metabolic toxemia, sub normal
body temp.
 At terminal stages, muscular weakness,
Treatment
 Continuous fluid and electrolytes
therapy
 Antibiotics
 Antipyretics
 Steroid therapy

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