Updated Daphnicyclidins

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Updated Daphnicyclidins

  1. 1. Retrosynthesis of Daphnicyclidins Sivappa Rasapalli (Shiva) [email_address]
  2. 2. Daphnicyclidins
  3. 3. Retrosynthesis of Daphnicyclidins A,D and H
  4. 4. Corrections and suggestions Thanks to Stephen
  5. 5. Corrections and suggestions
  6. 6. Modification for A- by European Chemist <ul><li>here's a suggestion out-of-the-blue (not fully thought through!).Why not removing </li></ul><ul><li>the methyl stereogenic center on the piperidine portion and install a lactam carbonyl? </li></ul><ul><li>This way maybe an alkylation might be able to set it right. </li></ul><ul><li>Also, as you do so you could envisage reconnecting the OR- and this carbonyl to form a gamma-lactone which got opened by the nitrogen to form the indolizidine. </li></ul><ul><li>Then you'd have a simple gamma-lactone fragment to disassemble from the rest of the molecule + finish the sequence with the RCM! </li></ul><ul><li>This will have to be a bit developed, but what do you feel? </li></ul><ul><li>European Chemist May 25, 2007 9:53 AM </li></ul>
  7. 7. Your role? This PPT was just to highlight the importance of this project by pointing out to the contributions of couple of chemists to the research proposal that I had posted here! This 5 days old post would further evolve considering the potential out there! It could be of any of your proposals or you could propose some alternative to the posted ones or you could be some body to try them out in the lab!
  8. 8. You can be part of the team if you want to contribute to the success of this project by sharing the scientific talent and resources that you have. You never know your idea and your result might catalyze the discovery of something new. Science progresses by co-operation and collaboration; this is an experiment in that direction in an open fashion. Do you want to be part of it ? U r welcome!

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