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2010 01 27 Surveying the ELN Landscape

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My talk from SMI ELN conference looking at the ELN landscape:
• Business drivers
- Comparing the different sectors and disciplines
• Build or buy?
• An overview of the solution space
• Patterns of success

Published in: Business, Technology

2010 01 27 Surveying the ELN Landscape

  1. 1. Surveying the ELN Landscape Simon Coles CTO & Co-Founder, Amphora Research Systems
  2. 2. http://www.amphora-research.com/ My blog: http://elnblog.com 2
  3. 3. Copies of these slides http://www.amphora-research.com/ My blog: http://elnblog.com 2
  4. 4. About Amphora • Started in ELNs in 1996 • Globally deployed, fully electronic ELN for Kodak • Grew from there... • Now work with large & small companies • Biotechs, Pharma, Chemicals http://www.amphora-research.com/ My blog: http://elnblog.com 3
  5. 5. Some people we work with http://www.amphora-research.com/
  6. 6. Some people we work with http://www.amphora-research.com/
  7. 7. What we do • Patent Evidence Creation & Preservation • Make lawyers happy • Which means you can make scientists happy http://www.amphora-research.com/ My blog: http://elnblog.com 5
  8. 8. What we do • Sometimes our stuff is used... • Standalone • In conjunction with other “ELN” products • With in house systems http://www.amphora-research.com/ My blog: http://elnblog.com 6
  9. 9. Why me? • We do the Patent Evidence problem • You still need to make the scientists happy • So we get a ring-side seat on some of these problems • We cross all the different ELN industries http://www.amphora-research.com/ My blog: http://elnblog.com 7
  10. 10. ELN Landscape • Business drivers - comparing the different sectors and disciplines • Build or buy? • An overview of the solution space • Patterns of success http://www.amphora-research.com/ My blog: http://elnblog.com 8
  11. 11. Why? • Why do we care about the ELN landscape? • Because it helps us all communicate • Perspective on the lessons learned in other areas http://www.amphora-research.com/ My blog: http://elnblog.com 9
  12. 12. The “ELN” Word • Very ambiguous • Probably best if you didn’t use it • Say what you mean http://www.amphora-research.com/ My blog: http://elnblog.com 10
  13. 13. What do you mean? • The term “ELN” means different things to different people • Somewhere the scientists will work • A Patent Evidence system (& long term record) http://www.amphora-research.com/ My blog: http://elnblog.com 11
  14. 14. What is an ELN? Corporate aspects (Records, IP protection, Sharing) Medicinal Chemistry Process Chemistry Molecular Biology Pharmacology Etc. http://www.amphora-research.com/ My blog: http://elnblog.com 12
  15. 15. Patent Evidence • Typically this is a broad, thin layer • Consistently applied across the whole company • Keep it out of the scientific systems • Single, well defined place • Under the control of Custodian http://www.amphora-research.com/ My blog: http://elnblog.com 13
  16. 16. Patent Evidence • Typically this is a broad, thin layer • Consistently applied across the whole company • Keep it out of the scientific systems • Single, well defined place • Under the control of Custodian http://www.amphora-research.com/ My blog: http://elnblog.com 13
  17. 17. Industry/Company Type • Life Sciences • Biotech or Pharma • Biology Vs Chemistry • Diverse Chemicals http://www.amphora-research.com/ My blog: http://elnblog.com 14
  18. 18. Biotech Vs Pharma • Pharma tend to be much more “Mature” organisations • Everything is done in an Enterprise Way • Often have a large amount of established code • Instincts are to buy, but have the resources to build • Biotech can be much lighter on their feet • Simpler problems • Smaller, younger organisations • Instinct is to build for competitive advantage, management often to buy http://www.amphora-research.com/ My blog: http://elnblog.com 15
  19. 19. Differences that make a Difference • There are 2 key aspects which impact the character of your ELN implementation • Regulated Vs Unregulated • Industry http://www.amphora-research.com/ My blog: http://elnblog.com 16
  20. 20. Regulated or not? • If you are regulated, chances you are talking about process automation, enforcement, and compliance • This isn’t easy, but it is • Relatively unambiguous • Fairly well mapped already http://www.amphora-research.com/ My blog: http://elnblog.com 17
  21. 21. ELNs in a Regulated Area • The functions of a “Notebook” will often be done electronically by something else • It won’t be called an “Electronic Lab Notebok” • Mixing regulated none regulated generally makes life unbearably exciting http://www.amphora-research.com/ My blog: http://elnblog.com 18
  22. 22. Chemistry Vs Biology • In Life Sciences, the biggest distinction is between Chemists and Biologists http://www.amphora-research.com/ My blog: http://elnblog.com 19
  23. 23. Chemistry • Chemistry is pretty structured • Buy (or build) them a Chemistry-centric ELN and let them get on with it • The selection process is detailed but at least the work relatively consistently http://www.amphora-research.com/ My blog: http://elnblog.com 20
  24. 24. Sources of Chemistry ELNs • If you’re a big pharma, you’re probably already set • With varying success - this isn’t easy • Solutions • Buy off the shelf • Build from what you have • Vendor capture http://www.amphora-research.com/ My blog: http://elnblog.com 21
  25. 25. Sources of Chemistry • In Biotechs, you probably can’t afford to build or do vendor capture • Unless Cheminformatics is a core strength • So you’re going to have do as much as you can with off-the-shelf (customised as needed) • Nice selection of vendors, have fun! http://www.amphora-research.com/ My blog: http://elnblog.com 22
  26. 26. Biology • Massive diversity • Lots of Microsoft Office and other “non ELN” applications • Best approach is to get out of their way http://www.amphora-research.com/ My blog: http://elnblog.com 23
