Micro-Reactor Technology (MRT)
A continuous reactor system for intermediate and API synthesis
Temperature and pressure control
The small reactor volumes allow tight temperature control
and – if needed – an almost instantaneous temperature
jump of hundreds of degrees centigrade. A wide pressure
range can be easily used for chemical transformations. To
date the ranges explored extend from -60°C to +300°C
with pressures up to 100 bar / 1,450 psi. Extension of these
limits will be possible if deemed necessary.
Glass reactors tolerate a wide range of chemical
substances such as corrosive and acidic media.
A visual inspection of the reaction mixture and its ﬂow
characteristics allows prompt interaction with the system
during the set-up phase and later on.
The mobile modular units offer the possibility to be used at
both locations: lab & kilo-lab alike. The same equipment &
parameter set can thereby be used for both development of
the process and subsequent kg production. As a result no
‘scale-up effects’ are envisaged.
Just let it run a couple of hours and you get your kilogram
quantities. Quality attributes of the product remain identical
at lab and kilo-lab. Variability all along the runs is minimized.
Schema Siegfried Examples
a. Aromatic boronic acid
b. Metalorganic reaction (double de-protonation)
c. Pinacolato-dichloromethylborane formation
d. Demethylation of MeO-Aryl
e. Nitration of an aromatic system
f. Epoxide opening with ammonia
g. Multi-step sequence; deprotonation,
silylation, alkylation, hydrolysis
h. α-Alkylation of a carboxylic acid
i. O-Nitration of an aromatic alcohol
j. Mono-nitration of an aliphatic diol
Nitration of an aliphatic alcohol
k. Ammonolysis of an ester
l. Oxidation with hydrogen peroxide
The process can be monitored by temperature
probes and / or Raman probes as needed.
a. b. c. d. e. f.
O R R O
OH O R
Cl O R NH2
B(OH)2 Cl O OH
RO O NO2 OH
OR CO2H Ary OH HO OH CO2R
RHN CO2H HO ONO2
Ary ONO2 CONH2
O Alk (Cl) O
g. h. i. j. k. l.
Siegfried Micro-Reactor Technology (MRT)
MRT equipment allows reactions beyond the classical design:
high pressure, low-temperature, tightly deﬁned residence
times and hazardous intermediates are no longer obstacles for
To address such reaction challenges Siegfried has established a pro-
ject group, implementing MRT into its technology platform.
MRT is now offered at lab and pilot scale, providing Siegfried’s
customers with the opportunity to realize the various demanding
chemical transformations they need.
If you are interested in how using MRT technology could solve your
chemical reaction challenges and bring value for your particular
projects please contact:
Untere Brühlstrasse 4 to Zürich
4800 Zoﬁngen FRANCE Exit Zofingen
Switzerland Basel Zürich
+41 62 746 12 12 Olten to Berne
+41 62 746 12 58
Process Development Berne
A1 A12 A2