  27. 27. Biology-specific ELNs • There are some biology-specific ELNs • Rely on the construction of templates for each area • Work well for very structured areas • Hard to deploy over a large area because of diversity • Quickly run into the “You’ve just made Excel harder to use” problem http://www.amphora-research.com/ My blog: http://elnblog.com 24
  28. 28. Examples • Biology in Janssen (IQPC Brussels 2007) • Really good example of in-depth analysis of process • 98% approval rate on a project that size is pretty stunning http://www.amphora-research.com/ My blog: http://elnblog.com 25
  29. 29. Small/Medium Chemicals • Lots of point solutions • Rarely have the money do to anything other than implement an off-the-shelf package in a small area • Relatively simple problem • Significant successes in certain cases http://www.amphora-research.com/ My blog: http://elnblog.com 26
  30. 30. Large Chemicals • Somewhat boring places you may or may not have heard of • But employ 1,000 of scientists and make most of the fun stuff in your house and car • e.g. companies like Kodak, BASF, PPG, Milliken, USG, etc. http://www.amphora-research.com/ My blog: http://elnblog.com 27
  31. 31. Large Chemicals • Massive diversity • R&D is typically very close to the customer • Tight timescales • Low tolerance for “non-value add” activities • Not as much “Chemistry” as you’d think http://www.amphora-research.com/ My blog: http://elnblog.com 28
  32. 32. Large Chemicals • The ELN project will “Open the can of worms” in terms of • The tools people are using • The records they are creating • The patent evidence that is generated http://www.amphora-research.com/ My blog: http://elnblog.com 29
  33. 33. General Purpose ELNs • “You all use the same Paper notebook don’t you?” • “So surely you can all use the same Electronic notebook?” http://www.amphora-research.com/ My blog: http://elnblog.com 30
  34. 34. General Purpose ELNs • You can do it for small numbers of users and certain styles of work • Where workflow is important • For large numbers of users • The diversity in process will kill you • You end up building an expensive version of Word & Excel http://www.amphora-research.com/ My blog: http://elnblog.com 31
  35. 35. General Purpose ELNs Functionality Number of users http://www.amphora-research.com/ My blog: http://elnblog.com 32
  36. 36. General Purpose ELNs Functionality Possible Number of users http://www.amphora-research.com/ My blog: http://elnblog.com 32
  37. 37. General Purpose ELNs Functionality Possible Possible Number of users http://www.amphora-research.com/ My blog: http://elnblog.com 32
  38. 38. General Purpose ELNs Functionality Possible Doomed to fail The organisation will frustrate you Possible Number of users http://www.amphora-research.com/ My blog: http://elnblog.com 32
  39. 39. Front end tools • Most organisations will end up providing different front ends to different users • Examples • BMS, Solvay, J&J, BASF, all the other large companies http://www.amphora-research.com/ My blog: http://elnblog.com 33
  40. 40. Patents • As a rule, what you need to do from a Patent perspective is pretty generic • You might have some specific needs, but 95% of what you need can be done off the shelf • This is one area where you want to stick with best practice and leave it alone http://www.amphora-research.com/ My blog: http://elnblog.com 34
  41. 41. Records Management • The Cinderella of ELN projects • Desperately important • Clearly something that’s dependent on your own processes http://www.amphora-research.com/ My blog: http://elnblog.com 35
  42. 42. Build or Buy? • I don’t believe there’s one true answer here • There’s a resurgence in components to allow a “Build” decision • e.g. Cheminformatics as a service • Decision will be down to • Internal capabilities • Degree of specialisation • Ultimately all project teams will be constructing an “ELN System” from components – whether they are called “ELN”s, or other lower-level parts http://www.amphora-research.com/ My blog: http://elnblog.com 36
  43. 43. Conclusions • Our original question • Some thoughts http://www.amphora-research.com/ My blog: http://elnblog.com 37
  44. 44. Our Questions • What’s the differences that make a difference? • What simple things can you do to increase your chance of success? http://www.amphora-research.com/ My blog: http://elnblog.com 38
  45. 45. Differences • Life Sciences Vs Everyone else • In Life Sciences • Biology Vs Chemistry • Biotech-ish Vs Pharma-ish • Regulated or not? http://www.amphora-research.com/ My blog: http://elnblog.com 39
  46. 46. Beware the ELN word • Say what you mean • Expect different front ends to support different work http://www.amphora-research.com/ My blog: http://elnblog.com 40
  47. 47. Changing the world • Unless you have been specifically charged with changing the workflow • Don’t pick the fight • You’re there to support the science • Today and in the future http://www.amphora-research.com/ My blog: http://elnblog.com 41
  48. 48. Conclusions • They’ve probably already got what they need anyway • Or a very good idea of what they need • That’s why they asked for an ELN in the first place http://www.amphora-research.com/ My blog: http://elnblog.com 42
  49. 49. Conclusion • If you are charged with changing the workflow • That’s your project, not “ELN” or whatever • Try to keep the scope as small as possible • Size and diversity will kill you http://www.amphora-research.com/ My blog: http://elnblog.com 43
  50. 50. Patent Evidence • Stick with best practice unless you really know what you are doing • One single system http://www.amphora-research.com/ My blog: http://elnblog.com 44
  51. 51. Conclusion • Chemistry - buy, or build, the best you can • Biology - get out of their way • Large chemicals - you’ll never fully understand everything in detail http://www.amphora-research.com/ My blog: http://elnblog.com 45
  52. 52. Thank You • Slides will be on our web site tonight • Any questions? http://www.amphora-research.com/ My blog: http://elnblog.com 46

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